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Max B-ND

Premier Research Labs
4.7
★ ★ ★ ★ ★
(192 ratings)
Niacin 30 mg
Vitamin B12 263 mcg
Biotin 334 mcg
Folate 1665 mcg
Product Image
Score75

A sophisticated liquid B complex with three B12 forms and folinic acid. High folate, label complexity, and limited serving value reduce broad appeal.

How scoring works
Quantity:2 Fluid Ounce(s) • (21 servings)
Goals:
General Health
Energy
Cardiovascular Support
Mood Support
Heart Health
Cognitive Support
Hair Health

Score 75

A sophisticated liquid B complex with three B12 forms and folinic acid. High folate, label complexity, and limited serving value reduce broad appeal.

How scoring works
$39.99($1.90 per serving)
Pure Formulas
$ 39.99
Report prices

Analysis

The liquid includes riboflavin 5-phosphate, pyridoxal 5-phosphate, folinic acid, and adenosyl-, hydroxy-, and methylcobalamin. Those forms provide sophisticated coverage at mostly moderate B-vitamin amounts.

Folate reaches 1,665 mcg, while the label lists some nutrients more than once by name and form. That presentation complicates interpretation, and the small bottle provides only 21 servings.

Liquid delivery may suit people who avoid capsules and want active B12 forms. Dose precision, high folate exposure, and weak serving value make it a specialized choice rather than a routine default.

Who is it for
  • People who prefer liquid supplements
  • Adults specifically seeking multiple active B12 forms
  • Users taking folinic acid with guidance
Best for
  • Active B12 form coverage
  • Liquid B-complex dosing
  • Normal energy metabolism

Pros

  • Includes three B12 forms
  • Uses folinic acid
  • Includes activated riboflavin and vitamin B6
  • Liquid format

Cons

  • Very high folate amount
  • Only 21 servings
  • Duplicated label entries complicate interpretation
  • Weak practical value

Warnings

  • The 1,665 mcg folate amount may be inappropriate without professional guidance
  • Measure the liquid carefully to avoid dosing errors
  • Confirm how duplicated nutrient entries should be interpreted on the current label

Nutrient quality

83 Highest impact

Multiple bioactive B12 forms, folinic acid, riboflavin phosphate, and P-5-P provide strong biochemical quality. Most amounts are moderate, but the folate serving is near the upper end of targeted use.

Ingredient transparency

85 Highest impact

All B-vitamin amounts and chemical forms are clearly listed without a hidden blend. Folate is not expressed as dietary folate equivalents, and the liquid base and complete usage directions are not supplied.

Customer satisfaction

72 High impact

The very strong average rating has a moderate review base. No review excerpts describe tolerance, effectiveness, or repeated complaints, so those experiences remain uncertain.

Value for money

54 Moderate impact

Excellent active forms provide real quality, but the short supply carries a substantial premium. The formula is difficult to justify for routine use when lower-cost active-form capsules are available.

Report analysis

Goals

General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportB CoverageB+ Formula Quality
Folate · 1665 mcgVitamin B12 · 263 mcg

The broad B-vitamin profile supports cellular energy, red blood cell formation, nerve function, and methylation. Three bioactive B12 forms and active folate provide good biochemical coverage with precise amounts.

The folate amount is high and is not labeled as dietary folate equivalents, while B12 remains in a maintenance-oriented range. The substantial B12 content helps reduce the concern that high folate could mask an unrecognized B12 deficiency.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Energy
Energy
Impact
Highest effect
A- Goal FitA+ Strength of SupportC+ CoverageB- Formula Quality
Vitamin B5 · 3.3 mgRiboflavin · 1.6 mgThiamin · 1 mgVitamin B12 · 263 mcg

Multiple active B-vitamin forms support metabolic energy production and normal nervous-system function. The three vitamin B12 forms together provide a substantial amount for people who need B12 support.

Amounts are fully disclosed, and methylcobalamin, adenosylcobalamin, hydroxycobalamin, P-5-P, and active riboflavin improve form quality. Repeated entries for several B vitamins add redundancy without creating a second energy pathway.

