SAMe 200 mg + Cofactors
Metabolic Maintenance
Score 78
This supplement combines 200 mg of SAMe with active B vitamins and absorbable forms of calcium and magnesium, aiming to support mood, cognitive function, and general well-being.
Score 78
This supplement combines 200 mg of SAMe with active B vitamins and absorbable forms of calcium and magnesium, aiming to support mood, cognitive function, and general well-being.
Analysis
This supplement features 200 mg of SAMe, a compound involved in various bodily processes, particularly those related to mood and joint comfort. It's thoughtfully combined with active forms of B vitamins, including Pyridoxal 5-Phosphate (Vitamin B6), Folate, and Methylcobalamin (Vitamin B12), which are vital cofactors that help the body properly utilize SAMe.
Beyond the core SAMe and B vitamin complex, the product also includes Calcium Citrate and Magnesium Bisglycinate. These are highly absorbable forms of minerals that support a wide range of bodily functions, from bone health and muscle function to nerve signaling, adding to the product's comprehensive approach to general well-being.
This combination can be particularly appealing to individuals looking for support for mood balance, cognitive function, and joint health, as the cofactors are designed to enhance the efficacy of the SAMe. The choice of bioavailable ingredient forms suggests a focus on effective absorption.
Pros
- Contains active, bioavailable forms of B vitamins (P5P, Methylcobalamin).
- Includes readily absorbed chelated mineral forms (Calcium Citrate, Magnesium Bisglycinate).
- Comprehensive formulation designed to support SAMe metabolism effectively.
- Provides a common and flexible 200mg dosage of SAMe per capsule.
Cons
- SAMe can be sensitive to environmental factors, which may affect stability over time.
- Some individuals may experience mild gastrointestinal upset or other minor side effects from SAMe.
- The price per serving is relatively high compared to some standalone SAMe products.
Warnings
- Individuals taking antidepressant medications should consult a healthcare professional before use.
- SAMe may cause mild digestive discomfort or restlessness in some sensitive individuals.
- Those with bipolar disorder should avoid SAMe unless under strict medical supervision.
$73.00($1.21 per serving)
 iHerb | $ 73.00 | |
| iHerb | $ 73.00 |
Goals
Impact
Highest effect
SAMe is often used to help balance mood, and the B vitamins included are crucial cofactors for the production of mood-regulating neurotransmitters in the brain.
Impact
High effect
SAMe plays a role in neurotransmitter synthesis, and the active B vitamins are essential for nerve health and energy metabolism in the brain, collectively contributing to cognitive function.
Impact
High effect
The combination of SAMe and active B vitamins supports methylation cycles critical for brain function, neurotransmitter health, and overall neuronal integrity.
Impact
High effect
SAMe is often used for its potential to support joint comfort and the healthy formation and maintenance of cartilage, contributing to overall joint mobility.
Impact
High effect
The B vitamins are fundamental for cellular energy production and metabolism, which can contribute to overall vitality. SAMe's role in various biochemical reactions may also indirectly support energy levels.
Impact
High effect
It supplies essential B vitamins and well-absorbed minerals, contributing to various metabolic functions, cellular health, and overall physiological well-being.
Impact
High effect
The B vitamins and SAMe are involved in pathways that can support mental clarity and sustained concentration by influencing neurotransmitter balance and brain energy.
Impact
High effect
SAMe serves as a methyl donor, playing a direct role in various methylation reactions that are key components of the body's natural detoxification pathways, especially in the liver.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 2 mg |
Folate | 333 mcg DFE |
Vitamin B12 | 500 mcg |
Calcium | 20 mg |
Magnesium | 20 mg |
SAMe | 200 mg |
Vitamin B12 85
The product provides a substantial dose of methylcobalamin, which is recognized as an active and highly bioavailable form of Vitamin B12, supporting its intended benefits.
SAMe 80
This supplement features a relevant 200mg dose of SAMe, combined with critical B vitamin cofactors that help facilitate its optimal metabolic utilization within the body.
Alternative products
90 Value 
SAMe 200 mg
NOW
This product offers a superior score compared to your current one while being significantly more affordable per serving. It focuses on delivering 200 mg of SAMe efficiently, making it a great choice if you prioritize the SAMe component and want excellent value.
92 Value 
Fully Active B Complex with Quatrefolic
Doctor's Best
This B-complex has an exceptionally high score and a very low price per serving. It provides robust support for energy, mood, and brain health with active forms of B vitamins (including Quatrefolic Folate and Methylcobalamin B12), which are important cofactors for SAMe's actions. It offers tremendous value for comprehensive B vitamin support.
