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Thyroid Support Complex

Pure Encapsulations
4.8
★ ★ ★ ★ ★
(23 ratings)
Tyrosine 500 mg
Ashwagandha 400 mg
Product Image
Score74

A substantial, well-disclosed thyroid blend offers depth but carries enough thyroid and cardiovascular activity to require professional oversight.

How scoring works
Quantity:60 Capsule(s) • (30 servings)
Goals:
Stress Relief
Mood Support
Energy
Testosterone Support
Productivity Boost
Brain Health

Score 74

A substantial, well-disclosed thyroid blend offers depth but carries enough thyroid and cardiovascular activity to require professional oversight.

How scoring works
$37.50($1.25 per serving)
Vitacost
$ 37.50
iHerb
$ 37.50
Report prices

Analysis

The nutrient base includes 150 mcg iodine, 200 mcg selenium, and 20 mg zinc. Tyrosine at 500 mg and ashwagandha at 400 mg provide substantial amino-acid and adaptogen amounts.

Forskolin, guggulsterones, and curcuminoids add clearly identified botanical actives. Their combination broadens the formula but also raises interaction and tolerance complexity.

The product fits professionally reviewed thyroid support more than general energy, sleep, or muscle gain. Two capsules and 30 servings are manageable, but users should not treat it as a routine multivitamin.

Who is it for
  • Adults following professionally guided thyroid support
  • Users who need iodine, selenium, and tyrosine together
  • People able to review botanical interactions
Best for
  • Clinician-reviewed thyroid routines
  • Stress support tied to thyroid management
  • Users seeking a comprehensive active formula

Pros

  • Strong iodine, selenium, and zinc disclosure
  • Provides 500 mg tyrosine
  • Provides 400 mg ashwagandha
  • Names forskolin, guggulsterones, and curcuminoids

Cons

  • Complex interaction profile
  • Not suitable for unsupervised thyroid use
  • Only 30 servings
  • Weak direct fit for sleep or muscle gain

Warnings

  • Iodine, tyrosine, ashwagandha, and guggul can alter thyroid-related management
  • Forskolin may lower blood pressure or interact with anticoagulant therapy
  • The 200 mcg selenium serving should not be stacked casually with other high-selenium products

Nutrient quality

81 Highest impact

Well-regarded mineral forms and standardized botanicals provide strong ingredient quality. Substantial selenium and zinc amounts require a clearer individual need for routine use.

.

Ingredient transparency

81 Highest impact

Active forms and amounts are individually disclosed without a hidden blend. Complete directions and inactive ingredients are not supplied.

.

Customer satisfaction

66 High impact

The supplied average rating is very strong. The rating base is modest and limits confidence in the average, but no detailed experience evidence was supplied.

.

Value for money

64 Moderate impact

Serving economics are weak. Formula limitations keep practical value moderate.

.
Report analysis

Goals

Stress Relief
Stress Relief
Impact
Highest effect
B Goal FitA- Strength of SupportB+ CoverageB+ Formula Quality
Vitamin D · 5 mcgAshwagandha · 400 mgVitamin C · 150 mg

Standardized ashwagandha directly supports adaptation to stress, while tyrosine and several thyroid-related nutrients address energy and endocrine function. The ashwagandha amount is meaningful and its active compounds are identified.

Iodine, forskolin, guggul, and tyrosine make the formula more thyroid focused and potentially stimulating than a simple calming supplement. People using thyroid medicine should review the concentrated iodine and thyroid-active botanicals with their clinician.

Study evidence
Ashwagandha Supportive 47 studies
Mood Support
Mood Support
Impact
Highest effect
B Goal FitB+ Strength of SupportB+ CoverageB+ Formula Quality
Vitamin D · 5 mcgAshwagandha · 400 mg

Ashwagandha, L-tyrosine, and turmeric cover stress adaptation, neurotransmitter production, and inflammatory support. The ashwagandha amount appears meaningful, although its withanolide percentage is not disclosed.

