SAMe with Vitamins B-6 B-12 and 5-MTHF
Designs for Health
SAMe with Vitamins B-6 B-12 and 5-MTHF
5.0
★ ★ ★ ★ ★
(11 ratings)
SAMe 200 mg
Score 60
High-quality SAMe with excellent B-vitamin cofactors, but significantly overpriced compared to alternatives.
Quantity: 30 Capsule(s) • (30 servings)
Goals: flag Joint Health flag Mood Support flag Detoxification flag Stress Relief
leaderboard Score 60
High-quality SAMe with excellent B-vitamin cofactors, but significantly overpriced compared to alternatives.
insights Analysis
Designs for Health SAMe with Vitamins B-6 B-12 and 5-MTHF is a thoughtfully formulated supplement that includes critical B vitamins (Methylcobalamin B12, Pyridoxal 5-Phosphate B6, and 5-Methyltetrahydrofolate) alongside SAMe. These cofactors are essential for maximizing the benefits of SAMe, particularly for mood support, as they participate in the methylation cycle. While the quality of ingredients and the brand's reputation are high, the cost per serving is prohibitive, making it difficult to recommend as a primary choice for most consumers when more affordable, albeit sometimes less comprehensive, alternatives exist.
- Includes essential and active B vitamin cofactors (B6, B12, 5-MTHF) that enhance SAMe's efficacy.
- Utilizes a stable form of SAMe (Disulfate P-Toluensulfate) for better absorption.
- Designs for Health is a professional-grade brand known for high-quality supplements.
- Extremely high price per serving, making it a poor value proposition.
- Low review count compared to market leaders, suggesting less widespread consumer adoption.
- Individuals should consult a healthcare professional before combining SAMe with certain medications, especially antidepressants, due to potential interactions.
$58.99($1.96 per serving)
 Pure Formulas | $ 58.99 |
Ingredients
| Ingredient | Amount per serving |
|---|---|
Vitamin B-6 | 5 mg |
Folate | 100 mcg |
Vitamin B12 | 50 mcg |
SAMe | 200 mg |
Categories
SAMe 60
This SAMe product is formulated with high-quality, stable SAMe and important cofactors, which is a strong point. However, its premium pricing makes it a less accessible and less competitive option within the broader SAMe market, despite its comprehensive ingredient profile.
Goals
The inclusion of active B vitamin cofactors is highly beneficial for mood support, as they directly facilitate neurotransmitter synthesis pathways. However, the high cost limits its practicality for consistent long-term use.
While SAMe is effective for joint health, the 200mg dose is a standard starting point and often requires higher daily intake for therapeutic effects. The B vitamins don't directly impact joint health, and the product's high cost makes it less appealing for managing this condition compared to more affordable plain SAMe options.
SAMe supports liver detoxification and general digestive health, and the B vitamins can assist in these metabolic processes. Despite the beneficial cofactors, the very high price makes it less competitive for this goal when compared to alternatives offering similar SAMe doses at a lower cost.
84 Value 
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Delivers a potent 400mg dose of SAMe from a stable form at a strong value, making it a cost-effective choice for higher dosing while maintaining quality.
50 Value 
SAMe 400 mg
Swanson
4.6
★★★★★
(265 ratings)
Offers a 400mg SAMe dose at a competitive price, providing good potency for the cost from a widely available brand, even if not the top tier.
55 Value 
SAMe 400 mg
Source Naturals
4.7
★★★★★
(191 ratings)
A higher 400mg SAMe dose option that balances potency with a reasonable price point, offering good overall value for individuals seeking a higher dosage.
98 Performance 
SAMe 200 mg + Cofactors
Metabolic Maintenance
4.6
★★★★★
(30 ratings)
A superior choice due to its comprehensive formulation, including SAMe with highly bioavailable forms of B vitamins (Methylcobalamin, P5P, Folate) plus Magnesium and Calcium, for enhanced methylation support.
85 Performance 
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
Offers a higher 400mg dose of SAMe per serving, which may be more beneficial for some individuals needing increased potency, though it does not include cofactors.
90 Performance 
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Provides a robust 400mg dose of SAMe from a stable form, representing a stronger SAMe concentration per serving for enhanced therapeutic effects, without cofactors.
92 Budget 
SAMe 200 mg
NOW
4.5
★★★★★
(1741 ratings)
Offers a substantial 200mg SAMe dose at a significantly more affordable price per serving compared to the original, though it does not include the additional B vitamins.
88 Budget 
SAMe 200
Jarrow Formulas
4.7
★★★★★
(263 ratings)
Provides a very cost-effective 200mg SAMe option from a highly popular and trusted brand, making it a budget-friendly choice without cofactors.
82 Budget 
SAMe 200 mg
Natural Factors
4.6
★★★★★
(578 ratings)
Delivers a 200mg SAMe dose at a considerably lower price point, offering a good basic SAMe supplement for those not requiring integrated cofactors.
84 Value
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Delivers a potent 400mg dose of SAMe from a stable form at a strong value, making it a cost-effective choice for higher dosing while maintaining quality.
50 Value
SAMe 400 mg
Swanson
4.6
★★★★★
(265 ratings)
Offers a 400mg SAMe dose at a competitive price, providing good potency for the cost from a widely available brand, even if not the top tier.
55 Value
SAMe 400 mg
Source Naturals
4.7
★★★★★
(191 ratings)
A higher 400mg SAMe dose option that balances potency with a reasonable price point, offering good overall value for individuals seeking a higher dosage.
98 Performance
SAMe 200 mg + Cofactors
Metabolic Maintenance
4.6
★★★★★
(30 ratings)
A superior choice due to its comprehensive formulation, including SAMe with highly bioavailable forms of B vitamins (Methylcobalamin, P5P, Folate) plus Magnesium and Calcium, for enhanced methylation support.
85 Performance
SAMe 400 mg
Life Extension
4.8
★★★★★
(2467 ratings)
Offers a higher 400mg dose of SAMe per serving, which may be more beneficial for some individuals needing increased potency, though it does not include cofactors.
90 Performance
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Provides a robust 400mg dose of SAMe from a stable form, representing a stronger SAMe concentration per serving for enhanced therapeutic effects, without cofactors.