Skin Health title image

Skin Health

Skin, Hair & Vision

Healthy-looking skin combines a comfortable surface with the structure and moisture that help it feel supple and resilient. Hydration, elasticity, texture, and an even-looking complexion are related but distinct priorities. Understanding which one matters most to you helps give skin-focused nutrition a clear direction. The skin barrier helps retain moisture, while underlying tissues provide much of the skin’s firmness and flexibility. Nutrients contribute to normal renewal, collagen formation, and antioxidant protection. Targeted ingredients are used for different aspects of this support, which is why a hydration-focused formula may differ from one centered on structural tissues. The most useful routine complements the care your skin receives every day. Changes in comfort, the feel of dryness, or the appearance of new growth and surface texture can each be worth following. Keeping your main priority clear makes it easier to assess progress consistently and choose support that fits your skin.

Warnings

  • Review vitamin A carefully: Excess preformed vitamin A can be harmful and needs particular caution during pregnancy or with retinoid medicines. Oral vitamin A is not interchangeable with a topical skin treatment.
  • Keep sun protection central: Antioxidant or beauty supplements do not replace appropriate sun protection. Continue protective clothing, shade, and suitable sunscreen, and seek assessment for persistent or changing skin lesions.
  • Tell clinicians about biotin: Supplemental biotin can interfere with some laboratory tests and produce misleading results. Tell the clinician and laboratory what you take; follow their advice about any pause before testing.
  • Check ingredient sources: Protein powders, collagen, bee products, and other ingredients may contain relevant allergens. Check the exact source and label, especially if you have a known food or bee-product allergy.
Ingredient overview

Goal guidance

Lifestyle changes

Keep skin care gentle and consistent, with moisturizing and everyday sun protection. Adequate sleep and avoiding smoking also fit a routine focused on maintaining healthy-looking skin.

Diet changes

Include enough protein, a variety of plants, and sources of unsaturated fat. Support normal hydration and choose supplements around the needs your everyday meals leave unmet.

Who this is for

Adults interested in skin hydration, elasticity, texture, and maintaining a comfortable, healthy-looking complexion.

Who should be careful

Review vitamin A carefully during pregnancy or alongside retinoid medicines. Check ingredient sources, overlapping nutrient amounts, and the potential for supplements such as biotin to affect laboratory tests.

Expected timeline

Skin changes are gradual. Compare comfort and appearance over several weeks under similar lighting, keeping your daily skincare routine consistent.

Common mistakes

Changing several skincare and supplement products together makes results difficult to interpret. Keep gentle cleansing, moisturizing, and sun protection consistent while introducing targeted support.

Ingredients

Collagen Protein
Impact
Highest effect
Typical dose2.5–15 g / day

Hydrolyzed collagen peptides are clinically shown to be well-absorbed and effective at increasing skin hydration, elasticity, and dermal collagen density. Supplementation helps counteract the age-related decline in collagen production, leading to a visible reduction in fine lines and wrinkles.

Focuses on
FirmnessHydrationClear SkinWound Healing
Most relevant for
Adults, particularly women, seeking to support skin moisture and elasticity through dietary nutricosmetics.

Potential benefits

  • Hydration and Firmness.Multiple meta-analyses of randomized trials indicate that oral hydrolyzed collagen can improve skin moisture levels and elasticity when taken for approximately 12 weeks.
  • Visible Wrinkle Reduction.Some clinical studies suggest that specific low-molecular-weight collagen peptides may decrease the appearance of fine lines and skin roughness.
  • Anti-Aging Support.Unconfirmed. While used to counteract age-related collagen decline, a major 2025 meta-analysis found no significant clinical evidence for preventing or treating skin aging when only high-quality, independent studies were considered.

Limitations

  • Impact of Industry Funding.Reported benefits for skin hydration and wrinkles are frequently associated with industry-funded research, while independent, high-quality studies often show no significant effect.
  • Ineffective for Fragile Skin.Research in postmenopausal women with dermatoporosis found that oral collagen did not improve skin thickness or elasticity, suggesting results may not extend to clinical skin fragility.
  • Preparation Specificity.The effectiveness of collagen is highly dependent on the molecular weight and bioavailability of specific peptides, making it difficult to generalize results across all products.
Things to consider

Meaningful improvements typically require consistent use for 8 to 12 weeks, and benefits may be influenced by co-factors like Vitamin C or the specific peptide blend used.

Study evidence

62 studies

Collagen supplements may improve skin hydration and elasticity, with some studies also reporting fewer wrinkles. Confidence is limited because benefits were not clear in higher-quality or independently funded studies, making broad claims that collagen prevents or reverses skin aging premature.

