Productivity Boost title image

Productivity Boost

Mental & Cognitive Health

Productivity is the ability to turn attention and effort into useful progress on the work that matters to you. It involves getting started, staying engaged, processing information, and maintaining enough mental stamina to finish important tasks. A productive routine also leaves you able to recover and return with fresh attention. Different demands call for different kinds of support. A short, concentrated task may place more emphasis on alertness, while a long day can make sustained mental energy and resilience under pressure more relevant. Cognitive nutrients and targeted ingredients address different parts of these needs, so their purpose should be clear within the wider routine. The most helpful outcomes are connected to the work itself. Completing a priority task, making fewer distracted switches, or maintaining clarity through a demanding session can each be meaningful. Choosing support around those outcomes helps keep the focus on useful effort and a pace you can sustain.

Warnings

  • Count all stimulants: Count caffeine from drinks and supplements together. Review intake if you notice jitteriness, palpitations, anxiety, or disrupted sleep.
  • Review potent cognitive ingredients: Review compounds such as huperzine and vinpocetine individually for suitability and interactions. Agree any ongoing use with an appropriately qualified professional.
  • Check medicine interactions: Ask a pharmacist or clinician to review your exact products alongside your medicines. The ingredient, amount, and treatment determine which combinations are suitable.
  • Protect sleep when using stimulants: Choose stimulant timing and amounts that leave sleep intact. Review the routine if alertness comes with poorer recovery, anxiety, or next-day fatigue.
Ingredient overview

Goal guidance

Lifestyle changes

Give your day a short list of priorities and focused periods for the work that matters most. Take regular breaks and leave a clear transition from work into recovery.

Diet changes

Keep meals and fluids convenient during busy days. Use caffeine deliberately, accounting for drinks and supplements together, and choose timing that leaves sleep intact.

Who this is for

Adults managing demanding work or study who want support for concentration, mental stamina, and performance under pressure.

Who should be careful

Check stimulants with medicines affecting attention, mood, heart rate, or blood pressure. Anxiety and sleep difficulties can affect suitability; huperzine and vinpocetine need more specific review.

Expected timeline

Some alertness effects are noticeable during a work session. Assess the wider routine through completed tasks, sustained attention, and how well you recover at the end of the day.

Common mistakes

More hours and more stimulants do not always produce better work. Set priorities, create focused work periods, and leave enough room for sleep and recovery.

Ingredients

Creatine Other Nutrients
Impact
Highest effect
Typical dose3000–5000 mg / day
Creatine plays a crucial role in recycling ATP, the primary energy currency of the cell. The brain is highly energy-demanding, and supplementing with creatine increases phosphocreatine stores, enhancing cognitive processing, memory, and resistance to mental fatigue.

Study evidence

16 studies

Creatine may modestly improve memory and some aspects of mental performance, especially under demanding conditions, but results in healthy adults are inconsistent. The available research does not establish that these effects translate into greater everyday productivity or better overall thinking ability.

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Iron Minerals
Impact
Highest effect
Typical dose18–45 mg / day
Iron is a critical component of hemoglobin, which carries oxygen to the brain. Even mild deficiency can impair energy levels, concentration, and overall cognitive performance. Ensuring adequate iron status is foundational for brain energy and productivity.

Study evidence

69 studies

Iron can improve physical work capacity and reduce fatigue when low iron status or iron-deficiency anemia limits performance. Cognitive benefits are less consistent, and the supplied evidence does not establish that extra iron boosts productivity in people whose iron status is already adequate.

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Magnesium Minerals
Impact
Highest effect
Typical dose200–400 mg / day
Magnesium is a cofactor in hundreds of enzymatic reactions vital for brain health. It regulates neurotransmitters like glutamate and GABA, supports learning and memory, and helps manage the body's stress response, all of which are crucial for sustained productivity.

Study evidence

10 studies

Magnesium shows some promise for perceived daytime functioning in people with sleep difficulties, but direct evidence for increased productivity is limited. The research does not establish lasting improvements in everyday work output or task completion.

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Omega-3 Fatty Acids
Impact
Highest effect
Typical dose1000–3000 EPA+DHA mg / day
Omega-3 fatty acids, particularly DHA, are a primary structural component of brain cells and neuronal membranes. Adequate levels are critical for neurotransmitter function, reducing neuroinflammation, and supporting memory and learning. EPA contributes to these effects and also supports mood.

