SAMe (S-Adenosylmethionine)
Pure Encapsulations
SAMe (S-Adenosylmethionine)
4.5
★ ★ ★ ★ ★
(18 ratings)
SAMe 200 mg
Score 55
A high-quality 200mg SAMe supplement from a reputable brand, but its extremely high price per serving provides poor value compared to alternatives, and it lacks extensive consumer reviews.
Quantity: 60 Capsule(s) • (60 servings)
Goals: flag Joint Health flag Mood Support flag Detoxification flag Stress Relief
leaderboard Score 55
A high-quality 200mg SAMe supplement from a reputable brand, but its extremely high price per serving provides poor value compared to alternatives, and it lacks extensive consumer reviews.
insights Analysis
Pure Encapsulations is a highly regarded brand in the supplement industry, known for its commitment to hypoallergenic formulations and ingredient purity, which is reflected in this SAMe product using the stable S-Adenosyl-L-Methionine Disulfate Tosylate form. Despite the brand's reputation for quality, the product's price per serving of $1.31 for 200mg is exceptionally high compared to numerous well-regarded alternatives that offer similar or even higher dosages at a significantly lower cost. Furthermore, the limited number of online reviews (18) makes it challenging to gauge widespread consumer satisfaction or common experiences with this particular offering.
- From a highly reputable brand known for quality and purity standards.
- Uses the stable and bioavailable S-Adenosyl-L-Methionine Disulfate Tosylate form of SAMe.
- 200mg dose is suitable for individuals starting SAMe or those sensitive to higher amounts.
- Very high price per serving ($1.31) makes it significantly more expensive than comparable alternatives.
- Low review count (18) limits insight into broad consumer experiences and effectiveness.
- 200mg may be an insufficient dose for many therapeutic goals, potentially requiring multiple costly servings.
- SAMe can interact with antidepressant medications, increasing the risk of serotonin syndrome; consult a healthcare professional before combining.
- Individuals with bipolar disorder should avoid SAMe as it can potentially induce manic episodes.
- Take SAMe on an empty stomach for optimal absorption, and ensure it is enteric-coated for stability (a common but unstated feature for quality SAMe).
$79.00($1.31 per serving)
 Pure Formulas | $ 79.00 | |
 Vitacost | $ 79.00 |
Ingredients
| Ingredient | Amount per serving |
|---|---|
SAMe | 200 mg |
Categories
SAMe 60
This product provides the active compound SAMe in a stable, recognized form from a reputable brand. Its score is moderated by the significantly higher price point compared to many other high-quality SAMe supplements available, which offer more competitive pricing for similar dosages without compromising on ingredient integrity.
Goals
SAMe is clinically studied for its mood-enhancing properties by supporting methylation processes critical for neurotransmitter synthesis. While 200mg is a common starting dose, many studies showing significant mood benefits use dosages of 400mg or higher, meaning this product might require multiple servings for optimal efficacy for some individuals, further increasing the already high cost.
SAMe plays a crucial role in liver detoxification and methylation, indirectly supporting overall digestive health by maintaining optimal liver function, a key organ in digestion and metabolism. The 200mg dose contributes to these vital processes, though higher doses are sometimes explored for more specific or intensive liver support.
SAMe has demonstrated efficacy in supporting joint health and reducing discomfort associated with osteoarthritis, often comparable to NSAIDs with fewer side effects. However, effective dosages for joint health typically range from 600mg to 1200mg daily, making the 200mg per serving less potent for this specific goal unless multiple capsules are taken, which becomes prohibitively expensive at this product's price point.
90 Value 
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Offers a robust 400mg SAMe dose from a stable form at an exceptionally attractive price per serving, providing superior overall value for higher potency.
84 Value 
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Delivers a potent 400mg dose of SAMe from a stable form at a strong value, making it a cost-effective choice for higher dosing.
80 Value 
SAMe 200 mg S-Adenosyl-Methionine
Life Extension
4.8
★★★★★
(1775 ratings)
A highly popular option offering a reliable 200mg SAMe dose at a very competitive price, providing excellent value for a trusted standalone product.
98 Performance 
SAMe 200 mg + Cofactors
Metabolic Maintenance
4.6
★★★★★
(30 ratings)
A superior choice due to its inclusion of optimal, bioavailable B vitamin cofactors, providing more comprehensive methylation support alongside SAMe.
95 Performance 
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★★★★★
(11 ratings)
Offers the added benefit of high-quality B vitamin cofactors, enhancing the efficacy of SAMe for mood and methylation pathways, a significant upgrade from a standalone SAMe.
85 Performance 
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
Provides a double dose of SAMe (400mg) for increased potency, which can be beneficial for specific needs where a higher concentration is desired.
92 Budget 
SAMe 200 mg
NOW
4.5
★★★★★
(1741 ratings)
Offers a stable form of SAMe at a significantly lower price per serving, providing excellent affordability without compromising on core ingredient quality.
88 Budget 
SAMe 200
Jarrow Formulas
4.7
★★★★★
(263 ratings)
Provides a very cost-effective 200mg SAMe option from a highly popular and trusted brand, making it much more budget-friendly than the original.
82 Budget 
SAMe 200 mg
Natural Factors
4.6
★★★★★
(578 ratings)
A more affordable SAMe option that still offers 200mg per serving, suitable for budget-conscious users who value a pure SAMe product.
90 Value
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Offers a robust 400mg SAMe dose from a stable form at an exceptionally attractive price per serving, providing superior overall value for higher potency.
84 Value
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Delivers a potent 400mg dose of SAMe from a stable form at a strong value, making it a cost-effective choice for higher dosing.
80 Value
SAMe 200 mg S-Adenosyl-Methionine
Life Extension
4.8
★★★★★
(1775 ratings)
A highly popular option offering a reliable 200mg SAMe dose at a very competitive price, providing excellent value for a trusted standalone product.
98 Performance
SAMe 200 mg + Cofactors
Metabolic Maintenance
4.6
★★★★★
(30 ratings)
A superior choice due to its inclusion of optimal, bioavailable B vitamin cofactors, providing more comprehensive methylation support alongside SAMe.
95 Performance
SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
5.0
★★★★★
(11 ratings)
Offers the added benefit of high-quality B vitamin cofactors, enhancing the efficacy of SAMe for mood and methylation pathways, a significant upgrade from a standalone SAMe.
85 Performance
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
Provides a double dose of SAMe (400mg) for increased potency, which can be beneficial for specific needs where a higher concentration is desired.