Highest effect
Milk Thistle
Botanical
Impact
Highest effect
Typical dose:150–450 mg / day
The active compound, Silymarin, protects liver cells from damage by stabilizing their membranes and scavenging free radicals produced during Phase I detoxification. It also stimulates liver cell regeneration, ensuring the organ maintains optimal function under metabolic stress.
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Molybdenum
Mineral
Impact
Highest effect
Typical dose:50–150 mcg / day
Molybdenum is crucial for the final step in metabolizing sulfur-containing amino acids. A deficiency can lead to an accumulation of toxic sulfites, causing neurological issues and other sensitivities. This makes it a key player in a specific but important detoxification pathway.
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Selenium
Mineral
Impact
Highest effect
Typical dose:55–200 mcg / day
Without adequate selenium, the body cannot effectively utilize and regenerate its primary antioxidant, glutathione. This mineral is critical for quenching free radicals generated during detoxification and for metabolizing certain heavy metals.
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Vitamin B6
Vitamin
Impact
Highest effect
Typical dose:25–100 mg / day
Vitamin B6 (along with Folate and B12) is required for homocysteine metabolism, a process linked to both methylation and the production of cysteine for glutathione. Adequate B6 ensures these vital liver pathways run efficiently to neutralize hormones and toxins.
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High effect
Choline
Vitamin
Impact
High effect
Typical dose:250–1000 mg / day
Choline is a key component of VLDL particles, which are necessary to export triglycerides from the liver. A deficiency can lead to non-alcoholic fatty liver disease (NAFLD), severely compromising the liver's ability to perform its metabolic and detoxification functions.
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Curcumin
Botanical
Impact
High effect
Typical dose:500–1000 mg / day
Curcumin, especially in a bioavailable form (e.g., combined with piperine), activates the Nrf2 genetic pathway. This pathway switches on the production of numerous protective enzymes, including those involved in glutathione synthesis and conjugation, enhancing the body's overall detoxification capacity.
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Glycine
Amino Acid
Impact
High effect
Typical dose:1000–3000 mg / day
The liver uses glycine to conjugate (bind to) and neutralize specific toxins, such as salicylates and benzoate preservatives. It is a key amino acid for ensuring the body can process a wide range of common chemical exposures.
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Taurine
Amino Acid
Impact
High effect
Typical dose:500–2000 mg / day
Taurine is used in a Phase II conjugation pathway to create bile salts. Healthy bile flow is critical for carrying toxins from the liver into the gut for excretion. Taurine also possesses antioxidant properties, further protecting liver cells.
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Vitamin C
Vitamin
Impact
High effect
Typical dose:500–2000 mg / day
Vitamin C directly quenches free radicals generated during Phase I detoxification. High concentrations are found in the liver, where it supports enzyme function and helps protect against damage from alcohol, drugs, and other toxins.
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Zinc
Mineral
Impact
High effect
Typical dose:15–30 mg / day
Zinc is required for the enzyme alcohol dehydrogenase, which breaks down alcohol in the liver. Its role in SOD helps manage the high levels of oxidative stress generated by detoxification processes, protecting cellular structures.
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Situational effect
Activated Charcoal
Other
Impact
Situational effect
Typical dose:1000–5000 mg / day
This is not a systemic detoxifier but a highly effective gut-level intervention. Its porous surface adsorbs a wide range of substances, making it invaluable for cases of food poisoning or acute exposure to certain toxins. It should only be used situationally, not daily.
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Green Tea
Botanical
Impact
Situational effect
Typical dose:250–750 mg / day
The polyphenols in green tea support detoxification by neutralizing free radicals and potentially enhancing the function of certain Phase II enzymes like GST (glutathione S-transferase). This provides broad antioxidant protection and support for the liver's conjugation pathways.
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Psyllium fiber
Botanical
Impact
Situational effect
Typical dose:5–10 g / day
The liver packages many toxins into bile, which is then released into the gut. Soluble fiber like psyllium creates a gel-like substance that traps this bile, carrying it out in the stool. This interrupts the enterohepatic circulation, which can otherwise allow toxins to be reabsorbed.
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