SuppHelper
search
Home›Supplements›Vitamin›Vitamin B12›MethylAssist Pure Encapsulations
Product Image

MethylAssist

Pure Encapsulations
4.7
★ ★ ★ ★ ★
(41 ratings)
Vitamin B12 1000 mcg
Vitamin B6 16 mg
Thiamin 75 mg
Product Image
Score 90

MethylAssist provides active, bioavailable forms of B6, Folate, and B12, alongside Benfotiamine (B1), aiming to support crucial methylation processes, nerve health, and energy.

scaleQuantity:90 Capsule(s) • (90 servings)
track_changesGoals:
flag Brain Health
flag Cognitive Support
flag Energy
flag Mood Support
flag Metabolism Boost
flag Anti-Aging
flag Bone Health
flag Cardiovascular Support

leaderboard Score 90

MethylAssist provides active, bioavailable forms of B6, Folate, and B12, alongside Benfotiamine (B1), aiming to support crucial methylation processes, nerve health, and energy.

insightsAnalysis

Pure Encapsulations MethylAssist is a specialized B vitamin complex designed to support methylation processes in the body. It features active forms of key B vitamins: Pyridoxal 5-Phosphate (B6), Metafolin (Folate), and Methylcobalamin (B12). These forms are often chosen because they are already in a metabolically active state, meaning the body can use them directly without conversion, which can be particularly beneficial for some individuals.

The inclusion of BenfoPure Benfotiamine, a lipid-soluble form of B1, is another thoughtful addition, often used for its enhanced absorption and ability to support nerve health and glucose metabolism. This product is geared towards those looking for comprehensive support for methylation, nerve function, energy production, and overall cellular health, often recommended for individuals focusing on specific metabolic pathways.

thumb_upPros
  • Utilizes active, highly bioavailable forms of B6 (P5P), Folate (Metafolin), and B12 (Methylcobalamin).
  • Includes BenfoPure Benfotiamine for enhanced B1 absorption and nerve support.
  • Excellent for supporting methylation pathways and cellular health.
  • Strong doses for targeted nutritional support.
  • Pure Encapsulations is a well-regarded brand for quality.
thumb_downCons
  • High price per serving compared to other B vitamin products.
  • May be overkill for individuals who do not require active B vitamin forms.
  • Specific formulation might not be necessary for general B vitamin supplementation.
warningWarnings
  • High doses of certain B vitamins may cause mild side effects in sensitive individuals; consult a professional if unsure.
  • Folate intake should be considered carefully, especially for those with specific health conditions; consult a professional.
  • Discontinue use if adverse reactions occur.
flagReport analysis
$64.00($0.71 per serving)
Walmart
$ 64.00
Pure Formulas
$ 64.00
Vitacost
$ 64.00
flagReport prices
track_changesGoals
flagCognitive Support
Impact
Highest effect
Active forms of B6, Folate, and B12 are critical cofactors for neurotransmitter synthesis and brain health, offering superior support for cognitive function.
View goal →
flagBrain Health
Impact
Highest effect
The specific, active forms of B6, Folate, and B12 are crucial for nerve health, myelin formation, and overall brain maintenance, making it highly effective for brain health.
View goal →
flagMood Support
Impact
Highest effect
By supporting methylation and neurotransmitter production with active B vitamins, this product can significantly contribute to balanced mood and emotional well-being.
View goal →
flagEnergy
Impact
Highest effect
The active B vitamins, including Benfotiamine, are directly involved in energy metabolism, providing efficient support for cellular energy production.
View goal →
flagMetabolism Boost
Impact
Highest effect
These B vitamins, especially Benfotiamine, play a key role in carbohydrate and fat metabolism, which contributes to a healthy metabolic rate.
View goal →
scienceIngredients
IngredientAmount per serving
Vitamin B6
16 mg
Folate
1667 mcg DFE
Vitamin B12
1000 mcg
BenfoPure Benfotiamine
75 mg
grain_off Gluten Free person Adults 18–50
flagReport overview
Vitamin B12 95
Provides 1000mcg of Methylcobalamin, an active and highly regarded form of B12, offering excellent support for neurological and energy needs.
scienceView ingredientinventory_2View products
Vitamin B6 95
Delivers 16mg of Pyridoxal 5-Phosphate (P5P), the active form of B6, ensuring direct utilization for its numerous enzymatic roles.
scienceView ingredientinventory_2View products
Thiamin 90
Includes 75mg of BenfoPure Benfotiamine, a lipid-soluble form of B1, which offers superior absorption and targeted benefits for nerve health.
scienceView ingredientinventory_2View products
inventory_2Alternative products
82 Value

GABA L-Theanine Stress B Lozenge Natural Mango Tangerine Flavor

KAL
4.6
★★★★★
(3228 ratings)
This alternative, with a high score, offers a significantly lower price per serving while addressing mood and stress with GABA and L-Theanine, in addition to a good range of B vitamins. It presents a strong value proposition for those seeking combined cognitive and calming support.
Other sellers (2)
82 Value

Multi-B Benfotiamine 150 mg

BenfoComplete.com
4.5
★★★★★
(994 ratings)
Featuring a targeted dose of Benfotiamine (active B1) alongside methylcobalamin B12 and other B vitamins, this product provides enhanced nerve support. It offers a high score and specialized ingredients at a much lower price per serving, making it an excellent value for nerve health.
Other sellers (1)
80 Value

