Highest effect
Vitamin D
Vitamin
Impact
Highest effect
Typical dose:1000–4000 IU / day
Adequate Vitamin D levels are crucial for proper insulin signaling and the function of leptin, a key hormone that regulates appetite and fat storage. Correcting a deficiency can improve the body's metabolic environment, making it more conducive to fat loss.
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High effect
Ashwagandha
Botanical
Impact
High effect
Typical dose:300–600 mg / day
Chronic stress elevates cortisol levels, which can lead to increased appetite, a preference for high-calorie foods, and fat deposition around the midsection. By modulating the stress response, Ashwagandha helps mitigate these negative effects, supporting better dietary choices and hormonal balance.
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Caffeine
Other
Impact
High effect
Typical dose:100–300 mg / day
Caffeine stimulates the central nervous system, which increases the rate of thermogenesis (heat production) and lipolysis (the breakdown of fat). It also enhances focus and reduces perceived exertion during workouts, leading to greater calorie expenditure.
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Creatine
Other
Impact
High effect
Typical dose:3–5 g / day
Losing weight often involves losing some muscle, which lowers your resting metabolic rate. Creatine helps preserve lean body mass and maintain high-intensity exercise performance, ensuring that weight lost is primarily from fat, not metabolically active muscle.
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Green Tea
Botanical
Impact
High effect
Typical dose:400–500 mg EGCG / day
The primary antioxidant in green tea, EGCG, inhibits an enzyme that degrades norepinephrine, a key hormone in fat breakdown. This allows norepinephrine to remain active longer, promoting a higher metabolic rate and increased fat burning, especially when combined with exercise.
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Psyllium fiber
Botanical
Impact
High effect
Typical dose:5–10 g / day
When mixed with water, psyllium forms a viscous, gel-like substance in the digestive tract. This slows stomach emptying and promotes a strong sense of satiety, making it an effective tool for managing hunger between meals and reducing portion sizes.
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Situational effect
5-HTP
Amino Acid
Impact
Situational effect
Typical dose:50–100 mg / day
By increasing serotonin synthesis in the brain, 5-HTP can promote feelings of satiety earlier in a meal. This is situationally effective for individuals who struggle with emotional eating or intense carbohydrate cravings, helping to enforce calorie control.
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Acetyl L-Carnitine
Other
Impact
Situational effect
Typical dose:1000–2000 mg / day
Carnitine acts as a shuttle for long-chain fatty acids across the mitochondrial membrane. While effects are modest in those with sufficient dietary intake, it can be particularly beneficial for individuals on plant-based diets or to enhance fat utilization during exercise.
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Chromium
Mineral
Impact
Situational effect
Typical dose:200–500 mcg / day
Chromium is a component of 'glucose tolerance factor,' a molecule that enhances the action of insulin. For individuals with some degree of insulin resistance, supplementation can lead to more stable blood sugar, reducing the energy crashes that often trigger cravings for sugary foods.
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Fish Oil
Fatty Acid
Impact
Situational effect
Typical dose:1000–2000 mg EPA+DHA / day
Obesity is often associated with a state of chronic, low-grade inflammation which can impair metabolic function. The anti-inflammatory properties of EPA and DHA help create a healthier cellular environment, potentially enhancing fat loss efforts and improving body composition.
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