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Multi-B Benfotiamine 150 mg

BenfoComplete.com
4.6
★ ★ ★ ★ ★
(1043 ratings)
Thiamin 150 mg
Vitamin B12 500 mcg
Vitamin B5 50 mg
Riboflavin 10 mg
Folate 100 mcg
Product Image
Score83
A practical high-benfotiamine complex with useful supporting B vitamins, though folate quality and amount are limited.
How scoring works
Quantity:120 Capsule(s) • (120 servings)
Goals:
Energy
General Health
Productivity Boost
Metabolism Boost
Cognitive Support
Brain Health

Score 83

A practical high-benfotiamine complex with useful supporting B vitamins, though folate quality and amount are limited.
How scoring works
$30.97($0.25 per serving)
Amazon
$ 30.97
iHerb
$ 34.83
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Analysis

Benfotiamine provides a well-absorbed thiamine form at a focused 150 mg amount. Methylcobalamin, pyridoxine, riboflavin, and calcium pantothenate add useful metabolic cofactors.

The folic acid amount is low and uses a form that requires conversion before use. Riboflavin and B6 also use standard rather than active coenzyme forms, so quality is mixed across the complex.

One capsule and clear amounts make it practical for users prioritizing benfotiamine. It is less complete for general daily nutrition or focused folate support.

Who is it for
  • Adults prioritizing benfotiamine
  • People seeking metabolic B-vitamin support
  • Users wanting methylcobalamin in the same capsule
Best for
  • Benfotiamine supplementation
  • Energy metabolism
  • Broad nerve-related cofactor support

Pros

  • High benfotiamine amount
  • Uses methylcobalamin
  • Clear one-capsule dosing

Cons

  • Low folic acid amount
  • Uses standard riboflavin
  • Not a complete general-health formula

Warnings

  • The pyridoxine amount should be included when stacking other B6 products
  • Folic acid may be unsuitable for users specifically advised to use methylfolate
  • People taking glucose-lowering medication should monitor for changes when adding high-dose benfotiamine

Nutrient quality

86 Highest impact

The formula mixes useful active forms with older conventional vitamin forms. The core B vitamins are supplied at useful amounts for broad nutritional support.

.

Ingredient transparency

83 Highest impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

.

Customer satisfaction

73 High impact

The average rating is moderately strong. The large rating volume provides a reliable satisfaction signal.

.

Value for money

89 Highest impact

The supply provides reasonable value per effective serving. The formula is not inflated by low-value extras.

.
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Goals

Energy
Energy
Impact
Highest effect
A Goal FitA Strength of SupportB- CoverageA Formula Quality
Vitamin B5 · 50 mgRiboflavin · 10 mgThiamin · 150 mgVitamin B12 · 500 mcg

High-dose benfotiamine, methylcobalamin, riboflavin, vitamin B6, folate, and vitamin B5 provide several cofactors used to turn food into cellular energy. The amounts are fully disclosed, and the stronger forms of thiamin and B12 improve the formulation's practical quality.

Support remains concentrated on nutrient metabolism rather than alertness or stress resilience. The formula is most likely to make a noticeable difference when intake or status of one of these B vitamins is inadequate, rather than acting like an immediate stimulant.

Study evidence
Riboflavin Mixed 6 studies
Thiamin Disputed 12 studies
Vitamin B12 Disputed 14 studies
General Health
General Health
Impact
Highest effect
A- Goal FitB Strength of SupportB CoverageA- Formula Quality
Folate · 100 mcgVitamin B12 · 500 mcg

A broad B-vitamin combination supports normal energy production and several cellular processes. Benfotiamine and methylcobalamin strengthen the form quality of two key actives.

Folic acid is modest and less direct than methylfolate, so folate support is not a major strength. The formula fits users seeking targeted B-vitamin coverage more than those wanting a complete general-health foundation.

Study evidence
Folate Supportive 80 studies
Vitamin B12 Adverse 66 studies
Productivity Boost
Productivity Boost
Impact
Highest effect
B Goal FitA Strength of SupportC+ CoverageA Formula Quality
Vitamin B12 · 500 mcgVitamin B12 · 500 mcgVitamin B6 · 10 mg

Methylcobalamin, benfotiamine, vitamin B6, riboflavin, and pantothenate support energy metabolism and neurotransmitter production. The active B12 form and individually disclosed amounts make the foundational contribution easy to assess.