The mood-relevant actives are embedded in a thyroid-support formula, so their effects may be tied to thyroid status rather than general emotional well-being. Iodine, guggul, and ashwagandha may affect thyroid activity, so people using thyroid medication need product-specific clinical guidance.

Study evidence
Ashwagandha Supportive 29 studies
Energy
Energy
Impact
High effect
C+ Goal FitB Strength of SupportB CoverageB Formula Quality
Iodine · 150 mcgVitamin D · 5 mcg

Tyrosine, iodine, selenium, and ashwagandha address thyroid-related metabolism and stress resilience. Several botanicals are supplied at plausible amounts with relevant active markers named.

The formula is specialized for thyroid support and does not provide direct mitochondrial fuel or acute alertness. Iodine, guggul, and ashwagandha may affect thyroid activity, so people using thyroid medication need product-specific clinical guidance.

Study evidence
Ashwagandha Supportive 9 studies
Iodine Adverse 3 studies
Vitamin D Supportive 32 studies
Testosterone Support
Testicular Health Support
Testosterone Support
Impact
High effect
B Goal FitB- Strength of SupportB- CoverageC Formula Quality
Zinc · 20 mgVitamin D · 5 mcgAshwagandha · 400 mg

Ashwagandha, zinc, selenium, and vitamin D3 address stress regulation and foundational endocrine nutrition. The thyroid-centered formula has meaningful overlap with testosterone support but is not built specifically for it.

Ashwagandha reaches a plausible extract amount, while its withanolide percentage is not stated and vitamin D is low. Iodine, guggul, and ashwagandha may affect thyroid activity, so people using thyroid medication need individualized clinical guidance.

Study evidence
Ashwagandha Supportive 17 studies
Selenium No effect 16 studies
Vitamin D Supportive 56 studies
Zinc Disputed 7 studies
Productivity Boost
Productivity Boost
Impact
High effect
B- Goal FitC+ Strength of SupportB- CoverageC Formula Quality
Zinc · 20 mg

Tyrosine and ashwagandha support neurotransmitter production and stress resilience, giving the thyroid-oriented formula real productivity relevance. Tyrosine is below the preferred standalone amount, while the ashwagandha extract lacks a stated standardization percentage.

Iodine, guggul, forskolin, tyrosine, and ashwagandha may all influence thyroid or metabolic activity. People using thyroid medicine or managing a thyroid condition need product-specific clinical guidance before use.

Study evidence
Ashwagandha Supportive 6 studies
Brain Health
Brain Health
Impact
High effect
B- Goal FitC+ Strength of SupportC+ CoverageC Formula Quality
Vitamin D · 5 mcgAshwagandha · 400 mg

L-tyrosine and ashwagandha provide relevant support for mental performance under stress. Their roles are more situational than broad, direct cognitive support.

Both amounts are clearly stated, but the ashwagandha extract lacks a standardization percentage. Iodine, guggul, and ashwagandha may alter thyroid activity, so people with thyroid conditions or taking thyroid hormone need tailored clinical guidance.

Study evidence
Ashwagandha Supportive 12 studies
Tyrosine Supportive 7 studies

Ingredients

IngredientAmount per serving
Vitamin A (Vitamin A Acetate)
 750 mcg
Vitamin C (Ascorbic Acid)
 150 mg
Vitamin D (Cholecalciferol, Vitamin D3)
 5 mcg
Iodine (Potassium Iodide)
 150 mcg
Zinc (Zinc Citrate)
 20 mg
Selenium (Selenomethionine)
 200 mcg
L-Tyrosine
500 mg
Ashwagandha (Withania somnifera) extract (Withanolides)
 400 mg
Forskohlii (Coleus forskohlii) extract (Forskolin)
 100 mg
Guggul (Commiphora mukul) extract (Guggulsterones)
 150 mg
Turmeric (Curcuma longa) extract (Curcuminoids)
 100 mg
Gluten Free Adults 18–50
Report overview
Tyrosine · 500 mg OverallScore70
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The preferred L-tyrosine form is provided at an amount that aligns with the usual range for acute cognitive support. Its exact quantity is clearly disclosed, although no specific sourcing or purity evidence is included. Tyrosine remains costly per gram because it is part of a broader thyroid formula, while iodine and ashwagandha warrant care for people managing thyroid conditions or using thyroid hormone.

