Histamine Block Plus
Seeking Health
Histamine Block Plus
4.6
★ ★ ★ ★ ★
(588 ratings)
Thiamin 20 mg
SAMe 100 mg
Niacin 25 mg
Riboflavin 10 mg
Copper 0.5 mg
Score 88.0
A premium, multi-faceted supplement specifically formulated to support histamine metabolism, cellular energy, and brain function, utilizing a unique blend of DAO, PQQ, SAMe, and active B vitamins.
Quantity: 60 Capsule(s)Servings size: 2 Capsule(s) (30 servings)
Selected goals:
Other goals:
Energy
Brain Health
Cognitive Support
Cardiovascular Support
Testosterone Support
leaderboard Score 88.0
A premium, multi-faceted supplement specifically formulated to support histamine metabolism, cellular energy, and brain function, utilizing a unique blend of DAO, PQQ, SAMe, and active B vitamins.
insights Analysis
Histamine Block Plus by Seeking Health is an advanced supplement designed to address a multifaceted range of health concerns, centered around its unique histamine-blocking capability via DAO2 enzyme from porcine kidney. Beyond this specialized function, it provides robust support for cellular energy, neurological health, and mood through ingredients like LifePQQ and SAMe. The product wisely utilizes activated forms of B vitamins (e.g., Pyridoxal 5-Phosphate, Riboflavin 5-Phosphate) and bioavailable chelated minerals, ensuring better absorption and utilization. While the individual dosages of some general vitamins and minerals might be lower than found in dedicated single-nutrient supplements, their synergistic combination in this formula contributes significantly to its broad therapeutic potential. Its high price per serving reflects the quality and uniqueness of its ingredients.
- Contains DAO enzyme for direct support against dietary histamine intolerance, a unique and highly beneficial feature.
- Includes premium ingredients like PQQ and SAMe, which are excellent for mitochondrial health, cognitive function, and mood support.
- Utilizes active and bioavailable forms of B vitamins (e.g., P5P, Riboflavin 5-Phosphate) for optimal absorption and utilization.
- Incorporates chelated mineral forms (e.g., Albion Dimagnesium Malate) for enhanced absorption.
- Offers a broad spectrum of nutrients that synergistically support multiple bodily systems and general well-being.
- The price per serving is relatively high, which might be a barrier for some users considering long-term daily supplementation.
- Some individual mineral doses (e.g., Copper 0.5mg, Magnesium 50mg) are lower than typically recommended for addressing specific deficiencies or therapeutic effects when used as standalone supplements.
- Contains porcine-derived DAO, making it unsuitable for individuals adhering to vegetarian, vegan, or certain religious dietary restrictions.
- Contains ingredients derived from porcine (pork), so it is not suitable for vegetarians, vegans, or individuals with specific dietary or religious restrictions.
- Individuals taking medications, especially antidepressants (due to SAMe), or those with underlying health conditions, should consult a healthcare professional before use.
- This product is designed to aid in the breakdown of dietary histamine and is not intended to treat severe allergic reactions or anaphylaxis.
$47.48($1.58 per serving)
 iHerb | $ 47.48 | |
 Pure Formulas | $ 65.00 | |
 Amazon | $ 65.00 |
bolt Effectiveness for goals
Diamine oxidase (DAO) is an enzyme primarily responsible for breaking down histamine ingested through food in the digestive tract. By metabolizing histamine in the gut, DAO helps to reduce the amount of histamine absorbed into the bloodstream. This process supports the body's natural ability to handle dietary histamine.
SAMe is a crucial methyl donor involved in many biochemical reactions, including the methylation of histamine. It supports the activity of histamine N-methyltransferase (HNMT), an enzyme that breaks down histamine within cells. This process helps to detoxify and inactivate histamine once it has entered the body's cells.
Yes, supporting both intestinal and cellular histamine breakdown pathways may offer a more comprehensive approach to managing histamine. DAO primarily addresses exogenous (dietary) histamine in the gut, while SAMe-dependent enzymes like HNMT handle endogenous and absorbed histamine within cells. Addressing both pathways helps the body process histamine more effectively.
Copper and zinc are essential minerals that act as cofactors for various enzymes, including those involved in histamine metabolism. Zinc, in particular, has been shown to be necessary for optimal diamine oxidase (DAO) activity. Adequate levels of these minerals are important for the proper function of DAO.
