5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
5-HTP with Vitamin B6 & Vitamin C
4.7
★ ★ ★ ★ ★
(5077 ratings)
5-HTP 100 mg
Vitamin B6 15 mg
Score 78.0
Lake Avenue Nutrition's 5-HTP provides a standard 100mg 5-HTP dose with B6 for mood and sleep support, but its name misleadingly includes Vitamin C which is not listed in the ingredients.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
Energy
Brain Health
leaderboard Score 78.0
Lake Avenue Nutrition's 5-HTP provides a standard 100mg 5-HTP dose with B6 for mood and sleep support, but its name misleadingly includes Vitamin C which is not listed in the ingredients.
insights Analysis
This Lake Avenue Nutrition product features 100mg of L-5-Hydroxytryptophan (5-HTP) derived from Griffonia simplicifolia seed extract, alongside 15mg of Vitamin B6 (Pyridoxine Hydrochloride). This combination of 5-HTP and B6 is a standard and effective formulation for supporting mood, stress, and sleep, with B6 acting as a crucial cofactor for 5-HTP conversion to serotonin. However, the product name explicitly mentions "Vitamin C," but this ingredient is notably absent from the provided ingredient list, raising concerns about product labeling accuracy and transparency.
- Contains a clinically relevant 100mg dose of 5-HTP, which is widely recognized for its benefits in supporting mood, anxiety reduction, and sleep quality.
- Includes 15mg of Vitamin B6, an essential cofactor that facilitates the body's conversion of 5-HTP into serotonin, thereby maximizing the supplement's efficacy.
- Offers a standard and proven combination for addressing the primary goals of mood and sleep support, making it a reliable option for many users.
- The product name explicitly states "with Vitamin C," but Vitamin C is not listed in the provided ingredients, which is a significant labeling inaccuracy and misleading for consumers.
- Uses Pyridoxine Hydrochloride as the form of Vitamin B6, which is generally less bioavailable compared to Pyridoxal-5-Phosphate (P-5-P), the active form preferred by many nutritionists.
- At 18 cents per serving, it is less cost-effective than some other 100mg 5-HTP options that offer similar or superior formulations and transparency.
$8.78($0.14 per serving)
 iHerb | $ 8.78 |
bolt Effectiveness for goals
Vitamin B6 acts as a necessary coenzyme for the conversion of 5-HTP into serotonin. Without adequate B6, the metabolism of 5-HTP may be inefficient. This interaction is key for 5-HTP's intended effects on neurotransmitter levels.
Because Vitamin B6 is required for the body to convert 5-HTP into serotonin, some suggest taking them together could optimize 5-HTP's action. This co-factor relationship is important for the intended biochemical pathway. However, the precise optimal dosing and balance are complex and still subjects of ongoing research.
Some research suggests 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in mood regulation. However, more extensive research is needed to confirm its efficacy for specific mood conditions.
Vitamin B6 is a crucial coenzyme involved in over 100 enzymatic reactions, including protein, fat, and carbohydrate metabolism. It plays vital roles in red blood cell formation, neurotransmitter synthesis, and maintaining normal homocysteine levels. It also supports immune function and brain health.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Preliminary studies indicate it might assist with sleep, but further robust research is needed to establish its full impact.
schedule Dosage, timing & forms
The recommended dietary allowance (RDA) for Vitamin B6 in adult men and women (19-50 years) is generally 1.3 mg per day. Needs can vary by age, pregnancy, or lactation status.
Typical starting dosages for 5-HTP often range from 50 to 100 mg per day. It is usually advised to begin with a lower dose and gradually increase if needed. Individual needs and responses can vary.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin. Some supplement protocols include Vitamin B6 to support this conversion. However, high doses of B6 could potentially affect peripheral 5-HTP conversion, which may be undesired.
5-HTP is often taken before bedtime due to its potential role in sleep, or divided into smaller doses throughout the day with meals to help minimize potential stomach upset. Optimal timing can vary based on individual goals and tolerance.
Some approaches suggest taking a moderate dose of P-5-P (the active form of B6) alongside 5-HTP to facilitate its conversion. The specific timing or ratio can be complex, and some sources recommend taking them at separate times or with specific forms of B6. Professional guidance is often sought for personalized strategies.
health_and_safety Safety & interactions
Combining 5-HTP with antidepressant medications, such as SSRIs, SNRIs, or MAOIs, is generally not recommended without strict medical supervision. This combination can lead to excessively high serotonin levels, potentially causing a serious and life-threatening condition known as serotonin syndrome. Always consult a healthcare professional before combining 5-HTP with any prescription medication.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin levels in the brain. It can occur if 5-HTP is combined with other substances that increase serotonin, such as antidepressants or other serotonergic drugs. Symptoms can range from mild (agitation, rapid heart rate, tremors) to severe (fever, seizures, unconsciousness), requiring immediate medical attention.
Yes, because Vitamin B6 facilitates the conversion of 5-HTP to serotonin, taking them together could potentially lead to higher serotonin levels than 5-HTP alone, especially at higher doses. This may increase the risk of serotonin-related side effects such as nausea, gastrointestinal upset, or, in rare cases, serotonin syndrome when combined with other serotonergic substances.
Vitamin B6 is a crucial cofactor for the enzyme that converts 5-HTP into serotonin in the body. Taking both supplements might enhance the conversion of 5-HTP, potentially leading to increased serotonin levels. This interaction is often considered in the formulation of 5-HTP supplements.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of certain anti-seizure medications like phenytoin and phenobarbital, and can also interfere with levodopa used for Parkinson's disease. Additionally, some drugs, like isoniazid, can deplete Vitamin B6 levels. It is advisable to consult a healthcare professional if you are on medication.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin C | 200 mg |
Vitamin B6 | 15 mg |
L-5-Hydroxytryptophan | 100 mg |
Categories
5-HTP 85.0
Offering 100mg of 5-HTP from Griffonia simplicifolia, this product provides a well-established and effective dosage for targeted mood and sleep support, making it a reliable source of the primary active ingredient.
Vitamin B6 75.0
The 15mg dose of Pyridoxine Hydrochloride is adequate to serve as a cofactor for 5-HTP conversion and provides general B6 benefits. However, the use of the HCl form rather than the more bioavailable P-5-P limits its score for optimal B6 delivery.
Goals
Mood Support 90.0
The 100mg 5-HTP dose combined with B6 is highly effective in increasing serotonin levels, which is fundamental for positive mood regulation and alleviating symptoms of low mood or emotional imbalance.
Sleep Support 88.0
5-HTP facilitates the body's natural production of melatonin, the sleep hormone, leading to improved sleep onset and quality. The presence of B6 ensures efficient conversion for this benefit.
Stress Relief 85.0
The serotonin-boosting effects of 5-HTP help to calm the nervous system and promote a sense of well-being, directly contributing to stress reduction. Improved sleep, a common benefit, further aids in managing stress.
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