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Hyaluronic Acid Other Nutrients
Impact
Highest effect
Typical dose120–240 mg / day

Hyaluronic Acid is a key molecule for skin hydration, capable of holding up to 1000 times its weight in water. Clinical trials demonstrate that oral supplementation is effectively absorbed and increases the skin's moisture content, leading to a visible reduction in dryness and wrinkles and improved skin smoothness.

Focuses on
FirmnessHydrationClear Skin
Most relevant for
Individuals looking to maintain skin moisture levels and address early signs of aging like fine lines.

Potential benefits

  • Improved Moisture Content.Daily oral supplementation has been shown to increase the water content of the skin's outer layer, helping to alleviate dryness from within.
  • Reduction in Wrinkles.Consistent use over 8 to 12 weeks may help suppress wrinkle formation and improve overall skin texture and smoothness.

Limitations

  • Delivery Method Differences.Most clinical evidence supports injectable fillers for volume; oral supplements may not provide the same structural or immediate results.
  • Inconsistent Elasticity Effects.While hydration is well-supported, the impact on skin elasticity is mixed, with several trials showing no significant improvement over a placebo.
  • Combination Supplement Uncertainty.Adding hyaluronic acid to multi-ingredient formulas, such as those containing collagen, may not provide additional benefits beyond the base ingredients.
Things to consider

Hyaluronic acid is generally well-tolerated, though localized treatments like microneedle patches may cause transient redness or a temporary increase in water loss.

Study evidence

96 studies

Hyaluronic Acid may improve skin hydration and the appearance of wrinkles, but much of the supplied evidence concerns injections rather than supplements. Oral research is promising but limited, and benefits from injected fillers or combination products cannot be assumed for every oral preparation.

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Vitamin C Vitamins
Impact
Highest effect
Typical dose250–1000 mg / day

The body cannot produce collagen without adequate Vitamin C, making it foundational for skin strength and repair. As a potent antioxidant, it neutralizes free radicals generated by sun exposure and pollution, working synergistically with Vitamin E to protect skin integrity.

Focuses on
FirmnessSun ProtectionClear SkinWound Healing
Most relevant for
Individuals looking to support natural skin repair or address appearance changes like fine wrinkles and roughness caused by sun exposure.

Potential benefits

  • Tissue Repair Support.Maintains scar strength and supports soft tissue healing following dental procedures or in chronic wound environments, particularly when intake is optimized above basic dietary requirements.
  • Reduced Appearance of Photoaging.Targeted topical application has been shown to significantly decrease skin roughness and the depth of fine wrinkles caused by long-term sun damage.
  • Skin Tone Management.Topical formulations may help improve the appearance of pigmentation and melasma, especially when used in conjunction with skin-penetrating techniques like microneedling.

Limitations

  • Route of Administration.Visible cosmetic improvements such as wrinkle reduction are well-documented for specific topical treatments but are less established for oral supplements.
  • Dependence on Baseline Status.The most significant wound-healing benefits from oral supplementation are observed in individuals with existing vitamin C deficiencies or complex recovery needs.
  • Preparation Specificity.Success in clinical studies often involves specialized delivery systems like microneedle patches or laser assistance, which may not translate to standard cosmetic creams.
Things to consider

Daily intakes near 10mg are insufficient for optimal scar strength; research suggests a range of 75mg to 110mg is needed to support normal collagen-related tissue repair.

Study evidence

53 studies

Vitamin C supports collagen-related tissue repair, and some topical formulations improve signs of sun-damaged skin. Oral supplementation has shown possible wound-healing benefits in selected clinical settings, but this does not establish better skin appearance from extra vitamin C when intake is already adequate.

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Zinc Minerals
Impact
Highest effect
Typical dose15–30 mg / day

Zinc is essential for the function of enzymes involved in skin repair and cell turnover. It possesses anti-inflammatory properties, making it particularly effective for managing inflammatory conditions like acne, and plays a role in protecting against UV-induced damage.

Focuses on
FirmnessHydrationSun ProtectionClear SkinWound Healing
Most relevant for
Individuals managing inflammatory acne, scalp flaking, or those seeking to support the healing of minor skin injuries.

Potential benefits

  • Reduces Inflammatory Acne.Clinical evidence indicates that both oral and topical zinc preparations can significantly decrease the number of inflammatory lesions in acne patients.
  • Supports Minor Wound Repair.Topical zinc applications, such as dressings or solutions, have been shown to accelerate the healing of uncomplicated surgical incisions and minor cutaneous wounds.
  • Controls Scalp Flaking.Zinc pyrithione is an effective topical treatment for reducing the severity of dandruff and seborrheic dermatitis by targeting underlying scalp conditions.

