Bone Health title image

Bone Health

Joint & Structural Health

Bones provide the framework for movement, protect vital structures, and act as a store of minerals used throughout the body. They are living tissue that is continually maintained and renewed. Supporting bone health therefore involves both the strength of the skeleton and the nutritional processes that help sustain it. Minerals provide much of bone’s hardness, while a protein framework contributes to its structure. Vitamin D, vitamin K, and other nutrients have distinct roles in the normal processes involved in bone maintenance. Considering those roles together helps create a balanced approach that reflects your dietary intake and individual needs. Bone health also connects with the muscle strength and balance that make movement feel confident and controlled. Your priorities may change across adulthood or with a shift in activity or nutritional intake. A focused routine brings these considerations together and supports a long-term view of skeletal health and everyday mobility.

Warnings

  • Review calcium and vitamin D totals: Excess intake can cause problems, including raised blood calcium in some circumstances. A history of kidney stones or relevant medical conditions warrants individual advice before adding higher-dose products.
  • Vitamin K and warfarin: If you take warfarin, discuss vitamin K supplements and substantial dietary changes with your care team. Consistent intake and appropriate monitoring matter; do not adjust either treatment on your own.
  • Minerals can affect medicine absorption: Calcium, magnesium, iron, and other minerals can interfere with the absorption of certain medicines. Ask a pharmacist about the specific combination and timing instead of applying one spacing rule to every product.
  • Kidney disease changes supplement safety: Kidney function affects how the body handles several minerals and other ingredients. Seek individual advice before adding products, especially potassium or magnesium, if you have kidney disease or relevant medicines.
Ingredient overview

Goal guidance

Lifestyle changes

Include weight-bearing activity, strength work, and balance practice suited to your ability. Build up gradually and make your everyday surroundings supportive of safe, confident movement.

Diet changes

Include calcium-containing foods and adequate protein within a varied diet. Consider vitamin D and other nutritional needs alongside your usual intake and any individual guidance.

Who this is for

Adults supporting bone health through changing nutritional needs, reduced intake, or a focus on maintaining strength and mobility.

Who should be careful

Seek advice with kidney disease, kidney stones, high blood calcium, or medicines affected by minerals or vitamin K. Strontium requires particular review because it can affect bone-density measurements and differs from prescribed treatments.

Expected timeline

Bone health develops over months and years. Follow an appropriate assessment schedule while tracking shorter-term improvements in strength, balance, and consistent nutrient intake.

Common mistakes

Focusing on one mineral can overlook the wider needs of bone health. Account for food sources, vitamin D, activity, and overlapping amounts across supplements.

Ingredients

Calcium Minerals
Impact
Highest effect
Typical dose500–1200 mg / day
Calcium is the most abundant mineral in the body, with over 99% stored in the skeleton. It serves as the main building block for bone tissue. Adequate intake is crucial to achieve peak bone mass during youth and to minimize bone loss with age.

Study evidence

144 studies

Calcium is essential for bones, and increasing intake can modestly improve bone density in some groups. Supplements do not consistently prevent fractures; benefits depend on context, and evidence for calcium combined with vitamin D cannot be attributed to calcium alone.

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Magnesium Minerals
Impact
Highest effect
Typical dose200–450 mg / day
Magnesium is a vital cofactor in over 300 enzymatic reactions, including those essential for bone formation. It helps regulate calcium transport and is required for the proper function of the parathyroid hormone, which controls bone breakdown. Deficiency can lead to impaired bone crystal formation.

Study evidence

48 studies

Magnesium status is associated with bone health, but supplementation has not consistently been shown to strengthen bones or prevent fractures. Findings vary, and favourable associations with bone density do not necessarily translate into lower fracture risk.

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Phosphorus Minerals
Impact
Highest effect
Typical dose500–1000 mg / day
Phosphorus works with calcium to form the mineral structure of bone. Dietary deficiency is rare, and excess intake can disrupt calcium balance, so supplementation is generally less relevant than maintaining an adequate dietary intake.