Study evidence
Riboflavin Mixed 6 studies
Vitamin B12 Disputed 14 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitA Strength of SupportC CoverageB Formula Quality
Vitamin B12 · 263 mcgVitamin B6 · 3 mgFolate · 1665 mcgNiacin · 30 mg

Folate, vitamin B12, and vitamin B6 support homocysteine metabolism and normal vascular function. Lowering homocysteine is reliable, although that does not consistently translate into fewer cardiovascular events.

Active folate and three B12 forms are clearly disclosed at high amounts within a broad B-vitamin blend. The formula is best suited to a documented nutrient or homocysteine need rather than broad cardiovascular prevention.

Study evidence
Folate Supportive 93 studies
Vitamin B12 No effect 33 studies
Vitamin B6 Supportive 35 studies
Mood Support
Mood Support
Impact
High effect
C+ Goal FitB+ Strength of SupportB- CoverageB+ Formula Quality
Folate · 1665 mcgVitamin B6 · 3 mgVitamin B12 · 263 mcg

Bioactive B12 forms, folinic acid, and P-5-P provide a coherent set of cofactors for methylation and neurotransmitter production. The strong folate amount is paired with substantial B12, which reduces concern about masking an unrecognized B12 deficiency.

Folinic acid still requires conversion before becoming methylfolate, and the liquid is not identified as sublingual. Missing DFE labeling, branded-source details, and independent testing reduce transparency despite the thoughtful mix of vitamin forms.

Study evidence
Folate Supportive 84 studies
Vitamin B12 Supportive 29 studies
Heart Health
Heart Health
Impact
High effect
C+ Goal FitB+ Strength of SupportC CoverageB+ Formula Quality
Vitamin B12 · 263 mcgVitamin B6 · 3 mgFolate · 1665 mcg

Folate, vitamin B12, vitamin B6, and riboflavin support homocysteine metabolism, a relevant cardiovascular pathway. Lowering homocysteine does not consistently translate into fewer cardiovascular events in broadly nourished populations.

Several active B-vitamin forms are used, including folinic acid, P-5-P, R-5-P, and three B12 forms. Repeated totals across some forms make their individual contributions unclear, and the folate amount is high enough to warrant care when stacking fortified products.

Study evidence
Folate Supportive 116 studies
Niacin Supportive 105 studies
Vitamin B12 No effect 42 studies
Vitamin B6 Supportive 44 studies
Cognitive Support
Cognitive Support
Impact
High effect
C- Goal FitA Strength of SupportC CoverageC+ Formula Quality
Thiamin · 1 mgVitamin B6 · 3 mgFolate · 1665 mcgVitamin B12 · 263 mcg

Active B-vitamin forms support methylation, energy metabolism, and neurotransmitter production, especially when nutrient status is low. The formula lacks a direct memory, attention, or cerebral blood-flow active.

Folinic acid, several bioactive B12 forms, P5P, and riboflavin phosphate improve form quality. Repeated forms of the same vitamins add redundancy without creating a distinct cognitive pathway.

Hair Health
Hair Health
Impact
High effect
C Goal FitB+ Strength of SupportD+ CoverageC+ Formula Quality
Biotin · 334 mcg

Folate, active B12 forms, and biotin may support follicle cell renewal when one of these nutrients is low. The liquid formula clearly lists active folate and three B12 forms at substantial amounts.

No iron, zinc, vitamin D, protein, or antioxidant active addresses other common hair pathways. The product is better aligned with a known B-vitamin gap than with broad hair support.

Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 1 mg
Riboflavin (R-5-P)
 1.6 mg
Niacin (Niacinamide, Vitamin B3)
 30 mg
Vitamin B6 (P-5-P, Pyridoxine Hydrochloride)
 3 mg
Folate (5-Formyltetrahydrofolate Calcium)
 1665 mcg
Vitamin B12 (Adenosylcobalamin, Hydroxycobalamin, Methylcobalamin)
 263 mcg
Biotin
334 mcg
Pantothenic Acid (Calcium D-Pantothenate, Vitamin B5)
 3.3 mg
Adults 18–50 Vegan Kosher Vegetarian
Report overview
Niacin (Niacinamide, Vitamin B3) · 30 mg OverallScore72
B+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

liquid niacinamide is a reasonable form for a general multivitamin or B-complex without a specialized NAD-plus claim. The 30 mg serving is appropriate for a multivitamin or B-complex. The serving cost is poor for a standard niacinamide B-complex.