View ingredientView products
Ashwagandha (Withanolides) · 400 mg OverallScore64
C Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

A withanolide-bearing extract and clear amount provide useful quality signals, but the label does not state a branded source or standardization percentage. The daily amount appears plausible for an extract, while the lack of an absorption enhancer and higher serving cost reduce its collection fit. Iodine, guggul, and ashwagandha may all affect thyroid activity, so people using thyroid medication need product-specific clinical guidance.

View ingredientView products
Loading alternative details
87 Performance

Ashwagandha KSM-66 600 mg

NutraBio
<p>Its label clearly provides 600 mg of KSM-66 Ashwagandha root extract as Withanolides, making it a more clearly defined ashwagandha option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s tyrosine coverage.</p>
82 Performance

Sleep Well Berry Flavored

Nature's Way
<p>Its label clearly provides 84 mg of Magnesium as Magnesium Citrate, making it a more clearly defined ashwagandha option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s tyrosine coverage.</p>
86 Performance

Anxiety & Stress Relief

Nature's Bounty
<p>Its label clearly provides 600 mg of Ashwagandha extract as Withanolides, making it a more clearly defined ashwagandha option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s tyrosine coverage.</p>
86 Budget

Ashwagandha

Jarrow Formulas
<p>Its label clearly provides 300 mg of Ashwagandha extract, preserving relevant ashwagandha coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s tyrosine coverage.</p>
86 Budget

L-Tyrosine 500 mg

NOW
<p>Its label clearly provides 500 mg of L-Tyrosine, preserving relevant tyrosine coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s ashwagandha coverage.</p>
86 Budget

Ashwagandha Extract 450 mg

Swanson
<p>Its label clearly provides 450 mg of Ashwagandha root extract as Withanolides, preserving relevant ashwagandha coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s tyrosine coverage.</p>
85 Value

L-Tyrosine Powder

Source Naturals
<p>Its label clearly provides 660 mg of L-Tyrosine, keeping the formula relevant to tyrosine. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s ashwagandha coverage.</p>
87 Value

Standardized Extract Ashwagandha 450 mg

NOW
<p>Its label clearly provides 450 mg of Ashwagandha extract as Total Withanolides, keeping the formula relevant to ashwagandha. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s tyrosine coverage.</p>
85 Value