Study evidence

44 studies

Phosphorus is essential for bone mineralization, but extra supplementation has not been shown to strengthen bones generally. Its effects depend on calcium intake, kidney function, and phosphorus status; both inadequate availability and excessive phosphorus exposure can be relevant to bone problems.

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Vitamin D Vitamins
Impact
Highest effect
Typical dose20–100 mcg / day
Without sufficient Vitamin D, the body cannot effectively absorb calcium from the diet, rendering calcium intake less effective. It is a critical hormone-like vitamin that directly regulates calcium and phosphorus homeostasis, which is fundamental to bone mineralization and maintaining density.

Study evidence

202 studies

Vitamin D is essential for bone mineralization, but extra supplementation does not reliably strengthen bones in people with adequate status. The clearest supplied fracture benefits involve Vitamin D combined with calcium in older adults; high-dose supplementation can reduce bone density.

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Vitamin K Vitamins
Impact
Highest effect
Typical dose90–400 mcg / day
Specifically, Vitamin K2 (menaquinone) is critical for directing calcium into the bones and teeth and away from soft tissues like arteries. It activates osteocalcin, a protein that incorporates calcium into bone, and Matrix Gla Protein (MGP), which prevents vascular calcification.

Study evidence

78 studies

Vitamin K helps activate proteins involved in bone mineralization, and supplements may improve some bone-density measures, particularly in postmenopausal women. However, clinical results are inconsistent, and changes in these proteins do not reliably translate into stronger bones or fewer fractures.

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Boron Minerals
Impact
High effect
Typical dose1–6 mg / day
Boron is a trace mineral that has a significant impact on bone metabolism. It influences the production and activity of steroid hormones, including estrogen and testosterone, which are important for maintaining bone density in both men and women.

Study evidence

5 studies

Boron influences mineral metabolism, which may be relevant to bone health, but the available research does not establish stronger bones or fewer fractures from supplementation. Findings mostly concern mineral handling and vary with magnesium intake, rather than demonstrating a consistent bone-density benefit.

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Studies

Explore published research for this goal.

Sources

Up to five highest-ranked published examples per ingredient. Study counts and charts include all published studies for the connection.