The formula is most likely to help productivity when low B-vitamin status contributes to fatigue or poor concentration. It does not provide a stimulant, adaptogen, or targeted nootropic for an immediate focus effect.

Study evidence
Vitamin B12 Supportive 15 studies
Vitamin B12 No effect 17 studies
Vitamin B6 Disputed 6 studies
Metabolism Boost
Metabolic B-Vitamins
Metabolism Boost
Impact
High effect
C+ Goal FitB+ Strength of SupportC+ CoverageA Formula Quality
Vitamin B12 · 500 mcgRiboflavin · 10 mgThiamin · 150 mgVitamin B5 · 50 mgVitamin B6 · 10 mg

Benfotiamine, riboflavin, vitamin B6, methylcobalamin, and pantothenate support core cellular energy reactions. These nutrients help correct metabolic bottlenecks when intake is low but are not direct thermogenic agents.

Several doses are substantial, and benfotiamine plus methylcobalamin improve form quality. The focused B-vitamin design provides useful depth without unnecessary botanical blends.

Study evidence
Riboflavin Mixed 5 studies
Thiamin Supportive 11 studies
Vitamin B12 Supportive 10 studies
Vitamin B5 Supportive 12 studies
Vitamin B6 Supportive 16 studies
Cognitive Support
Cognitive Support
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageA Formula Quality
Thiamin · 150 mgVitamin B6 · 10 mgFolate · 100 mcgVitamin B12 · 500 mcg

Benfotiamine and complementary B vitamins support brain energy, neurotransmitter metabolism, and normal nerve function. Methylcobalamin provides a useful vitamin B12 amount, while the folic acid contribution is small and less direct than methylfolate.

The formula offers broad foundational nutrient support but no direct memory botanical, cerebral-circulation active, or membrane lipid. Benefits are therefore most likely when B-vitamin intake or status is inadequate.

Study evidence
Folate Supportive 68 studies
Thiamin Supportive 30 studies
Vitamin B12 Disputed 84 studies
Vitamin B6 Supportive 17 studies
Brain Health
Brain Health
Impact
High effect
C+ Goal FitB- Strength of SupportC+ CoverageC+ Formula Quality
Folate · 100 mcgVitamin B12 · 500 mcgVitamin B6 · 10 mgThiamin · 150 mg

Benfotiamine and several B vitamins provide foundational support for nerve energy metabolism and methylation. The formula may matter most when intake is inadequate and is less targeted than a dedicated memory or focus supplement.

Methylcobalamin and benfotiamine are favorable forms, while folic acid is less direct than methylfolate. Repeated high-potency B-vitamin forms broaden coverage but also add some redundancy.

Study evidence
Folate Supportive 90 studies
Thiamin Supportive 48 studies
Vitamin B12 Supportive 74 studies
Hair Health
Hair Health
Impact
Moderate effect
D- Goal FitC Strength of SupportD- CoverageC+ Formula Quality

The formula supplies several nutrients that can matter when deficiency affects hair. It is primarily a broad nutritional product rather than a targeted hair intervention.

Bioactive methylcobalamin is useful for B12 deficiency, while the broader B-vitamin blend is not a direct hair-growth treatment. The formula lacks iron, zinc, biotin, and structural protein.

Study evidence
Vitamin B12 Disputed 17 studies

Ingredients

IngredientAmount per serving
Benfotiamine
150 mg
Vitamin B2 (Riboflavin)
 10 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 10 mg
Folic Acid (Vitamin B9)
 100 mcg
Vitamin B12 (Methylcobalamin)
 500 mcg
Vitamin B5 (Calcium D-Pantothenate)
 50 mg
Adults 18–50
Report overview
Thiamin · 150 mg OverallScore96
A Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Benfotiamine supplies a highly bioavailable thiamin form at a targeted high-potency dose. Several complementary B vitamins broaden the formula beyond isolated thiamin support. Clear amounts and favorable per-serving value make it a practical B-complex choice.

View ingredientView products
Vitamin B12 (Methylcobalamin) · 500 mcg OverallScore71
A- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Methylcobalamin provides a bioactive B12 form with clear label disclosure. The amount supports more than basic maintenance but does not reach the threshold set for higher therapeutic needs. Standard capsules are practical to swallow, while the cost per active amount is relatively high even after accounting for the preferred form.

