Detox & Liver Health
Reg'Activ
Detox & Liver Health
4.7
★ ★ ★ ★ ★
(170 ratings)
Methionine
Milk Thistle 250 mg
Selenium 100 mcg
Score 65.0
A liver support supplement with Milk Thistle, NAC, L-Methionine, and a unique probiotic for detoxification. Offers good ingredient synergy but with moderate dosages at a higher price point compared to many alternatives.
Quantity: 60 Capsule(s)Servings size: 2 Capsule(s) (30 servings)
Selected goals:
Other goals:
Immunity
Detoxification
Skin Health
Brain Health
Hair Health
leaderboard Score 65.0
A liver support supplement with Milk Thistle, NAC, L-Methionine, and a unique probiotic for detoxification. Offers good ingredient synergy but with moderate dosages at a higher price point compared to many alternatives.
insights Analysis
Reg'Activ Detox & Liver Health is formulated with a combination of ingredients aimed at supporting liver function and general detoxification pathways. Key components include Milk Thistle, known for its hepatoprotective properties, N-Acetyl-Cysteine (NAC) as a glutathione precursor, and L-Methionine, an amino acid involved in methylation and sulfur metabolism essential for detox. A distinguishing feature is the inclusion of Lactobacillus fermentum ME-3, a probiotic strain with documented antioxidant and glutathione-producing capabilities, which adds a unique dimension to its detoxification claims. The product also contains Selenium in the well-absorbed selenomethionine form, further enhancing its antioxidant profile and immune support. While the ingredient choices are sound for the stated goals, the potency of some key ingredients like L-Methionine (50mg) and NAC (200mg) is on the lower end compared to doses often recommended for more intensive liver support, or found in more cost-effective alternatives. The price per serving of $1.33 is relatively high, especially when considering alternative products that offer higher dosages or a broader spectrum of liver-supporting compounds at a more competitive price point.
- Contains a synergistic blend of ingredients targeting liver health and detoxification.
- Includes Lactobacillus fermentum ME-3, a unique probiotic strain that contributes to glutathione production and antioxidant activity.
- Utilizes Selenomethionine, a highly bioavailable form of Selenium.
- Provides essential amino acids and herbal extracts known for their roles in detoxification pathways.
- Dosages of L-Methionine (50mg) and N-Acetyl-Cysteine (200mg) are relatively low for significant therapeutic impact compared to some other formulations.
- The price per serving ($1.33) is on the higher side, especially when benchmarked against other multi-ingredient liver support supplements or single-ingredient alternatives.
- Claims for 'Skin Health', 'Hair Health', and 'Nail Health' are less directly supported by the ingredient profile compared to specialized products for these specific goals.
- Individuals with allergies to any ingredients, especially milk thistle, should exercise caution.
- Pregnant or nursing women, individuals on medication, or those with pre-existing medical conditions should consult a healthcare professional before using this product.
$39.96($1.33 per serving)
 Pure Formulas | $ 39.96 | |
 iHerb | $ 40.00 | |
 Vitacost | $ 49.95 |
bolt Effectiveness for goals
Milk thistle, particularly its active compound silymarin, has been extensively studied for its hepatoprotective properties. It is widely recognized for its potential to support liver health by protecting liver cells from toxins and aiding in their regeneration. Many traditional and some modern uses focus on liver support.
Yes, selenium is a key component of several antioxidant enzymes, such as glutathione peroxidase. These enzymes help protect cells from damage caused by free radicals, contributing to overall cellular health. Its role in antioxidant defense is well-established in scientific literature.
Research indicates that silymarin in milk thistle has antioxidant, anti-inflammatory, and antifibrotic properties that may help protect the liver. Studies have explored its potential benefits in various liver conditions, often showing promising results in mitigating liver damage. It's commonly used as a complementary therapy for liver health.
Yes, silymarin, the primary active complex in milk thistle, is recognized for its potent antioxidant properties. It helps reduce oxidative stress in the liver and other tissues by scavenging free radicals. This antioxidant action is considered a key mechanism behind its protective effects.