L-Tyrosine 500 mg

Jarrow Formulas
<p>Its label clearly provides 500 mg of L-Tyrosine, keeping the formula relevant to tyrosine. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s ashwagandha coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsEnergy Mood Support forAshwagandha
  2. An Examination into the Anti-stress and Anti-fatigue Effects of an Ashwagandha Extract (Ashwa.30™) in Stressed Adults: A Randomised, Double-Blind, Placebo-controlled Trial.
    Lopresti AL; Smith SJ; Bethapudi B; R AA; Mundkinajeddu D; D'Souza P; Lakshmikanthan S · Advances in therapy · 2026
    Randomized trial60 participantsEnergy forAshwagandha
  3. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.
    Lopresti AL; Drummond PD; Smith SJ · American journal of men's health · 2020
    Randomized trial57 participantsEnergy forAshwagandha
  4. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
    Deshpande A; Irani N; Balkrishnan R; Benny IR · Sleep medicine · 2021
    Randomized trial150 participantsSleep Support forAshwagandha
  5. Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis.
    Fatima K; Malik J; Muskan F; Raza G; Waseem A; Shahid H; Jaffery SF; Khan U; Zaheer MK; Shaikh Y; Rashid AM · Human psychopharmacology · 2024
    Meta-analysis254 participants5 studies pooledSleep Support Mood Support forAshwagandha
  6. Effects of Withania somnifera (L.) Dunal (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
    Zhu X; Zeng Q; Lei Y; Xu D · Frontiers in pharmacology · 2026
    Meta-analysis1,249 participants20 studies pooledMuscle Gain Fitness Testosterone Support forAshwagandha
  7. Effects of Root Extract of Ashwagandha (Withania somnifera) on Perception of Recovery and Muscle Strength in Female Athletes.
    Coope OC; Reales Salguero A; Spurr T; Páez Calvente A; Domenech Farre A; Jordán Fisas E; Lloyd B; Gooderick J; Abad Sangrà M; Roman-Viñas B · European journal of sport science · 2025
    Randomized trial30 participantsMuscle Gain forAshwagandha
  8. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsBrain Health Cognitive Support Energy forAshwagandha
  9. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsBrain Health Cognitive Support forAshwagandha
  10. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsBrain Health Cognitive Support Productivity Boost forAshwagandha
  11. A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.
    Saxena A; Lopresti A; Sharif M; Elon N; Suri R; Langade DK · Frontiers in nutrition · 2026
    Randomized trial85 participantsBrain Health forAshwagandha
  12. Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.
    Gopukumar K; Thanawala S; Somepalli V; Rao TSS; Thamatam VB; Chauhan S · Evidence-based complementary and alternative medicine : eCAM · 2022
    Randomized trial130 participantsBrain Health Stress Relief forAshwagandha
  13. Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.
    Bilgin S; Bozyılan E; Buzdağlı Y; Karaç Öcal Y; Gürkan O; Toktaş S; İnan H; Egil İ; Yarayan YE · Frontiers in nutrition · 2026
    Randomized trial24 participantsBrain Health forTyrosine
  14. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
    Jongkees BJ; Hommel B; Kühn S; Colzato LS · Journal of psychiatric research · 2016
    Narrative reviewBrain Health forTyrosine
  15. Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.
    Hensel C; Becker M; Düzel S; Demuth I; Norman K; Steinhagen-Thiessen E; Gallinat J; Lindenberger U; Kühn S · NeuroImage · 2019
    Cross-sectional study286 participantsBrain Health forTyrosine
  16. Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.
    Plini ERG; Melnychuk MC; Harkin A; Dahl MJ; McAuslan M; Kühn S; Boyle RT; Whelan R; Andrews R; Düzel S; Drewelies J; Wagner GG; Lindenberger U; Norman K; Robertson IH; Dockree PM · The journal of nutrition, health & aging · 2023
    Cross-sectional study398 participantsBrain Health forTyrosine
  17. Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
    Jongkees BJ · Cognitive, affective & behavioral neuroscience · 2021
    Randomized trial45 participantsBrain Health forTyrosine
  18. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
    Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
    Randomized trial54 participantsCognitive Support forAshwagandha
  19. Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.
    Naik S; Muralidhar G; Rao BS; Agarwal S; Jain M · Journal of medicine and life · 2026
    Randomized trial58 participantsCognitive Support forAshwagandha
  20. Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
    Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
    Randomized trialEnergy forAshwagandha
  21. Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
    Vittal M; Vinciguerra M · Biogerontology · 2025
