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MediBolic

Thorne
4.5
★ ★ ★ ★ ★
(33 ratings)
Glycine 500 mg
Isoleucine 300 mg
Resveratrol 50 mg
Green Tea 200 mg
Product Image
Score58
A high-quality but overbuilt nutrition powder with strong forms, major fiber, and a large opaque blend.
How scoring works
Quantity:25 Ounce(s) • (14 servings)
Goals:
Anti-Aging

Score 58

A high-quality but overbuilt nutrition powder with strong forms, major fiber, and a large opaque blend.
How scoring works
$65.95($4.71 per serving)
iHerb
$ 65.95
Pure Formulas
$ 75.00
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Analysis

The powder provides 18 g protein, 10 g partially hydrolyzed guar gum, 1 g betaine, and broad vitamin and mineral coverage. Active B-vitamin forms, chelated minerals, vitamin D3, and natural vitamin E are meaningful quality strengths.

A 22.8 g proprietary blend is listed alongside numerous separately dosed ingredients, making the formula architecture difficult to interpret. Vitamin A, vitamin C, vitamin E, thiamine, chromium, and biotin are supplied at aggressive amounts for routine use.

The product tries to combine meal nutrition, fiber, metabolic ingredients, green tea, and resveratrol. Complexity and cost make it best suited to a specific professional plan rather than casual anti-aging use.

Who is it for
  • Adults following a specific metabolic nutrition plan
  • People seeking protein plus substantial soluble fiber
Best for
  • High-fiber meal supplementation
  • Broad micronutrient intake

Pros

  • Provides 18 g protein
  • Includes 10 g partially hydrolyzed guar gum
  • Uses several active and chelated nutrient forms

Cons

  • Large proprietary blend is opaque
  • Several vitamin amounts are aggressive
  • High routine cost

Warnings

  • Vitamin K can affect warfarin dosing, so users should maintain consistent intake under professional guidance.
  • The 400 mcg chromium amount may add to glucose-lowering effects of insulin and diabetes medicines.
  • High-dose vitamin E may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Nutrient quality

74 High impact

Chelated minerals, methylcobalamin, active B6, and a green-tea phytosome are strong forms. Protein, fiber, vitamin C, and several minerals are meaningful, while glycine, resveratrol, and isoleucine are modest.

Ingredient transparency

58 Moderate impact

Many components are quantified, but the large proprietary blend prevents a fully clear accounting. Excipients and daily directions are absent from the supplied data, which leaves some label details uncertain.

Customer satisfaction

61 Moderate impact

The aggregate satisfaction average is favorable, though no detailed feedback is supplied. The limited volume supports only moderate confidence in the aggregate signal.

Value for money

37 Lower impact

Premium forms and broad nutrition support quality, but specialty active depth is uneven. The serving cost is very high for users seeking only the highlighted botanicals or amino acids.

Report analysis

Goals

Impact
High effect
B- Goal FitC- Strength of SupportB- CoverageC Formula Quality
Folate · 500 mcg DFEMagnesium · 150 mgVitamin B12 · 100 mcgVitamin K · 100 mcgVitamin D · 25 mcgGreen Tea · 200 mgGlycine · 500 mg

Fiber, protein, betaine, magnesium, green tea phytosome, resveratrol, glycine, and micronutrients address metabolic, antioxidant, and structural aspects of healthy aging. The meal-style formula offers unusually broad pathway coverage.

Several featured longevity actives are below stronger focused doses, including glycine and resveratrol, while EGCG yield is not disclosed. People using warfarin should account for the included vitamin K and keep intake consistent with their anticoagulation plan.

Study evidence
Glycine Mixed 14 studies
Green Tea Supportive 9 studies
Magnesium Supportive 12 studies
Resveratrol No effect 7 studies
Vitamin K Supportive 27 studies