View ingredientView products
Vitamin B5 (Calcium D-Pantothenate) · 50 mg OverallScore66
B Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value

Calcium D-pantothenate is a stable, well-absorbed form of vitamin B5 with clear source disclosure. The 50 mg amount supports general maintenance but is below the ranges used for more intensive goals. Value is limited because reaching a much higher active amount would require many servings.

View ingredientView products
Loading alternative details
81 Performance

Fully Active B Complex with Quatrefolic

Doctor's Best
<p>Its label clearly provides 40 mg of Vitamin C as Ascorbic Acid, making it a more clearly defined vitamin b12 and thiamin and folate and riboflavin and vitamin b5 option. Compared with the original, its ingredient and goal alignment is stronger, although the input does not provide independent testing or absorption evidence.</p>
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>Its label clearly provides 800 mcg of Folate as Quatrefolic (6S)-5-Methyltetrahydrofolate Glucosamine Salt, making it a more clearly defined vitamin b12 and folate option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s thiamin and riboflavin and vitamin b5 coverage.</p>
86 Performance

B-6 B-12 Folic Acid Drop Ins Natural Mixed Berry Flavor

KAL
<p>Its label clearly provides 10 mg of Vitamin B-6 as Pyridoxal 5-Phosphate, making it a more clearly defined vitamin b12 and folate option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s thiamin and riboflavin and vitamin b5 coverage.</p>
71 Budget

B 50 Complex

Thompson
<p>Its label clearly provides 50 mg of Thiamine as Thiamine Mononitrate, preserving relevant thiamin and folate and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s vitamin b12 coverage.</p>
74 Budget

B 50 Complex

Spring Valley
<p>Its label clearly provides 50 mg of Thiamine, preserving relevant thiamin and folate and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s vitamin b12 coverage.</p>
79 Budget

B-100 Complex

21st Century
<p>Its label clearly provides 100 mg of Vitamin B1 as Thiamine Mononitrate, preserving relevant vitamin b12 and thiamin and riboflavin and vitamin b5 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s folate coverage.</p>
81 Value

Super B-Complex

Nature Made
<p>Its label clearly provides 150 mg of Vitamin C as Ascorbic Acid, keeping the formula relevant to thiamin and folate and riboflavin. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b12 and vitamin b5 coverage.</p>
86 Value

B-6 B-12 Methyl Folate Mixed Berry

KAL
<p>Its label clearly provides 3 mg of Vitamin B-6 as Pyridoxal 5-Phosphate Monohydrate, keeping the formula relevant to vitamin b12 and folate. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s thiamin and riboflavin and vitamin b5 coverage.</p>
79 Value

