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Sinuplex

Metagenics
4.7
★ ★ ★ ★ ★
(26 ratings)
Stinging Nettle 100 mg
Bromelain 50 mg
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Score70
A sensible quercetin-led sinus blend with broad coverage, but several supporting ingredients are too modest or poorly specified to drive the result.
How scoring works
Quantity:120 Tablet(s) • (120 servings)
Goals:
Anti-Inflammatory Support

Score 70

A sensible quercetin-led sinus blend with broad coverage, but several supporting ingredients are too modest or poorly specified to drive the result.
How scoring works
$49.95($0.41 per serving)
Pure Formulas
$ 49.95
iHerb
$ 52.95
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Analysis

Quercetin leads the formula, with vitamin C, nettle root, bromelain, and N-acetylcysteine adding antioxidant, botanical, enzyme, and glutathione-related support. The combination fits seasonal sinus discomfort better than testosterone support.

All amounts are disclosed, but bromelain activity units and nettle extraction details are missing. Bromelain and N-acetylcysteine are especially modest, so their systemic contribution may be limited.

Adults wanting a compact sinus-support tablet may appreciate the broad mechanism coverage. Shoppers seeking a strong bromelain or nettle formula will find better value in a more concentrated, standardized option.

Who is it for
  • Adults seeking multi-ingredient seasonal sinus support
  • People who want quercetin with vitamin C and small supporting actives
Best for
  • Quercetin-led histamine-response support
  • Broad but moderate sinus-focused coverage

Pros

  • Coherent sinus-support combination
  • All active amounts are disclosed
  • Meaningful quercetin amount
  • Single-tablet serving

Cons

  • Bromelain amount is modest
  • Bromelain activity units are missing
  • N-acetylcysteine amount is small
  • Nettle extract ratio is not stated

Warnings

  • Bromelain may increase bleeding tendency with anticoagulant or antiplatelet medicines
  • Bromelain may cause reactions in people sensitive to pineapple
  • N-acetylcysteine may add to the blood-pressure-lowering effect of nitrates
  • Nettle may add to diuretic effects

Nutrient quality

70 High impact

The ingredient selection is coherent for sinus and inflammation-oriented support. Modest amounts and missing activity specifications limit likely depth.

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Ingredient transparency

76 High impact

All active amounts are disclosed without a hidden blend. Form details, daily-use directions, and non-active ingredients are missing.

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Customer satisfaction

62 Moderate impact

The available rating is strong and the sample is small. Detailed feedback was not supplied, so repeated complaints and alignment with the intended use remain uncertain.

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Value for money

69 High impact

The long supply provides moderate value for a broad formula. Modest doses and limited specifications prevent stronger effective-serving value.

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Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Moderate effect
C+ Goal FitD Strength of SupportC+ CoverageB+ Formula Quality
Vitamin C · 150 mg

Quercetin, vitamin C, stinging nettle, bromelain, and N-acetylcysteine cover histamine, antioxidant, enzyme, and glutathione pathways. Quercetin has the strongest amount, while bromelain and N-acetylcysteine are too small for dependable systemic effects.

Missing bromelain activity units and nettle concentration details weaken potency assessment. The formula is coherent for sinus inflammation but offers uneven depth.

Study evidence
Bromelain Supportive 12 studies
Stinging Nettle Supportive 5 studies
Vitamin C Supportive 50 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 150 mg
Quercetin
200 mg
Stinging Nettle Root Extract
100 mg
Bromelain
50 mg
N-Acetylcysteine
25 mg
Gluten Free Adults 18–50
Report overview
Stinging Nettle · 100 mg OverallScore42
F Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyD- Value

Root specificity is clear, but it does not match the formula’s sinus and allergy purpose as well as leaf would. The low extract amount and absent concentration detail further limit nettle potency. A low serving cost keeps the broader formula affordable without creating strong nettle value.

View ingredientView products
Bromelain · 50 mg OverallScore31
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The formula supplies a clearly stated but modest bromelain amount within a sinus-support combination. Missing activity units, source details, and timing directions limit confidence in systemic effectiveness. High dose-adjusted cost makes the bromelain-specific value weak.

View ingredientView products
Loading alternative details
84 Performance

Stinging Nettles

Swanson Superior Herbs
A combination of 250 mg nettle leaf extract identified by silicic acid and 67.5 mg nettle root extract provides more detailed nettle coverage. Bromelain and quercetin are absent, but the leaf-and-root design gives the nettle portion greater depth.
86 Performance

Bromelain 2400 GDU/g - 500 mg

NOW
A 500 mg bromelain dose with stated enzyme activity provides much clearer digestive and anti-inflammatory enzyme support. Nettle and quercetin are absent, so the improvement is specific to bromelain strength and disclosure.
83 Performance

High Potency Bromelain 3000 GDU 500 mg

Doctor's Best
A 500 mg bromelain dose with high stated enzyme activity gives stronger potency information than formulas listing weight alone. Nettle, quercetin, and vitamin C are absent, making it a targeted enzyme option rather than a broad blend.
81 Budget