  1. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledCalcium
  2. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsCalcium
  3. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsCalcium
  4. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsCalcium
  5. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsCalcium
  6. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledMagnesium
  7. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledMagnesium
  8. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsMagnesium
  9. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewMagnesium
  10. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsMagnesium
  11. Dairy product consumption, eating habits, sedentary behaviour and physical activity association with bone mineral density among adolescent boys: a cross-sectional observational study.
    Kopiczko A; Czapla M; Juárez-Vela R; Ross C; Uchmanowicz B · BMC pediatrics · 2024
    Cross-sectional study115 participantsPhosphorus
  12. Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial.
    Insogna KL; Rauch F; Kamenický P; Ito N; Kubota T; Nakamura A; Zhang L; Mealiffe M; San Martin J; Portale AA · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Single-arm trial14 participantsPhosphorus
  13. Early high calcium and phosphorus intake by parenteral nutrition prevents short-term bone strength decline in preterm infants.
    Pereira-da-Silva L; Costa A; Pereira L; Filipe A; Virella D; Leal E; Moreira A; Rosa M; Mendes L; Serelha M · Journal of pediatric gastroenterology and nutrition · 2011
    Randomized trialPhosphorus
  14. Phosphate Metabolism in Health and Disease.
    Peacock M · Calcified tissue international · 2021
    Narrative reviewPhosphorus
  15. Expert consensus on clinical management of metabolic bone disease of prematurity (2021).
    Yan-Mei C; Xin-Zhu L; Rong Z; Xi-Hong L; Xiao-Mei T; Ping-Yang C; Zhi-Chun F; Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association; Neonatal Nutrition and Health Management Group, Professional Committee of Child Health, Chinese Medical Doctor Association; Editorial Committee of Chinese Journal of Contemporary Pediatrics. · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Guideline / consensusPhosphorus
  16. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsVitamin D
  17. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewVitamin D
  18. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledVitamin D
  19. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsVitamin D
  20. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsVitamin D
  21. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledVitamin K
  22. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsVitamin K
  23. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsVitamin K
  24. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledVitamin K
  25. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsVitamin K
  26. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBoron
  27. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBoron
  28. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBoron
  29. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBoron
  30. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBoron
  31. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
    Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
    Randomized trial51 participantsCollagen
  32. Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
    Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Randomized trialCollagen
  33. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
    Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
    Randomized trial39 participantsCollagen
  34. Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
    Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
    Methods validation study189 participantsCollagen
  35. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
    Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
    Randomized trial51 participantsCollagen
  36. The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.
    Ju Y; Xiong W; Pang Y; Chen Z; Hou J; Zheng S; Li Z; Liu T; Xia H; Xia M; Zhong Y; Li J; Jiang X · Biological trace element research · 2026
    Scoping review18 studies pooledCopper
  37. Association between dietary copper, iron, zinc, selenium intake and osteopenia or osteoporosis in elderly hypertensive patients: a retrospective cohort study.
    Chen M; Jia L; Gao R · Frontiers in nutrition · 2024
    Cohort study5,286 participantsCopper
  38. Associations of dietary copper intake with total bone mineral density and lumbar spine bone mineral density in American adults.
    Hu M; Wang Z; Li C; Zheng Y; Hu J · Medicine · 2025
    Cross-sectional studyCopper
  39. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsCopper
  40. Association between dietary copper intake and bone mineral density in children and adolescents aged 8-19 years: A cross-sectional study.
    Cui A; Yan J; Li H; Fan Z; Wei X; Wang H; Zhuang Y · PloS one · 2024
    Cross-sectional study6,965 participantsCopper
  41. Implantoplasty Versus Glycine Air Abrasion for the Surgical Treatment of Peri-implantitis: A Randomized Clinical Trial.
    Lasserre JF; Brecx MC; Toma S · The International journal of oral & maxillofacial implants · 2020
    Randomized trial31 participantsGlycine
  42. Amino Acid Intakes Are Associated With Bone Mineral Density and Prevalence of Low Bone Mass in Women: Evidence From Discordant Monozygotic Twins.
    Jennings A; MacGregor A; Spector T; Cassidy A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Cross-sectional study135 participantsGlycineLysine
  43. Type V osteogenesis imperfecta: a new form of brittle bone disease.
    Glorieux FH; Rauch F; Plotkin H; Ward L; Travers R; Roughley P; Lalic L; Glorieux DF; Fassier F; Bishop NJ · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2001
    Other3 participantsGlycine
  44. Associations of Dietary and Circulating Choline and Glycine With Bone Mineral Density: UK Biobank Analyses With Mendelian Randomization.
    Chen S; Lu R; Zhang Y; Li Y; Cao X; Yang H; Lin J · International journal of endocrinology · 2026
    Cross-sectional study18,769 participantsGlycine
  45. Metabolomic insights into amino acid signatures and pathways associated with osteoporosis in Iranian elderly population.
    Dehghanbanadaki H; Soltani A; Majidi Z; Rezaei-Tavirani M; Shafiee G; Ostovar A; Bandarian F; Najjar N; Larijani B; Nabipour I; Khashayar P; Fahimfar N; Razi F · Frontiers in medicine · 2025
    Cross-sectional study1,916 participantsGlycine
  46. Dietary L-lysine and calcium metabolism in humans.
    Civitelli R; Villareal DT; Agnusdei D; Nardi P; Avioli LV; Gennari C · Nutrition (Burbank, Los Angeles County, Calif.) · 1993
    Clinical trial75 participantsLysine
  47. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsManganese
  48. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewManganese
  49. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyManganese
  50. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsManganese
  51. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsManganese
  52. Human bone collagen synthesis is a rapid, nutritionally modulated process.
    Babraj JA; Smith K; Cuthbertson DJ; Rickhuss P; Dorling JS; Rennie MJ · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2005
    Methods validation study8 participantsProline
  53. Osteogenesis imperfecta: recent findings shed new light on this once well-understood condition.
    Basel D; Steiner RD · Genetics in medicine : official journal of the American College of Medical Genetics · 2009
    Narrative reviewProline
  54. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledVitamin C
  55. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledVitamin C
  56. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsVitamin C
  57. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsVitamin C
  58. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsVitamin C
  59. Increased incidence of fractures in middle-aged and elderly men with low intakes of phosphorus and zinc.
    Elmståhl S; Gullberg B; Janzon L; Johnell O; Elmståhl B · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 1999
    Cohort study6,576 participantsZinc
  60. Zinc Supplementation Increases Procollagen Type 1 Amino-Terminal Propeptide in Premenarcheal Girls: A Randomized Controlled Trial.
    Berger PK; Pollock NK; Laing EM; Chertin V; Bernard PJ; Grider A; Shapses SA; Ding KH; Isales CM; Lewis RD · The Journal of nutrition · 2016
    Randomized trial147 participantsZinc
  61. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth.
    Merialdi M; Caulfield LE; Zavaleta N; Figueroa A; Costigan KA; Dominici F; Dipietro JA · The American journal of clinical nutrition · 2004
    Randomized trial242 participantsZinc
  62. The effects of zinc supplementation on serum zinc, alkaline phosphatase activity and fracture healing of bones.
    Sadighi A; Roshan MM; Moradi A; Ostadrahimi A · Saudi medical journal · 2009
    Randomized trial60 participantsZinc
  63. Is Zinc an Important Trace Element on Bone-Related Diseases and Complications? A Meta-analysis and Systematic Review from Serum Level, Dietary Intake, and Supplementation Aspects.
    Ceylan MN; Akdas S; Yazihan N · Biological trace element research · 2021
    Meta-analysis40 studies pooledZinc
  64. Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009-2018.
    Wei H; Jin Z; Zhou L; Tang G; Chai S; Che X; Tan Y; Zeng W · Frontiers in endocrinology · 2025
    Cross-sectional study1,315 participantsFolate
  65. Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.