Ingredients

IngredientAmount per serving
Calories
140 Calorie(s)
Total Fat
8 Gram(s)
Total Carbohydrates
16 Gram(s)
Protein
18 Gram(s)
Vitamin A
2250 mcg
Vitamin C (Ascorbic Acid)
500 mg
Vitamin D (Vitamin D3)
25 mcg
Vitamin E (D-Alpha-Tocopherol)
134 mg
Vitamin K (Vitamin K1)
100 mcg
Thiamine (Thiamine Hydrochloride)
50 mg
Riboflavin (Riboflavin 5'-Phosphate Sodium)
4 mg
Niacin
40 mg
Vitamin B6 (Pyridoxal 5-Phosphate)
5 mg
Folate
500 mcg DFE
Vitamin B12 (Methylcobalamin)
100 mcg
Biotin
500 mcg
Pantothenic Acid (Calcium Pantothenate)
46 mg
Choline (Choline Citrate)
11 mg
Calcium (Calcium Citrate, DimaCal Dicalcium Malate)
150 mg
Magnesium (Albion DiMagnesium Malate, Magnesium Citrate)
150 mg
Zinc (TRAACS Zinc Bisglycinate Chelate)
10 mg
Selenium (L-Selenomethionine)
75 mcg
Copper (TRAACS Copper Bisglycinate Chelate)
500 mcg
Manganese (TRAACS Manganese Bisglycinate Chelate)
5 mg
Chromium (TRAACS Chromium Nicotinate Glycinate Chelate)
400 mcg
Potassium (Potassium Citrate)
100 mg
Proprietary Blend
22.8 Gram(s)
partially hydrolyzed Guar Gum
10 Gram(s)
Betaine Anhydrous (Trimethylglycine)
1 Gram(s)
Jambolan extract
750 mg
Glycine
500 mg
L-Isoleucine
300 mg
Cinnamon bark extract
250 mg
Green Tea Phytosome (Camellia sinensis extract, Phospholipid complex)
200 mg
Trans-Resveratrol
50 mg
Boron (Bororganic Boron Glycinate Complex)
100 mcg
Gluten Free Adults 18–50
Report overview
Glycine · 500 mg OverallScore52
F Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB- Value

The glycine amount is clearly listed but remains below a useful intermediate dose. A large meal-replacement serving makes glycine titration impractical, and no premium source is identified. The high price is supported by extensive fiber, protein, micronutrients, and botanical actives rather than glycine alone. Vitamin K can conflict with warfarin therapy.

Isoleucine · 300 mg OverallScore50
B+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Separately listed L-isoleucine avoids reliance on the protein content, but the powder is not described as micronized or instantized. The 300 mg amount is too small to provide strong exercise-fuel support by itself. Exact amount disclosure is helpful, yet the high serving cost and absent sport certification make it weak value for isoleucine.

Resveratrol · 50 mg OverallScore48
C Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value