Sublingual Liquid B Complex

Nature's Bounty
<p>Its label clearly provides 1.70 mg of Riboflavin as Riboflavin 5'-Phosphate Sodium, keeping the formula relevant to vitamin b12 and vitamin b5. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s thiamin and folate and riboflavin coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age.
    Rotstein A; Kodesh A; Goldberg Y; Reichenberg A; Levine SZ · Evidence-based mental health · 2022
    Cohort study27,188 participantsGeneral Health forFolate
  2. Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials.
    Nakanishi N; Abe Y; Matsuo M; Tampo A; Yamada K; Hatakeyama J; Yoshida M; Yamamoto R; Higashibeppu N; Nakamura K; Kotani J · Clinical nutrition (Edinburgh, Scotland) · 2024
    Meta-analysis3,494 participants35 studies pooledMetabolism Boost forThiamin
  3. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  4. High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial.
    Bager P; Bossen L; Gantzel R; Grønbæk H · PloS one · 2024
    Randomized trial36 participantsEnergy forThiamin
  5. Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
    Webster MJ · European journal of applied physiology and occupational physiology · 1998
    Randomized trial6 participantsMetabolism Boost forVitamin B5
  6. Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.
    Kanti G; Anadol-Schmitz E; Bobrov P; Strassburger K; Kahl S; Zaharia OP; Sarabhai T; Karusheva Y; Burkart V; Markgraf DF; Trenkamp S; Ziegler D; Szendroedi J; Roden M; GDS Group · The Journal of clinical endocrinology and metabolism · 2021
    Cross-sectional study249 participantsMetabolism Boost forVitamin B12
  7. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  8. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin Energy forThiamin
  9. Folate Biomarkers, Folate Intake, and Risk of Death From All Causes, Cardiovascular Disease, and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
    Fallah M; Karim Dehnavi M; Lotfi K; Aminianfar A; Azadbakht L; Esmaillzadeh A · Nutrition reviews · 2025
    Meta-analysis423,304 participants25 studies pooledGeneral Health forFolate
  10. Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.
    Munipalli B; Strothers S; Rivera F; Malavet P; Mitri G; Abu Dabrh AM; Dawson NL · Mayo Clinic proceedings. Innovations, quality & outcomes · 2022
    Observational study2,142 participantsEnergy forVitamin B12
  11. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  12. Cross-Sectional Study of the Prevalence of Cobalamin Deficiency and Vitamin B12 Supplementation Habits among Vegetarian and Vegan Children in the Czech Republic.
    Světnička M; Sigal A; Selinger E; Heniková M; El-Lababidi E; Gojda J · Nutrients · 2022
    Cross-sectional study200 participantsMetabolism Boost forVitamin B12
  13. Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients.
    Vine J; Lee JH; Simpson MD; Grossestreuer AV; Sorour K; Zubair MM; Moskowitz A; Berg KM; Liu X; Donnino MW · Resuscitation · 2026
    Randomized trial74 participantsMetabolism Boost forThiamin
  14. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  15. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  16. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
    González-Domínguez R; Castellano-Escuder P; Lefèvre-Arbogast S; Low DY; Du Preez A; Ruigrok SR; Lee H; Helmer C; Pallàs M; Urpi-Sarda M; Sánchez-Pla A; Korosi A; Lucassen PJ; Aigner L; Manach C; Thuret S; Samieri C; Andres-Lacueva C · Alzheimer's research & therapy · 2022
    Observational studyMetabolism Boost forVitamin B5
  17. A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartum anemia.
    Van Der Woude DA; De Vries J; Van Wijk EM; Verzijl JM; Pijnenborg JM · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2015
    Randomized trial112 participantsGeneral Health forFolate
  18. Association between serum vitamin B12 level and frailty in older adults.
    Dokuzlar O; Soysal P; Isik AT · Northern clinics of Istanbul · 2022
    Cross-sectional study335 participantsEnergy forVitamin B12
  19. Metabolic failure due to thiamine deficiency during critical illness.
    Cobilinschi C; Andrei CA; Grinţescu IM; Mirea L · Current opinion in clinical nutrition and metabolic care · 2024
    Narrative reviewEnergy forThiamin
  20. First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders.
    Olivieri G; Bordugo A; Burnyte B; Costetti A; Couce ML; Diogo L; Feillet F; Froese DS; Greco B; Gueant JL; Hannibal L; Hörster F; Kožich V; La Marca G; Manoli I; Mochel F; Orazi L; Pérez B; Schiff M; Schwahn BC; Schwartz I; Stepien KM; Sykut-Cegielska J; Tangeraas T; Zetterström RH; Dionisi-Vici C; Huemer M · Journal of inherited metabolic disease · 2026
    Guideline / consensusMetabolism Boost forVitamin B12
  21. Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.
    Tan KML; Tint MT; Cabral RM; Lau R; Kee MZL; Garg V; De Iorio M; Tan SSL; Eriksson JG · Scientific reports · 2026
    Cohort study662 participantsMetabolism Boost forThiamin