Study evidence

46 studies

Omega-3 may improve selected memory, attention or mental-speed measures, but research is inconsistent and many trials find no benefit. These cognitive findings do not establish a reliable productivity boost, and favorable associations with fish intake are not proof that supplements improve work performance.

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Vitamin B12 Vitamins
Impact
Highest effect
Typical dose500–2500 mcg / day
Vitamin B12 is essential for converting food into usable energy (ATP) and for the synthesis of neurotransmitters. A deficiency, which is common, can directly lead to mental fog, poor concentration, and fatigue, making adequate levels foundational for productivity.

Study evidence

24 studies

Vitamin B12 has not been shown to reliably boost everyday productivity in people with adequate nutritional status. Some nutrient combinations improve laboratory task performance or mental fatigue, but their effects cannot be assigned to B12 alone, and findings about low B12 do not establish enhancement benefits.

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Vitamin B12 Vitamins
Impact
Highest effect
Typical dose500–2500 mcg / day
Vitamin B12 is essential for converting food into usable energy (ATP) and for the synthesis of neurotransmitters. A deficiency, which is common, can directly lead to mental fog, poor concentration, and fatigue, making adequate levels foundational for productivity.

Study evidence

24 studies

Vitamin B12 has not been shown to reliably boost everyday productivity in people with adequate nutritional status. Some nutrient combinations improve laboratory task performance or mental fatigue, but their effects cannot be assigned to B12 alone, and findings about low B12 do not establish enhancement benefits.

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Studies

Explore published research for this goal.

Sources

Up to five highest-ranked published examples per ingredient. Study counts and charts include all published studies for the connection.

