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Glutathione

notesDescription

Glutathione, often referred to as the 'master antioxidant', is a tripeptide molecule found in virtually every cell of the body. It is endogenously synthesized from the amino acids L-cysteine, L-glutamic acid, and glycine, and its primary function involves protecting the body from damage by reactive oxygen species, heavy metals, and various toxins. This makes it fundamental for maintaining cellular integrity and overall health. Beyond its direct antioxidant activity, glutathione is vital for numerous cellular processes including DNA synthesis and repair, protein synthesis, enzyme activation, and immune system function. It is particularly concentrated in the liver, where it assists in the detoxification of both endogenous and exogenous compounds, making it a cornerstone of the body's natural defense system against environmental pollutants and metabolic waste products. Maintaining adequate levels of glutathione is crucial for health, especially as levels can decline with age, poor nutrition, chronic stress, and exposure to toxins. Supplementation or supporting its natural production through precursors and cofactors is often pursued to bolster antioxidant defenses, support liver health, and enhance immune responses, contributing to cellular vitality and disease prevention.

ecoSources
AsparagusAvocadosSpinachBroccoliBrussels sproutsGarlicOnionsCabbageLean protein sources (for precursor amino acids)
Cheapest Glutathione supplements
Discover the most affordable Glutathione supplements designed to provide effective anti-inflammatory support, helping you find the best value for your health needs.
Best Glutathione supplements
Explore our top picks for glutathione supplements, carefully selected to help you find the best options for anti-inflammatory support.
Value Glutathione supplements
Compare top-rated Glutathione amino acid supplements to find the best value for anti-inflammatory support.
check_circleOptimal Dosage
Minimum250 mg
Maximum1000 mg
report_problemSafety & Toxicity
track_changesGoals
Anti-Inflammatory Support
local_hospitalAnti-Inflammatory Support
Impact
High effect
Glutathione is crucial for cellular defense against oxidative stress, a primary driver of chronic inflammation. Supplementing directly (with a bioavailable form) bolsters the body's ability to quench inflammatory fires, protecting cells from damage and supporting detoxification pathways.
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Cysteine
Cysteine is a crucial precursor amino acid for glutathione synthesis, directly enhancing the body's ability to produce glutathione.
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Glutamic Acid
Glutamic Acid is one of the three essential amino acids required for the body to synthesize glutathione.
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Glycine
Glycine is a foundational amino acid necessary for the endogenous production of glutathione.
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Vitamin C
Vitamin C helps regenerate oxidized glutathione back to its active form, extending its antioxidant capacity.
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Selenium
Selenium is a cofactor for the enzyme glutathione peroxidase, which uses glutathione to neutralize harmful peroxides.
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Milk Thistle
Milk Thistle (silymarin) is known to support liver health and may help increase hepatic glutathione levels.
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Vitamin E
Vitamin E and Glutathione work synergistically as antioxidants, where Vitamin E protects cell membranes and glutathione recycles Vitamin E, enhancing overall antioxidant defense.
inventory_2Recommended products
85 Best Brocco-Glutathione

Brocco-Glutathione

Nature's Answer
4.6
★★★★★
(2118 ratings)
Glutathione: 1000 mg
A robust supplement featuring a high dose of Setria Glutathione combined with organic Broccoli extract for comprehensive cellular and antioxidant support.
Buy for $32.99(from Vitacost)
Other sellers (2)
70 Budget L-Glutathione 100 mg

L-Glutathione 100 mg

Swanson
4.6
★★★★★
(1501 ratings)
Glutathione: 100 mg
A simple, well-priced L-Glutathione supplement in the Setria form, suitable for foundational support or a maintenance dose.
Buy for $16.09(from iHerb)
Other sellers (1)
69 Value Reduced L-Glutathione 250 mg

Reduced L-Glutathione 250 mg

Solgar
4.7
★★★★★
(1015 ratings)
Glutathione: 250 mg
A 250 mg reduced L-Glutathione capsule from a respected brand, offering basic antioxidant support.
Buy for $15.29(from Vitacost)
Other sellers (3)
72 Best Liposomal Glutathione 500 mg

Liposomal Glutathione 500 mg

NuMedica
4.0
★★★★★
(5 ratings)
Glutathione: 500 mg
A liquid liposomal glutathione product providing 500 mg of glutathione, along with some B vitamins, with a focus on enhanced absorption, but includes a proprietary blend.
Buy for $62.95(from Pure Formulas)
Other sellers
82 Budget Glutathione Cysteine & C

Glutathione Cysteine & C

Life Extension
5.0
★★★★★
(6 ratings)
Glutathione: 50 mg
This product offers a synergistic blend of glutathione, its precursor cysteine, and Vitamin C, designed to support the body’s natural antioxidant defenses through multiple pathways at an economical price.
Buy for $16.5(from Vitacost)
Other sellers (1)
79 Best L-Glutathione Reduced with Setria 250 Milligrams

L-Glutathione Reduced with Setria 250 Milligrams

Montiff
5.0
★★★★★
(6 ratings)
Glutathione: 250 mg
A 250 mg capsule of Setria L-Glutathione, offering a stable and recognized form of this important antioxidant.
Buy for $42.46(from Pure Formulas)
Other sellers
75 Budget Glutathione 250 mg

Glutathione 250 mg

NOW
4.6
★★★★★
(12266 ratings)
Glutathione: 250 mg
A basic, affordable 250 mg glutathione capsule from NOW, suitable for everyday antioxidant support.
Buy for $14.79(from Vitacost)
Other sellers (5)
88 Budget Glutathione 500 mg