Limitations

  • Inconsistent for Chronic Ulcers.Systematic reviews find that oral zinc supplementation does not reliably improve the healing rates of chronic pressure, venous, or diabetic foot ulcers.
  • Variable Barrier Efficacy.While used for moisture-related dermatitis, zinc oxide may be less effective or cost-efficient than newer barrier films or specific herbal preparations in clinical settings.
  • Condition Specificity.Zinc has shown no significant benefit for certain inflammatory conditions such as rosacea or psoriasis in available clinical studies.
Things to consider

Repeated use of some zinc-containing adhesives may cause skin dryness or barrier disruption similar to pathological dry skin diseases.

Study evidence

66 studies

Zinc is important for normal skin function, and zinc treatments can help some conditions, particularly inflammatory acne and certain forms of dermatitis. Benefits depend on the formulation and problem being treated; oral supplements have not consistently improved wound healing or general skin health.

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Astaxanthin Other Nutrients
Impact
High effect
Typical dose4–12 mg / day

Astaxanthin is a potent carotenoid that accumulates in the skin, providing protection against UVA-induced oxidative stress. Clinical studies have shown it can improve skin texture, elasticity, and moisture content while reducing the appearance of wrinkles and age spots.

Focuses on
FirmnessHydrationSun ProtectionClear Skin
Most relevant for
Individuals looking to support skin hydration and flexibility through antioxidant supplementation.

Potential benefits

  • Skin Elasticity.Meta-analyses of human trials indicate that oral astaxanthin supplementation can significantly help restore and maintain skin elasticity.
  • Moisture Content.Clinical evidence suggests astaxanthin improves the skin's moisture-holding capacity and may reduce transepidermal water loss.
  • UV Stress Resistance.Unconfirmed. Some studies suggest astaxanthin may increase the skin's resistance to UV-induced redness, though its effectiveness for general sun protection remains unproven in broader reviews.

Limitations

  • Uncertain Wrinkle Effects.While some individual trials are positive, pooled data from meta-analyses have found no consistent or significant reduction in wrinkle depth.
  • Insufficient Photoaging Evidence.Systematic reviews conclude there is currently limited evidence to confirm that astaxanthin effectively treats or prevents long-term sun-induced skin aging.
  • Study Confounders.Several supportive findings come from studies using astaxanthin in combination with other ingredients like collagen, making its independent impact less certain.

Study evidence

12 studies

Astaxanthin may modestly improve skin moisture and elasticity, but evidence for reducing wrinkles or protecting against sun-related aging is inconsistent. Small human studies provide promising signals, while broader reviews leave uncertainty about how reliable and noticeable these benefits are.

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Ceramide Other Nutrients
Impact
High effect
Typical dose20–80 mg / day

Ceramides are waxy lipids that make up over 50% of the skin's protective barrier. Oral supplementation with plant-derived ceramides (phytoceramides) has been shown to migrate to the stratum corneum, improving skin barrier function, increasing hydration, and reducing dryness and itching.

Focuses on
Hydration
Most relevant for
Individuals seeking to address dry skin or support their natural skin moisture barrier through oral supplementation.

Potential benefits

  • Barrier Support.Unconfirmed. Ceramides are primary lipids in the skin barrier, but the benefit of oral supplementation for skin health is unproven as no research was provided.
  • Moisture Retention.Unconfirmed. Oral phytoceramides are proposed to reduce water loss, though this specific outcome for skin health remains unconfirmed in the current data.

Limitations

  • Lack of Clinical Evidence.No linked research studies were provided to verify the efficacy of oral ceramides for improving skin health.
  • Unconfirmed Mechanism.The specific process of how oral phytoceramides migrate to and influence the skin is not supported by evidence in the supplied text.

Study evidence

No published studies for this goal yet.

View ingredient ->

Studies

Explore published research for this goal.

Sources

Up to five highest-ranked published examples per ingredient. Study counts and charts include all published studies for the connection.

