EstroFactors
Metagenics
Score 78
A highly specialized and comprehensive formula for estrogen metabolism and hormonal balance, featuring active folate (Metafolin) and B12 (Methylcobalamin), alongside various botanicals and other compounds.
Score 78
A highly specialized and comprehensive formula for estrogen metabolism and hormonal balance, featuring active folate (Metafolin) and B12 (Methylcobalamin), alongside various botanicals and other compounds.
Analysis
Metagenics EstroFactors is a complex and highly specialized dietary supplement formulated to support healthy estrogen metabolism and hormonal balance. It features a broad spectrum of ingredients, including Mixed Carotenoids, Vitamins A, E, Riboflavin, Vitamin B6 (Pyridoxine Hydrochloride), Folate (Metafolin), Vitamin B12 (Methylcobalamin), Biotin, and a host of botanical extracts and active compounds like BioResponse DIM, Green Tea Leaf Extract, N-Acetyl-L-Cysteine, and Hops.
The product notably includes active forms of Folate (Metafolin) and Vitamin B12 (Methylcobalamin), which are excellent for bioavailability. However, Vitamin B6 is in the standard Pyridoxine Hydrochloride form. The comprehensive nature of the formula suggests it is for individuals seeking sophisticated support for hormonal health, particularly related to estrogen balance, rather than a simple B vitamin supplement.
Its strength lies in its multi-faceted approach to a very specific health goal. The extensive list of ingredients aims for synergistic effects. This product is best suited for individuals consulting with a healthcare professional regarding hormonal support, given its targeted and potent formulation.
Pros
- Highly specialized and comprehensive formula for estrogen metabolism
- Includes active forms of Folate (Metafolin) and Vitamin B12 (Methylcobalamin)
- Contains a wide array of supporting ingredients like BioResponse DIM, Green Tea, NAC
- Provides a broad spectrum of vitamins (A, E, Riboflavin, B6, Folate, B12)
Cons
- Very high price per serving ($2.66)
- Uses Pyridoxine Hydrochloride for Vitamin B6, which requires conversion
- Not a general B vitamin supplement, highly specific purpose
- Low review count makes broad customer satisfaction assessment difficult
Warnings
- Due to its specialized nature and potent ingredients, this product should only be used under the guidance of a healthcare professional.
- Not recommended for pregnant or nursing individuals, or those with hormone-sensitive conditions.
- May interact with certain medications; disclose all supplements to your doctor.
$79.95($2.66 per serving)
 iHerb | $ 79.95 | |
| iHerb | $ 79.95 |
Goals
Impact
Highest effect
The product includes ingredients like BioResponse DIM, Green Tea Extract, and NAC, which are known to support liver detoxification pathways, particularly for estrogen metabolism, alongside B vitamins crucial for methylation.
Impact
Highest effect
With specific ingredients like DIM and NAC, coupled with B vitamins for methylation, this formula provides excellent and targeted support for the body's detoxification processes, especially for estrogen.
Impact
Highest effect
Hormonal balance plays a significant role in mood regulation. With active B vitamins and ingredients aimed at estrogen metabolism, this product may help contribute to a more stable mood.
Impact
Highest effect
Active folate and B12 are crucial for nervous system health. The comprehensive support for hormonal balance can profoundly impact brain function and vitality over time.
Impact
Highest effect
By supporting healthy estrogen metabolism and providing antioxidants and active B vitamins, the product targets cellular health and processes linked to healthy aging.
Impact
Highest effect
Balancing estrogen metabolism, supported by the botanical extracts, alongside the neurotransmitter-supporting active B vitamins, can strongly contribute to emotional stability and a balanced mood.
Impact
Highest effect
The blend offers robust support for brain health by ensuring optimal B vitamin status and promoting healthy hormonal balance, which are both critical for neurological vitality and function.
Impact
High effect
Active folate and B12 are vital for neurotransmitter synthesis and overall brain function. The broader hormonal balance supported by other ingredients may also indirectly benefit cognitive clarity.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin A | 750 mcg |
Vitamin E | 36.2 mg |
Riboflavin | 1 mg |
Vitamin B6 | 50 mg |
Folate | 340 mcg DFE |
Vitamin B12 | 30 mcg |
Rice Protein Matrix and Polyphenols | 250 mg |
BioResponse DIM | 150 mg |
Green Tea Leaf Extract | 100 mg |
N-Acetyl-L-Cysteine | 50 mg |
7-Hydroxymatairesinol (HMR) Potassium Acetate Complex | 50 mg |
Proprietary Mix | 50 mg |
Mixed Carotenoids | 1.8 mg |
Vitamin B12 95
The product provides Vitamin B12 as Methylcobalamin, which is the active and most bioavailable form, ensuring optimal utilization by the body for its various functions.