    Narrative reviewEnergy forAshwagandha
  22. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsEnergy Productivity Boost forAshwagandha
  23. Association of radioactive iodine treatment with survivorship symptoms and primary care utilisation in women of reproductive age with thyroid cancer: a retrospective cohort study.
    Devanarayan P; Hartman M; Partin M · Family medicine and community health · 2026
    Cohort study10,882 participantsEnergy forIodine
  24. Energy level and fatigue after surgery for thyroid cancer: A population-based study of patient-reported outcomes.
    Hughes DT; Reyes-Gastelum D; Kovatch KJ; Hamilton AS; Ward KC; Haymart MR · Surgery · 2020
    Cohort study2,584 participantsEnergy forIodine
  25. Health-Related Quality of Life in Differentiated Thyroid Cancer Survivors: A Cross-Sectional Study From Turkey.
    Gültekin A; Kahraman MY; Şengöz T; Şimşek FS · Head & neck · 2026
    Cross-sectional study202 participantsEnergy forIodine
  26. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  27. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  28. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  29. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  30. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  31. Effects of an Aqueous Extract of Withania somnifera on Strength Training Adaptations and Recovery: The STAR Trial.
    Ziegenfuss TN; Kedia AW; Sandrock JE; Raub BJ; Kerksick CM; Lopez HL · Nutrients · 2019
    Randomized trial38 participantsFitness forAshwagandha
  32. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults.
    Choudhary B; Shetty A; Langade DG · Ayu · 2016
    Randomized trial50 participantsFitness forAshwagandha
  33. Effects of Ashwagandha ( Withania somnifera) standardized root extract on physical endurance and VO 2max in healthy adults performing resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study.
    Verma N; Gupta SK; Patil S; Tiwari S; Mishra AK · F1000Research · 2024
    Randomized trial80 participantsFitness forAshwagandha
  34. Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists.
    Shenoy S; Chaskar U; Sandhu JS; Paadhi MM · Journal of Ayurveda and integrative medicine · 2013
    Randomized trial40 participantsFitness forAshwagandha
  35. Association between composite dietary antioxidant index and handgrip strength in American adults: Data from National Health and Nutrition Examination Survey (NHANES, 2011-2014).
    Wu D; Wang H; Wang W; Qing C; Zhang W; Gao X; Shi Y; Li Y; Zheng Z · Frontiers in nutrition · 2024
    Cross-sectional study6,019 participantsFitness forZinc
  36. Serum essential elements and muscle health in Chinese adults: a community-based study.
    Ye H; Wang D; Liu S; Yao N; Gui Z; Huang Z; Zeng Y; Liu L; Wan H; Shen J · Nutrition & metabolism · 2025
    Cross-sectional study5,389 participantsFitness forZinc
  37. [Survey of the dietary status and physical activity level and fitness of college freshmen in Chengdu].
    Han H; Lv X; Wang D · Wei sheng yan jiu = Journal of hygiene research · 2010
    Cross-sectional study1,200 participantsFitness forZinc
  38. A comprehensive review of the physiology and evidence base to guide the use of ergogenic and medical supplements for enhanced cycling performance.
    Rowland A; Edwards S; Prieto-Bellver G; Menz B; Rowland A; Cornelisse E; Karapetis CS; Wallen MP; Hopkins AM · Journal of the International Society of Sports Nutrition · 2026
    Narrative reviewFitness forZinc
  39. Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
    van Dronkelaar C; Fultinga M; Hummel M; Kruizenga H; Weijs PJM; Tieland M · Journal of the American Medical Directors Association · 2023
    Systematic review45 studies pooledFitness forZinc
  40. A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, three-arm, placebo-controlled efficacy and safety study.
    West RE; Biswas A; Rao R; Tayade H; Ademola J · Journal of medicine and life · 2026
    Randomized trial141 participantsMood Support forAshwagandha
  41. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.
    Chandrasekhar K; Kapoor J; Anishetty S · Indian journal of psychological medicine · 2013
    Randomized trial64 participantsMood Support Stress Relief forAshwagandha
  42. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledMood Support forAshwagandha
  43. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis.
    Cheah KL; Norhayati MN; Husniati Yaacob L; Abdul Rahman R · PloS one · 2021
    Meta-analysis400 participants5 studies pooledProductivity Boost forAshwagandha
  44. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study.
    Langade D; Thakare V; Kanchi S; Kelgane S · Journal of ethnopharmacology · 2021