  1. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledCollagen
  2. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledCollagen
  3. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsCollagen
  4. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsCollagen
  5. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledCollagen
  6. Efficacy and Safety of Sodium Hyaluronate Gel for Facial Skin Rejuvenation.
    Liao Z; Hong W; Wang S; Hou Y; Lu S; Chen R; Zhang Y; Chen J; Liu Y; Luo S · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2026
    Randomized trial420 participantsHyaluronic Acid
  7. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study.
    Hsu TF; Su ZR; Hsieh YH; Wang MF; Oe M; Matsuoka R; Masuda Y · Nutrients · 2021
    Randomized trial40 participantsHyaluronic Acid
  8. Safety and efficacy of hyaluronic acid injectable filler in the treatment of nasolabial fold wrinkle: a randomized, double-blind, self-controlled clinical trial.
    Li XZ; Chiang CF; Lin YH; Chen TM; Wang CH; Tzeng YS; Cui HY · The Journal of dermatological treatment · 2023
    Randomized trial95 participantsHyaluronic Acid
  9. A Split-Face Study of the Effects of a Stabilized Hyaluronic Acid-Based Gel of Nonanimal Origin for Facial Skin Rejuvenation Using a Stamp-Type Multineedle Injector: A Randomized Clinical Trial.
    Roh NK; Kim MJ; Lee YW; Choe YB; Ahn KJ · Plastic and reconstructive surgery · 2016
    Randomized trial25 participantsHyaluronic Acid
  10. Long-term Safety and Effectiveness of Cold-Crosslinked Hyaluronic Acid Fillers: Multicenter, Randomized, Controlled, Double-Blind Study.
    Kaminer MS; Avelar RL; Baumann L; Callender V; Dayan SH; Green JB; Grekin SK; Guyon S · Aesthetic surgery journal · 2025
    Randomized trial140 participantsHyaluronic Acid
  11. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsVitamin C
  12. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsVitamin C
  13. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsVitamin C
  14. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsVitamin C
  15. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsVitamin C
  16. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledZinc
  17. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsZinc
  18. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsZinc
  19. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsZinc
  20. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSeleniumVitamin EZinc
  21. The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
    Ito N; Seki S; Ueda F · Nutrients · 2018
    Randomized trial23 participantsAstaxanthin
  22. Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1 and -12 expression: a comparative study with placebo.
    Yoon HS; Cho HH; Cho S; Lee SR; Shin MH; Chung JH · Journal of medicinal food · 2015
    Randomized trial44 participantsAstaxanthin
  23. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers.
    Chalyk NE; Klochkov VA; Bandaletova TY; Kyle NH; Petyaev IM · Nutrition research (New York, N.Y.) · 2018
    Single-arm trial31 participantsAstaxanthin
  24. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity.
    Phetcharat L; Wongsuphasawat K; Winther K · Clinical interventions in aging · 2016
    Randomized trial34 participantsAstaxanthin
  25. Cosmetic benefits of astaxanthin on humans subjects.
    Tominaga K; Hongo N; Karato M; Yamashita E · Acta biochimica Polonica · 2012
    Other66 participantsAstaxanthin
  26. Noninferiority of Copper Dressings Than Negative Pressure Wound Therapy in Healing Diabetic Wounds: A Randomized Clinical Trial.
    Melamed E; Dabbah J; Israel T; Kan I; Pinzur MS; Roth T; Borkow G · Advances in wound care · 2026
    Randomized trialCopper
  27. Improvement of facial skin characteristics using copper oxide containing pillowcases: a double-blind, placebo-controlled, parallel, randomized study.
    Borkow G; Gabbay J; Lyakhovitsky A; Huszar M · International journal of cosmetic science · 2010
    Randomized trial57 participantsCopper
  28. Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
    Huang Y; Qi L; Liu Z; Jiang Y; Wang J; Liu L; Li Y; Zhang L; Feng G · ACS applied materials & interfaces · 2023
    Animal experimentCopper
  29. Engineering copper nanoparticle/polysaccharide-immobilized cotton gauze for accelerated healing of Staphylococcus aureus-infected dermal wounds.
    Sahoo M; Banerjee T; Virkar S; Das S; Biswas S; Mitra D · Journal of materials chemistry. B · 2026
    Animal experimentCopper
  30. Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings.
    Melamed E; Rovitsky A; Roth T; Assa L; Borkow G · Medicina (Kaunas, Lithuania) · 2021
    Single-arm trialCopper
  31. Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study.
    Chung BY; Park SY; Jung MJ; Kim HO; Park CW · Annals of dermatology · 2022
    Randomized trial50 participantsGamma Linolenic Acid
  32. Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response.