Stinging Nettle Root 500 mg

Swanson
A much lower serving cost provides 500 mg of stinging nettle in a simple single-ingredient formula. Bromelain, quercetin, and vitamin C are absent, so it suits someone prioritizing nettle rather than the original combined support.
81 Budget

Bromelain 500 mg

AN Amazing Nutrition Amazing Formulas
A much lower serving cost provides 500 mg of bromelain with a concise label. Nettle and quercetin are absent, and enzyme activity units are not supplied, so the lower cost comes with a narrower and less characterized formula.
82 Budget

Bromelain 500 mg

Natural Factors
A lower serving cost provides 500 mg of pineapple-derived bromelain and a long supply. Enzyme activity is not stated and nettle is absent, making it a focused bromelain alternative rather than a complete replacement.
83 Value

Nettle Root 250 mg

California Gold Nutrition EuroHerbs
A low serving cost provides a clearly identified nettle root extract using Urtica dioica and Urtica urens. Bromelain and quercetin are absent, but the focused formula offers useful nettle quality and serving value.
83 Value

Stinging Nettle Root Extract 250 mg

NOW
A moderate serving cost provides 500 mg of stinging nettle extract in a concise formula. Missing bromelain and quercetin limit breadth, while the concentrated nettle amount supports better value for a nettle-first goal.
81 Value

Bromelain 500 mg

The Vitamin Shoppe
A low serving cost and long supply provide 500 mg of pineapple-derived bromelain. Enzyme activity units are missing and nettle is absent, but the simple formula is cost-effective for focused bromelain use.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
    Mendes ML; do Nascimento-Júnior EM; Reinheimer DM; Martins-Filho PR · Medicina oral, patologia oral y cirugia bucal · 2019
    Meta-analysis6 studies pooledAnti-Inflammatory Support forBromelain
  2. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial.
    Akbar Karami A; Sheikhsoleimani M; Reza Memarzadeh M; Haddadi E; Bakhshpour M; Mohammadi N; Mehdi Mirhashemi S · Pakistan journal of biological sciences : PJBS · 2021
    Randomized trial60 participantsAnti-Inflammatory Support forStinging Nettle
  3. Is bromelain an effective drug for the control of pain and inflammation associated with impacted third molar surgery? Systematic review and meta-analysis.
    de A C Almeida R; de Sousa Lima FCM; do E Vasconcelos BC · International journal of oral and maxillofacial surgery · 2019
    Meta-analysis252 participants5 studies pooledAnti-Inflammatory Support forBromelain
  4. [Recommendations of the DGRh Committee on Complementary Medicine and Nutrition on the application of selected phytotherapeutic drugs and herbal medicines in rheumatology].
    Keyßer G; Seifert O; Frohne I; Michalsen A; Pfeil A; Reuß-Borst M; Sander O · Zeitschrift fur Rheumatologie · 2025
    Guideline / consensusAnti-Inflammatory Support forStinging Nettle
  5. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.
    Ordesi P; Pisoni L; Nannei P; Macchi M; Borloni R; Siervo S · Quintessence international (Berlin, Germany : 1985) · 2016
    Randomized trial80 participantsAnti-Inflammatory Support forBromelain
  6. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.
    Müller S; März R; Schmolz M; Drewelow B; Eschmann K; Meiser P · Phytotherapy research : PTR · 2013
    Randomized trial12 participantsAnti-Inflammatory Support forBromelain
  7. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
    Colletti A; Procchio C; Pisano M; Martelli A; Pellizzato M; Cravotto G · Nutrients · 2024
    Randomized trial42 participantsAnti-Inflammatory Support forBromelain
  8. Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
    Muhammad ZA; Ahmad T · JPMA. The Journal of the Pakistan Medical Association · 2019
    Narrative reviewAnti-Inflammatory Support forBromelain
  9. The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trial.
    Namazi N; Esfanjani AT; Heshmati J; Bahrami A · Pakistan journal of biological sciences : PJBS · 2012
    Randomized trial50 participantsAnti-Inflammatory Support forStinging Nettle
  10. Safety, Tolerability, and Efficacy of Hox Alpha, a Dry Extract from Stinging Nettle Leaves versus OTC NSAIDs in Osteoarthritis: A Retrospective, Propensity-Matched 12-Week Analysis from the German Pain e-Registry (SIPHARO Study).
    Überall MA; Küster MA; Müller-Schwefe PCG; Müller-Schwefe GHH · Journal of pain research · 2026
    Cohort study2,146 participantsAnti-Inflammatory Support forStinging Nettle
  11. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain
    C Randall, H Randall, F Dobbs, C Hutton, H Sanders · Journal of the Royal Society of Medicine · 2000
    Randomized trial27 participantsAnti-Inflammatory Support forStinging Nettle
  12. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  13. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  14. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  15. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  16. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C