  22. Exploring auxotrophy and engineering vitamin B6 prototrophy in the acetogen Clostridium sp. AWRP.
    Kwon SJ; Lee J; Lee HS · Applied and environmental microbiology · 2024
    Clinical trialMetabolism Boost forVitamin B5
  23. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  24. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  25. Association of folate intake with cardiovascular-disease mortality and all-cause mortality among people at high risk of cardiovascular-disease.
    Xu X; Wei W; Jiang W; Song Q; Chen Y; Li Y; Zhao Y; Sun H; Yang X · Clinical nutrition (Edinburgh, Scotland) · 2022
    Cohort study14,234 participantsGeneral Health forFolate
  26. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  27. Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism.
    Carmel R; Melnyk S; James SJ · Blood · 2003
    Observational study39 participantsMetabolism Boost forVitamin B12
  28. A cross-sectional study of nutritional status in healthy, young, physically-active German omnivores, vegetarians and vegans reveals adequate vitamin B12 status in supplemented vegans.
    Storz MA; Müller A; Niederreiter L; Zimmermann-Klemd AM; Suarez-Alvarez M; Kowarschik S; Strittmatter M; Schlachter E; Pasluosta C; Huber R; Hannibal L · Annals of medicine · 2023
    Cross-sectional study115 participantsEnergy forVitamin B12
  29. Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.
    Dhir S; Tarasenko M; Napoli E; Giulivi C · Frontiers in psychiatry · 2026
    Narrative reviewMetabolism Boost forThiamin
  30. Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
    Spry C; van Schalkwyk DA; Strauss E; Saliba KJ · Infectious disorders drug targets · 2010
    Narrative reviewMetabolism Boost forVitamin B5
  31. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  32. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  33. Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis.
    Mazur M; Ndokaj A; Salerno C; Vallone J; Ardan R; Bietolini S; Carrouel F; Wilk A; Sarig R; Ottolenghi L; Bourgeois D · Frontiers in pharmacology · 2026
    Meta-analysis6,098 participants16 studies pooledMetabolism Boost forVitamin B12
  34. Megaloblastic anaemia: prevalence and causative factors.
    Khanduri U; Sharma A · The National medical journal of India · 2008
    Observational study175 participantsEnergy forVitamin B12
  35. High-resolution plasma metabolomics and thiamine status in critically Ill adult patients.
    Gundogan K; Nellis MM; Ozer NT; Ergul SS; Sahin GG; Temel S; Yuksel RC; Teeny S; Alvarez JA; Sungur M; Jones DP; Ziegler TR · Metabolomics : Official journal of the Metabolomic Society · 2024
    Cross-sectional study76 participantsMetabolism Boost forThiamin
  36. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis.
    Jonczyk R; Ronconi S; Rychlik M; Genschel U · Plant molecular biology · 2008
    OtherMetabolism Boost forVitamin B5
  37. Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses.
    Bo Y; Zhu Y; Tao Y; Li X; Zhai D; Bu Y; Wan Z; Wang L; Wang Y; Yu Z · Frontiers in public health · 2021
    Meta-analysis108 studies pooledGeneral Health forFolate
  38. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  39. Pathophysiology, prevention, and treatment of beriberi after gastric surgery.
    Wilson RB · Nutrition reviews · 2021
    Narrative reviewMetabolism Boost forThiamin
  40. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  41. Optimum nutrition: thiamin, biotin and pantothenate.
    Bender DA · The Proceedings of the Nutrition Society · 1999
    Narrative reviewMetabolism Boost forVitamin B5
  42. Diagnosis and treatment of vitamin B12 deficiency in children.
    Kanvinde P; Khurana R; Mudaliar S · Frontiers in nutrition · 2026
    Narrative reviewMetabolism Boost forVitamin B12
  43. Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.
    Bedson E; Bell D; Carr D; Carter B; Hughes D; Jorgensen A; Lewis H; Lloyd K; McCaddon A; Moat S; Pink J; Pirmohamed M; Roberts S; Russell I; Sylvestre Y; Tranter R; Whitaker R; Wilkinson C; Williams N · Health technology assessment (Winchester, England) · 2015
    Randomized trial475 participantsGeneral Health forFolate
  44. PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
    Morais T; Couto G; Rocha R; Santana G · Arquivos de gastroenterologia · 2026
    Systematic reviewEnergy forThiamin
  45. Insights Into Thiamine Supplementation in Patients With Septic Shock.
    Costa NA; Pereira AG; Sugizaki CSA; Vieira NM; Garcia LR; de Paiva SAR; Zornoff LAM; Azevedo PS; Polegato BF; Minicucci MF · Frontiers in medicine · 2022
    Narrative reviewMetabolism Boost forThiamin
  46. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  47. Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.
    Sun J; Ding W; Liu X; Zhao M; Xi B · Journal of human hypertension · 2022
    Other77 participantsMetabolism Boost forVitamin B5
  48. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  49. Thiamine-dependent processes and treatment strategies in neurodegeneration.