Glutathione 500 mg

NOW
4.6
★★★★★
(100022 ratings)
Glutathione: 500 mg
A high-dose glutathione supplement enhanced with Milk Thistle and Alpha Lipoic Acid, offering comprehensive internal support.
Buy for $22.65(from Amazon)
Other sellers (6)
78 Best Liposomal Glutathione Liquid

Liposomal Glutathione Liquid

Pure Encapsulations
5.0
★★★★★
(2 ratings)
Glutathione: 100 mg
A liposomal liquid glutathione supplement from Pure Encapsulations, providing 100 mg per serving with enhanced absorption in mind.
Buy for $60(from Pure Formulas)
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70 Best Homocysteine Plus with Setria Glutathione

Homocysteine Plus with Setria Glutathione

Allergy Research Group
5.0
★★★★★
(3 ratings)
Glutathione: 50 mg
A specialized formula combining a low dose of L-Glutathione with B vitamins, zinc, TMG, and L-Serine, primarily aimed at supporting homocysteine metabolism.
Buy for $27.39(from Pure Formulas)
Other sellers
75 Best Liposomal Glutathione with Lemon Mint

Liposomal Glutathione with Lemon Mint

Quicksilver Scientific
4.5
★★★★★
(15 ratings)
Glutathione: 100 mg
A premium liquid liposomal glutathione with 100 mg of Opitac Glutathione and Phosphatidylcholine, designed for enhanced absorption and a pleasant taste.
Buy for $45(from Pure Formulas)
Other sellers
85 Best L-Glutathione Reduced 500 mg

L-Glutathione Reduced 500 mg

Healthy Origins
4.6
★★★★★
(38 ratings)
Glutathione: 500 mg
A powerful 500 mg reduced Setria L-Glutathione in a veggie cap, offering premium antioxidant support from Healthy Origins.
Buy for $24.99(from Vitacost)
Other sellers (2)
65 Best Reduced Glutathione

Reduced Glutathione

Pure Encapsulations
4.6
★★★★★
(30 ratings)
Glutathione: 100 mg
A simple, reduced L-Glutathione supplement delivering a 100 mg dose in a basic capsule form.
Buy for $59(from Pure Formulas)
Other sellers
82 Best Glutathione-SR

Glutathione-SR

Thorne
4.6
★★★★★
(3280 ratings)
Glutathione: 175 mg
A sustained-release glutathione supplement from Thorne, providing 175 mg per capsule for potentially prolonged absorption.
Buy for $54(from Pure Formulas)
Other sellers (3)
85 Value Glutathione 500 mg

Glutathione 500 mg

NOW
4.6
★★★★★
(55008 ratings)
Glutathione: 500 mg
A high-potency 500 mg reduced glutathione supplement, enhanced with Milk Thistle and Alpha-Lipoic Acid, offered in an economical 120-count bottle for comprehensive antioxidant and liver support.
Buy for $37.91(from Amazon)
Other sellers (3)
78 Budget High Potency L-Glutathione 200 mg

High Potency L-Glutathione 200 mg

Swanson Ultra
4.7
★★★★★
(1192 ratings)
Glutathione: 200 mg
A straightforward capsule offering 200 mg of Setria L-Glutathione, designed to support cellular health and antioxidant processes.
Buy for $15.99(from iHerb)
Other sellers (2)
68 Budget Supplemelts Sublingual L-Glutathione Natural Orange Flavor 50 mg

Supplemelts Sublingual L-Glutathione Natural Orange Flavor 50 mg

Swanson Ultra
4.6
★★★★★
(672 ratings)
Glutathione: 50 mg
A sublingual tablet with 50 mg of Setria L-Glutathione, offering an alternative delivery method with a modest dose.
Buy for $18.99(from iHerb)
Other sellers (1)
78 Value Glutathione Booster

Glutathione Booster

Carlson
4.7
★★★★★
(1214 ratings)
Glutathione: 20 mg
This Carlson supplement combines glutathione precursors and supportive nutrients to encourage the body's natural glutathione production, offering broad antioxidant and detoxification support.
Buy for $47.18(from Pure Formulas)
Other sellers (3)
83 Best Glutathione Reduced 500 mg

Glutathione Reduced 500 mg

Jarrow Formulas
4.5
★★★★★
(46677 ratings)
Glutathione: 500 mg
A high-dose 500 mg reduced L-Glutathione supplement in a large, economical veggie cap bottle from Jarrow Formulas, ideal for long-term antioxidant support.
Buy for $51.99(from Pure Formulas)
Other sellers (5)
68 Value Premier Glutathione Complex

Premier Glutathione Complex

Premier Research Labs
4.8
★★★★★
(5 ratings)
Glutathione: 125 mg
A glutathione complex offering a modest 125 mg of L-Glutathione within a proprietary 'PhytoActiv Support' blend and added calcium.
Buy for $39.54(from Pure Formulas)
Other sellers
75 Value Reduced L-Glutathione 150 mg

Reduced L-Glutathione 150 mg

Klaire Labs
5.0
★★★★★
(5 ratings)
Glutathione: 150 mg
A 150 mg reduced L-Glutathione supplement with chelated Magnesium, offering moderate antioxidant support with added mineral benefits.
Buy for $56.99(from Pure Formulas)
Other sellers
analyticsProduct stats
sellPrice per product
Average$46.30
Median$40.29
restaurantPrice per serving
Average$1.04
Median$0.70
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