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Activated Quercetin

Source Naturals
4.7
★ ★ ★ ★ ★
(1800 ratings)
Vitamin C 788 mg
Bromelain 300 mg
Product Image
Score79
A high-potency quercetin and vitamin C formula with a meaningful bromelain weight. Missing enzyme activity and basic delivery forms are the main quality limitations.
How scoring works
Quantity:100 Capsule(s) • (33 servings)
Goals:
Anti-Inflammatory Support
Immunity
General Health
Vision Support
Skin Health

Score 79

A high-potency quercetin and vitamin C formula with a meaningful bromelain weight. Missing enzyme activity and basic delivery forms are the main quality limitations.
How scoring works
$25.05($0.75 per serving)
iHerb
$ 27.18
Pure Formulas
$ 25.05
Vitacost
$ 27.65
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Analysis

Quercetin provides the main flavonoid dose, while vitamin C adds antioxidant and collagen-related support. Bromelain complements the combination with an enzyme component, and magnesium citrate makes a small supporting contribution.

The active weights are substantial and individually disclosed rather than hidden in a proprietary blend. Quercetin has no enhanced-absorption system, and bromelain lacks activity units, so its actual enzymatic strength cannot be confirmed from weight alone.

The smaller bottle suits adults who want to try a high-potency quercetin combination for antioxidant or inflammatory-balance support. A three-capsule serving and medication-related bleeding concerns make it less convenient for some users.

Who is it for
  • Adults seeking a substantial quercetin combination
  • People wanting antioxidant support with added bromelain
Best for
  • Antioxidant and inflammatory-balance support
  • Trying the formula in a smaller package

Pros

  • Substantial quercetin amount
  • Meaningful vitamin C serving
  • Bromelain weight is clearly disclosed
  • No proprietary active blend

Cons

  • Bromelain activity units are missing
  • Quercetin lacks an enhanced-absorption system
  • Requires three capsules per serving
  • Magnesium amount is nutritionally minor

Warnings

  • Bromelain and quercetin may increase bruising or bleeding with anticoagulant or antiplatelet medicines.
  • Stop use before planned surgery according to the surgical team’s instructions because bromelain may affect bleeding.
  • The vitamin C amount may cause stomach upset and may not suit people prone to calcium-oxalate kidney stones.

Nutrient quality

85 Highest impact

Substantial active weights and a coherent combination support strong nutrient quality. Basic forms and missing bromelain activity units limit potency confidence.

Ingredient transparency

84 Highest impact

Every active weight is disclosed without a hidden blend. Bromelain source, enzyme activity, meal timing, and inactive ingredients remain incomplete.

Customer satisfaction

72 High impact

The aggregate rating is strong and backed by extensive feedback volume. Detailed comments are not supplied, so recurring experiences cannot be assessed.

Value for money

71 High impact

Meaningful core doses partly justify the premium serving cost. The focused formula offers reasonable rather than leading category value.

Report analysis

Goals

Anti-Inflammatory Support
Impact
Highest effect
A- Goal FitA- Strength of SupportA CoverageA+ Formula Quality
Vitamin C · 788 mg

High-dose quercetin with bromelain and vitamin C provides strong multi-pathway inflammation support. Missing bromelain activity units and a basic quercetin form leave some absorption and potency uncertainty.

The combination balances meaningful doses across direct and antioxidant pathways. Bromelain and quercetin may increase bleeding risk with anticoagulant or antiplatelet medicines.

Study evidence
Bromelain Supportive 12 studies
Magnesium Supportive 41 studies
Vitamin C Supportive 50 studies
Immunity
Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageA Formula Quality
Magnesium · 50 mgVitamin C · 788 mg

Vitamin C, quercetin, and bromelain create a coherent antioxidant and inflammatory-response formula with meaningful disclosed amounts. Vitamin C has the strongest immune evidence, while quercetin and bromelain provide less certain complementary support.

Missing bromelain activity units make enzyme potency difficult to confirm, and the unbuffered vitamin C form may be acidic. Bromelain may increase bleeding risk when combined with anticoagulant or antiplatelet medicines.

Study evidence
Bromelain Not classified 1 study
Vitamin C Supportive 53 studies
General Health
Impact
Highest effect
B Goal FitB+ Strength of SupportB+ CoverageA Formula Quality
Magnesium · 50 mgVitamin C · 788 mg

Substantial quercetin and vitamin C amounts create broader antioxidant support than a basic single-vitamin formula. Bromelain complements the flavonoid-focused design, and every active amount is stated.