89 Value 
B12 Methylcobalamin 1000 mcg
Natural Factors
For supporting energy, cognitive function, and homocysteine metabolism, this product delivers 1000 mcg of active Methylcobalamin B12 at a remarkably low cost per serving and a high score. If you're looking for an excellent value solely for the crucial B12 cofactor from your original product, this is a strong candidate.
88 Performance 
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
This product offers a very similar combination to your current one, providing 200 mg of SAMe along with excellent active forms of B6 (Pyridoxal 5-Phosphate), B12 (Methylcobalamin), and Folate (5-MTHF). The inclusion of 5-MTHF for folate is a key enhancement for those seeking optimal B vitamin support related to SAMe metabolism and mood/cognitive goals.
93 Performance 
SAMe 400 mg
Lake Avenue Nutrition
If you're looking to potentially increase your SAMe intake, this option provides 400 mg per serving, double the amount in your current product, with a very high overall score. While it focuses solely on SAMe without added cofactors, the higher dose can be a significant benefit for intense mood or joint support goals.
93 Performance 
PureGenomics B-Complex
Pure Encapsulations
While it doesn't contain SAMe, this B-complex is outstanding for supporting the 'cofactor' aspect of your current product and directly contributes to goals like mood, energy, and brain health. It features highly active forms of B vitamins, including Riboflavin 5-Phosphate, Pyridoxal 5-Phosphate (B6), Adenosylcobalamin + Hydroxycobalamin (B12), and quality Folate, offering comprehensive B vitamin support. You could pair this with a separate SAMe product for a more tailored approach.
90 Budget
SAMe 200 mg
NOW
This option provides the core 200 mg of SAMe at a significantly lower cost per serving compared to your current product. It's a straightforward choice if your primary focus is on getting SAMe itself, and you're open to potentially getting other cofactors separately or from your diet.
80 Budget 
SAMe 200
Jarrow Formulas
Another cost-effective way to get 200 mg of SAMe per serving. It's a solid choice if you're looking to maintain your SAMe intake while keeping the price per serving down, similar to the NOW brand but from a different reputable manufacturer.
78 Budget 
SAMe 200 mg S-Adenosyl-Methionine
Life Extension
This product offers 200 mg of SAMe, matching the dosage and overall score of your current product but at about half the price per serving. It's a great option if you want to keep the SAMe dosage consistent and save on cost, accepting that it doesn't include the added cofactors.
90 Value
SAMe 200 mg
NOW
This product offers a superior score compared to your current one while being significantly more affordable per serving. It focuses on delivering 200 mg of SAMe efficiently, making it a great choice if you prioritize the SAMe component and want excellent value.
92 Value
Fully Active B Complex with Quatrefolic
Doctor's Best
This B-complex has an exceptionally high score and a very low price per serving. It provides robust support for energy, mood, and brain health with active forms of B vitamins (including Quatrefolic Folate and Methylcobalamin B12), which are important cofactors for SAMe's actions. It offers tremendous value for comprehensive B vitamin support.
89 Value
B12 Methylcobalamin 1000 mcg
Natural Factors
For supporting energy, cognitive function, and homocysteine metabolism, this product delivers 1000 mcg of active Methylcobalamin B12 at a remarkably low cost per serving and a high score. If you're looking for an excellent value solely for the crucial B12 cofactor from your original product, this is a strong candidate.
88 Performance
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
This product offers a very similar combination to your current one, providing 200 mg of SAMe along with excellent active forms of B6 (Pyridoxal 5-Phosphate), B12 (Methylcobalamin), and Folate (5-MTHF). The inclusion of 5-MTHF for folate is a key enhancement for those seeking optimal B vitamin support related to SAMe metabolism and mood/cognitive goals.
93 Performance
SAMe 400 mg
Lake Avenue Nutrition
If you're looking to potentially increase your SAMe intake, this option provides 400 mg per serving, double the amount in your current product, with a very high overall score. While it focuses solely on SAMe without added cofactors, the higher dose can be a significant benefit for intense mood or joint support goals.
93 Performance
PureGenomics B-Complex
Pure Encapsulations
While it doesn't contain SAMe, this B-complex is outstanding for supporting the 'cofactor' aspect of your current product and directly contributes to goals like mood, energy, and brain health. It features highly active forms of B vitamins, including Riboflavin 5-Phosphate, Pyridoxal 5-Phosphate (B6), Adenosylcobalamin + Hydroxycobalamin (B12), and quality Folate, offering comprehensive B vitamin support. You could pair this with a separate SAMe product for a more tailored approach.