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Wellness ImmuNitric

Source Naturals
4.6
★ ★ ★ ★ ★
(27 ratings)
Arginine 2400 mg
Citrulline 600 mg
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Score73
A well-dosed arginine powder has a coherent cardiovascular design, with low citrulline and meaningful sodium as the main trade-offs.
How scoring works
Quantity:8 Ounce(s) • (30 servings)
Goals:
Cardiovascular Support
Energy

Score 73

A well-dosed arginine powder has a coherent cardiovascular design, with low citrulline and meaningful sodium as the main trade-offs.
How scoring works
$18.54($0.61 per serving)
Pure Formulas
$ 18.54
iHerb
$ 0.00
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Analysis

Arginine hydrochloride reaches a useful 2.4 g serving, while 600 mg of L-citrulline adds a supporting nitric-oxide precursor. Folate and vitamin B6 contribute to homocysteine metabolism, giving the cardiovascular concept some added logic.

Citrulline remains below common standalone performance amounts and is unlikely to carry the formula. The powder also supplies 260 mg of sodium per serving, which may matter to users managing sodium intake.

A single mixed serving is more practical than taking several tablets for the same arginine amount. It fits exercise and circulation goals, not people seeking stimulation, mitochondrial energy, or a broad heart formula.

Who is it for
  • Adults seeking powder-based nitric-oxide support
  • People focused on exercise blood flow
  • Users who want folate and vitamin B6 included
Best for
  • Arginine-led circulation support
  • Workout stamina support
  • People avoiding multi-tablet servings

Pros

  • Strong 2.4 g arginine serving
  • Pure citrulline amount is disclosed
  • Folate and vitamin B6 add pathway support

Cons

  • Citrulline remains below performance dosing
  • Contains 260 mg of sodium per serving
  • Does not address broader energy pathways

Warnings

  • Arginine and citrulline may add to nitrates, antihypertensives, or PDE-5 inhibitors and lower blood pressure excessively.
  • The sodium content may matter for people following a sodium-restricted plan.
  • Arginine may trigger herpes simplex recurrences in susceptible users.

Nutrient quality

85 Highest impact

A substantial arginine amount and relevant cofactors provide good vascular-support depth. Modest citrulline and ambiguous duplicate folate entries prevent a stronger assessment.

Ingredient transparency

69 High impact

Core amino-acid quantities are clear and no proprietary blend is used. Duplicate folate entries, missing directions, and absent excipients reduce label clarity.

Customer satisfaction

62 Moderate impact

The supplied average rating is very strong and the rating volume is limited. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money

77 High impact

The formula provides fair value for its cost. It remains moderately competitive but does not clearly lead the category.

Report analysis

Goals

Cardiovascular Support
Cardiovascular Support
Impact
High effect
B+ Goal FitB Strength of SupportC+ CoverageA Formula Quality
Arginine · 2400 mgVitamin B6 · 7.5 mgFolate · 425 mcg DFECitrulline · 600 mg

Arginine provides a substantial nitric-oxide precursor dose, while citrulline and B vitamins add supporting roles. The formula is focused on endothelial function rather than lipid or cardiac-energy support.

Every active amount is disclosed and the powder or tablet serving makes the core dose easy to assess. Citrulline remains below the range commonly used for strong standalone vasodilation.

Study evidence
Arginine Supportive 47 studies
Citrulline Supportive 33 studies
Folate Supportive 93 studies
Energy
Physical Stamina
Energy
Impact
High effect
B- Goal FitB- Strength of SupportC CoverageA- Formula Quality

Arginine and citrulline support nitric oxide production and exercise blood flow, which can contribute to workout stamina. The formula does not address alertness, mitochondrial fuel, or stress resilience.

Arginine is supplied at a useful amount, while citrulline is below common performance levels. Both amino acids are clearly disclosed and the formula remains compact.

Study evidence
Arginine No effect 7 studies
Citrulline No effect 14 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Carbohydrates
1 Gram(s)
Vitamin B6 (Pyridoxine Hydrochloride)
 7.5 mg
Folate (Calcium Folinate, Folic Acid)
 425 mcg DFE
Sodium
260 mg
L-Arginine (L-Arginine Hydrochloride)
 2400 mg
L-Citrulline
600 mg
Adults 18–50
Report overview
Arginine (L-Arginine Hydrochloride) · 2400 mg OverallScore78
C+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB+ Value
A clearly identified hydrochloride form and strong dose suit focused arginine use. Immediate-release powder is easy to take in one serving but does not prolong delivery. Cost per gram is favorable for the disclosed arginine amount.
View ingredientView products
Citrulline · 600 mg OverallScore44
B- Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

Pure L-Citrulline is named and its individual amount is disclosed. The 600 mg serving is too small to provide a meaningful citrulline dose. Citrulline-specific value is poor because the cost per active gram is high.