Vitamin B6 60
Vitamin B6 is provided as Pyridoxine Hydrochloride, a widely used but non-active form that needs to be converted by the body to its active coenzyme form (P-5-P).
Alternative products
92 Value 
Fully Active B Complex with Quatrefolic
Doctor's Best
Delivers a full B-complex with active and highly bioavailable forms of B6, Folate (Quatrefolic, similar to Metafolin), and B12 (Methylcobalamin) at a dramatically lower price per serving, offering exceptional value for high-quality B vitamin support.
92 Value 
Sublingual Methylcobalamin (Vitamon B12) 5000 mcg
Solgar
If potent, active B12 is a priority, this sublingual Methylcobalamin offers an excellent dose in a highly active form with an outstanding score at a significantly more affordable price point.
85 Value 
Methyl B12 3000 mcg Berry Flavor
Country Life
This product combines high-dose active Methylcobalamin B12 with Folate. Its solid score and inclusion of these key active forms make it a strong value choice for foundational B vitamin intake.
92 Performance
Fully Active B Complex with Quatrefolic
Doctor's Best
Offers a comprehensive array of highly active B vitamins including P5P B6, Quatrefolic Folate, and Methylcobalamin B12, providing more potent and broad-ranging support for energy, mood, and cognitive health.
93 Performance 
PureGenomics B-Complex
Pure Encapsulations
This premium B-complex provides a wide range of highly active and well-utilized B vitamin forms, ensuring superior absorption and efficacy for overall vitality and metabolic support, especially important for individuals seeking advanced B vitamin support.
88 Performance 
B6 Complex
Pure Encapsulations
Provides very high doses of both active Pyridoxal 5-Phosphate (P5P) B6 and other forms of B6, along with multiple active B12 forms and other B vitamins, offering enhanced and targeted B vitamin support.
92 Budget
Fully Active B Complex with Quatrefolic
Doctor's Best
Offers a comprehensive range of active B vitamins, including Methylcobalamin B12 and Quatrefolic Folate (similar to Metafolin), at a significantly more affordable price per serving for foundational B vitamin support.
93 Budget 
PureGenomics B-Complex
Pure Encapsulations
Provides a wide array of highly active and well-utilized B vitamin forms, including various active B12s and P5P B6, for comprehensive metabolic and energy support, at a much lower cost.
92 Budget 
HomocysteX Plus
Seeking Health
Features several superior, active forms of B vitamins like P5P B6, Quatrefolic Folate, and MecobalActive B12, offering highly bioavailable support for metabolic processes at a fraction of the original's price.
92 Value
Fully Active B Complex with Quatrefolic
Doctor's Best
Delivers a full B-complex with active and highly bioavailable forms of B6, Folate (Quatrefolic, similar to Metafolin), and B12 (Methylcobalamin) at a dramatically lower price per serving, offering exceptional value for high-quality B vitamin support.
92 Value
Sublingual Methylcobalamin (Vitamon B12) 5000 mcg
Solgar
If potent, active B12 is a priority, this sublingual Methylcobalamin offers an excellent dose in a highly active form with an outstanding score at a significantly more affordable price point.
85 Value
Methyl B12 3000 mcg Berry Flavor
Country Life
This product combines high-dose active Methylcobalamin B12 with Folate. Its solid score and inclusion of these key active forms make it a strong value choice for foundational B vitamin intake.
92 Performance
Fully Active B Complex with Quatrefolic
Doctor's Best
Offers a comprehensive array of highly active B vitamins including P5P B6, Quatrefolic Folate, and Methylcobalamin B12, providing more potent and broad-ranging support for energy, mood, and cognitive health.
93 Performance
PureGenomics B-Complex
Pure Encapsulations
This premium B-complex provides a wide range of highly active and well-utilized B vitamin forms, ensuring superior absorption and efficacy for overall vitality and metabolic support, especially important for individuals seeking advanced B vitamin support.
88 Performance
B6 Complex
Pure Encapsulations
Provides very high doses of both active Pyridoxal 5-Phosphate (P5P) B6 and other forms of B6, along with multiple active B12 forms and other B vitamins, offering enhanced and targeted B vitamin support.