Plain ascorbic acid offers no stomach-comfort advantage, while the magnesium amount is too small for strong mineral support. The three-capsule serving is best suited to users seeking the full combination rather than vitamin C alone.

Study evidence
Bromelain Supportive 11 studies
Magnesium Supportive 114 studies
Vitamin C Supportive 56 studies
Vision Support
Impact
High effect
C+ Goal FitB+ Strength of SupportC CoverageB- Formula Quality
Vitamin C · 788 mg

Vitamin C and quercetin offer broad antioxidant activity that may help protect ocular tissues from oxidative stress. The combination is less established for vision than macular carotenoids or complete antioxidant-mineral eye formulas.

The vitamin C and quercetin amounts are substantial and clearly listed, while bromelain mainly serves a general absorption or inflammation role. Bromelain and quercetin may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Study evidence
Vitamin C Disputed 24 studies
Skin Health
Impact
High effect
C Goal FitB Strength of SupportC+ CoverageB Formula Quality
Vitamin C · 788 mg

Vitamin C and quercetin provide substantial antioxidant support, while vitamin C also aids normal collagen synthesis. Bromelain may assist the broader inflammatory strategy, but direct evidence for visible skin outcomes from the full formula is limited.

The combination covers oxidative defense and a collagen cofactor without a structural or hydration active. Clear main-active amounts support depth, although the product remains more general antioxidant support than dedicated skin care.

Study evidence
Vitamin C Supportive 53 studies
Digestive Health
Impact
Moderate effect
B- Goal FitC- Strength of SupportC- CoverageB- Formula Quality
Bromelain · 300 mgMagnesium · 50 mg

Bromelain may aid protein digestion, while quercetin and vitamin C offer secondary antioxidant and barrier-related support. The formula is primarily an antioxidant product rather than a comprehensive digestive aid.

The bromelain weight is meaningful, but missing activity units and timing guidance prevent a potency judgment. Bromelain may increase bleeding risk with anticoagulants or antiplatelet medicines.

Study evidence
Bromelain Supportive 2 studies

Ingredients

IngredientAmount per serving
Protein
500 mg
Vitamin C (Ascorbic Acid)
788 mg
Magnesium (Magnesium Citrate)
50 mg
Quercetin
1 Gram(s)
Bromelain
300 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The 788 mg vitamin C dose fits the optimal range, but it uses basic unbuffered ascorbic acid. Its amount is clearly separated from quercetin, bromelain, and magnesium, which supports label clarity. Cost per gram of vitamin C is poor because the serving price also covers the broader multi-ingredient formula.

Bromelain · 300 mg OverallScore37
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

