SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
SAMe with Vitamins B-6 B-12 and 5-MTHF
5.0
★ ★ ★ ★ ★
(11 ratings)
SAMe 200 mg
Score 60.0
High-quality SAMe with excellent B-vitamin cofactors, but significantly overpriced compared to alternatives.
Quantity: 30 Capsule(s)Servings size: 1 Capsule(s) (30 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 60.0
High-quality SAMe with excellent B-vitamin cofactors, but significantly overpriced compared to alternatives.
insights Analysis
Designs for Health SAMe with Vitamins B-6 B-12 and 5-MTHF is a thoughtfully formulated supplement that includes critical B vitamins (Methylcobalamin B12, Pyridoxal 5-Phosphate B6, and 5-Methyltetrahydrofolate) alongside SAMe. These cofactors are essential for maximizing the benefits of SAMe, particularly for mood support, as they participate in the methylation cycle. While the quality of ingredients and the brand's reputation are high, the cost per serving is prohibitive, making it difficult to recommend as a primary choice for most consumers when more affordable, albeit sometimes less comprehensive, alternatives exist.
- Includes essential and active B vitamin cofactors (B6, B12, 5-MTHF) that enhance SAMe's efficacy.
- Utilizes a stable form of SAMe (Disulfate P-Toluensulfate) for better absorption.
- Designs for Health is a professional-grade brand known for high-quality supplements.
- Extremely high price per serving, making it a poor value proposition.
- Low review count compared to market leaders, suggesting less widespread consumer adoption.
- Individuals should consult a healthcare professional before combining SAMe with certain medications, especially antidepressants, due to potential interactions.
$58.99($1.96 per serving)
 Pure Formulas | $ 58.99 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B-6 | 5 mg |
Folate | 100 mcg |
Vitamin B12 | 50 mcg |
SAMe | 200 mg |
Categories
SAMe 60.0
This SAMe product is formulated with high-quality, stable SAMe and important cofactors, which is a strong point. However, its premium pricing makes it a less accessible and less competitive option within the broader SAMe market, despite its comprehensive ingredient profile.
Goals
Mood Support 75.0
The inclusion of active B vitamin cofactors is highly beneficial for mood support, as they directly facilitate neurotransmitter synthesis pathways. However, the high cost limits its practicality for consistent long-term use.
Joint Health 60.0
While SAMe is effective for joint health, the 200mg dose is a standard starting point and often requires higher daily intake for therapeutic effects. The B vitamins don't directly impact joint health, and the product's high cost makes it less appealing for managing this condition compared to more affordable plain SAMe options.
Digestive Health 60.0
SAMe supports liver detoxification and general digestive health, and the B vitamins can assist in these metabolic processes. Despite the beneficial cofactors, the very high price makes it less competitive for this goal when compared to alternatives offering similar SAMe doses at a lower cost.
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