View ingredientView products
Vitamin B12 (Adenosylcobalamin, Hydroxycobalamin, Methylcobalamin) · 263 mcg OverallScore71
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Three bioactive B12 forms provide broader coenzyme coverage without cyanocobalamin. Their combined amount suits maintenance needs but remains below the higher therapeutic threshold. The liquid lacks a stated sublingual design, and the high cost per active B12 amount limits value.

View ingredientView products
Biotin · 334 mcg OverallScore59
B+ Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC Value

The liquid delivery is clean and easy to take, but the label does not identify the biologically active d-biotin isomer. Its biotin amount is closer to basic daily support than the higher doses commonly used for hair and nail goals. The broader B-vitamin formula adds useful co-factors, so biotin-only cost comparisons would understate its value.

View ingredientView products
Loading alternative details
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
A more refined choice supplies methylcobalamin and branded methylfolate in a focused two-nutrient formula. Compared with Max B-ND, it provides a more focused active-form combination for vitamin B12 and folate support. The concentrated vitamin B12 amount is better suited to targeted use than basic maintenance.
82 Performance

BioActive Vitamin B

Terry Naturally
A more refined choice supplies P-5-P, methylcobalamin, and methylfolate in a compact formula. Compared with Max B-ND, it provides a more focused active-form combination for vitamin B12 and folate support. The vitamin B6 amount may still be more than many people need over the long term.
86 Performance

B-6 B-12 Methyl Folate Mixed Berry

KAL
A more refined choice supplies active vitamin B6, methylfolate, and methylcobalamin. Compared with Max B-ND, it provides a more focused active-form combination for vitamin B12 and folate support. The concentrated vitamin B12 amount is more appropriate for targeted use than routine maintenance.
84 Budget

Super B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
A lower-cost serving still supplies broad everyday B-vitamin coverage with vitamin C and a moderate vitamin B6 amount. Compared with Max B-ND, it is much less costly per serving, though the nutrient forms or scope are less refined. Its forms are basic, and the substantial biotin amount should be disclosed before blood tests.
77 Budget

Vitamin B12 & Folic Acid Natural Raspberry Flavor

Bluebonnet EarthSweet Chewables
A lower-cost serving still supplies a focused combination of vitamin B12 and folate in a chewable. Compared with Max B-ND, it is much less costly per serving, though the nutrient forms or scope are less refined. Cyanocobalamin and folic acid are less refined forms than the source product uses.
79 Budget

Sublingual Liquid B-12 2000 mcg with B-Complex

Solgar
A lower-cost serving still supplies a liquid B-complex with active riboflavin and broad supporting coverage. Compared with Max B-ND, it is much less costly per serving, though the nutrient forms or scope are less refined. Cyanocobalamin, pyridoxine, and unspecified folate and biotin forms limit form quality.
80 Value

B-Complex

Advanced Nutrition by Zahler
A strong value choice combines benfotiamine, pantethine, methylcobalamin, active riboflavin, methylfolate, and P-5-P with favorable serving economics. Compared with Max B-ND, it retains meaningful B-vitamin support with a more favorable serving value. Moderate dosing improves balance, although the formula remains positioned above basic B-complex options.
74 Value

BX3

Pure Vegan
A strong value choice combines methylcobalamin with folate, vitamin B6, and trimethylglycine with favorable serving economics. Compared with Max B-ND, it retains meaningful B-vitamin support with a more favorable serving value. Folic acid and the small trimethylglycine amount weaken the otherwise useful B12-centered formula.
81 Value