Explicit trans-resveratrol naming supports isomer confidence, but purity and source details are sparse. Standard powder delivery does not address poor absorption, and the serving remains low. The high normalized cost makes it a poor fit for focused resveratrol use.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults - A randomized controlled trial.
    Huhn S; Beyer F; Zhang R; Lampe L; Grothe J; Kratzsch J; Willenberg A; Breitfeld J; Kovacs P; Stumvoll M; Trampel R; Bazin PL; Villringer A; Witte AV · NeuroImage · 2019
    Randomized trial60 participantsAnti-Aging forResveratrol
  2. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin.
    Chiu AE; Chan JL; Kern DG; Kohler S; Rehmus WE; Kimball AB · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2005
    Randomized trial40 participantsAnti-Aging forGreen Tea
  3. Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
    Mansouri F; Feliziani G; Bordoni L; Gabbianelli R · Journal of the Academy of Nutrition and Dietetics · 2025
    Meta-analysis11 studies pooledAnti-Aging forResveratrol
  4. Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly.
    Fischer K; Melo van Lent D; Wolfsgruber S; Weinhold L; Kleineidam L; Bickel H; Scherer M; Eisele M; van den Bussche H; Wiese B; König HH; Weyerer S; Pentzek M; Röhr S; Maier W; Jessen F; Schmid M; Riedel-Heller SG; Wagner M · Nutrients · 2018
    Cohort study2,622 participantsAnti-Aging forGreen Tea
  5. Associations of green tea, coffee, and soft drink consumption with longitudinal changes in leukocyte telomere length.
    Sohn I; Shin C; Baik I · Scientific reports · 2023
    Cohort study1,952 participantsAnti-Aging forGreen Tea
  6. Can teatime increase one's lifetime?
    Nakachi K; Eguchi H; Imai K · Ageing research reviews · 2003
    Cohort studyAnti-Aging forGreen Tea
  7. Influences of tea consumption on self-rated health and life satisfaction among older adults: Evidence from the CLHLS.
    Zou M; Sun C; Yang M; Li C; Wang S; Zheng D; Wang J; Yu L; Sun L; Wang Y; Chen H; Zeng Y · PsyCh journal · 2025
    Cohort study78,345 participantsAnti-Aging forGreen Tea
  8. Tea and bone health: steps forward in translational nutrition.
    Shen CL; Chyu MC; Wang JS · The American journal of clinical nutrition · 2014
    Narrative reviewAnti-Aging forGreen Tea
  9. Accelerated biological aging, mediating amino acids, and risk of incident type 2 diabetes: a prospective cohort study.
    Zhang Z; Wang J; Yu B; Sun Y; Chen Y; Lu Y; Wang N; Xia F · Journal of endocrinological investigation · 2025
    Cohort study95,773 participantsAnti-Aging forGlycine
  10. Dietary protein and amino acid intakes for mitigating sarcopenia in humans.
    He W; Connolly ED; Cross HR; Wu G · Critical reviews in food science and nutrition · 2025
    Narrative reviewAnti-Aging forGlycine
  11. Age-Related Neurochemical Changes in the Vestibular Nuclei.
    Smith PF · Frontiers in neurology · 2016
    Narrative reviewAnti-Aging forGlycine
  12. SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.
    Zhang QS; Wang JN; Yang TL; Li SY; Li JQ; Liu DN; Shang H; Zhang ZN · EBioMedicine · 2025
    Observational studyAnti-Aging forGlycine
  13. Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study.
    Cui M; Jiang Y; Zhao Q; Zhu Z; Liang X; Zhang K; Wu W; Dong Q; An Y; Tang H; Ding D; Chen X · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort studyAnti-Aging forGlycine
  14. Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging.
    Shirai Y; Kuriki K; Otsuka R; Kato Y; Nishita Y; Tange C; Tomida M; Imai T; Ando F; Shimokata H · Public health nutrition · 2021
    Cohort study1,305 participantsAnti-Aging forGreen Tea
  15. Dietary Magnesium May Be Protective for Aging of Bone and Skeletal Muscle in Middle and Younger Older Age Men and Women: Cross-Sectional Findings from the UK Biobank Cohort.
    Welch AA; Skinner J; Hickson M · Nutrients · 2018
    Cross-sectional study156,575 participantsAnti-Aging forMagnesium
  16. Higher Magnesium Intake Is Associated with a Lower Risk of Frailty in Older Adults.
    Dominguez LJ; Mérida DM; Donat-Vargas C; Banegas JR; Veronese N; Barbagallo M; Rodríguez-Artalejo F; Guallar-Castillón P · Journal of the American Medical Directors Association · 2024
    Cohort study1,900 participantsAnti-Aging forMagnesium
  17. Ca:Mg Ratio, APOE Cytosine Modifications, and Cognitive Function: Results from a Randomized Trial.
    Zhu X; Borenstein AR; Zheng Y; Zhang W; Seidner DL; Ness R; Murff HJ; Li B; Shrubsole MJ; Yu C; Hou L; Dai Q · Journal of Alzheimer's disease : JAD · 2021
    Randomized trial250 participantsAnti-Aging forMagnesium
  18. The Association between Dietary Nutrient Intake and Acceleration of Aging: Evidence from NHANES.
    Ma J; Li P; Jiang Y; Yang X; Luo Y; Tao L; Guo X; Gao B · Nutrients · 2024
    Cross-sectional study4,692 participantsAnti-Aging forMagnesium
  19. Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging.
    Zhang B; Zhang X; Ma L; Li D; Li Y; Lin S; Peng L; He L · Experimental gerontology · 2026
    Cross-sectional study8,125 participantsAnti-Aging forMagnesium
  20. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults.
    Witte AV; Kerti L; Margulies DS; Flöel A · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014
    Randomized trial46 participantsAnti-Aging forResveratrol
  21. Resveratrol levels and all-cause mortality in older community-dwelling adults.
    Semba RD; Ferrucci L; Bartali B; Urpí-Sarda M; Zamora-Ros R; Sun K; Cherubini A; Bandinelli S; Andres-Lacueva C · JAMA internal medicine · 2014
    Cohort study783 participantsAnti-Aging forResveratrol
  22. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
    Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
    Randomized trial134 participantsAnti-Aging forResveratrol
  23. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging forVitamin K
  24. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  25. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  26. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  27. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K