    Liu CT; Karasik D; Xu H; Zhou Y; Broe K; Cupples LA; Cpgm de Groot L; Ham A; Hannan MT; Hsu YH; Jacques P; McLean RR; Paul L; Selhub J; Trajanoska K; van der Velde N; van Schoor N; Kiel DP · The American journal of clinical nutrition · 2021
    Cohort study4,310 participantsFolate
  66. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health.
    Rondanelli M; Tartara A; Fossari F; Vecchio V; Faliva MA; Naso M; Perna S; Nichetti M; Peroni G · Current aging science · 2022
    Narrative review35,298 participants29 studies pooledFolateVitamin B6
  67. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
    Cagnacci A; Baldassari F; Rivolta G; Arangino S; Volpe A · Bone · 2004
    Cross-sectional study161 participantsFolate
  68. Dietary intake of folate, but not vitamin B2 or B12, is associated with increased bone mineral density 5 years after the menopause: results from a 10-year follow-up study in early postmenopausal women.
    Rejnmark L; Vestergaard P; Hermann AP; Brot C; Eiken P; Mosekilde L · Calcified tissue international · 2008
    Cohort study1,869 participantsFolate
  69. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.
    Jehle S; Hulter HN; Krapf R · The Journal of clinical endocrinology and metabolism · 2013
    Randomized trial201 participantsPotassium
  70. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.
    Frassetto L; Morris RC; Sebastian A · The Journal of clinical endocrinology and metabolism · 2005
    Randomized trial170 participantsPotassium
  71. Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
    Jehle S; Zanetti A; Muser J; Hulter HN; Krapf R · Journal of the American Society of Nephrology : JASN · 2007
    Randomized trial161 participantsPotassium
  72. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women.
    Moseley KF; Weaver CM; Appel L; Sebastian A; Sellmeyer DE · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013
    Randomized trial52 participantsPotassium
  73. Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives.
    He FJ; Marciniak M; Carney C; Markandu ND; Anand V; Fraser WD; Dalton RN; Kaski JC; MacGregor GA · Hypertension (Dallas, Tex. : 1979) · 2010
    Randomized trial42 participantsPotassium
  74. Evaluating the Protective Role of Vitamin A Supplementation in Periodontal Health: A Comprehensive Systematic Review and Meta-Analysis.
    Luca MM; Buzatu R; Bumbu BA · Journal of clinical medicine · 2024
    Meta-analysisVitamin A
  75. Dietary vitamin A intake and bone health in the elderly: the Rotterdam Study.
    de Jonge EA; Kiefte-de Jong JC; Campos-Obando N; Booij L; Franco OH; Hofman A; Uitterlinden AG; Rivadeneira F; Zillikens MC · European journal of clinical nutrition · 2016
    Cohort study5,288 participantsVitamin A
  76. Vitamin A and its dervatives effect on bone mineral density, a systematic review.
    Khojah Q; AlRumaihi S; AlRajeh G; Aburas A; AlOthman A; Ferwana M · Journal of family medicine and primary care · 2022
    Systematic review8 studies pooledVitamin A
  77. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study.
    Wang Q; Yu H; Kong Y · BMC musculoskeletal disorders · 2024
    Cross-sectional study1,536 participantsVitamin A
  78. Association of dietary consumption and serum levels of vitamin A and β-carotene with bone mineral density in Chinese adults.
    Chen GD; Zhu YY; Cao Y; Liu J; Shi WQ; Liu ZM; Chen YM · Bone · 2016
    Cohort study3,154 participantsVitamin A
  79. Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial.
    Enneman AW; Swart KM; van Wijngaarden JP; van Dijk SC; Ham AC; Brouwer-Brolsma EM; van der Zwaluw NL; Dhonukshe-Rutten RA; van der Cammen TJ; de Groot LC; van Meurs J; Lips P; Uitterlinden AG; Zillikens MC; van Schoor NM; van der Velde N · Calcified tissue international · 2016
    Randomized trial1,111 participantsVitamin B12
  80. Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women.
    McLean RR; Jacques PF; Selhub J; Fredman L; Tucker KL; Samelson EJ; Kiel DP; Cupples LA; Hannan MT · The Journal of clinical endocrinology and metabolism · 2008
    Cohort study1,002 participantsVitamin B12
  81. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans.
    Morris MS; Jacques PF; Selhub J · Bone · 2006
    Cross-sectional study1,550 participantsVitamin B12
  82. The role of B-vitamin intake, B-vitamin-rich dietary patterns, the B-vitamin deficiency index in bone mineral density among school-aged children.
    Tan L; Zhang Y; Cui N; Huang S; Weng S; Bao M; Jiang Y; Huang M; Yang X · Pediatric research · 2026
    Cross-sectional study1,026 participantsVitamin B12
  83. Hyperhomocysteinemia is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density.
    De Martinis M; Sirufo MM; Nocelli C; Fontanella L; Ginaldi L · International journal of environmental research and public health · 2020
    Cross-sectional study252 participantsVitamin B12
  84. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial.
    Brossfield AV; McMahon DJ; Fernando J; Omeragic B; Majeed R; Agarwal S; Sroga GE; Wang B; Vashishth D; Rubin MR · The Journal of clinical endocrinology and metabolism · 2025