    Morse PF; Horrobin DF; Manku MS; Stewart JC; Allen R; Littlewood S; Wright S; Burton J; Gould DJ; Holt PJ · The British journal of dermatology · 1989
    Meta-analysis9 studies pooledGamma Linolenic Acid
  33. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy.
    Manku MS; Horrobin DF; Morse N; Kyte V; Jenkins K; Wright S; Burton JL · Prostaglandins, leukotrienes, and medicine · 1983
    Non-randomized trial50 participantsGamma Linolenic Acid
  34. Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people.
    Brosche T; Platt D · Archives of gerontology and geriatrics · 2005
    Non-randomized trial29 participantsGamma Linolenic Acid
  35. Effects of oral supplementation with evening primrose oil for six weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients.
    Yoshimoto-Furuie K; Yoshimoto K; Tanaka T; Saima S; Kikuchi Y; Shay J; Horrobin DF; Echizen H · Nephron · 1999
    Randomized trial16 participantsGamma Linolenic Acid
  36. The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial.
    Duperray J; Sergheraert R; Chalothorn K; Tachalerdmanee P; Perin F · Journal of cosmetic dermatology · 2022
    Randomized trial124 participantsGluthathione
  37. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women.
    Watanabe F; Hashizume E; Chan GP; Kamimura A · Clinical, cosmetic and investigational dermatology · 2014
    Randomized trial30 participantsGluthathione
  38. Systematic Review of the Efficacy and Safety of Topical Glutathione in Dermatology.
    Khanna R; Rambhia P; Chapas A · The Journal of clinical and aesthetic dermatology · 2025
    Systematic review5 studies pooledGluthathione
  39. Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor--a pilot study.
    Becker K; Pons-Kühnemann J; Fechner A; Funk M; Gromer S; Gross HJ; Grünert A; Schirmer RH · Redox report : communications in free radical research · 2006
    Randomized trialGluthathione
  40. Glutathione and its antiaging and antimelanogenic effects.
    Weschawalit S; Thongthip S; Phutrakool P; Asawanonda P · Clinical, cosmetic and investigational dermatology · 2020
    Randomized trial57 participantsGluthathione
  41. Assessment of the skin efficacy and acceptability of a cosmetic product in the treatment of the forearm hypertrichosis in female patients.
    Berardesca E; Cameli N; Piacentini M; Veraldi S; Celleno L · Journal of cosmetic dermatology · 2021
    Non-randomized trial69 participantsGlycine
  42. Antiirritant properties of polyols and amino acids.
    Korponyai C; Kovács RK; Erös G; Dikstein S; Kemény L · Dermatitis : contact, atopic, occupational, drug · 2011
    Clinical trialGlycine
  43. Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial.
    Stockfleth E; Beti H; Orasan R; Grigorian F; Mescheder A; Tawfik H; Thielert C · The British journal of dermatology · 2008
    Randomized trial503 participantsGreen Tea
  44. Efficacy, safety and tolerability of green tea catechins in the treatment of external anogenital warts: a systematic review and meta-analysis.
    Tzellos TG; Sardeli C; Lallas A; Papazisis G; Chourdakis M; Kouvelas D · Journal of the European Academy of Dermatology and Venereology : JEADV · 2011
    Meta-analysis1,247 participants3 studies pooledGreen Tea
  45. Green Tea Catechin Association with Ultraviolet Radiation-Induced Erythema: A Systematic Review and Meta-Analysis.
    Kapoor MP; Sugita M; Fukuzawa Y; Timm D; Ozeki M; Okubo T · Molecules (Basel, Switzerland) · 2021
    Meta-analysis100 participants6 studies pooledGreen Tea
  46. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women.
    Heinrich U; Moore CE; De Spirt S; Tronnier H; Stahl W · The Journal of nutrition · 2011
    Randomized trial60 participantsGreen Tea
  47. Efficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial.
    Zhao H; Zhu W; Zhao X; Li X; Zhou Z; Zheng M; Meng X; Kong L; Zhang S; He D; Xing L; Yu J · JAMA dermatology · 2022
    Randomized trial180 participantsGreen Tea
  48. Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study.
    Chernyshova MP; Pristenskiy DV; Lozbiakova MV; Chalyk NE; Bandaletova TY; Petyaev IM · Journal of dairy science · 2019
    Randomized trialLycopene
  49. Topical lycopene emulgel significantly improves biophysical parameters of human skin.
    Sohail M; Muhammad Faran Ashraf Baig M; Akhtar N; Chen Y; Xie B; Li B · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022
    Clinical trialLycopene
  50. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
    Aust O; Stahl W; Sies H; Tronnier H; Heinrich U · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2005
    Randomized trialLycopene
  51. Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.
    Kim J; Park MK; Li WQ; Qureshi AA; Cho E · JAMA dermatology · 2024
    Cohort study123,570 participantsLycopene
  52. β-Carotene and other carotenoids in protection from sunlight.
    Stahl W; Sies H · The American journal of clinical nutrition · 2013
