SAMe 400 mg
Protocol For Life Balance
SAMe 400 mg
4.9
★ ★ ★ ★ ★
(46 ratings)
SAMe 400 mg
Score 70.0
A high-dose 400mg SAMe product from a reputable professional brand, offering good efficacy but at a higher price point than many market competitors and with limited online reviews.
Quantity: 60 Tablet(s)Servings size: 1 Tablet(s) (30 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 70.0
A high-dose 400mg SAMe product from a reputable professional brand, offering good efficacy but at a higher price point than many market competitors and with limited online reviews.
insights Analysis
Protocol For Life Balance is recognized as a professional-grade brand, often favored by practitioners for its stringent quality control and effective formulations, with this product providing a clinically relevant 400mg dose of SAMe per tablet. While the dosage aligns well with recommendations for mood and joint support, its price per serving of $1.09 remains considerably higher than many high-quality SAMe alternatives on the market. The relatively low number of consumer reviews (46) also provides less comprehensive public feedback compared to more widely reviewed products in the SAMe category.
- Provides a robust 400mg dose per serving, suitable for therapeutic use in mood and joint support.
- Sourced from a professional-grade brand known for quality and purity standards.
- Convenient 60-count bottle offers a good supply for consistent use.
- The price per serving ($1.09) is on the higher end compared to other quality 400mg SAMe supplements.
- Relatively low review count (46) offers less general consumer feedback on efficacy and satisfaction.
- Specific form of SAMe is not detailed beyond 'SAMe' in the ingredients list, although it is likely the stable disulfate tosylate form.
- Individuals with bipolar disorder should avoid SAMe as it can potentially induce manic episodes.
- SAMe can interact with antidepressant medications, increasing the risk of serotonin syndrome; consult a healthcare professional before combining.
- New users should consider starting with a lower dose (e.g., 200mg) to assess tolerance before increasing to 400mg.
$65.47($2.18 per serving)
 iHerb | $ 65.47 | |
 Pure Formulas | $ 72.00 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
SAMe | 400 mg |
Categories
SAMe 75.0
This product delivers a well-dosed amount of SAMe from a trusted professional brand, making it a reliable choice within the SAMe supplement category. Its score reflects its strong dosage and brand quality, tempered slightly by its price point which, while offering better value than some premium brands, isn't the most competitive among all available alternatives.
Goals
Mood Support 80.0
A 400mg dose is a common and effective starting point for SAMe in supporting mood and combating depressive symptoms, aligning well with clinical research for neurotransmitter balance. This dosage is more likely to yield noticeable effects for many individuals compared to lower 200mg options, offering substantial support for emotional well-being.
Joint Health 75.0
The 400mg dosage serves as a good foundational amount for addressing joint discomfort and promoting cartilage health, with many studies supporting its role in osteoarthritis management. While some individuals with more significant joint issues may eventually benefit from higher daily doses, this product provides a solid therapeutic starting point.
Digestive Health 70.0
SAMe at 400mg effectively contributes to essential liver detoxification pathways and bile production, which are crucial for optimal digestive function and overall metabolic health. This dosage provides significant support for liver health, a primary component of digestive well-being and nutrient processing.
Recommended Alternatives
50 Value 
SAMe 400 mg
Swanson
4.6
★★★★★
(265 ratings)
Offers a 400mg SAMe dose at a competitive price, providing good potency for the cost from a widely available and established brand.
60 Value 
SAMe 400 mg
NOW
4.7
★★★★★
(959 ratings)
Provides a reliable 400mg SAMe dose from a trusted brand, offering a solid balance of quality and value for those seeking this potency.
55 Value 
SAMe 400 mg
Source Naturals
4.7
★★★★★
(191 ratings)
A higher 400mg SAMe dose option that balances potency with a reasonable price point, offering good overall value for individuals seeking a higher dosage.
98 Performance 
SAMe 200 mg + Cofactors
Metabolic Maintenance
4.6
★★★★★
(30 ratings)
Offers comprehensive support with bioavailable cofactors, enhancing the overall efficacy and methylation benefits, even at a 200mg SAMe dose, making it superior for holistic support.
95 Performance 
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★★★★★
(11 ratings)
Provides high-quality SAMe with essential, active B vitamin cofactors for a more complete approach to mood and methylation, a step up in formulation.
68 Performance 
SAMe (S-Adenosylmethionine)
Pure Encapsulations
4.5
★★★★★
(18 ratings)
While similar in dosage, Pure Encapsulations is renowned for its exceptional purity and quality standards, making it a preferred choice for those prioritizing brand integrity.
90 Budget 
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Offers the same 400mg SAMe dose at a significantly lower price per serving, providing much better affordability from a well-regarded brand.
84 Budget 
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
A highly cost-effective option for a 400mg SAMe dose from a stable form, offering significant savings for the same potency.
85 Budget 
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
Provides a 400mg SAMe dose at a more competitive price point from a highly reviewed and trusted brand, enhancing its value.
50 Value
SAMe 400 mg
Swanson
4.6
★★★★★
(265 ratings)
Offers a 400mg SAMe dose at a competitive price, providing good potency for the cost from a widely available and established brand.
60 Value
SAMe 400 mg
NOW
4.7
★★★★★
(959 ratings)
Provides a reliable 400mg SAMe dose from a trusted brand, offering a solid balance of quality and value for those seeking this potency.
55 Value
SAMe 400 mg
Source Naturals
4.7
★★★★★
(191 ratings)
A higher 400mg SAMe dose option that balances potency with a reasonable price point, offering good overall value for individuals seeking a higher dosage.
98 Performance
SAMe 200 mg + Cofactors
Metabolic Maintenance
4.6
★★★★★
(30 ratings)
Offers comprehensive support with bioavailable cofactors, enhancing the overall efficacy and methylation benefits, even at a 200mg SAMe dose, making it superior for holistic support.
95 Performance
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★★★★★
(11 ratings)
Provides high-quality SAMe with essential, active B vitamin cofactors for a more complete approach to mood and methylation, a step up in formulation.
68 Performance
SAMe (S-Adenosylmethionine)
Pure Encapsulations
4.5
★★★★★
(18 ratings)
While similar in dosage, Pure Encapsulations is renowned for its exceptional purity and quality standards, making it a preferred choice for those prioritizing brand integrity.