    Gibson GE; Blass JP · Antioxidants & redox signaling · 2007
    Narrative reviewMetabolism Boost forThiamin
  50. Thiamine deficiency-related brain dysfunction in chronic liver failure.
    Butterworth RF · Metabolic brain disease · 2009
    Narrative reviewEnergy forThiamin
  51. Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy.
    Delaney NF; Sharma R; Tadvalkar L; Clish CB; Haller RG; Mootha VK · Proceedings of the National Academy of Sciences of the United States of America · 2018
    OtherMetabolism Boost forVitamin B5
  52. Vitamin B12 Supplementation: Is More Always Better?
    Yepes-Calderón M; Doorenbos CSE; Stegmann ME; Touw DJ; Harmsen HJM; Heiner-Fokkema MR; van Spronsen FJ; Corpeleijn E; Bakker SJL · Nutrients · 2026
    Narrative reviewEnergy forVitamin B12
  53. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  54. Thiamine-responsive inborn errors of metabolism.
    Duran M; Wadman SK · Journal of inherited metabolic disease · 1985
    Narrative reviewMetabolism Boost forThiamin
  55. Dual-omics analysis reveals B vitamin regulation and metabolism in Areca Catechu inflorescence.
    Jiang W; Liu X; Li W; Yang J; Li P; Xie M; Zhou G · BMC genomics · 2026
    OtherMetabolism Boost forVitamin B5
  56. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  57. Adjunctive folate for major mental disorders: A systematic review.
    Zheng W; Li W; Qi H; Xiao L; Sim K; Ungvari GS; Lu XB; Huang X; Ning YP; Xiang YT · Journal of affective disorders · 2021
    Meta-analysis1,520 participants14 studies pooledGeneral Health forFolate
  58. Trends in energy and nutrient intake and risk of inadequate intakes in Catalonia, Spain (1992-2003).
    Serra-Majem L; Ribas-Barba L; Salvador G; Jover L; Raidó B; Ngo J; Plasencia A · Public health nutrition · 2008
    Cross-sectional study4,701 participantsEnergy forVitamin B12
  59. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  60. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis.
    Wang Z; Zhu W; Xing Y; Jia J; Tang Y · Nutrition reviews · 2022
    Meta-analysis46,175 participants95 studies pooledBrain Health Cognitive Support forFolate
  61. Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
    Catena A; Muñoz-Machicao JA; Torres-Espínola FJ; Martínez-Zaldívar C; Diaz-Piedra C; Gil A; Haile G; Györei E; Molloy AM; Decsi T; Koletzko B; Campoy C · The American journal of clinical nutrition · 2016
    Randomized trial136 participantsBrain Health forFolate
  62. Folic acid supplementation improves cognitive function in participants with cerebral small vascular disease-related cognitive impairment: a randomized controlled trial.
    Liu Y; Yu Z; Cai Z; Zhao L; Wang Y; Guo Y; Su X; Miao Y; Yi B; Wang Y; Zhang X · The journal of prevention of Alzheimer's disease · 2025
    Randomized trial220 participantsBrain Health forFolate
  63. Circulating folate concentrations and the risk of mild cognitive impairment: A prospective study on the older Chinese population without folic acid fortification.
    Fu J; Liu Q; Zhu Y; Sun C; Duan H; Huang L; Zhou D; Wang Z; Zhao J; Li Z; Ma F; Li W; Liu H; Zhang X; Chen Y; Wang G; Du Y; Huang G · European journal of neurology · 2022
    Cohort study3,974 participantsBrain Health forFolate
  64. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment.
    Jang S; Han JW; Shin J; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo J; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Kim KW · Psychiatry investigation · 2020
    Cohort study3,910 participantsBrain Health forFolate
  65. Can thiamine substitution restore cognitive function in alcohol use disorder?
    Listabarth S; Vyssoki B; Marculescu R; Gleiss A; Groemer M; Trojer A; Harrer C; Weber S; König D · Alcohol and alcoholism (Oxford, Oxfordshire) · 2023
    Clinical trial50 participantsBrain Health forThiamin
  66. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy.
    Galvin R; Bråthen G; Ivashynka A; Hillbom M; Tanasescu R; Leone MA; EFNS · European journal of neurology · 2011
    Guideline / consensusBrain Health forThiamin
  67. Diagnosis and treatment of Wernicke's encephalopathy: A systematic literature review.
    Cantu-Weinstein A; Branning R; Alamir M; Weleff J; Do M; Nero N; Anand A · General hospital psychiatry · 2024
    Systematic review688 participants27 studies pooledBrain Health forThiamin
  68. Vitamin Supplementation and Dementia: A Systematic Review.
    Gil Martínez V; Avedillo Salas A; Santander Ballestín S · Nutrients · 2022
    Systematic reviewBrain Health forThiamin
  69. Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.
    Jia W; Wang H; Li C; Shi J; Yong F; Jia H · Journal of translational medicine · 2024
    Cross-sectional study2,422 participantsBrain Health Cognitive Support forThiamin
  70. Relationship between vitamin B12 levels and motor development: A systematic review.
    Dos Santos MERA; da Silva KG; da Silva Souza AP; da Silva ABJ; da Silva RF; da Silva EHA; de Souza SL; Barros WMA · Clinical nutrition ESPEN · 2024
