St. John's Wort Extract
21st Century
St. John's Wort Extract
4.5
★ ★ ★ ★ ★
(1083 ratings)
St. John's Wort 300 mg
Score 75.0
A cost-effective St. John's Wort extract, offering a concentrated form for potentially better efficacy, from a widely available brand with solid reviews.
Quantity: 60 Capsule(s)Servings size: 1 Vegetarian Capsule(s) (60 servings)
Selected goals:
Other goals:
Mood Support
Stress Relief
Sleep Support
leaderboard Score 75.0
A cost-effective St. John's Wort extract, offering a concentrated form for potentially better efficacy, from a widely available brand with solid reviews.
insights Analysis
This 21st Century product is explicitly an 'extract' (300mg of Hypericum perforatum), which is generally preferred over whole herb products for its concentrated and potentially more consistent potency. While it doesn't state the exact percentage of hypericin standardization, being an extract implies a more refined product. It offers an excellent price per serving ($0.09), making it a very cost-effective option for an extract. The high number of positive reviews suggests good consumer reception. This product presents a good balance of extract form, dosage, and affordability.
- Explicitly an extract
- Excellent price per serving
- Good dosage for an extract
- High review count
- Does not explicitly state hypericin standardization percentage
- St. John's Wort can interact with numerous medications, including antidepressants, birth control, and blood thinners. Consult a healthcare professional before use, especially if on other medications.
- Photosensitivity may occur.
$5.93($0.09 per serving)
 Amazon | $ 0.00 | |
 iHerb | $ 5.93 |
bolt Effectiveness for goals
Some research suggests St. John's Wort may be effective for mild to moderate depression. Its use for severe depression is not well-supported by evidence. Consultation with a healthcare professional is advisable before considering use.
For mild to moderate depression, some studies suggest St. John's Wort can be similarly effective to certain conventional antidepressants. However, it may have a different side effect profile and significant drug interactions. This comparison does not extend to all types or severities of depression.
Scientific research indicates that St. John's Wort extracts can be effective for treating mild to moderate depression, often showing comparable efficacy to some standard antidepressants. However, results can vary depending on the extract used and the specific study design. Research on its effectiveness for other conditions is less conclusive.
For mild to moderate depression, some studies suggest St. John's Wort may be as effective as certain prescription antidepressants. However, results can vary, and it is not generally recommended as a substitute for standard care for severe depression.
Clinical studies indicate that St. John's Wort can be effective for relieving symptoms of mild depression. Its efficacy in this context has been compared to that of some conventional antidepressants. However, individual responses may vary.
schedule Dosage, timing & forms
Common dosages of St. John's Wort extract often range from 300 mg to 900 mg per day. These dosages typically provide standardized amounts of active compounds like hypericin or hyperforin. It's important to check the product label for specific recommendations.
The effects of St. John's Wort are generally not immediate and may take several weeks to become noticeable. Individuals typically report feeling benefits after two to four weeks of consistent daily use. It's important to continue taking it as directed for the recommended duration.
The effects of St. John's Wort are typically not immediate and may take several weeks to become noticeable. Individuals often report initial changes within 2 to 4 weeks, with more pronounced benefits potentially appearing after 4 to 6 weeks of consistent use. This gradual onset is common for many herbal supplements.
Common dosages for St. John's Wort extracts, often standardized to hypericin or hyperforin, typically range from 300 mg to 900 mg per day. These doses are usually divided into two or three administrations throughout the day. The specific dosage can vary based on the extract's standardization and the product's concentration.
St. John's Wort is typically taken two to three times per day. Dividing the daily dose helps maintain consistent levels of its active compounds in the body. Always follow the specific instructions provided on the supplement's label or by a qualified healthcare professional.
health_and_safety Safety & interactions
No, St. John's Wort should not be taken with antidepressant medications, especially selective serotonin reuptake inhibitors (SSRIs). Combining them can lead to a serious condition called serotonin syndrome, which involves symptoms like confusion, rapid heart rate, and high fever. Always consult a healthcare professional before combining St. John's Wort with any prescription drugs.
Yes, St. John's Wort can interact significantly with many antidepressant medications. This interaction may lead to a serious condition called serotonin syndrome, which involves symptoms like confusion, rapid heart rate, and high blood pressure. It is crucial to consult a healthcare professional before combining St. John's Wort with any antidepressant.