The blend supplies a meaningful bromelain amount alongside a substantial quercetin dose. Enzyme activity, botanical source, and timing instructions are missing, so potency and use are not fully clear. The standard capsules lack stated acid protection, and bromelain cost efficiency is weak despite the added ingredients.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  2. Serum vitamin C and spinal pain: a nationwide study.
    Dionne CE; Laurin D; Desrosiers T; Abdous B; Le Sage N; Frenette J; Mondor M; Pelletier S · Pain · 2017
    Cross-sectional study4,742 participantsGeneral Health forVitamin C
  3. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  4. Association between hemoglobin A1c, Vitamin C, and microbiome in diabetic foot ulcers and intact skin: A cross-sectional study.
    Tong KPS; Green SJ; Ortiz J; Wu SC · Health science reports · 2024
    Cross-sectional study42 participantsSkin Health forVitamin C
  5. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.
    Ordesi P; Pisoni L; Nannei P; Macchi M; Borloni R; Siervo S · Quintessence international (Berlin, Germany : 1985) · 2016
    Randomized trial80 participantsAnti-Inflammatory Support forBromelain
  6. Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
    Mendes ML; do Nascimento-Júnior EM; Reinheimer DM; Martins-Filho PR · Medicina oral, patologia oral y cirugia bucal · 2019
    Meta-analysis6 studies pooledAnti-Inflammatory Support General Health forBromelain
  7. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain.
    Müller S; März R; Schmolz M; Drewelow B; Eschmann K; Meiser P · Phytotherapy research : PTR · 2013
    Randomized trial12 participantsAnti-Inflammatory Support General Health Immunity forBromelain
  8. An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
    Colletti A; Procchio C; Pisano M; Martelli A; Pellizzato M; Cravotto G · Nutrients · 2024
    Randomized trial42 participantsAnti-Inflammatory Support forBromelain
  9. Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
    Muhammad ZA; Ahmad T · JPMA. The Journal of the Pakistan Medical Association · 2019
    Narrative reviewAnti-Inflammatory Support forBromelain
  10. Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.
    Dibaba DT; Xun P; He K · European journal of clinical nutrition · 2014
    Meta-analysis32,918 participants7 studies pooledAnti-Inflammatory Support forMagnesium
  11. Efficacy and safety of magnesium glycinate as add on therapy in hypomagnesemic asthma and chronic obstructive pulmonary disease patients: A randomised controlled study assessing inflammatory biomarkers.
    Maddirevula MK; Rajanandh MG; Wesley B · Pulmonary pharmacology & therapeutics · 2026
    Randomized trial224 participantsAnti-Inflammatory Support forMagnesium
  12. Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Razzaghi R; Pidar F; Momen-Heravi M; Bahmani F; Akbari H; Asemi Z · Biological trace element research · 2018
    Randomized trial70 participantsAnti-Inflammatory Support forMagnesium
  13. The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
    Wang W; Wang J; Yang Y; Shi Y · Frontiers in nutrition · 2025
    Meta-analysis444 participants8 studies pooledAnti-Inflammatory Support forMagnesium
  14. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.
    Veronese N; Pizzol D; Smith L; Dominguez LJ; Barbagallo M · Nutrients · 2022
    Meta-analysis889 participants17 studies pooledAnti-Inflammatory Support forMagnesium
  15. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  16. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  17. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  18. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  19. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  20. The role of enzyme supplementation in digestive disorders.
    Roxas M · Alternative medicine review : a journal of clinical therapeutic · 2009
    Narrative reviewDigestive Health forBromelain
  21. Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.
    Delgarm P; Mokhtare M; Ebrahimi Daryani N; Abolghasemi J; Rahideh ST · Scientific reports · 2025
    Randomized trial70 participantsDigestive Health forBromelain
  22. Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial.
    Majid OW; Al-Mashhadani BA · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2014
    Randomized trial45 participantsGeneral Health forBromelain
  23. Bromelain-based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long-term outcomes.
    Shoham Y; Gasteratos K; Singer AJ; Krieger Y; Silberstein E; Goverman J · International wound journal · 2023
    Systematic review34 studies pooledGeneral Health forBromelain
  24. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults.
    Walker AF; Bundy R; Hicks SM; Middleton RW · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2003
    Randomized trial77 participantsGeneral Health forBromelain
  25. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials.
    De Oliveira GS; Castro-Alves LJ; Khan JH; McCarthy RJ · Anesthesiology · 2013
    Meta-analysis1,257 participants20 studies pooledGeneral Health forMagnesium
  26. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2).
    Woods KL; Fletcher S · Lancet (London, England) · 1994
    Randomized trial2,316 participantsGeneral Health forMagnesium
  27. Association of magnesium sulfate use with mortality in critically ill patients with sepsis: a retrospective propensity score-matched cohort study.
    Gu WJ; Duan XJ; Liu XZ; Cen Y; Tao LY; Lyu J; Yin HY · British journal of anaesthesia · 2023
    Cohort study10,999 participantsGeneral Health forMagnesium
  28. Hypomagnesemia and Mortality in Incident Hemodialysis Patients.
    Li L; Streja E; Rhee CM; Mehrotra R; Soohoo M; Brunelli SM; Kovesdy CP; Kalantar-Zadeh K · American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016
    Cohort study9,359 participantsGeneral Health forMagnesium
  29. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.
    Jaripur M; Ghasemi-Tehrani H; Askari G; Gholizadeh-Moghaddam M; Clark CCT; Rouhani MH · Reproductive biology and endocrinology : RB&E · 2022
    Randomized trial64 participantsGeneral Health forMagnesium
  30. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  31. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  32. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  33. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  34. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  35. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  36. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  37. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  38. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  39. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  40. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  41. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  42. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  43. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  44. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  45. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  46. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  47. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C