    Systematic review1,559 participants8 studies pooledBrain Health forVitamin B12
  71. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.
    Zhou L; Bai X; Huang J; Tan Y; Yang Q · Nutricion hospitalaria · 2023
    Randomized trial115 participantsBrain Health Cognitive Support forVitamin B12
  72. Structural and Functional Brain Changes Associated with Vitamin B12 Deficiency using Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.
    Alghamdi A · Current medical imaging · 2023
    Meta-analysis12 studies pooledBrain Health forVitamin B12
  73. Maternal vitamin B12, vitamin D, and folic acid status during pregnancy and child neurodevelopment: a systematic review.
    Franco L; de Andrade CVF; Margini LV; Sousa N · Frontiers in neuroscience · 2026
    Systematic review22 studies pooledBrain Health forVitamin B12
  74. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline.
    Marino FR; Rogers G; Miller JW; Selhub J; Mez J; Crane PK; Mukherjee S; Saykin AJ; Hohman TJ; Trittschuh EH; Au R; Jacques PF; Hwang PH · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Cohort study1,994 participantsBrain Health forVitamin B12
  75. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China.
    Ma F; Wu T; Zhao J; Han F; Marseglia A; Liu H; Huang G · The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Randomized trial180 participantsCognitive Support forFolate
  76. Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.
    Michelakos T; Kousoulis AA; Katsiardanis K; Dessypris N; Anastasiou A; Katsiardani KP; Kanavidis P; Stefanadis C; Papadopoulos FC; Petridou ET · Journal of aging and health · 2013
    Meta-analysis8,122 participants9 studies pooledCognitive Support forFolate
  77. Homocysteine and folate as risk factors for dementia and Alzheimer disease.
    Ravaglia G; Forti P; Maioli F; Martelli M; Servadei L; Brunetti N; Porcellini E; Licastro F · The American journal of clinical nutrition · 2005
    Cohort study816 participantsCognitive Support forFolate
  78. Folate mediates cognitive impairment of aged people with periodontitis.
    Liu F; Liu Y; Feng Y; Zhao J; Wang M; Ye M; Zhang Y; Gan X; Pan Q; Shen J · Nutritional neuroscience · 2025
    Cross-sectional study1,966 participantsCognitive Support forFolate
  79. Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.
    Measelle JR; Baldwin DA; Gallant J; Chan K; Green TJ; Wieringa FT; Borath M; Prak S; Hampel D; Shahab-Ferdows S; Allen LH; Kroeun H; Whitfield KC · Annals of the New York Academy of Sciences · 2021
    Randomized trial335 participantsCognitive Support forThiamin
  80. What is the impact of thiamine deficiency on cognitive function in patients with alcohol use disorder? - A systematic review.
    Teixeira J; Pereira I; Castanho M; Simões do Couto F · European journal of internal medicine · 2025
    Systematic reviewCognitive Support forThiamin
  81. Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014.
    Ji K; Sun M; Hong Y; Li L; Wang X; Li C; Yang S; Du W; Xu K; Zhou H · Heliyon · 2024
    Cross-sectional study2,896 participantsCognitive Support forThiamin
  82. A systematic review of treatments for alcohol-related cognitive impairment: lessons from the past and gaps for future interventions.
    Caballeria E; Oliveras C; Nuño L; Balcells-Oliveró M; Gual A; López-Pelayo H · Psychological medicine · 2021
    Systematic review26 studies pooledCognitive Support forThiamin
  83. Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.
    Behere RV; Deshmukh AS; Otiv S; Gupte MD; Yajnik CS · Frontiers in endocrinology · 2021
    Systematic review46 studies pooledCognitive Support forVitamin B12
  84. Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial.
    Thomas S; Thomas T; Bosch RJ; Ramthal A; Bellinger DC; Kurpad AV; Duggan CP; Srinivasan K · Maternal and child health journal · 2019
    Randomized trial218 participantsCognitive Support forVitamin B12
  85. Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design.
    Ma F; Zhou X; Li Q; Zhao J; Song A; An P; Du Y; Xu W; Huang G · Current Alzheimer research · 2020
    Randomized trial240 participantsCognitive Support Productivity Boost forVitamin B12
  86. Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study.
    Cruz-Rodríguez J; Canals-Sans J; Hernández-Martínez C; Voltas-Moreso N; Arija V · Maternal & child nutrition · 2023
    Cohort study249 participantsCognitive Support Productivity Boost forVitamin B12
  87. Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
    Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
    Randomized trial200 participantsCognitive Support forVitamin B6
  88. Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
    Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
    Cross-sectional study2,716 participantsCognitive Support forVitamin B6
  89. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsCognitive Support forVitamin B6
