SAMe (S-Adenosylmethionine)
Pure Encapsulations
SAMe (S-Adenosylmethionine)
4.5
★ ★ ★ ★ ★
(18 ratings)
SAMe 200 mg
Score 55.0
A high-quality 200mg SAMe supplement from a reputable brand, but its extremely high price per serving provides poor value compared to alternatives, and it lacks extensive consumer reviews.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 55.0
A high-quality 200mg SAMe supplement from a reputable brand, but its extremely high price per serving provides poor value compared to alternatives, and it lacks extensive consumer reviews.
insights Analysis
Pure Encapsulations is a highly regarded brand in the supplement industry, known for its commitment to hypoallergenic formulations and ingredient purity, which is reflected in this SAMe product using the stable S-Adenosyl-L-Methionine Disulfate Tosylate form. Despite the brand's reputation for quality, the product's price per serving of $1.31 for 200mg is exceptionally high compared to numerous well-regarded alternatives that offer similar or even higher dosages at a significantly lower cost. Furthermore, the limited number of online reviews (18) makes it challenging to gauge widespread consumer satisfaction or common experiences with this particular offering.
- From a highly reputable brand known for quality and purity standards.
- Uses the stable and bioavailable S-Adenosyl-L-Methionine Disulfate Tosylate form of SAMe.
- 200mg dose is suitable for individuals starting SAMe or those sensitive to higher amounts.
- Very high price per serving ($1.31) makes it significantly more expensive than comparable alternatives.
- Low review count (18) limits insight into broad consumer experiences and effectiveness.
- 200mg may be an insufficient dose for many therapeutic goals, potentially requiring multiple costly servings.
- SAMe can interact with antidepressant medications, increasing the risk of serotonin syndrome; consult a healthcare professional before combining.
- Individuals with bipolar disorder should avoid SAMe as it can potentially induce manic episodes.
- Take SAMe on an empty stomach for optimal absorption, and ensure it is enteric-coated for stability (a common but unstated feature for quality SAMe).
$79.00($1.31 per serving)
 Pure Formulas | $ 79.00 | |
 Vitacost | $ 79.00 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
SAMe | 200 mg |
Categories
SAMe 60.0
This product provides the active compound SAMe in a stable, recognized form from a reputable brand. Its score is moderated by the significantly higher price point compared to many other high-quality SAMe supplements available, which offer more competitive pricing for similar dosages without compromising on ingredient integrity.
Goals
Mood Support 60.0
SAMe is clinically studied for its mood-enhancing properties by supporting methylation processes critical for neurotransmitter synthesis. While 200mg is a common starting dose, many studies showing significant mood benefits use dosages of 400mg or higher, meaning this product might require multiple servings for optimal efficacy for some individuals, further increasing the already high cost.
Digestive Health 60.0
SAMe plays a crucial role in liver detoxification and methylation, indirectly supporting overall digestive health by maintaining optimal liver function, a key organ in digestion and metabolism. The 200mg dose contributes to these vital processes, though higher doses are sometimes explored for more specific or intensive liver support.
Joint Health 55.0
SAMe has demonstrated efficacy in supporting joint health and reducing discomfort associated with osteoarthritis, often comparable to NSAIDs with fewer side effects. However, effective dosages for joint health typically range from 600mg to 1200mg daily, making the 200mg per serving less potent for this specific goal unless multiple capsules are taken, which becomes prohibitively expensive at this product's price point.
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