  1. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation.
    Turner CE; Byblow WD; Gant N · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Randomized trial15 participantsCreatine
  2. Creatine supplementation and cognitive performance in elderly individuals.
    McMorris T; Mielcarz G; Harris RC; Swain JP; Howard A · Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2008
    Randomized trial32 participantsCreatine
  3. The effects of creatine supplementation on cognitive performance-a randomised controlled study.
    Sandkühler JF; Kersting X; Faust A; Königs EK; Altman G; Ettinger U; Lux S; Philipsen A; Müller H; Brauner J · BMC medicine · 2023
    Randomized trial123 participantsCreatine
  4. Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation.
    Gordji-Nejad A; Matusch A; Kleedörfer S; Jayeshkumar Patel H; Drzezga A; Elmenhorst D; Binkofski F; Bauer A · Scientific reports · 2024
    Randomized trialCreatine
  5. Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal.
    Hammett ST; Wall MB; Edwards TC; Smith AT · Neuroscience letters · 2010
    Non-randomized trialCreatine
  6. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials.
    Low M; Farrell A; Biggs BA; Pasricha SR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014
    Meta-analysis7,089 participants32 studies pooledIron
  7. Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial.
    Murray-Kolb LE; Wenger MJ; Scott SP; Rhoten SE; Lung'aho MG; Haas JD · The Journal of nutrition · 2017
    Randomized trial150 participantsIron
  8. Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China.
    Li R; Chen X; Yan H; Deurenberg P; Garby L; Hautvast JG · The American journal of clinical nutrition · 1994
    Randomized trial80 participantsIron
  9. The Effect of Iron-Fortified Lentils on Blood and Cognitive Status among Adolescent Girls in Bangladesh.
    Barnett AL; Wenger MJ; Yunus FM; Jalal C; DellaValle DM · Nutrients · 2023
    Randomized trial359 participantsIron
  10. Daily iron supplementation for improving anaemia, iron status and health in menstruating women.
    Low MS; Speedy J; Styles CE; De-Regil LM; Pasricha SR · The Cochrane database of systematic reviews · 2016
    Meta-analysis8,506 participants67 studies pooledIron
  11. Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.
    Tao MH; Chuang SC; Wu IC; Chan HT; Cheng CW; Chen HL; Lee MM; Chang HY; Hsiung CA; Hsu CC · European journal of nutrition · 2024
    Cohort study5,663 participantsMagnesium
  12. Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients.
    Tu X; Qiu H; Lin S; He W; Huang G; Zhang X; Wu Y; He J · Neuropsychiatric disease and treatment · 2022
    Cohort study327 participantsMagnesium
  13. The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial.
    Lopresti AL; Smith SJ · Frontiers in nutrition · 2026
    Randomized trial100 participantsMagnesium
  14. Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
    Lai XN; Sadhwani V; Ng WM; Gani A · Cureus · 2025
    Cohort study667 participantsMagnesium
  15. Magnesium Depletion Score as a Novel Predictor of Cognitive Impairment: A Population-Based Cross-Sectional Study From NHANES.
    Chen M; Xue R; Zhang M; Zhang J; Zheng J; Ye D; Sun J · Journal of the American Medical Directors Association · 2025
    Cross-sectional study2,768 participantsMagnesium
  16. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial.
    Stonehouse W; Conlon CA; Podd J; Hill SR; Minihane AM; Haskell C; Kennedy D · The American journal of clinical nutrition · 2013
    Randomized trial176 participantsOmega-3
  17. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study.
    Nilsson A; Radeborg K; Salo I; Björck I · Nutrition journal · 2013
    Randomized trial40 participantsOmega-3
  18. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials.
    Patan MJ; Kennedy DO; Husberg C; Hustvedt SO; Calder PC; Khan J; Forster J; Jackson PA · The American journal of clinical nutrition · 2021
    Randomized trial310 participantsOmega-3
  19. Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8-12 years old malnourished Mexican children: a randomized, double-blind, placebo and treatment clinical trial.
    Portillo-Reyes V; Pérez-García M; Loya-Méndez Y; Puente AE · Research in developmental disabilities · 2014
    Randomized trial59 participantsOmega-3
  20. Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults: 25 y of follow up.
    Mao X; Chen C; Xun P; Daviglus M; Steffen LM; Jacobs DR; Van Horn L; Sidney S; Zhu N; He K · Nutrition (Burbank, Los Angeles County, Calif.) · 2020
    Cohort study3,231 participantsOmega-3
  21. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsVitamin B12Vitamin B12
  22. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisVitamin B12Vitamin B12Zinc
  23. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsVitamin B12Vitamin B12
  24. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsVitamin B12Vitamin B12
  25. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsVitamin B12Vitamin B12
  26. Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011-2014.
    Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
    Cross-sectional study2,421 participantsVitamin B6
  27. Effect of megavitamin treatment on mental performance and plasma vitamin B6 concentrations in mentally retarded young adults.
    Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
    Non-randomized trialVitamin B6
  28. Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
    Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
    Cohort studyVitamin B6
  29. Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
    Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
    Case-control study49 participantsVitamin B6
  30. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsVitamin B6
  31. Zinc supplementation improved cognitive performance and taste acuity in Indian adolescent girls.
    Tupe RP; Chiplonkar SA · Journal of the American College of Nutrition · 2010
    Randomized trial180 participantsZinc
  32. Linkages of biomarkers of zinc with cognitive performance and taste acuity in adolescent girls.
    Chiplonkar SA; Kawade R · International journal of food sciences and nutrition · 2015
    Cross-sectional study403 participantsZinc
  33. Associations Between Serum Selenium, Zinc, and Copper Levels and Cognitive Function in the Elderly.
    Charernwat P; Chansirikarnjana S; Panpunuan P; Sritara P; Sirivarasai J · Nutrients · 2025
    Cross-sectional study854 participantsZinc
  34. Comparative analysis of methyl-donor nutrient intakes and RCPM cognitive performance among school-aged children.
    Apprey C; Asamoah-Boakye O; Annaful VT; Annan RA · Clinical nutrition ESPEN · 2022