St. John's Wort can interact significantly with many medications, reducing their effectiveness or increasing side effects. Common side effects may include photosensitivity, upset stomach, fatigue, and restlessness. It is important to discuss its use with a healthcare provider.
Yes, St. John's Wort significantly interacts with medications used for HIV/AIDS (e.g., protease inhibitors, NNRTIs) and immunosuppressants used after organ transplantation (e.g., cyclosporine). It can dramatically reduce the levels and effectiveness of these critical drugs. Such combinations are generally contraindicated and should be strictly avoided.
Yes, St. John's Wort is known to reduce the effectiveness of hormonal contraceptives, including birth control pills. This interaction can potentially lead to unintended pregnancy. It is recommended to use an alternative or additional method of contraception while taking St. John's Wort.
Ingredients
| Ingredient | Amount per serving |
|---|---|
St. John's Wort extract | 300 mg |
Categories
St. John's Wort 75.0
This product is an extract offered at an excellent price, making it a strong value proposition within the St. John's Wort collection. Although it doesn't explicitly state hypericin standardization, being an extract generally implies higher potency than raw herb.
Goals
Mood Support 78.0
As an extract, it offers potentially more concentrated and consistent active compounds for mood support compared to whole herb products, at a very competitive price.
Stress Relief 75.0
The extract form at a common dosage (300mg) provides a solid basis for stress reduction, likely more effective and consistent than unstandardized whole herb.
Sleep Support 70.0
By effectively addressing mood and stress with its extract formulation, it is likely to have a more pronounced indirect positive effect on sleep quality compared to unstandardized options.
Recommended Alternatives
90 Value 
St. John's Wort 300 mg
NOW
4.5
★★★★★
(3444 ratings)
Combines exceptional quality and standardization with a very low price per serving, offering outstanding value compared to other non-standardized extracts.
92 Value 
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
Delivers a potent and standardized extract at a fraction of the cost per serving, providing significantly better efficacy and consistency for superior value.
78 Value 
St. John's Wort Extract
Swanson Superior Herbs
4.7
★★★★★
(344 ratings)
Provides a cost-effective standardized extract, presenting a substantial upgrade in quality and consistent potency for a much better price per serving.
92 Performance
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
A superior standardized extract delivering more consistent and potent benefits for mood and stress support compared to non-standardized forms.
90 Performance
St. John's Wort 300 mg
NOW
4.5
★★★★★
(3444 ratings)
Known for its strict quality control, this standardized extract offers reliable potency for effective mood and stress relief.
90 Performance 
St. John's Wort Extended Release
NaturesPlus Herbal Actives
4.6
★★★★★
(394 ratings)
Features an extended-release formula of standardized extract, providing sustained benefits and enhanced bioavailability for optimal mood and stress management.
78 Budget
St. John's Wort Extract
Swanson Superior Herbs
4.7
★★★★★
(344 ratings)
A high-quality standardized extract available at a lower price per serving, offering better potency and value compared to this non-standardized extract.
90 Budget
St. John's Wort 300 mg
NOW
4.5
★★★★★
(3444 ratings)
Provides a premium standardized extract at a significantly more affordable price per serving, representing superior quality and value.
92 Budget
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
Offers a highly potent, standardized extract at a competitive price point, providing excellent value for superior quality and consistency.
90 Value
St. John's Wort 300 mg
NOW
4.5
★★★★★
(3444 ratings)
Combines exceptional quality and standardization with a very low price per serving, offering outstanding value compared to other non-standardized extracts.
92 Value
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
Delivers a potent and standardized extract at a fraction of the cost per serving, providing significantly better efficacy and consistency for superior value.
78 Value
St. John's Wort Extract
Swanson Superior Herbs
4.7
★★★★★
(344 ratings)
Provides a cost-effective standardized extract, presenting a substantial upgrade in quality and consistent potency for a much better price per serving.
92 Performance
St. John's Wort Extract 300 mg
Lake Avenue Nutrition
4.6
★★★★★
(4042 ratings)
A superior standardized extract delivering more consistent and potent benefits for mood and stress support compared to non-standardized forms.
90 Performance
St. John's Wort 300 mg
NOW
4.5
★★★★★
(3444 ratings)
Known for its strict quality control, this standardized extract offers reliable potency for effective mood and stress relief.
90 Performance
St. John's Wort Extended Release
NaturesPlus Herbal Actives
4.6
★★★★★
(394 ratings)
Features an extended-release formula of standardized extract, providing sustained benefits and enhanced bioavailability for optimal mood and stress management.