Pyridoxal 5'-Phosphate
Thorne
Pyridoxal 5'-Phosphate
Vitamin B6 33.8 mg
Score 100.0
The gold standard for B6 supplementation, offering the highly active and bioavailable P-5-P form for superior efficacy and safety.
Quantity: 180 Capsule(s) • (180 servings)
Goals:
Detoxification
Stress Relief
Score 100.0
The gold standard for B6 supplementation, offering the highly active and bioavailable P-5-P form for superior efficacy and safety.
Analysis
Thorne Pyridoxal 5'-Phosphate provides 33.8mg of Vitamin B6 exclusively as Pyridoxal 5-Phosphate (P-5-P). This is the gold standard for B6 supplementation because it is the metabolically active form, meaning it can be immediately utilized by the body without requiring conversion in the liver. This direct bioavailability minimizes the risk of toxicity (like peripheral neuropathy) that can occur with high doses of the less active pyridoxine hydrochloride form. The dosage is therapeutically effective for a wide range of needs related to energy, brain health, and mood support, and Thorne is a highly respected brand known for its purity and scientific backing. Its higher price per serving is justified by the superior form and brand quality, offering excellent long-term value for health.
Pros
- Contains Pyridoxal 5-Phosphate (P-5-P), the active coenzyme form of B6, for superior bioavailability and efficacy.
- Significantly lower risk of peripheral neuropathy compared to pyridoxine hydrochloride, even at higher doses.
- Therapeutically effective dosage (33.8mg) for comprehensive B6 support.
- Produced by Thorne, a highly reputable brand known for quality and purity.
Cons
- Higher price per serving compared to basic pyridoxine HCl B6 supplements, though justified by quality.
$47.70($0.26 per serving)
 iHerb | $ 47.70 | |
 Pure Formulas | $ 53.00 | |
 Amazon | $ 53.00 |
Effectiveness for goals
Yes, Vitamin B6 is a widely recognized and often recommended treatment for nausea and vomiting in pregnancy, commonly known as morning sickness. It is considered a first-line pharmacological therapy for mild to moderate symptoms. Pregnant individuals should consult their healthcare provider before taking any supplements.
Vitamin B6, or pyridoxine, is crucial for over 100 enzyme reactions, primarily involved in protein metabolism, red blood cell formation, and nervous system health. It plays a key role in metabolic processes that convert food into energy. Maintaining adequate B6 levels supports overall health and proper bodily functions.
Absolutely, Vitamin B6 is vital for brain development and function, and for maintaining a healthy nervous system. It is involved in the synthesis of several key neurotransmitters, such as serotonin, dopamine, and GABA, which regulate mood, sleep, and cognitive processes. Adequate B6 intake is essential for proper nerve signaling.
Some studies suggest that Vitamin B6 supplementation may help reduce certain PMS symptoms, particularly mood swings, irritability, and breast tenderness. The exact mechanism is not fully understood, but it may involve its role in neurotransmitter synthesis. However, evidence is mixed, and more robust research is needed.
Vitamin B6 is involved in the production of neurotransmitters like serotonin and norepinephrine, which are critical for mood regulation. Some research indicates that B6 supplementation may positively influence mood and reduce symptoms of depression, particularly in individuals with a deficiency. However, it should not replace prescribed treatments for mental health conditions.
Dosage, timing & forms
The Recommended Dietary Allowance (RDA) for adult men and women (19-50 years) is 1.3 mg per day. For those over 50, it is 1.7 mg for men and 1.5 mg for women. These recommendations are for healthy individuals.
Yes, taking excessively high doses of Vitamin B6, particularly from supplements, can be harmful. The most well-known adverse effect is sensory neuropathy, which can cause numbness and tingling in the extremities. This risk increases with doses significantly above the Tolerable Upper Intake Level (UL) of 100 mg/day.
The Tolerable Upper Intake Level (UL) for Vitamin B6 in adults is 100 mg per day. Consuming amounts significantly above this UL, particularly from supplements, can lead to adverse effects like peripheral neuropathy. It is advisable not to exceed this limit without professional guidance.
There is no specific "best" time to take Vitamin B6; it can be taken at any time of day. Consistency in taking the supplement is generally more important than the exact timing. Some individuals may prefer to take it with a meal to avoid potential stomach upset.
Vitamin B6 supplements commonly contain pyridoxine hydrochloride (pyridoxine HCl). The active coenzyme form, pyridoxal 5'-phosphate (P5P), is also available in some supplements. Other forms like pyridoxal and pyridoxamine also exist in food.
Safety & interactions
Long-term intake of high doses, typically exceeding 200 mg per day, can lead to sensory peripheral neuropathy, characterized by numbness, tingling, and pain in the extremities. Other less common side effects might include skin lesions, photosensitivity, and gastrointestinal issues. These effects usually resolve after discontinuing supplementation.
For adults, the tolerable upper intake level (UL) for Vitamin B6 is set at 100 mg per day from supplements and fortified foods. Consuming amounts above this UL regularly increases the risk of adverse effects, primarily neurological damage. This limit is established to prevent potential harm.
The primary and most concerning symptom of Vitamin B6 toxicity, typically from chronic high doses, is sensory peripheral neuropathy. This involves symptoms like numbness, tingling, and burning pain, often starting in the hands and feet. Other less common signs might include skin lesions or gastrointestinal upset.
Yes, Vitamin B6 can interact with several medications. For instance, it may reduce the effectiveness of levodopa (used for Parkinson's disease) and can interact with anti-seizure medications like phenytoin and phenobarbital. It is important to consult a healthcare provider when combining Vitamin B6 supplements with prescription drugs.
Vitamin B6 is generally considered safe during pregnancy and breastfeeding when taken within recommended dietary allowances. Higher doses might be used under medical supervision for specific conditions like severe morning sickness. Always discuss any supplementation with a healthcare provider to ensure appropriate dosing.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 33.8 mg |
Gluten Free Women 18–50
Report overviewCategories
Vitamin B6 100.0
This product represents the best in the Vitamin B6 collection by exclusively offering the active Pyridoxal 5-Phosphate (P-5-P) form. This ensures superior bioavailability, efficacy, and safety compared to other B6 products, making it the top choice for anyone seeking high-quality B6 supplementation.
Goals
Energy 100.0
P-5-P is directly involved as a cofactor in numerous enzymatic reactions related to energy metabolism, including the breakdown of carbohydrates, fats, and proteins. Its active form ensures maximal utilization by the body, providing highly efficient support for cellular energy production.
Brain Health 100.0
As the active form, P-5-P is critical for the synthesis of major neurotransmitters like serotonin, dopamine, and GABA, which are essential for mood, cognition, and nerve function. Its direct bioavailability ensures optimal support for brain health without the risks associated with inactive forms.
Mood Support 100.0
P-5-P plays a direct and vital role in the metabolic pathways that produce mood-regulating neurotransmitters. By providing the active form, this supplement optimally supports emotional balance and reduces symptoms associated with B6 deficiency, making it exceptionally effective for mood.
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