    Cross-sectional study2,073 participantsZinc
  35. Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial.
    Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
    Randomized trial62 participantsAcetyl L-CarnitineAcetyl L-Carnitine
  36. Treatment of dementia with neurotransmission modulation.
    Doggrell SA; Evans S · Expert opinion on investigational drugs · 2004
    Narrative reviewAlpha-GPC
  37. Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.
    Kerksick CM · Nutrients · 2024
    Randomized trial20 participantsAlpha-GPC
  38. Effects of caffeine on alertness.
    Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
    Randomized trial24 participantsCaffeine
  39. Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
    Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
    Randomized trial22 participantsCaffeine
  40. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
    Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
    Randomized trial68 participantsCaffeine
  41. A review of caffeine's effects on cognitive, physical and occupational performance.
    McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
    Narrative reviewCaffeine
  42. Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
    Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
    Meta-analysis7 studies pooledCaffeine
  43. Acute Cordyceps militaris supplementation and elevated resting oxygen uptake with faster reaction times: A randomized crossover trial
    Hamidreza Farzan, Maryam Koushkie Jahromi · PLOS ONE · 2026
    Randomized trial12 participantsCordycepsCordycepsCordyceps
  44. No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study.
    Schaffler K; Wolf OT; Burkart M · Pharmacopsychiatry · 2014
    Randomized trial144 participantsEleutheroEleuthero
  45. Effect of Huperzine A on Cognitive Function and Perception of Effort during Exercise: A Randomized Double-Blind Crossover Trial.
    Wessinger CM; Inman CL; Weinstock J; Weiss EP · International journal of exercise science · 2025
    Randomized trial15 participantsHuperzine
  46. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsRhodiola
  47. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsRhodiola
  48. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsRhodiola
  49. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
    Spasov AA; Wikman GK; Mandrikov VB; Mironova IA; Neumoin VV · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2000
    Randomized trialRhodiola
  50. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
    Ivanova Stojcheva E; Quintela JC · Molecules (Basel, Switzerland) · 2022
    Narrative reviewRhodiola
  51. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialTheanine
  52. Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
    Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
    Meta-analysis1,168 participants31 studies pooledTheanine
  53. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsTheanine
  54. Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
    Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
    Narrative reviewTheanine
  55. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
    Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
    Randomized trial48 participantsTheanine
  56. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
    Cheah KL; Norhayati MN; Husniati Yaacob L; Abdul Rahman R · PloS one · 2021
    Meta-analysis400 participants5 studies pooledAshwagandha
  57. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.
    Langade D; Thakare V; Kanchi S; Kelgane S · Journal of ethnopharmacology · 2021
    Randomized trial80 participantsAshwagandha
  58. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.
    Pingali U; Pilli R; Fatima N · Pharmacognosy research · 2014
    Randomized trial20 participantsAshwagandha
  59. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsAshwagandha
  60. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsAshwagandha
  61. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.
    Calabrese C; Gregory WL; Leo M; Kraemer D; Bone K; Oken B · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Randomized trial54 participantsBacopa
  62. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials.
    Pase MP; Kean J; Sarris J; Neale C; Scholey AB; Stough C · Journal of alternative and complementary medicine (New York, N.Y.) · 2012
    Systematic review6 studies pooledBacopa
  63. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial.
    Stough C; Downey LA; Lloyd J; Silber B; Redman S; Hutchison C; Wesnes K; Nathan PJ · Phytotherapy research : PTR · 2009
    Randomized trial107 participantsBacopa
  64. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.
    Kongkeaw C; Dilokthornsakul P; Thanarangsarit P; Limpeanchob N; Norman Scholfield C · Journal of ethnopharmacology · 2014
    Meta-analysis518 participants9 studies pooledBacopa
  65. An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performance.
    Downey LA; Kean J; Nemeh F; Lau A; Poll A; Gregory R; Murray M; Rourke J; Patak B; Pase MP; Zangara A; Lomas J; Scholey A; Stough C · Phytotherapy research : PTR · 2014
    Randomized trial24 participantsBacopa
  66. Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
    Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
    Meta-analysis782 participants4 studies pooledGinkgoGinkgo
  67. Dietary Flavonoids and Human Cognition: A Meta-Analysis.
    Cheng N; Bell L; Lamport DJ; Williams CM · Molecular nutrition & food research · 2022
    Meta-analysis5,519 participants80 studies pooledGinkgoGinkgo
  68. Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial.
    Gavrilova SI; Preuss UW; Wong JW; Hoerr R; Kaschel R; Bachinskaya N; GIMCIPlus Study Group · International journal of geriatric psychiatry · 2015
    Randomized trial160 participantsGinkgoGinkgo
  69. Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial.
    Cui M; You T; Zhao Y; Liu R; Guan Y; Liu J; Liu X; Wang X; Dong Q · Frontiers in pharmacology · 2023
    Randomized trial201 participantsGinkgoGinkgo
  70. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
    Le Bars PL; Katz MM; Berman N; Itil TM; Freedman AM; Schatzberg AF · JAMA · 1997
    Randomized trial309 participantsGinkgoGinkgo
  71. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.
    La Monica MB; Raub B; Ziegenfuss EJ; Hartshorn S; Grdic J; Gustat A; Sandrock J; Ziegenfuss TN · Nutrients · 2023
    Randomized trialHericium mushroom
  72. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.
    Grozier CD; Alves VA; Killen LG; Simpson JD; O'Neal EK; Waldman HS · International journal of exercise science · 2025
    Non-randomized trial24 participantsHericium mushroom