    Randomized trial55 participantsVitamin B6
  85. Dietary B vitamin intake and risk of hip fracture: the Singapore Chinese Health Study.
    Dai Z; Wang R; Ang LW; Yuan JM; Koh WP · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Cohort study63,257 participantsVitamin B6
  86. Hip fracture patients may be vitamin B6 deficient. Controlled study of serum pyridoxal-5'-phosphate.
    Reynolds TM; Marshall PD; Brain AM · Acta orthopaedica Scandinavica · 1993
    Case-control study103 participantsVitamin B6
  87. Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls.
    Saito M; Fujii K; Marumo K · Calcified tissue international · 2006
    Case-control study50 participantsVitamin B6
  88. Effects of Curcumin on Bone Loss and Biochemical Markers of Bone Turnover in Patients with Spinal Cord Injury.
    Hatefi M; Ahmadi MRH; Rahmani A; Dastjerdi MM; Asadollahi K · World neurosurgery · 2018
    Non-randomized trial100 participantsCurcumin
  89. The Effect of Selected Herbal Medicines on Bone Turnover Markers: A Systematic Review and Meta-Analysis.
    Kheiridoost-Langaroodi H; Shakouri SK; Amirpour M; Iranshahi AM; Farshbaf-Khalili A · Journal of family & reproductive health · 2022
    Meta-analysis968 participants16 studies pooledCurcumin
  90. Efficacy of nanomicelle curcumin, Nigella sativa oil, and their combination on bone turnover markers and their safety in postmenopausal women with primary osteoporosis and osteopenia: A triple-blind randomized controlled trial.
    Kheiridoost H; Shakouri SK; Shojaei-Zarghani S; Dolatkhah N; Farshbaf-Khalili A · Food science & nutrition · 2023
    Randomized trial120 participantsCurcumin
  91. The Effect of Curcumin on Postmenopausal Symptoms: A Systematic Review Based on Randomized Controlled Trials.
    Akyakar B; Şahin İN; Ağagündüz D; Szép D; Budán F · International journal of molecular sciences · 2025
    Systematic review12 studies pooledCurcumin
  92. Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study.
    Riva A; Togni S; Giacomelli L; Franceschi F; Eggenhoffner R; Feragalli B; Belcaro G; Cacchio M; Shu H; Dugall M · European review for medical and pharmacological sciences · 2017
    Non-randomized trial57 participantsCurcumin
  93. Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study.
    Mei Z; Chen GC; Hu J; Lin C; Sun Z; Liu C; Geng X; Yuan C; Qi Q; Zheng Y · The American journal of clinical nutrition · 2021
    Cohort study492,713 participantsOmega-3
  94. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
    Matsuzaki K; Hossain S; Wakatsuki H; Tanabe Y; Ohno M; Kato S; Shido O; Hashimoto M · Phytotherapy research : PTR · 2023
    Randomized trial52 participantsOmega-3
  95. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans.
    Griel AE; Kris-Etherton PM; Hilpert KF; Zhao G; West SG; Corwin RL · Nutrition journal · 2007
    Randomized trial23 participantsOmega-3
  96. The Relationship Between Omega-3, Omega-6 and Total Polyunsaturated Fat and Musculoskeletal Health and Functional Status in Adults: A Systematic Review and Meta-analysis of RCTs.
    Abdelhamid A; Hooper L; Sivakaran R; Hayhoe RPG; Welch A; PUFAH Group · Calcified tissue international · 2020
    Meta-analysis7,288 participants28 studies pooledOmega-3
  97. Dietary intake of fish, n-3 polyunsaturated fatty acids and risk of hip fracture: A systematic review and meta-analysis on observational studies.
    Sadeghi O; Djafarian K; Ghorabi S; Khodadost M; Nasiri M; Shab-Bidar S · Critical reviews in food science and nutrition · 2019
    Meta-analysis292,657 participants10 studies pooledOmega-3
  98. The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study.
    Teughels W; Celik GU; Tarce M; De Cock I; Persyn SM; Haytac MC · BMC oral health · 2021
    Randomized trial21 participantsSilicon
  99. Calcium Phosphate Modified with Silicon vs. Bovine Hydroxyapatite for Alveolar Ridge Preservation: Densitometric Evaluation, Morphological Changes and Histomorphometric Study.
    Cadenas-Vacas G; Martínez-Rodríguez N; Barona-Dorado C; Sánchez-Labrador L; Cortés-Bretón Brinkmann J; Meniz-García C; Martínez-González JM · Materials (Basel, Switzerland) · 2021
    Non-randomized trialSilicon
  100. Silicon: a review of its potential role in the prevention and treatment of postmenopausal osteoporosis.
    Price CT; Koval KJ; Langford JR · International journal of endocrinology · 2013
    Narrative reviewSilicon
  101. Osteogenic Effect of a Bioactive Calcium Alkali Phosphate Bone Substitute in Humans.
    Knabe C; Adel-Khattab D; Rezk M; Cheng J; Berger G; Gildenhaar R; Wilbig J; Günster J; Rack A; Heiland M; Knauf T; Stiller M · Bioengineering (Basel, Switzerland) · 2023
    Clinical trial38 participantsSilicon
  102. Silicon and bone health.
    Jugdaohsingh R · The journal of nutrition, health & aging · 2007
    Narrative reviewSilicon