Flush-Free Niacin 250 mg
NOW
Flush-Free Niacin 250 mg
4.6
★ ★ ★ ★ ★
(2119 ratings)
Niacin 500 mg
Score 85.0
A high-dose, flush-free niacin option suitable for those seeking the benefits of niacin without the uncomfortable side effects, though its effectiveness for aggressive cholesterol management may be less than nicotinic acid.
Quantity: 180 Capsule(s)Servings size: 2 Veg Capsule(s) (90 servings)
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Mood Support
Stress Relief
Brain Health
Heart Health
Skin Health
leaderboard Score 85.0
A high-dose, flush-free niacin option suitable for those seeking the benefits of niacin without the uncomfortable side effects, though its effectiveness for aggressive cholesterol management may be less than nicotinic acid.
insights Analysis
NOW Flush-Free Niacin provides a substantial 500mg dose of niacin in a form that typically avoids the "flush." This is achieved through Inositol Hexanicotinate, where niacin is bound to inositol, allowing for slower release and reduced flushing. While excellent for general B3 benefits and avoiding discomfort, some nutritionists and studies suggest that Inositol Hexanicotinate may not be as effective as pure nicotinic acid for significant cholesterol lowering at equivalent doses, although it still offers metabolic and energy support.
- High dosage (500mg Niacin equivalent)
- 'Flush-free' formulation significantly improves user experience
- Good for general B3 benefits
- Potentially less effective for aggressive cholesterol management compared to equivalent doses of nicotinic acid
- Higher price per serving compared to basic nicotinic acid
- Individuals with specific health conditions should consult a healthcare professional before taking high doses of niacin, even flush-free forms.
$14.39($0.15 per serving)
 Vitacost | $ 14.39 | |
 Daily Vita | $ 15.10 | |
 iHerb | $ 15.91 |
bolt Effectiveness for goals
Niacin is known as one of the most effective agents for increasing high-density lipoprotein (HDL) cholesterol levels. It can significantly raise HDL, which is often considered beneficial for cardiovascular health. However, studies have shown that this increase in HDL does not always translate to a reduction in cardiovascular events.
While Niacin can contribute to lowering LDL cholesterol, its primary effect on lipids is typically a more significant reduction in triglycerides and an increase in HDL cholesterol. For LDL reduction, it is generally considered less potent than statins and often used in conjunction with other lipid-lowering therapies if prescribed.
Yes, Niacin is highly effective at reducing elevated triglyceride levels. It achieves this by decreasing the liver's production of very low-density lipoprotein (VLDL), which is a precursor to triglycerides and LDL cholesterol. This makes it a common consideration for individuals with hypertriglyceridemia.
Niacin, also known as vitamin B3, is primarily recognized for its role in preventing and treating pellagra, a deficiency disease. In supplement form, it has been extensively studied for its effects on cholesterol and triglyceride levels. Its physiological functions include energy metabolism and DNA repair.
Niacin can be used in combination with statins to further improve lipid profiles, particularly to increase HDL and lower triglycerides. However, some studies have shown that adding Niacin to statin therapy does not consistently provide additional cardiovascular benefits and may increase the risk of side effects such as myopathy (muscle pain) when taken with certain statins. Medical supervision is essential for this combination.
schedule Dosage, timing & forms
Nicotinic acid is the form most commonly associated with the 'niacin flush' and is often used at higher doses for specific health support under medical supervision. Niacinamide (nicotinamide) generally does not cause flushing and is often preferred for general vitamin B3 supplementation, though it has different metabolic effects compared to nicotinic acid. Their applications can differ significantly.
'Flush-free' niacin, often inositol hexanicotinate, is a form where niacin is chemically bound to inositol, a sugar-like compound. This bond leads to a slow, gradual release of niacin in the body, significantly reducing or eliminating the rapid vasodilation that causes the common flushing sensation. It's often chosen by individuals sensitive to the flush.
To minimize the niacin flush from immediate-release nicotinic acid, individuals can start with a very low dose and gradually increase it over time. Taking it with a non-fatty meal, avoiding hot beverages or alcohol around the time of dosing, and potentially taking aspirin 30 minutes beforehand (if medically appropriate and advised) can also help. Slow and steady increases in dosage are key.
Immediate-release niacin (nicotinic acid) is absorbed quickly, leading to a rapid peak effect and often a pronounced, but temporary, flush. Extended-release forms are designed to release niacin slowly over several hours, which can help reduce the intensity and duration of the flush and may allow for less frequent dosing. The slower release aims to improve tolerance.
Niacin is available in several forms, including nicotinic acid (immediate-release and extended-release), niacinamide (nicotinamide), and inositol hexanicotinate (often marketed as 'no-flush' niacin). Each form has distinct properties and effects within the body. The choice of form can influence how it is absorbed and its potential side effects.
health_and_safety Safety & interactions
The niacin flush is a common side effect characterized by redness, itching, warmth, and tingling, primarily on the face, neck, and chest. It is caused by the release of prostaglandins, which dilate blood vessels. Taking niacin with food, starting with a low dose and gradually increasing it, or taking a low-dose aspirin before niacin may help reduce the flush.
High doses of niacin, particularly sustained-release forms, have been associated with elevated liver enzymes and, in rare cases, liver toxicity. Regular monitoring of liver function by a healthcare professional is often recommended when taking high-dose niacin. Individuals with pre-existing liver conditions should avoid niacin unless specifically advised by a doctor.
Yes, niacin can interact with several medications. It may enhance the effects of blood pressure-lowering drugs, potentially causing hypotension, and can increase the risk of myopathy when taken with statins. Niacin might also interact with blood thinners, antidiabetic medications, and gout medications. Consulting a healthcare provider about all current medications before starting niacin is important.
Individuals with active liver disease, severe hypotension, active peptic ulcer disease, or active bleeding should generally avoid niacin supplements. Those with a history of gout, diabetes, or gallbladder disease should also use niacin with caution and under medical supervision. Consultation with a healthcare provider is essential to determine suitability.
High doses of niacin, particularly nicotinic acid, can sometimes increase blood glucose levels. This effect is more pronounced in individuals with diabetes or prediabetes. People managing their blood sugar should monitor their levels closely if taking niacin and discuss its use with a healthcare provider.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Niacin | 500 mg |
Inositol | 135 mg |
Categories
Niacin 85.0
This is a premium niacin product due to its flush-free nature and substantial dosage, appealing to a wide range of users who want the benefits of Niacin without the common side effects.
Goals
Energy 90.0
A 500mg dose provides ample niacin to support robust energy production, as it plays a critical role in converting macronutrients into cellular energy.
Metabolism Boost 90.0
This high dose of niacin actively participates in numerous metabolic pathways, significantly supporting the efficient breakdown of carbohydrates, fats, and proteins for energy and cellular function.
Skin Health 85.0
Niacin, in this form, still supports skin health through its role in cellular repair and metabolism, and the absence of flush makes it a more pleasant option for long-term use without causing temporary skin redness.
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