Glutathione 250 mg
NOW
Glutathione 250 mg
4.6
★ ★ ★ ★ ★
(11303 ratings)
Glutathione 250 mg
Score 80.0
A very popular and cost-effective standard dose glutathione supplement from a trusted brand.
Quantity: 60 Capsule(s)Servings size: 1 Veg Capsule(s) (60 servings)
Selected goals:
Other goals:
Anti-Aging
Detoxification
Skin Health
Anti-Inflammatory Support
leaderboard Score 80.0
A very popular and cost-effective standard dose glutathione supplement from a trusted brand.
insights Analysis
NOW's Glutathione 250 mg product is a highly popular option, evidenced by its extensive review count. It provides a standard dose of glutathione in capsule form. While it doesn't explicitly state 'Setria' or 'Reduced' in the ingredients, NOW Foods is a reputable brand, and their glutathione products are generally understood to be in the reduced, active form. Its primary strength is its very competitive price per serving, offering good value for a 250mg dose. This balance of dose, price, and brand reputation makes it a strong contender for general glutathione supplementation.
- Excellent price per serving for a 250mg dose.
- From a highly reputable brand with extensive positive reviews.
- Common and generally effective dosage for daily use.
- Does not explicitly state 'Setria' or 'Reduced' on the ingredient list, though typically implied.
$13.49($0.22 per serving)
 Amazon | $ 13.49 | |
 Vitacost | $ 14.69 | |
 Daily Vita | $ 15.10 | |
 Pure Formulas | $ 15.57 | |
 iHerb | $ 15.91 | |
 Walmart | $ 18.88 |
bolt Effectiveness for goals
The effectiveness of oral glutathione supplementation for directly increasing intracellular glutathione levels is a subject of ongoing research. While some studies suggest that specific forms, like liposomal or S-acetyl-glutathione, may help raise plasma glutathione, traditional forms face challenges with absorption. The body's natural synthesis of glutathione is a primary regulator of its levels.
The effectiveness of oral glutathione can vary due to challenges with absorption and degradation in the digestive system. Some forms, like liposomal or S-acetyl glutathione, are designed to improve bioavailability. Research on the systemic impact of various oral forms is ongoing.
Traditional reduced glutathione supplements have historically faced challenges with absorption due to degradation in the digestive tract. Newer forms, such as liposomal or S-acetyl-glutathione, are specifically designed to improve bioavailability and are generally considered more effectively absorbed. Research continues to evaluate the optimal delivery methods for glutathione.
Glutathione is a primary antioxidant in the body, crucial for neutralizing free radicals and combating oxidative stress. Supplementation is hypothesized to support the body's natural antioxidant defenses. The extent of this effect can depend on the supplement form and individual physiological factors.
Some research suggests that high doses of oral glutathione might have skin-lightening effects by inhibiting melanin production, but the evidence is not conclusive and often involves specific populations. These studies often require high dosages and more robust, larger-scale research is needed to confirm efficacy for this purpose. It is not approved for this use by major health authorities.
schedule Dosage, timing & forms
Liposomal glutathione encapsulates glutathione in tiny lipid bubbles (liposomes), which are designed to protect it from degradation in the digestive tract. This delivery method aims to enhance its absorption and bioavailability compared to standard oral reduced glutathione. The liposomal structure helps transport the glutathione more efficiently into the bloodstream.
N-acetylcysteine (NAC) is a precursor that the body uses to synthesize its own glutathione. While not glutathione itself, supplementing with NAC is a common strategy to support the body's endogenous glutathione production. It provides cysteine, a crucial amino acid needed for glutathione synthesis.
Oral glutathione dosages can vary widely depending on the specific form and individual needs, often ranging from 250 mg to 1000 mg per day. It's best to follow the manufacturer's recommendations on the product label. Consulting with a healthcare professional can provide personalized guidance.
Typical oral glutathione dosages can range from 250 mg to 1000 mg per day. The specific amount may vary depending on the product formulation and individual needs. It is advisable to follow the manufacturer's recommendations.
Reduced glutathione (GSH) is the active form naturally found in the body, but it can be prone to degradation during digestion when taken orally. S-acetyl glutathione is a modified form designed for improved stability and bioavailability. The acetyl group is intended to protect it until absorption, allowing it to be cleaved off inside cells to release active glutathione.
health_and_safety Safety & interactions
Oral glutathione is generally considered safe for most adults when taken in appropriate doses. Some individuals have reported mild side effects such as abdominal cramps, bloating, or allergic reactions like rash. Inhaled glutathione might cause asthma exacerbation in sensitive individuals.
Oral glutathione supplements are generally well-tolerated by most individuals. Some people might experience mild gastrointestinal discomfort, such as abdominal cramps or bloating. Rarely, allergic reactions like rash have been reported, and inhaled forms might trigger asthma in susceptible individuals.
