Flavonoid
Description
Flavonoids are a vast family of plant pigments and phytonutrients, characterized by their polyphenolic chemical structure. These compounds are ubiquitous in the plant kingdom, imparting vibrant colors to fruits and vegetables, and playing crucial roles in plant defense mechanisms against environmental stressors. Their presence in our diet is significant due to their potential health-promoting properties. With over 8,000 distinct compounds identified, flavonoids are categorized into several subgroups, including anthocyanins, flavones, flavonols, flavanones, isoflavones, and flavanols. Each subgroup has a unique chemical structure and is found in different plant sources, contributing to the diverse range of effects observed. For instance, anthocyanins give berries their red and purple hues, while flavanols are abundant in green tea and cocoa. In the human body, flavonoids primarily act as potent antioxidants, effectively neutralizing harmful free radicals and reducing cellular damage caused by oxidative stress. Beyond this, they exhibit anti-inflammatory, antiviral, and anticarcinogenic activities. Research suggests their involvement in supporting cardiovascular health, enhancing cognitive function, and modulating immune responses, making them a subject of extensive scientific interest.
Sources
Berries (e.g., blueberries, strawberries, raspberries, European Elder, Acerola)Citrus fruitsApplesGrapesOnionsKaleParsleySoybeansTea (especially Green Tea)CocoaRed wineTurmericGinkgo Biloba
Optimal Dosage
Minimum50 mg
Maximum200 mg
Safety & Toxicity
Toxicity Threshold2000 mg
Toxicity EffectHeadache, digestive issues
Goals
Digestive Health
Impact
High effect
Flavonoids, such as quercetin, can reduce the release of histamine and other inflammatory mediators from mast cells in the gut, calming reactivity. They also reinforce tight junctions and reduce oxidative stress, contributing to a healthier gut barrier.
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Vision Support
Impact
Moderate effect
Typical dose:50–200 mg (of extract standardized for anthocyanins)
'Flavonoid' is a very broad category. While specific members like anthocyanins show promise for improving microcirculation and reducing eye fatigue, the evidence is not as robust or foundational as the AREDS2 ingredients. A lower priority and more moderate effectiveness rating are more appropriate.
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Interactions
Positive Interactions
Vitamin C
Vitamin C can help regenerate oxidized flavonoids, enhancing their antioxidant capacity and overall effectiveness.
Vitamin E
Working together, flavonoids and Vitamin E provide a comprehensive antioxidant defense, protecting cell membranes from oxidative damage.
Selenium
Selenium, as a component of antioxidant enzymes, can work synergistically with flavonoids to bolster the body's defense against oxidative stress.
Zinc
Zinc supports the function of several antioxidant enzymes, creating a synergistic effect with flavonoids in combating oxidative stress.
Coenzyme Q-10
Flavonoids can enhance the antioxidant network alongside Coenzyme Q-10, supporting cellular energy production and overall antioxidant protection.
Astaxanthin
As powerful antioxidants, Astaxanthin and flavonoids can offer synergistic protection against free radicals and inflammation.
Lycopene
Lycopene, another potent antioxidant, can complement the protective effects of flavonoids, particularly in cell protection against oxidative damage.
carotenoids
Flavonoids and carotenoids (like Lycopene and Astaxanthin) collectively contribute to a broader spectrum of antioxidant and immune support.
Curcumin
Curcumin, known for its potent anti-inflammatory and antioxidant properties, works synergistically with flavonoids to enhance these beneficial effects.
Resveratrol
Resveratrol, another polyphenol, shares similar antioxidant and anti-inflammatory benefits with flavonoids, leading to enhanced protective effects when combined.
Green Tea
Green Tea contains catechins, a type of flavonoid, and combining it with other flavonoids can enhance the overall antioxidant and health-promoting effects.
Gluthathione
Flavonoids can support the body's natural Glutathione production and activity, enhancing the master antioxidant system for better detoxification and oxidative stress reduction.
Glutathione
Flavonoids can support the body's natural Glutathione production and activity, enhancing the master antioxidant system for better detoxification and oxidative stress reduction.
Recommended products
Best 
Acerola Cherry Chewable C 500 mg Fruit Flavor
Source Naturals
Flavonoid: 24 mg
This chewable Vitamin C supplement offers a robust 1000mg dose per serving, blending two forms of Vitamin C with bioflavonoids for broad support, all in a convenient fruit-flavored tablet.
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Ultra Potent-C 500
Metagenics
Flavonoid: 16 mg
This product delivers a solid dose of Vitamin C with small amounts of supporting nutrients, but the potency of its Glutathione and Cysteine components is notably low.
Budget 
Wellness Formula
Source Naturals
Flavonoid: 60 mg
This formula combines a broad array of vitamins, minerals, and traditional herbs into one product, primarily supporting immune system function and general health.
Budget 
Wellness Formula
Source Naturals
Flavonoid: 60 mg
This formula combines a broad array of vitamins, minerals, and traditional herbs into one product, primarily supporting immune system function and general health.
Best 
Wellness Formula
Source Naturals
Flavonoid: 60 mg
This tablet formula offers a wide array of vitamins, minerals, and traditional herbs in one product, primarily supporting immune system function and general health, with good value.
Best 
Advanced Therapeutics Lutein Rx-Eye
NaturesPlus
Flavonoid: 125 mg
This supplement offers targeted vision support with FloraGLO Lutein and Zeaxanthin, combined with a comprehensive blend of antioxidants and essential vitamins and minerals for overall health.
Best 
TurmeriPro
Oregon's Wild Harvest
Flavonoid: 112 mg
This product combines Turmeric extract, Bromelain, and Citrus Bioflavonoids in a capsule, aiming to support your body's natural inflammatory response and contribute to joint comfort.
Budget 
Metabolic C 500 mg
Source Naturals
Flavonoid: 100 mg
This product delivers Vitamin C in the specialized PureWay-C form with added citrus bioflavonoids, offering a convenient way to support daily wellness at an accessible price.
Best 
Super Antioxidant Formula
Bluebonnet
Flavonoid: 100 mg
This is a comprehensive antioxidant blend featuring key vitamins, minerals, and a wide range of botanical extracts and specialized compounds for broad cellular support.
Best 
Eye Antioxidant
Bluebonnet
Flavonoid: 100 mg
This product combines a robust mix of vitamins, minerals, and antioxidants to support eye health and provide general cellular protection.
Best 
Eye Antioxidant
Bluebonnet
Flavonoid: 100 mg
A comprehensive blend of vitamins, minerals, and antioxidants, with a primary focus on supporting eye health and general cellular protection through well-chosen ingredient forms.
Best 
Vitamin C with Flavonoids
Thorne
Flavonoid: 75 mg
This product delivers a standard dose of ascorbic acid Vitamin C and citrus bioflavonoids, providing reliable daily support from a recognized brand.
Best 
Quercetin Complex
Natrol
Flavonoid: 66 mg
This complex combines a high dose of Vitamin C with a substantial amount of Quercetin and additional bioflavonoids, catering to those seeking enhanced flavonoid and antioxidant support beyond basic Vitamin C.
Best 
Vision Sharp Multi-Nutrient Eye Health
Irwin Naturals
Flavonoid: 30 mg
A comprehensive softgel supplement designed to support vision and overall eye health, blending essential vitamins, minerals, omega-3s, and targeted botanicals like lutein and bilberry for daily maintenance.
Product stats
Price per product
Average$26.84
Median$23.76
Price per serving
Average$0.74
Median$0.44
Price distribution
Price per serving distribution
Price per
Paired ingredients