Neurobion USA High Potency Formula

OTC Pharmaceutical Products
4.8
★★★★★
(60 ratings)
This alternative provides high potencies of standard B1, B6, and B12, achieving a good score at a much lower price per serving. It's a cost-effective choice for robust foundational B vitamin support for energy, nerve health, and metabolism.
Other sellers (0)
92 Performance

HomocysteX Plus

Seeking Health
4.8
★★★★★
(2077 ratings)
This alternative achieves an even higher score and offers a more comprehensive blend of active B vitamins (including active B2, B6, Folate, and B12) along with Trimethylglycine (TMG). This broader spectrum of methylated and active forms provides enhanced support for methylation, cognitive function, and cardiovascular health.
Other sellers (2)
90 Performance

Methylfolate B Complex

Codeage
4.8
★★★★★
(730 ratings)
While maintaining a top-tier score, this product provides a broader active B-complex, including Riboflavin 5-Phosphate (active B2) and Betaine (TMG), in addition to active B6, Folate, and B12. This can offer a more comprehensive approach to methylation support and overall B vitamin benefits.
Other sellers (4)
90 Performance

Activated Homocysteine

Swanson
4.8
★★★★★
(168 ratings)
This alternative shares the same high score as your current product but offers a distinct and excellent profile for methylation and cognitive support. It includes active B6, Folate (Quatrefolic), Methylcobalamin B12, and Trimethylglycine (TMG), which can be a preferred combination for certain health goals over Benfotiamine.
Other sellers (0)
88 Budget

Activated B-Complex High Bioavailability

Swanson
4.9
★★★★★
(1526 ratings)
This comprehensive B-complex provides a wide array of B vitamins in their active forms, including Benfotiamine, Pyridoxal 5-Phosphate, Methylcobalamin, and L-5-Methyltetrahydrofolate. It offers a comparable high-quality formulation at a significantly lower cost per serving.
Other sellers (1)
88 Budget

B-6 B-12 Folic Acid Drop Ins Natural Mixed Berry Flavor

KAL
4.8
★★★★★
(3080 ratings)
This alternative focuses on active forms of B6 (Pyridoxal 5-Phosphate), Folate ((6S)-5-Methyltetrahydrofolate), and a high dose of B12 (Methylcobalamin). It provides potent support for nerve and cognitive health at a substantially lower price per serving.
Other sellers (2)
82 Budget

BioActive Vitamin B

Terry Naturally
4.8
★★★★★
(50 ratings)
Offering active forms of B6 (Pyridoxal 5-Phosphate), B12 (Methylcobalamin), and Folate ((6S)-5-Methylfolate), this alternative provides targeted B vitamin support. It delivers a good score and advanced ingredient forms at a much more accessible price per serving.
Other sellers (2)
82 Value

GABA L-Theanine Stress B Lozenge Natural Mango Tangerine Flavor

KAL
4.6
★★★★★
(3228 ratings)
This alternative, with a high score, offers a significantly lower price per serving while addressing mood and stress with GABA and L-Theanine, in addition to a good range of B vitamins. It presents a strong value proposition for those seeking combined cognitive and calming support.
Other sellers (2)
82 Value

Multi-B Benfotiamine 150 mg

BenfoComplete.com
4.5
★★★★★
(994 ratings)
Featuring a targeted dose of Benfotiamine (active B1) alongside methylcobalamin B12 and other B vitamins, this product provides enhanced nerve support. It offers a high score and specialized ingredients at a much lower price per serving, making it an excellent value for nerve health.
Other sellers (1)
80 Value

Neurobion USA High Potency Formula

OTC Pharmaceutical Products
4.8
★★★★★
(60 ratings)
This alternative provides high potencies of standard B1, B6, and B12, achieving a good score at a much lower price per serving. It's a cost-effective choice for robust foundational B vitamin support for energy, nerve health, and metabolism.
Other sellers (0)
92 Performance

HomocysteX Plus

Seeking Health
4.8
★★★★★
(2077 ratings)
This alternative achieves an even higher score and offers a more comprehensive blend of active B vitamins (including active B2, B6, Folate, and B12) along with Trimethylglycine (TMG). This broader spectrum of methylated and active forms provides enhanced support for methylation, cognitive function, and cardiovascular health.
Other sellers (2)
90 Performance

Methylfolate B Complex

Codeage
4.8
★★★★★
(730 ratings)
While maintaining a top-tier score, this product provides a broader active B-complex, including Riboflavin 5-Phosphate (active B2) and Betaine (TMG), in addition to active B6, Folate, and B12. This can offer a more comprehensive approach to methylation support and overall B vitamin benefits.
Other sellers (4)
90 Performance

Activated Homocysteine

Swanson
4.8
★★★★★
(168 ratings)
This alternative shares the same high score as your current product but offers a distinct and excellent profile for methylation and cognitive support. It includes active B6, Folate (Quatrefolic), Methylcobalamin B12, and Trimethylglycine (TMG), which can be a preferred combination for certain health goals over Benfotiamine.
Other sellers (0)
flagReport alternatives

SuppHelper

Compare supplements smarter. Science-backed, user-rated, updated daily.

Explore

  • Compare Supplements
  • Health Goals
  • Stacks

Legal

  • Privacy Policy
  • Terms of Use
  • Medical Disclaimer

Stay in the Loop

© 2025 SuppHelper. All rights reserved.