There is limited information on significant drug interactions with glutathione supplements. However, it is always advisable to consult a healthcare professional, especially when taking prescription medications. They can assess potential interactions based on your specific health profile.
The maximum safe dosage for glutathione can vary depending on the form, individual health, and specific application. While studies have used oral doses up to 1000 mg/day, it is crucial to follow product label instructions and consult a healthcare provider for personalized guidance. Excessive doses may not provide additional benefits and could lead to unknown effects.
Insufficient research is available regarding the safety of glutathione supplementation during pregnancy and breastfeeding. For this reason, it is generally recommended to avoid use or consult a healthcare provider before considering supplementation. A healthcare professional can weigh the potential benefits against any unknown risks.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Glutathione | 250 mg |
Categories
Glutathione 85.0
This product is a leading choice within the glutathione category, balancing an effective dose with an attractive price point and strong brand trust, making it highly competitive.
Goals
Anti-Aging 80.0
250mg is a recognized dose for contributing to anti-aging effects by bolstering antioxidant defenses, and its affordability makes consistent use feasible for long-term cellular protection.
Detoxification 80.0
It provides effective support for the body's detoxification systems at a dose and price that makes it accessible for daily use, supporting liver function efficiently.
Skin Health 80.0
Its antioxidant properties can positively influence skin health by protecting against environmental damage, and its widespread availability makes it a popular choice for this goal among consumers.
Recommended Alternatives
95 Value 
Glutathione 500 mg
NOW
4.6
★★★★★
(50447 ratings)
Provides double the glutathione dose (500mg) and synergistic ingredients at a price per serving only slightly higher than the original 250mg product, making it excellent value.
92 Value 
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Offers a high 500mg dose from a reputable brand for a very competitive price, particularly in the larger bottle size, making it a strong value proposition for high potency.
80 Value 
Liver Refresh
NOW
4.8
★★★★★
(19787 ratings)
While containing 100mg of glutathione, it offers a broad spectrum of liver-supporting ingredients like Milk Thistle and NAC at a competitive price, providing comprehensive detoxification support.
95 Performance 
Glutathione 500 mg
NOW
4.6
★★★★★
(50021 ratings)
Offers a higher dose (500mg) and includes Alpha-Lipoic Acid and Milk Thistle, enhancing its overall effectiveness for detox and antioxidant support.
92 Performance
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Provides a significantly higher dose (500mg) of reduced glutathione from a highly-regarded brand with a large number of positive reviews, indicating strong user satisfaction.
80 Performance 
Brocco-Glutathione
Nature's Answer
4.6
★★★★★
(1995 ratings)
Features 250mg of Setria Glutathione, a premium form, combined with broccoli extract which supports the body's natural glutathione processes, offering a unique synergistic approach.
85 Budget 
L-Glutathione 100 mg
Swanson
4.6
★★★★★
(1271 ratings)
Offers Setria Glutathione at a significantly lower price per serving, making it a more budget-friendly option if a lower dose is sufficient.
95 Budget
Glutathione 500 mg
NOW
4.6
★★★★★
(50021 ratings)
While slightly more expensive per serving, it provides double the glutathione dose (500mg) and additional synergistic ingredients, offering a higher total amount of active ingredients for a very marginal cost increase.
75 Budget 
High Potency L-Glutathione 200 mg
Swanson Ultra
4.6
★★★★★
(498 ratings)
Offers Setria Glutathione at a slightly lower dosage but still good value, and only marginally higher price per serving than the original.
95 Value
Glutathione 500 mg
NOW
4.6
★★★★★
(50447 ratings)
Provides double the glutathione dose (500mg) and synergistic ingredients at a price per serving only slightly higher than the original 250mg product, making it excellent value.
92 Value
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Offers a high 500mg dose from a reputable brand for a very competitive price, particularly in the larger bottle size, making it a strong value proposition for high potency.
80 Value
Liver Refresh
NOW
4.8
★★★★★
(19787 ratings)
While containing 100mg of glutathione, it offers a broad spectrum of liver-supporting ingredients like Milk Thistle and NAC at a competitive price, providing comprehensive detoxification support.
95 Performance
Glutathione 500 mg
NOW
4.6
★★★★★
(50021 ratings)
Offers a higher dose (500mg) and includes Alpha-Lipoic Acid and Milk Thistle, enhancing its overall effectiveness for detox and antioxidant support.
92 Performance
Glutathione Reduced 500 mg
Jarrow Formulas
4.5
★★★★★
(24077 ratings)
Provides a significantly higher dose (500mg) of reduced glutathione from a highly-regarded brand with a large number of positive reviews, indicating strong user satisfaction.
80 Performance
Brocco-Glutathione
Nature's Answer
4.6
★★★★★
(1995 ratings)
Features 250mg of Setria Glutathione, a premium form, combined with broccoli extract which supports the body's natural glutathione processes, offering a unique synergistic approach.