Vitamin C is a powerful antioxidant that plays a role in immune function and can influence histamine levels. It may help to modulate the release of histamine from mast cells and support its degradation. Additionally, Vitamin C's antioxidant properties contribute to reducing oxidative stress, which can be linked to inflammatory processes.
schedule Dosage, timing & forms
Typical daily dosages for PQQ range from 10 mg to 20 mg for general supplementation. However, specific needs and product formulations may lead to varied recommended amounts.
Vitamin C can be taken at any time of day, and it is water-soluble. To maintain consistent levels, some prefer to divide the dose or take it with a meal to enhance absorption and reduce potential stomach upset.
Capsules generally offer precise dosing, can mask unpleasant tastes, and are often easier to swallow than tablets. They can also protect sensitive ingredients from degradation and allow for targeted release within the digestive system.
DAO enzymes are generally recommended to be taken shortly before meals to help with the breakdown of histamine from food. This timing allows the enzyme to be present in the digestive tract when food is consumed.
SAMe is often recommended to be taken on an empty stomach, at least 30 minutes before or 2 hours after a meal. This can help with its absorption and bioavailability.
health_and_safety Safety & interactions
SAMe can potentially interact with antidepressants, including SSRIs, SNRIs, and MAOIs. This combination may increase the risk of serotonin syndrome, a serious condition. It is important to consult a healthcare professional before combining them.
Individuals with bipolar disorder should exercise caution with SAMe, as it may potentially induce manic or hypomanic episodes. It is crucial to discuss SAMe use with a mental healthcare provider if you have this condition.
Certain medications and substances can inhibit Diamine Oxidase (DAO) activity, potentially affecting histamine metabolism. Examples include some antihistamines, antidepressants, and alcohol. Consulting a healthcare professional is advisable if you are taking such substances.
Yes, porcine kidney extract is derived from pork. Individuals with pork allergies should avoid products containing it, and those with dietary restrictions, such as vegetarian or kosher diets, should be aware of its animal origin.
Zinc and copper compete for absorption in the body, and high doses of zinc over time can potentially lead to copper deficiency. While the amounts in many formulas are generally balanced, chronic high supplemental zinc intake may warrant monitoring copper levels.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin C | 100 mg |
Thiamine | 20 mg |
Riboflavin | 10 mg |
Niacin | 25 mg |
Vitamin B6 | 7 mg |
Pantothenic Acid | 10 mg |
Magnesium | 50 mg |
Zinc | 5 mg |
Copper | 0.5 mg |
Alpha-Ketoglutaric Acid | 150 mg |
SAMe | 100 mg |
LifePQQ | 7 mg |
DAO2 | 2.1 mg |
Categories
SAMe 75.0
The product delivers 100mg of SAMe, which is a beneficial inclusion for mood and methylation support in a combined formula. Dedicated SAMe products often provide 200-400mg, but 100mg is a respectable amount within a broader supplement context.
Thiamin 60.0
With 20mg of Thiamine, the product provides a good dose for general metabolic support. While higher doses are available in specialized Thiamin products (e.g., 100-500mg), it offers a solid contribution within this multi-nutrient blend.
Riboflavin 60.0
The product includes 10mg of Riboflavin in its active 5-phosphate form, which is highly bioavailable and beneficial for energy production. However, standalone Riboflavin supplements often provide higher doses (e.g., 100-400mg) for specific therapeutic applications.
Goals
General Health 90.0
This product offers a robust spectrum of essential vitamins (B-complex, C) and minerals (Magnesium, Zinc, Copper) in bioavailable forms. The unique additions of DAO, PQQ, and SAMe provide comprehensive support extending beyond basic nutritional gaps, making it highly beneficial for overall health maintenance.
Mood Support 90.0
SAMe is a highly effective ingredient for mood regulation, as it plays a crucial role in methylation processes that affect neurotransmitter synthesis (serotonin, dopamine, norepinephrine). B vitamins also provide foundational support for neurological pathways influencing mood.
Brain Health 85.0
PQQ is recognized for its neuroprotective effects and ability to stimulate new mitochondrial growth in brain cells. SAMe contributes to neurotransmitter synthesis and methylation, both vital for optimal brain function and neuronal communication.
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