    Randomized trial80 participantsProductivity Boost forAshwagandha
  45. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.
    Pingali U; Pilli R; Fatima N · Pharmacognosy research · 2014
    Randomized trial20 participantsProductivity Boost forAshwagandha
  46. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
    Lopresti AL; Smith SJ; Malvi H; Kodgule R · Medicine · 2019
    Randomized trial60 participantsStress Relief forAshwagandha
  47. Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels.
    Mishra DN; Kumar M · Heliyon · 2024
    Randomized trial60 participantsStress Relief forAshwagandha
  48. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study.
    Salve J; Pate S; Debnath K; Langade D · Cureus · 2020
    Randomized trial60 participantsStress Relief forAshwagandha
  49. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial.
    Chauhan S; Srivastava MK; Pathak AK · Health science reports · 2024
    Randomized trial50 participantsTestosterone Support forAshwagandha
  50. Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
    Smith SJ; Lopresti AL; Teo SYM; Fairchild TJ · Advances in nutrition (Bethesda, Md.) · 2021
    Systematic review32 studies pooledTestosterone Support forAshwagandha
  51. Do "testosterone boosters" really increase serum total testosterone? A systematic review.
    Morgado A; Tsampoukas G; Sokolakis I; Schoentgen N; Urkmez A; Sarikaya S · International journal of impotence research · 2024
    Systematic review3 studies pooledTestosterone Support forAshwagandha
  52. Safety and Tolerability of Withania somnifera Root Extract in Healthy Male Participants: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Vaidya N; Agarwal R; Kshirsagar P; Ganu G; Nagore D; Mehta A; Vora A; Nair S · Food science & nutrition · 2025
    Randomized trial40 participantsTestosterone Support forAshwagandha
  53. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study.
    Safarinejad MR; Safarinejad S · The Journal of urology · 2009
    Randomized trial468 participantsTestosterone Support forSelenium
  54. The association between metal exposure and semen quality in Chinese males: The mediating effect of androgens.
    Liu P; Yuan G; Zhou Q; Liu Y; He X; Zhang H; Guo Y; Wen Y; Huang S; Ke Y; Chen J · Environmental pollution (Barking, Essex : 1987) · 2020
    Cross-sectional study1,136 participantsTestosterone Support forSelenium
  55. In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among girls in Mexico City.
    Ashrap P; Sánchez BN; Téllez-Rojo MM; Basu N; Tamayo-Ortiz M; Peterson KE; Meeker JD; Watkins DJ · Environmental research · 2019
    Observational study132 participantsTestosterone Support forSelenium
  56. Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, south east Nigeria.
    Oluboyo AO; Adijeh RU; Onyenekwe CC; Oluboyo BO; Mbaeri TC; Odiegwu CN; Chukwuma GO; Onwuasoanya UF · African journal of medicine and medical sciences · 2013
    Observational studyTestosterone Support forSelenium
  57. EVALUATION OF MALE SEX HORMONES AND TRACE ELEMENTS IN MALE TYPE 2 DIABETIC PATIENTS ATTENDING NNAMDI AZIKIWE UNIVERSITY TEACHING HOSPITAL DIABETIC CLINICS.
    Ubajaka CF; Meludu SC; Dioka CE; Onah CE; Osuji CU; Modebe IA; Ifeadike GC; Okwara JE; Amah UK; Nnebue CC · Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria · 2015
    Cross-sectional studyTestosterone Support forSelenium
  58. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  59. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  60. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  61. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  62. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D
  63. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
    Meeker JD; Rossano MG; Protas B; Padmanahban V; Diamond MP; Puscheck E; Daly D; Paneth N; Wirth JJ · Fertility and sterility · 2010
    Cross-sectional study219 participantsTestosterone Support forZinc
  64. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review.
    Santos HO; Cadegiani FA; Forbes SC · Clinical therapeutics · 2022
    Scoping reviewTestosterone Support forZinc
  65. Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men's Health, Germination, Sperm Quality, and Fertilization.
    Fallah A; Mohammad-Hasani A; Colagar AH · Journal of reproduction & infertility · 2020
    Narrative reviewTestosterone Support forZinc
  66. Clinical, endocrinological and biochemical effects of zinc deficiency.
    Prasad AS · Clinics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc
  67. Clinical, endocrinologic, and biochemical effects of zinc deficiency.
    Prasad AS · Special topics in endocrinology and metabolism · 1986
    Narrative reviewTestosterone Support forZinc