Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
Meta-analysis10 studies pooledflagImmunity forscienceVitamin C
- Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagImmunity forscienceVitamin C
- The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review.
SeyedAlinaghi S; Shahidi R; Mojdeganlou H; Akhtaran FK; Maroufi SF; Maroufi SP; Mirzapour P; Karimi A; Khodaei S; Pour MM; Mehraeen E; Dadras O · Journal of health, population, and nutrition · 2024
Systematic review28 studies pooledflagImmunity forscienceVitamin C
- Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
Wieland LS; Piechotta V; Feinberg T; Ludeman E; Hutton B; Kanji S; Seely D; Garritty C · BMC complementary medicine and therapies · 2021
Systematic review5 studies pooledflagImmunity forscienceEuropean Elder
- Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.
Crawford C; Brown LL; Costello RB; Deuster PA · Nutrients · 2022
Systematic review39 studies pooledflagImmunity forscienceEuropean Elder
- Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children.
Su G; Chen X; Liu Z; Yang L; Zhang L; Stålsby Lundborg C; Wen Z; Guo X; Qin X; Liang J; Liu X · The Cochrane database of systematic reviews · 2017
Systematic reviewflagImmunity forscienceAstragalus
- Astragalus in the prevention of upper respiratory tract infection in children with nephrotic syndrome: evidence-based clinical practice.
Zou C; Su G; Wu Y; Lu F; Mao W; Liu X · Evidence-based complementary and alternative medicine : eCAM · 2013
Systematic reviewflagImmunity forscienceAstragalus
- Astragalus mongholicus (Fisch.) Bge Improves Peripheral Treg Cell Immunity Imbalance in the Children With Viral Myocarditis by Reducing the Levels of miR-146b and miR-155.
Zhang Z; Dai X; Qi J; Ao Y; Yang C; Li Y · Frontiers in pediatrics · 2020
Randomized trial68 participantsflagImmunity forscienceAstragalus
- Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
Randomized trial107 participantsflagAnti-Inflammatory Support forscienceVitamin C
- The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
Meta-analysis1,162 participants10 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
Meta-analysis852 participants8 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
Systematic review811 participants17 studies pooledflagAnti-Inflammatory Support forscienceVitamin C
- Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
Randomized trial44 participantsflagAnti-Inflammatory Support forscienceVitamin C
- Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.
Tiralongo E; Wee SS; Lea RA · Nutrients · 2016
Randomized trial312 participantsflagGeneral Health flagImmunity forscienceEuropean Elder
- COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
Silveira D; Prieto-Garcia JM; Boylan F; Estrada O; Fonseca-Bazzo YM; Jamal CM; Magalhães PO; Pereira EO; Tomczyk M; Heinrich M · Frontiers in pharmacology · 2023
Narrative reviewflagGeneral Health forscienceEuropean Elder
- Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
Meta-analysis69 studies pooledflagGeneral Health forscienceVitamin C
- Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
Guideline / consensusflagGeneral Health forscienceVitamin C
- Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
Cohort study598 participantsflagGeneral Health forscienceVitamin C
- Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
Cohort study12,530 participantsflagGeneral Health forscienceVitamin C
- Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
Cohort study19,496 participantsflagGeneral Health forscienceVitamin C
- Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies.
Sun T; Zhao R; Zhang Y; Li D; Shan X; Tang X; Zheng Y · Frontiers in pharmacology · 2025
Meta-analysis776 participants9 studies pooledflagImmunity forscienceAstragalus
- [Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis].
Su L; Mao JC; Gu JH · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2008
Randomized trial43 participantsflagImmunity forscienceAstragalus
- [Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor].
Duan P; Wang ZM · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2003
Randomized trial120 participantsflagImmunity forscienceAstragalus
- [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis].
Mao SP; Cheng KL; Zhou YF · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 2004
Randomized trial168 participantsflagImmunity forscienceAstragalus
- Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials
Jessie Hawkins, Christy Baker, Lindsey Cherry, Erich Dunne · Complementary Therapies in Medicine · 2019
Meta-analysis180 participants4 studies pooledflagImmunity forscienceEuropean Elder
- Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections
Z Zakay-Rones, E Thom, T Wollan, J Wadstein · Journal of International Medical Research · 2004
Randomized trial60 participantsflagImmunity forscienceEuropean Elder
- Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
Meta-analysis2,334 participants14 studies pooledflagImmunity forscienceVitamin C
- Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
Meta-analysisflagImmunity forscienceVitamin C
- New evidence for antioxidant properties of vitamin C.
Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
Randomized trial20 participantsflagImmunity forscienceVitamin C
- Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
Calder PC; Kreider RB; McKay DL · Nutrients · 2025
Systematic review13 studies pooledflagImmunity forscienceVitamin C
- Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation.
Proksch E; Nissen HP · The Journal of dermatological treatment · 2009
Randomized trialflagSkin Health forscienceVitamin B5
- Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study.
Udompataikul M; Limpa-o-vart D · Journal of drugs in dermatology : JDD · 2012
Non-randomized trial30 participantsflagSkin Health forscienceVitamin B5
- Panthenyl triacetate transformation, stimulation of metabolic pathways, and wound-healing properties in the human skin.
Dell'Acqua G; Schweikert K · Journal of cosmetic science · 2012
Randomized trialflagSkin Health forscienceVitamin B5
- Dexpanthenol modulates gene expression in skin wound healing in vivo.
Heise R; Skazik C; Marquardt Y; Czaja K; Sebastian K; Kurschat P; Gan L; Denecke B; Ekanayake-Bohlig S; Wilhelm KP; Merk HF; Baron JM · Skin pharmacology and physiology · 2013
Clinical trialflagSkin Health forscienceVitamin B5
- A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne.
Yang M; Moclair B; Hatcher V; Kaminetsky J; Mekas M; Chapas A; Capodice J · Dermatology and therapy · 2014
Randomized trial48 participantsflagSkin Health forscienceVitamin B5
- Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
Randomized trial23 participantsflagSkin Health forscienceVitamin C
- Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
Randomized trial149 participantsflagSkin Health forscienceVitamin C
- Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
Randomized trial25 participantsflagSkin Health forscienceVitamin C
- Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
Randomized trial16 participantsflagSkin Health forscienceVitamin C
- Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
Cross-sectional study4,025 participantsflagSkin Health forscienceVitamin C