    Narrative reviewLycopene
  53. A randomized, investigator-blinded, controlled pilot study to evaluate the safety and efficacy of a poly-N-acetyl glucosamine-derived membrane material in patients with venous leg ulcers.
    Kelechi TJ; Mueller M; Hankin CS; Bronstone A; Samies J; Bonham PA · Journal of the American Academy of Dermatology · 2012
    Randomized trial82 participantsN-Acetyl Glucosamine
  54. Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies.
    Fulco I; Erba P; Valeri RC; Vournakis J; Schaefer DJ · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2016
    Randomized trial20 participantsN-Acetyl Glucosamine
  55. Preparation, characterization, and moisturizing effect of liposomes containing glucosamine and N-acetyl glucosamine.
    Malaekeh-Nikouei B; Golmohammadzadeh S; Salmani-Chamanabad S; Mosallaei N; Jamialahmadi K · Journal of cosmetic dermatology · 2014
    Clinical trialN-Acetyl Glucosamine
  56. The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skin.
    Mammone T; Gan D; Fthenakis C; Marenus K · Journal of cosmetic science · 2009
    Clinical trialN-Acetyl Glucosamine
  57. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine.
    Bissett DL; Robinson LR; Raleigh PS; Miyamoto K; Hakozaki T; Li J; Kelm GR · Journal of cosmetic dermatology · 2007
    Randomized trial50 participantsN-Acetyl Glucosamine
  58. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsOmega-3
  59. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsOmega-3
  60. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsOmega-3
  61. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsOmega-3
  62. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsOmega-3
  63. Improvement of crow's feet lines by topical application of 1-carbamimidoyl-L-proline (CLP).
    Kawashima M; Yokose U; Hachiya A; Fujimura T; Tsukahara K; Kawada H; Kitahara T; Takema Y; Terui T; Nakagawa H · European journal of dermatology : EJD · 2014
    Randomized trial126 participantsProline
  64. Collagen synthesis in human musculoskeletal tissues and skin.
    Babraj JA; Cuthbertson DJ; Smith K; Langberg H; Miller B; Krogsgaard MR; Kjaer M; Rennie MJ · American journal of physiology. Endocrinology and metabolism · 2005
    Methods validation studyProline
  65. Genotype-phenotype spectrum of PYCR1-related autosomal recessive cutis laxa.
    Dimopoulou A; Fischer B; Gardeitchik T; Schröter P; Kayserili H; Schlack C; Li Y; Brum JM; Barisic I; Castori M; Spaich C; Fletcher E; Mahayri Z; Bhat M; Girisha KM; Lachlan K; Johnson D; Phadke S; Gupta N; Simandlova M; Kabra M; David A; Nijtmans L; Chitayat D; Tuysuz B; Brancati F; Mundlos S; Van Maldergem L; Morava E; Wollnik B; Kornak U · Molecular genetics and metabolism · 2014
    Case series33 participantsProline
  66. Collagen structure in skin from fibromyalgia patients.
    Ribel-Madsen S; Gronemann ST; Bartels EM; Danneskiold-Samsøe B; Bliddal H · International journal of tissue reactions · 2006
    Case-control study35 participantsProline
  67. Thermoresponsive propolis gel for gingival wound healing post-depigmentation: A prospective clinical study.
    Pattnaik N; Mohanty S; Singh DK; Sahoo A; Pathi J; Jalaluddin M · Journal of Taibah University Medical Sciences · 2026
    Randomized trial66 participantsPropolis
  68. Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review.
    Münstedt K · Complementary therapies in medicine · 2019
    Systematic review6 studies pooledPropolis
  69. Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial.
    Afkhamizadeh M; Aboutorabi R; Ravari H; Fathi Najafi M; Ataei Azimi S; Javadian Langaroodi A; Yaghoubi MA; Sahebkar A · Natural product research · 2018
    Randomized trialPropolis
  70. Effect of propolis on wound healing in sacrococcygeal pilonidal disease: A randomized controlled clinical trial.
    Kubat M; Karabulut Z; Şengül S · Pakistan journal of pharmaceutical sciences · 2022
    Randomized trial33 participantsPropolis
  71. Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by Polish studies.
    Rojczyk E; Klama-Baryła A; Łabuś W; Wilemska-Kucharzewska K; Kucharzewski M · Journal of ethnopharmacology · 2021
    Systematic reviewPropolis
  72. Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging.
    Du YM; Zeng J; Li M; Wang YB; Wu Y; Qi RQ; Gao XH; Chen HD · Journal of cosmetic dermatology · 2021
    Non-randomized trial32 participantsResveratrol
  73. Exploring resveratrol-enriched collagen dressings for diabetic foot ulcers: A retrospective study of wound healing outcomes.
    Sezikli İ; Kendirci M · Journal of tissue viability · 2025
    Cohort study41 participantsResveratrol
  74. Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin.
    Moyano-Mendez JR; Fabbrocini G; De Stefano D; Mazzella C; Mayol L; Scognamiglio I; Carnuccio R; Ayala F; La Rotonda MI; De Rosa G · Drug development and industrial pharmacy · 2016
    Clinical trialResveratrol