Selenium is an essential trace mineral that plays a crucial role in thyroid hormone metabolism. It is a component of selenoproteins, which help regulate thyroid function and protect the thyroid gland from oxidative damage. Research indicates a link between adequate selenium intake and proper thyroid function.
schedule Dosage, timing & forms
For adults, the Recommended Dietary Allowance (RDA) for selenium is typically 55 micrograms (mcg) per day. However, specific dosages in supplements may vary based on individual needs and product formulations. Always refer to product labels and consult with a qualified professional.
Selenium can generally be taken at any time of day, with or without food. Some individuals may prefer to take it with a meal to avoid potential stomach upset, though this is not commonly reported. Consistency is often more important than the specific timing.
Selenium supplements are commonly available in organic forms like selenomethionine and selenocysteine, and inorganic forms such as sodium selenite and sodium selenate. Selenomethionine is often preferred due to its higher bioavailability. The chosen form can influence absorption.
health_and_safety Safety & interactions
Yes, excessive intake of selenium can lead to selenosis, a condition caused by selenium toxicity. Symptoms can include hair loss, brittle nails, gastrointestinal issues, and neurological problems. It is important not to exceed the tolerable upper intake level (UL) of 400 mcg per day for adults.
Milk thistle can interact with various medications, particularly those metabolized by the CYP450 enzyme system in the liver, such as certain statins, anticoagulants, and diabetes medications. It may also affect the effectiveness of oral contraceptives. Always consult your doctor if you are on medication.
Milk thistle is generally well-tolerated, but some individuals may experience mild gastrointestinal issues like nausea, diarrhea, or bloating. Allergic reactions, especially in people sensitive to plants in the Asteraceae family (e.g., ragweed, marigolds, daisies), are also possible. If you experience severe reactions, discontinue use and consult a doctor.
Excessive selenium intake, known as selenosis, can lead to symptoms like hair loss, brittle nails, skin rash, garlic breath, and fatigue. In severe cases, it can cause neurological problems or heart issues. It's important to adhere to recommended daily allowances.
Selenium may interact with certain medications, including some chemotherapy drugs and blood thinners. It could potentially affect the absorption or effectiveness of these drugs. It's advisable to discuss selenium supplementation with a healthcare provider if you are taking any medications.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Selenium | 100 mcg |
Lactobacillus fermentum ME-3 | 60 mg |
Milk Thistle fruit extract | 250 mg |
N-Acetyl-Cysteine | 200 mg |
L-Methionine | 50 mg |
Categories
Selenium 75.0
The product contains 100mcg of Selenium in the Selenomethionine form, which is highly bioavailable and provides effective antioxidant and thyroid support, aligning well with general health and immunity goals.
Milk Thistle 70.0
The 250mg of Milk Thistle fruit extract is a good foundational dose for liver support. While it's effective, the lack of specified standardization to silymarin and the availability of alternatives offering higher standardized doses for a lower price slightly impacts its score.
Methionine 60.0
The inclusion of 50mg of L-Methionine is beneficial for liver detoxification and methylation pathways. However, this dosage is comparatively low when stacked against dedicated methionine supplements or comprehensive liver formulas that often provide 200-500mg per serving.
Goals
Immunity 75.0
Selenium and N-Acetyl-Cysteine (NAC) are both vital for immune function due to their antioxidant properties and roles in glutathione synthesis. The unique probiotic strain, Lactobacillus fermentum ME-3, also supports immune health by enhancing the body's antioxidant defenses.
General Health 70.0
The combination of liver-supporting ingredients like Milk Thistle, antioxidants like NAC and Selenium, and the probiotic for gut health contributes to overall well-being by aiding the body's natural processes and reducing oxidative stress.
Detoxification 70.0
Milk Thistle, N-Acetyl-Cysteine (NAC) as a glutathione precursor, and L-Methionine are well-recognized for their roles in supporting the liver's natural detoxification processes. The addition of Lactobacillus fermentum ME-3 further enhances detox capabilities through its glutathione-producing action.
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