5-HTP Plus+ 200 mg
NatureWise
5-HTP Plus+ 200 mg
4.4
★ ★ ★ ★ ★
(5151 ratings)
5-HTP 200 mg
Score 88.0
NatureWise 5-HTP Plus+ offers a potent 200mg dose with essential B6 for enhanced serotonin conversion, making it a strong choice for comprehensive mood and sleep support.
Quantity: 30 Capsule(s)Servings size: 1 Vegetarian Capsule(s) (30 servings)
Selected goals:
Other goals:
Stress Relief
Mood Support
Sleep Support
leaderboard Score 88.0
NatureWise 5-HTP Plus+ offers a potent 200mg dose with essential B6 for enhanced serotonin conversion, making it a strong choice for comprehensive mood and sleep support.
insights Analysis
NatureWise 5-HTP Plus+ delivers a high 200mg dose of 5-HTP, which is an advanced dosage for individuals seeking strong support for mood, stress, and sleep. A key advantage of this product is the inclusion of 5mg of Vitamin B6 (as Pyridoxal 5-Phosphate, P-5-P), the active coenzyme form of B6. B6 is essential for the conversion of 5-HTP to serotonin, making this formulation potentially more effective than standalone 5-HTP products. While its price per serving is on the higher end compared to basic options, the combination of a high dose and the crucial cofactor contributes significantly to its overall efficacy and value for those needing comprehensive support.
- High 200mg dosage provides strong support for mood, stress, and sleep.
- Includes Vitamin B6 (P-5-P), a crucial cofactor for 5-HTP conversion, enhancing effectiveness.
- NatureWise is a reputable brand known for quality supplements.
- Higher price per serving compared to many other 5-HTP products.
- Does not include Vitamin C, another potential cofactor for serotonin synthesis.
- 5-HTP should not be taken with antidepressant medications (SSRIs, MAOIs) or other serotonin-modulating drugs due to the risk of serotonin syndrome.
- Consult a healthcare professional before use, especially if pregnant, nursing, or taking other medications.
- May cause mild gastrointestinal discomfort (nausea, diarrhea) in some individuals, particularly at higher doses.
$13.11($0.43 per serving)
 Amazon | $ 13.11 | |
 Vitacost | $ 13.99 | |
 Walmart | $ 13.99 | |
 iHerb | $ 14.57 |
bolt Effectiveness for goals
5-HTP is a precursor to serotonin, a neurotransmitter that plays a key role in mood regulation. Some studies suggest that 5-HTP supplementation may help support a balanced mood, particularly in individuals with lower serotonin levels. However, it is not a treatment for mood disorders and should not replace professional medical advice.
As 5-HTP converts to serotonin, which can then be converted into melatonin, it is thought to play a role in sleep regulation. Some research indicates that 5-HTP may help improve sleep quality and reduce the time it takes to fall asleep for certain individuals. Consistent evidence across all populations is still being gathered.
5-Hydroxytryptophan (5-HTP) is a precursor to serotonin, a neurotransmitter involved in mood, sleep, and appetite. Some research suggests it may help support these functions by increasing serotonin levels, but more definitive studies are needed to establish broad effectiveness across all individuals. Individual results can vary depending on various factors.
Some research suggests that 5-HTP may help support mood by increasing serotonin levels in the brain. Serotonin is a neurotransmitter involved in feelings of well-being and happiness. However, more extensive research is needed to fully understand its effects.
5-HTP is a precursor to serotonin, which can then be converted into melatonin, a hormone that regulates sleep-wake cycles. Some studies indicate that 5-HTP may contribute to improved sleep quality and duration. Individual responses can vary.
schedule Dosage, timing & forms
Many sources suggest beginning with a low dose, such as 50 mg, taken once or twice daily. This approach allows individuals to assess their tolerance and response. Doses can be gradually increased if needed, often under professional guidance.
5-HTP is often taken in the evening, sometimes 30-60 minutes before bedtime, particularly if supporting sleep is a goal. For other uses, it may be taken throughout the day, often divided into multiple doses. Timing can vary based on individual response and desired effects.
5-HTP is often taken in the evening, particularly if used for sleep support. For other purposes, it can be taken throughout the day, sometimes with meals to help minimize potential stomach upset.
While specific recommendations vary, dosages beyond 300-500 mg per day are generally not advised without professional guidance. Higher doses may increase the risk of side effects. It is important to adhere to recommended serving sizes or consult a healthcare provider.
Taking 5-HTP with food may help reduce gastrointestinal side effects like nausea, which some individuals experience. However, some sources suggest taking it on an empty stomach might enhance absorption for specific uses. Following product label instructions is generally recommended.
health_and_safety Safety & interactions
Yes, 5-HTP can have significant interactions with antidepressant medications, including SSRIs (Selective Serotonin Reuptake Inhibitors) and MAOIs (Monoamine Oxidase Inhibitors). Combining 5-HTP with these drugs can elevate serotonin levels excessively, increasing the risk of serotonin syndrome. Consultation with a healthcare provider is essential before combining them.
No, combining 5-HTP with antidepressant medications such as selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase inhibitors (MAOIs) is not recommended. This combination can significantly increase serotonin levels, potentially leading to serotonin syndrome. It is crucial to consult a healthcare professional before combining supplements with prescription drugs.