  75. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
    Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
    Randomized trial134 participantsResveratrol
  76. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.
    Montenegro L; Parenti C; Turnaturi R; Pasquinucci L · Pharmaceutics · 2020
    Clinical trial12 participantsResveratrol
  77. Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
    Chu AC · Dermatologica · 1985
    Randomized trial38 participantsSelenium
  78. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
    Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
    Randomized trial1,312 participantsSelenium
  79. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
    Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
    Randomized trial121 participantsSelenium
  80. The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
    Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
    Clinical trial31 participantsSelenium
  81. The Efficacy of a Silicone Sheet in Postoperative Scar Management.
    Kim JS; Hong JP; Choi JW; Seo DK; Lee ES; Lee HS · Advances in skin & wound care · 2018
    Randomized trialSilicon
  82. A non-inferiority study to compare the effect of silica gel fiber dressing with alginate dressing on healing of venous leg ulcers.
    Zhang L; Yang J; Wang H; Cai Y; Zhao W; Dong R; Liu D; Lu X · Wound management & prevention · 2023
    Randomized trial130 participantsSilicon
  83. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsBiotinSilicon
  84. Retrospective Study on the Clinical Superiority of the Vacuum-Assisted Closure System with a Silicon-based Dressing over the Conventional Tie-over Bolster Technique in Skin Graft Fixation.
    Chou PR; Wu SH; Hsieh MC; Huang SH · Medicina (Kaunas, Lithuania) · 2020
    Cohort study26 participantsSilicon
  85. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars.
    O'Brien L; Pandit A · The Cochrane database of systematic reviews · 2006
    Meta-analysis559 participants13 studies pooledSilicon
  86. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsVitamin E
  87. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledVitamin E
  88. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewVitamin E
  89. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialVitamin E
  90. Intervention with flaxseed and borage oil supplements modulates skin condition in women.
    De Spirt S; Stahl W; Tronnier H; Sies H; Bejot M; Maurette JM; Heinrich U · The British journal of nutrition · 2009
    Randomized trialFlax
  91. Development of Phytocosmeceutical Microemulgel Containing Flaxseed Extract and Its In Vitro and In Vivo Characterization.
    Tasneem R; Khan HMS; Rasool F; Khan KU; Umair M; Esatbeyoglu T; Korma SA · Pharmaceutics · 2023
    Non-randomized trial13 participantsFlax
  92. Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition.
    Neukam K; De Spirt S; Stahl W; Bejot M; Maurette JM; Tronnier H; Heinrich U · Skin pharmacology and physiology · 2011
    Randomized trial26 participantsFlax
  93. Wound coverage by the linen dressing accelerates ulcer healing.
    Skórkowska-Telichowska K; Mierziak-Darecka J; Wrobel-Kwiatkowska M; Gebarowski T; Szopa J; Zuk M · Postepy dermatologii i alergologii · 2022
    Clinical trialFlax
  94. The Role of Flaxseed in Improving Human Health.
    Nowak W; Jeziorek M · Healthcare (Basel, Switzerland) · 2023
    Narrative reviewFlax
  95. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsBiotin
  96. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsBiotin
  97. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsBiotin
  98. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsBiotin
  99. Photosensitizer Radachlorin®: Skin cancer PDT phase II clinical trials.
    Kochneva EV; Filonenko EV; Vakulovskaya EG; Scherbakova EG; Seliverstov OV; Markichev NA; Reshetnickov AV · Photodiagnosis and photodynamic therapy · 2011
    Randomized trialChlorophyll
  100. Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study.
    Song BH; Lee DH; Kim BC; Ku SH; Park EJ; Kwon IH; Kim KH; Kim KJ · Journal of the American Academy of Dermatology · 2014
    Randomized trial24 participantsChlorophyll
  101. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
    Hakozaki T; Minwalla L; Zhuang J; Chhoa M; Matsubara A; Miyamoto K; Greatens A; Hillebrand GG; Bissett DL; Boissy RE · The British journal of dermatology · 2002
    Randomized trial138 participantsNiacin
  102. Niacinamide: A B vitamin that improves aging facial skin appearance.
    Bissett DL; Oblong JE; Berge CA · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial50 participantsNiacin
  103. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
    Chiu PC; Chan CC; Lin HM; Chiu HC · Journal of cosmetic dermatology · 2008
    Randomized trial52 participantsNiacin
