Highest effect
Coenzyme Q-10
Other
Impact
Highest effect
Typical dose:100–300 mg / day
Coenzyme Q10 (CoQ10) is a critical component of the mitochondrial electron transport chain, which generates cellular energy (ATP). The heart has a very high concentration of mitochondria and is highly dependent on CoQ10. Supplementation supports cardiac energy, improves heart function, and can help offset CoQ10 depletion caused by statin medications.
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Fish Oil
Fatty Acid
Impact
Highest effect
Typical dose:1000–4000 mg / day
Rich in the Omega-3 fatty acids EPA and DHA, which are integral to cell membranes throughout the body. They have extensive clinical evidence for improving lipid profiles (especially triglycerides), reducing systemic inflammation, and supporting endothelial function, which is critical for blood vessel health.
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Magnesium
Mineral
Impact
Highest effect
Typical dose:200–400 mg / day
Magnesium is a cofactor in hundreds of enzymatic reactions, including those vital for cardiovascular health. It helps maintain the electrical stability of heart cells, counteracts calcium to promote vasodilation (blood vessel relaxation), and improves insulin sensitivity, all of which contribute to a healthy cardiovascular system. Deficiency is common and linked to increased cardiovascular risk.
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Vitamin K
Vitamin
Impact
Highest effect
Typical dose:90–200 mcg / day
While often known for blood clotting (Vitamin K1), the K2 form (specifically MK-7) is vital for cardiovascular health. It activates proteins that inhibit calcium deposition in arterial walls, a key factor in atherosclerosis and arterial stiffening. This helps maintain blood vessel elasticity and function.
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High effect
Hawthorn
Botanical
Impact
High effect
Typical dose:300–1000 mg / day
Hawthorn extract has a long history of use and is supported by modern clinical trials for its positive effects on heart function. Its active compounds, including flavonoids and procyanidins, enhance coronary artery blood flow, improve the strength of the heart's contractions, and provide antioxidant protection to cardiac tissue.
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Psyllium fiber
Botanical
Impact
High effect
Typical dose:5–15 g / day
Psyllium is a viscous, soluble fiber that forms a gel in the intestines. This gel traps bile acids (which are made from cholesterol) and prevents their reabsorption, forcing the liver to pull more cholesterol from the bloodstream to produce new bile acids. This mechanism is a proven strategy for managing LDL cholesterol levels.
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Taurine
Amino Acid
Impact
High effect
Typical dose:500–3000 mg / day
Taurine is one of the most abundant amino acids in the heart. It plays a role in regulating calcium levels within heart cells, which is essential for proper contraction and rhythm. It also has antioxidant properties and supports the function of the endothelium, contributing to blood pressure regulation.
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Situational effect
Curcumin
Botanical
Impact
Situational effect
Typical dose:500–1500 mg / day
Curcumin, the active component of turmeric, is a potent inhibitor of inflammatory pathways, such as NF-kappaB. Chronic inflammation is a key driver of cardiovascular disease. Curcumin helps protect the endothelium (the lining of blood vessels) and reduces oxidative damage. Standard curcumin has poor bioavailability; effectiveness is highly dependent on using an enhanced-absorption formula (e.g., with piperine or phytosomes).
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Green Tea
Botanical
Impact
Situational effect
Typical dose:400–800 mg / day
The catechins in green tea, especially epigallocatechin gallate (EGCG), have been shown to improve the flexibility of blood vessels and reduce oxidative stress. This supports healthy blood pressure and circulation. It also has mild benefits for lipid profiles, making it a good overall supportive supplement.
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Resveratrol
Botanical
Impact
Situational effect
Typical dose:150–500 mg / day
Resveratrol is a polyphenol that has been shown to activate SIRT1, a gene associated with longevity and metabolic health. It enhances nitric oxide production, which supports vasodilation, and its antioxidant properties help mitigate the oxidative stress that can damage blood vessel linings.
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