  90. Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
    Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
    Cohort study926 participantsCognitive Support forVitamin B6
  91. Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
    Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
    Observational study4,553 participantsCognitive Support forVitamin B6
  92. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  93. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Boost forRiboflavin
  94. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  95. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  96. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  97. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  98. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  99. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  100. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  101. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12
  102. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forVitamin B12
  103. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  104. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  105. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  106. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12
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    Chuang CZ; Boyles A; Legardeur B; Su J; Japa S; Lopez-S A · The American journal of the medical sciences · 2006
    Non-randomized trial34 participantsMetabolism Boost forRiboflavin
  108. Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
    Rossouw JE; Labadarios D; Krasner N; Davis M; Williams R · Scandinavian journal of gastroenterology · 1978
    Single-arm trialMetabolism Boost forThiamin
  109. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).
    Saravanan P; Sukumar N; Adaikalakoteswari A; Goljan I; Venkataraman H; Gopinath A; Bagias C; Yajnik CS; Stallard N; Ghebremichael-Weldeselassie Y; Fall CHD · Diabetologia · 2022
    Cohort study4,746 participantsMetabolism Boost forVitamin B12
  110. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  111. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  112. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  113. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  114. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  115. Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Meli AM; Ali A; Mhd Jalil AM; Mohd Yusof H; Tan MMC · Medicina (Kaunas, Lithuania) · 2022
    Meta-analysisProductivity Boost forVitamin B12
  116. Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
    Vogiatzoglou A; Smith AD; Nurk E; Drevon CA; Ueland PM; Vollset SE; Nygaard HA; Engedal K; Tell GS; Refsum H · Psychosomatic medicine · 2013
    Cross-sectional study1,935 participantsProductivity Boost forVitamin B12
  117. Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.
    Balatacı U; Ay B · Frontiers in pediatrics · 2026
    Case-control study108 participantsProductivity Boost forVitamin B12
  118. Association between vitamin B12 levels and cognitive impairment in older adults.
    Aguilar-Navarro SG; Carbajal-Silva JC; Palacios-Hernández MGI; Gutiérrez-Gutierrez LA; Ávila-Funes JA; Mimenza-Alvarado AJ · Gaceta medica de Mexico · 2023
    Cross-sectional study241 participantsProductivity Boost forVitamin B12
  119. Effects of vitamin B12 on performance and circadian rhythm in normal subjects.
    Mayer G; Kröger M; Meier-Ewert K · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 1997
    Randomized trial20 participantsProductivity Boost forVitamin B12
  120. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1.
    An Y; Feng L; Zhang X; Wang Y; Wang Y; Tao L; Qin Z; Xiao R · Clinical epigenetics · 2020
    Cohort study2,533 participantsProductivity Boost forVitamin B12
  121. Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance: the Maine-Syracuse study.
    Elias MF; Robbins MA; Budge MM; Elias PK; Brennan SL; Johnston C; Nagy Z; Bates CJ · Psychosomatic medicine · 2008
    Cross-sectional study812 participantsProductivity Boost forVitamin B12
  122. Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011-2014.
    Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
    Cross-sectional study2,421 participantsProductivity Boost forVitamin B6
  123. Effect of megavitamin treatment on mental performance and plasma vitamin B6 concentrations in mentally retarded young adults.
    Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
    Non-randomized trialProductivity Boost forVitamin B6
  124. Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
    Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
    Cohort studyProductivity Boost forVitamin B6
  125. Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
    Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
    Case-control study49 participantsProductivity Boost forVitamin B6
  126. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsProductivity Boost forVitamin B6