Yes, 5-HTP can potentially contribute to serotonin syndrome, especially when taken with other medications that increase serotonin levels. Serotonin syndrome is a serious condition caused by excessive serotonin activity in the brain. It is crucial to avoid combining 5-HTP with such medications without professional guidance.
Serotonin syndrome is a potentially serious condition caused by excessive serotonin activity in the brain. Taking 5-HTP, which increases serotonin levels, especially with other serotonergic medications, may elevate this risk. Symptoms can include agitation, rapid heart rate, confusion, and muscle rigidity.
Yes, 5-HTP may interact with other substances that affect serotonin levels, including triptans for migraines, dextromethorphan (found in cough medicines), and certain herbal supplements like St. John's Wort. Combining these can increase the risk of serotonin syndrome. Always discuss all current medications and supplements with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B6 | 5 mg |
5-HTP | 200 mg |
Categories
5-HTP 88.0
A top-tier option within the 5-HTP category, standing out due to its high potency and the inclusion of a vital cofactor, making it a highly effective and comprehensive choice.
Goals
Stress Relief 90.0
The potent 200mg dose, coupled with B6, offers robust support for stress management by optimizing serotonin synthesis, leading to better emotional resilience and stability.
Mood Support 90.0
The high 5-HTP dosage and the presence of the essential B6 cofactor make this an excellent choice for effectively boosting and stabilizing mood by maximizing serotonin production.
Sleep Support 85.0
The strong 5-HTP dose and B6 can significantly aid in melatonin production, contributing to improved sleep onset and quality, although a dedicated sleep blend might offer more direct sleep support for complex sleep issues.
Recommended Alternatives
95 Value 
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
At only 12 cents per serving for a 100mg dose with both B6 and C, it offers outstanding value by providing a complete and highly effective cofactor profile at a much lower cost per serving than the original.
90 Value 
5-HTP 100 mg
Doctor's Best
4.7
★★★★★
(12256 ratings)
A highly cost-effective option at 11 cents per serving for a 100mg dose, providing excellent pure 5-HTP value if the higher dose and B6 from the original aren't strictly necessary for the user's needs.
85 Value 
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Offers 100mg 5-HTP with both B6 and C at 18 cents per serving, presenting a very good value for a comprehensive formulation, though less potent than the 200mg original.
95 Performance
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
While a 100mg dose, it includes both B6 and C, providing a more comprehensive cofactor profile for optimal serotonin synthesis, potentially outperforming the original for those prioritizing full cofactor support over a higher single dose of 5-HTP.
85 Performance 
Advanced Sleep Melatonin + 5-HTP Time Release
Natrol
4.5
★★★★★
(8298 ratings)
Although a lower 5-HTP dose (50mg), its combination of time-release 5-HTP, melatonin, and B6 offers a more specialized and potentially superior solution specifically for complex sleep issues.
70 Performance 
5-HTP
Nature's Way
4.5
★★★★★
(829 ratings)
While at a higher price per serving, this option combines 100mg of 5-HTP with both B6 and C, which are crucial cofactors for enhanced absorption and conversion of 5-HTP.
90 Budget
5-HTP 100 mg
Doctor's Best
4.7
★★★★★
(12256 ratings)
Offers a standard 100mg dose at a significantly lower 11 cents per serving, providing excellent value if a lower dose is sufficient for the user's needs.
85 Budget 
5-HTP 100 mg
NOW
4.7
★★★★★
(48226 ratings)
Provides a 100mg dose at 13 cents per serving from a highly reputable brand, offering a more economical option without sacrificing quality.
80 Budget 
5-HTP 100 mg Extra Strength
Swanson
4.8
★★★★★
(3247 ratings)
Delivers a 100mg dose at an incredibly low 11 cents per serving, representing a highly budget-friendly alternative for general 5-HTP support.
95 Value
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
At only 12 cents per serving for a 100mg dose with both B6 and C, it offers outstanding value by providing a complete and highly effective cofactor profile at a much lower cost per serving than the original.
90 Value
5-HTP 100 mg
Doctor's Best
4.7
★★★★★
(12256 ratings)
A highly cost-effective option at 11 cents per serving for a 100mg dose, providing excellent pure 5-HTP value if the higher dose and B6 from the original aren't strictly necessary for the user's needs.
85 Value
5-HTP with Vitamin B6 & Vitamin C
Lake Avenue Nutrition
4.7
★★★★★
(5077 ratings)
Offers 100mg 5-HTP with both B6 and C at 18 cents per serving, presenting a very good value for a comprehensive formulation, though less potent than the 200mg original.
95 Performance
5-HTP Enhanced with Vitamins B6 and C
Doctor's Best
4.8
★★★★★
(5265 ratings)
While a 100mg dose, it includes both B6 and C, providing a more comprehensive cofactor profile for optimal serotonin synthesis, potentially outperforming the original for those prioritizing full cofactor support over a higher single dose of 5-HTP.
85 Performance
Advanced Sleep Melatonin + 5-HTP Time Release
Natrol
4.5
★★★★★
(8298 ratings)
Although a lower 5-HTP dose (50mg), its combination of time-release 5-HTP, melatonin, and B6 offers a more specialized and potentially superior solution specifically for complex sleep issues.
70 Performance
5-HTP
Nature's Way
4.5
★★★★★
(829 ratings)
While at a higher price per serving, this option combines 100mg of 5-HTP with both B6 and C, which are crucial cofactors for enhanced absorption and conversion of 5-HTP.