  104. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    Chen AC; Martin AJ; Choy B; Fernández-Peñas P; Dalziell RA; McKenzie CA; Scolyer RA; Dhillon HM; Vardy JL; Kricker A; St George G; Chinniah N; Halliday GM; Damian DL · The New England journal of medicine · 2015
    Randomized trial386 participantsNiacin
  105. Nicotinamide for Skin Cancer Chemoprevention.
    Breglio KF; Knox KM; Hwang J; Weiss R; Maas K; Zhang S; Yao L; Madden C; Xu Y; Hartman RI; Wheless L · JAMA dermatology · 2025
    Cohort study33,822 participantsNiacin
  106. Psychosocial Burden in People with Atopic Dermatitis: Effects of a Substance-Free Basic Skincare in a Randomized Health Care Study.
    Braren-von Stülpnagel C; Augustin M; Sommer R; Westphal L · Skin pharmacology and physiology · 2024
    Randomized trial79 participantsOmega-6
  107. Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis.
    Schäfer L; Kragballe K · The Journal of investigative dermatology · 1991
    Cross-sectional study15 participantsOmega-6
  108. Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years.
    Pike KC; Calder PC; Inskip HM; Robinson SM; Roberts GC; Cooper C; Godfrey KM; Lucas JS · Clinical & developmental immunology · 2013
    Cohort study865 participantsOmega-6
  109. Plasma omega-3 and omega-6 concentrations and risk of cutaneous basal and squamous cell carcinomas in Australian adults.
    Wallingford SC; Hughes MC; Green AC; van der Pols JC · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014
    Cohort study1,191 participantsOmega-6
  110. Maternal PUFA status and offspring allergic diseases up to the age of 18 months.
    Yu YM; Chan YH; Calder PC; Hardjojo A; Soh SE; Lim AL; Fisk HL; Teoh OH; Goh A; Saw SM; Kwek K; Gluckman PD; Godfrey KM; Chong YS; Shek LP; Pan A; Chong MF; van Bever HP; GUSTO study group · The British journal of nutrition · 2015
    Cohort study960 participantsOmega-6
  111. Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh.
    Zablotska LB; Chen Y; Graziano JH; Parvez F; van Geen A; Howe GR; Ahsan H · Environmental health perspectives · 2008
    Cross-sectional study10,628 participantsRiboflavin
  112. Effect of intake of selected nutrients on skin firmness and elasticity in women.
    Podgórska A; Kicman A; Naliwajko S; Wacewicz-Muczyńska M; Niczyporuk M · Frontiers in nutrition · 2024
    Cross-sectional study59 participantsRiboflavin
  113. The efficacy of oral ivermectin vs. sulfur 10% ointment for the treatment of scabies.
    Alipour H; Goldust M · Annals of parasitology · 2015
    Randomized trial420 participantsSulfur
  114. Sulfur cream blowing and parching combined with compound ketoconazole cream versus compound ketoconazole cream alone in patients with palmoplantar keratotic eczema: a pilot study.
    Qin X; Chen Q; Zhu Z; Li J; Kang X · American journal of translational research · 2025
    Non-randomized trial116 participantsSulfur
  115. Clinical features of 170 Chinese scabies cases and the therapeutic efficacy of sulfur ointment.
    Zhang G; Cui M; Zhang Y; Qin S; Du W; Xie H; Zhu Z; Xu J; Liang B · PLoS neglected tropical diseases · 2026
    Single-arm trial170 participantsSulfur
  116. Treatment of human scabies by sulfur and permethrin.
    Kenawi MZ; Morsy TA; Abdalla KF; el Hady HM · Journal of the Egyptian Society of Parasitology · 1994
    Non-randomized trial16 participantsSulfur
  117. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing.
    Muizzuddin N; Benjamin R · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2022
    Clinical trial83 participantsSulfur
  118. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledVitamin A
  119. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsVitamin A
  120. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsVitamin A
  121. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewVitamin A
  122. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialVitamin A
  123. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation.
    Proksch E; Nissen HP · The Journal of dermatological treatment · 2009
    Randomized trialVitamin B5
  124. Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study.
    Udompataikul M; Limpa-o-vart D · Journal of drugs in dermatology : JDD · 2012
    Non-randomized trial30 participantsVitamin B5
  125. Panthenyl triacetate transformation, stimulation of metabolic pathways, and wound-healing properties in the human skin.
    Dell'Acqua G; Schweikert K · Journal of cosmetic science · 2012
    Randomized trialVitamin B5
  126. Dexpanthenol modulates gene expression in skin wound healing in vivo.
    Heise R; Skazik C; Marquardt Y; Czaja K; Sebastian K; Kurschat P; Gan L; Denecke B; Ekanayake-Bohlig S; Wilhelm KP; Merk HF; Baron JM · Skin pharmacology and physiology · 2013
    Clinical trialVitamin B5
  127. A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne.
    Yang M; Moclair B; Hatcher V; Kaminetsky J; Mekas M; Chapas A; Capodice J · Dermatology and therapy · 2014
    Randomized trial48 participantsVitamin B5