B-Complex with Folic Acid plus Vitamin C

Nature's Bounty
A strong value choice combines broad B-vitamin coverage at generally moderate amounts with favorable serving economics. Compared with Max B-ND, it retains meaningful B-vitamin support with a more favorable serving value. Conventional forms and duplicated thiamine entries limit form quality and label clarity.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health forBiotin
  2. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  5. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  6. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  7. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  8. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  9. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  10. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  11. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  12. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  13. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12
  14. Association between serum pyridoxal 5'-phosphate levels and all-cause, cardiovascular mortality, and cardiovascular disease in adults: a population-based cohort study.
    Xuan C; Liu RH; Zhao C; Li J; Zhou TT; Tian QW; He GW · Therapeutic advances in chronic disease · 2024
    Cohort studyCardiovascular Support forVitamin B6
  15. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus.
    MacKenzie KE; Wiltshire EJ; Gent R; Hirte C; Piotto L; Couper JJ · Pediatrics · 2006
    Randomized trial124 participantsCardiovascular Support forVitamin B6
  16. Pyridoxine improves endothelial function in cardiac transplant recipients.
    Miner SE; Cole DE; Evrovski J; Forrest Q; Hutchison S; Holmes K; Ross HJ · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2001
    Randomized trial31 participantsCardiovascular Support forVitamin B6
  17. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women.
    Rimm EB; Willett WC; Hu FB; Sampson L; Colditz GA; Manson JE; Hennekens C; Stampfer MJ · JAMA · 1998
    Cohort study80,082 participantsCardiovascular Support Heart Health forVitamin B6
  18. Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.
    MEND-CABG II Investigators; Alexander JH; Emery RW; Carrier M; Ellis SJ; Mehta RH; Hasselblad V; Menasche P; Khalil A; Cote R; Bennett-Guerrero E; Mack MJ; Schuler G; Harrington RA; Tardif JC · JAMA · 2008
    Randomized trial3,023 participantsCardiovascular Support forVitamin B6
  19. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  20. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  21. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  22. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  23. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  24. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  25. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  26. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  27. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  28. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  29. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  30. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  31. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  32. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  33. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  34. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  35. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  36. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  37. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  38. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  39. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  40. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  41. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  42. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  43. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  44. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  45. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  46. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  47. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  48. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
  49. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients.
    Qin X; Li J; Spence JD; Zhang Y; Li Y; Wang X; Wang B; Sun N; Chen F; Guo J; Yin D; Sun L; Tang G; He M; Fu J; Cai Y; Shi X; Ye P; Chen H; Zhao S; Chen M; Gao C; Kong X; Hou FF; Huang Y; Huo Y · Stroke · 2017
    Randomized trial20,702 participantsHeart Health forFolate
  50. Periconception Red Blood Cell Folate and Offspring Congenital Heart Disease : Nested Case-Control and Mendelian Randomization Studies.
    Chen H; Zhang Y; Wang D; Chen X; Li M; Huang X; Jiang Y; Dou Y; Wang Y; Ma X; Sheng W; Jia B; Yan W; Huang G; SPCC (Shanghai Preconception Cohort) Group · Annals of internal medicine · 2022
    Case-control study985 participantsHeart Health forFolate
  51. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies.
    Jayedi A; Zargar MS · Critical reviews in food science and nutrition · 2020
    Meta-analysis369,746 participants11 studies pooledHeart Health forFolate Heart Health forVitamin B6
  52. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledHeart Health forFolate
  53. The association between folic acid supplementation and congenital heart defects: Systematic review and meta-analysis.
    Wondemagegn AT; Afework M · SAGE open medicine · 2022