View ingredientView products
Loading alternative details
67 Performance

Pump-Ocalypse Blue Raz

Bucked Up
Glycerol, citrulline, arginine, and agmatine form a coherent stimulant-free pump formula, but several amounts are moderate rather than full strength. An opaque mushroom blend and low betaine amount weaken dose quality and disclosure. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
78 Performance

L-Arginine L-Citrulline Complex

Source Naturals
A large supply of focused arginine and citrulline offers reasonable routine value. The arginine amount is modest, the citrulline amount is far below targeted use, and arginine may add to blood-pressure-lowering medicines. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
78 Performance

Arginine & Citrulline 500 mg / 250 mg

NOW Sports
A large supply of clearly disclosed L-arginine and L-citrulline offers efficient routine value. Very low serving amounts mean targeted nitric-oxide or exercise use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
74 Budget

Wellness ImmuNitric

Source Naturals
A substantial arginine amount with modest citrulline and B-vitamin support creates a coherent vascular formula at favorable value. Duplicate folate entries reduce clarity, and the three-tablet serving may add to the effects of nitrates or blood-pressure medicines. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
79 Budget

L-Arginine + L-Citrulline 750 mg

Nutricost
A large supply of clearly separated L-arginine and L-citrulline provides economical but basic nitric-oxide support. Both amounts are too low for targeted performance use without taking multiple capsules. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Budget

L-Arginine L-Citrulline Complex 1000 mg

Best Naturals
L-arginine hydrochloride and free-form citrulline provide a focused combination with good supply economy. The arginine amount is only moderate and the citrulline amount is far below targeted performance use. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Value

L-Arginine L-Citrulline Complex

Source Naturals
A focused arginine-citrulline tablet provides moderate arginine at reasonable value. The citrulline amount is far below targeted performance use, and arginine may add to the effects of nitrates or blood-pressure medicines. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
77 Value

Arginine & Citrulline 500 mg/250 mg

NOW Sports
Clearly disclosed L-arginine and L-citrulline provide a focused nitric-oxide formula at a low serving cost. Both amounts are far below targeted performance ranges, so meaningful use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
80 Value

Nitric Oxide Booster

Nutricost Performance
Three arginine forms provide a moderate combined amount and clear nitric-oxide focus at favorable value. Citrulline remains underdosed, and the undisclosed citrulline-malate ratio makes its active contribution uncertain. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
    Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
    Randomized trial15 participantsCardiovascular Support forCitrulline
  2. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  3. Effects of l-citrulline supplementation and watermelon consumption on longer-term and postprandial vascular function and cardiometabolic risk markers: a meta-analysis of randomised controlled trials in adults.
    Smeets ETHC; Mensink RP; Joris PJ · The British journal of nutrition · 2026
    Meta-analysis17 studies pooledCardiovascular Support forCitrulline
  4. Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Rodrigues-Krause J; Krause M; Rocha IMGD; Umpierre D; Fayh APT · Nutrients · 2019
    Meta-analysis13 studies pooledCardiovascular Support forArginine
  5. The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials.
    Hadi A; Arab A; Moradi S; Pantovic A; Clark CCT; Ghaedi E · The British journal of nutrition · 2020
    Meta-analysis12 studies pooledCardiovascular Support forArginine
  6. Oral citrulline supplementation in pregnancies with preeclampsia: a multicenter, randomized, double-blind clinical trial.
    Winer N; Misbert E; Masson D; Girault A; Alexandre-Gouabau MC; Ducarme G; Dochez V; Thubert T; Boivin M; Ferchaud-Roucher V; Péré M; Darmaun D · The American journal of clinical nutrition · 2025
    Randomized trial115 participantsCardiovascular Support forCitrulline
  7. Serum concentrations of L-arginine and L-homoarginine in male patients with intermittent claudication: a cross-sectional and prospective investigation in the CAVASIC Study.
    Vogl L; Pohlhammer J; Meinitzer A; Rantner B; Stadler M; Peric S; Hammerer-Lercher A; Klein-Weigel P; Fraedrich G; Kronenberg F; Kollerits B · Atherosclerosis · 2015
    Cohort study478 participantsCardiovascular Support forArginine
  8. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  9. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  10. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  11. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  12. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
    Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
    Meta-analysis415 participants15 studies pooledCardiovascular Support forCitrulline
  13. Micronutrient Supplementation to Reduce Cardiovascular Risk.
    An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
    Meta-analysis883,627 participants884 studies pooledCardiovascular Support forCitrulline
  14. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
    Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Randomized trial10 participantsCardiovascular Support forCitrulline
  15. Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
    Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
    Randomized trial25 participantsCardiovascular Support forCitrulline
  16. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  17. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  18. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  19. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  20. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  21. Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
    Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
    Randomized trial15 participantsEnergy forArginine
  22. The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
    Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
    Non-randomized trial505 participantsEnergy forArginine
  23. Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
    Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
    Randomized trial29 participantsEnergy forArginine
  24. L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
    Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
    Randomized trial8 participantsEnergy forArginine
  25. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
    Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
    Randomized trial20 participantsEnergy forArginine
  26. Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
    Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
    Meta-analysis137 participants8 studies pooledEnergy forCitrulline
  27. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
    Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
    Randomized trial22 participantsEnergy forCitrulline
  28. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
    Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
    Randomized trial41 participantsEnergy forCitrulline
  29. Citrulline/malate promotes aerobic energy production in human exercising muscle.
    Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
    Single-arm trial18 participantsEnergy forCitrulline
  30. The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
    Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
    Randomized trial12 participantsEnergy forCitrulline