    Meta-analysis37 studies pooledHeart Health forFolate
  54. Differential effect of two nicotinic acid preparations on low-density lipoprotein subclass distribution in patients classified as low-density lipoprotein pattern A, B, or I.
    Superko HR; McGovern ME; Raul E; Garrett B · The American journal of cardiology · 2004
    Randomized trial180 participantsHeart Health forNiacin
  55. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
    Villines TC; Stanek EJ; Devine PJ; Turco M; Miller M; Weissman NJ; Griffen L; Taylor AJ · Journal of the American College of Cardiology · 2010
    Randomized trial315 participantsHeart Health forNiacin
  56. The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
    Thoenes M; Oguchi A; Nagamia S; Vaccari CS; Hammoud R; Umpierrez GE; Khan BV · International journal of clinical practice · 2008
    Randomized trial50 participantsHeart Health forNiacin
  57. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease.
    Duggal JK; Singh M; Attri N; Singh PP; Ahmed N; Pahwa S; Molnar J; Singh S; Khosla S; Arora R · Journal of cardiovascular pharmacology and therapeutics · 2010
    Meta-analysis5,137 participants7 studies pooledHeart Health forNiacin
  58. Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
    Sahebkar A · Vascular medicine (London, England) · 2014
    Meta-analysis441 participants7 studies pooledHeart Health forNiacin
  59. Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
    Hansen CS; Jensen JS; Ridderstråle M; Vistisen D; Jørgensen ME; Fleischer J · Journal of diabetes and its complications · 2018
    Cross-sectional study469 participantsHeart Health forVitamin B12
  60. Vitamin B12 and folate status in early pregnancy and cardiometabolic risk factors in the offspring at age 5-6 years: findings from the ABCD multi-ethnic birth cohort.
    Krikke GG; Grooten IJ; Vrijkotte TG; van Eijsden M; Roseboom TJ; Painter RC · BJOG : an international journal of obstetrics and gynaecology · 2016
    Cohort study1,950 participantsHeart Health forVitamin B12
  61. Orthostatic tolerance in older patients with vitamin B12 deficiency before and after vitamin B12 replacement.
    Moore A; Ryan J; Watts M; Pillay I; Clinch D; Lyons D · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2004
    Non-randomized trial16 participantsHeart Health forVitamin B12
  62. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.
    Liang X; Huang D; Bi Y; He Y; Mao T; Liu Q; Hu G; Tong J; Chen L; Wang Y; An X; Jiang X; Tahir MF · Journal of human hypertension · 2024
    Observational study596 participantsHeart Health forVitamin B12
  63. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I.
    Ishihara J; Iso H; Inoue M; Iwasaki M; Okada K; Kita Y; Kokubo Y; Okayama A; Tsugane S; JPHC Study Group · Journal of the American College of Nutrition · 2008
    Cohort study40,803 participantsHeart Health forVitamin B6
  64. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis.
    Miao Y; Guo Y; Chen Y; Lin Y; Lu Y; Guo Q · Nutrition reviews · 2024
    Meta-analysisHeart Health forVitamin B6
  65. Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy.
    Tavani A; Pelucchi C; Parpinel M; Negri E; La Vecchia C · European journal of clinical nutrition · 2005
    Case-control study985 participantsHeart Health forVitamin B6
  66. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials.
    Firth J; Teasdale SB; Allott K; Siskind D; Marx W; Cotter J; Veronese N; Schuch F; Smith L; Solmi M; Carvalho AF; Vancampfort D; Berk M; Stubbs B; Sarris J · World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Systematic review10,951 participants33 studies pooledMood Support forFolate
  67. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis.
    Jin X; Cheng Z; Yu X; Tao Q; Huang R; Wang S · Journal of affective disorders · 2022
    Meta-analysis26,275 participants15 studies pooledMood Support forFolate
  68. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials.
    Borges-Vieira JG; Cardoso CKS · Nutritional neuroscience · 2023
    Systematic review2,256 participants20 studies pooledMood Support forFolate Mood Support forVitamin B12
  69. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses.
    Gao S; Khalid A; Amini-Salehi E; Radkhah N; Jamilian P; Badpeyma M; Zarezadeh M · Food science & nutrition · 2024
    Meta-analysis11 studies pooledMood Support forFolate
  70. Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study.
    Passeri M; Cucinotta D; Abate G; Senin U; Ventura A; Stramba Badiale M; Diana R; La Greca P; Le Grazie C · Aging (Milan, Italy) · 1993
    Randomized trial96 participantsMood Support forFolate
  71. Subjective well-being in older adults: folate and vitamin B12 independently predict positive affect.
    Edney LC; Burns NR; Danthiir V · The British journal of nutrition · 2016
    Cohort study391 participantsMood Support forVitamin B12
  72. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Arija V · Journal of reproductive and infant psychology · 2025
    Cohort study336 participantsMood Support forVitamin B12
  73. The biological relationship among depression, vitamins B9, B12, and D, and genetic variants: a systematic review.
    Soriano-Gonzalez R; Ramirez-Olea H; Gonzalez-Soltero R; Chavez-Santoscoy RA · Frontiers in nutrition · 2025
    Systematic review24 studies pooledMood Support forVitamin B12
  74. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B12