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Ascorbic Acid with Bioflavonoids

NutriBiotic Immunity
4.8
★ ★ ★ ★ ★
(2375 ratings)
Vitamin C 2000 mg
Flavonoid (mixture) 500 mg
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Score86
Flexible, economical powder works well for users who can divide the dose, while acidity and a very high suggested serving are notable limits.
How scoring works
Quantity:16 Ounce(s) • (181 servings)
Goals:
Anti-Inflammatory Support
General Health
Immunity
Skin Health
Vision Support

Score 86

Flexible, economical powder works well for users who can divide the dose, while acidity and a very high suggested serving are notable limits.
How scoring works

Also available as

1 option
8 servings C 2000 mg, Flavonoid (mixture) 500 mg • 8 Ounce(s) • 90 servings $12.37 ($0.13 per serving)
$21.74($0.12 per serving)
Vitacost
$ 23.93
iHerb
$ 21.74
Report prices

Analysis

The focused powder combines L-ascorbic acid with lemon bioflavonoids and avoids a crowded ingredient list. Its loose format makes it possible to use less than the suggested serving or split intake across the day.

The full serving is very high, and taking that much at once may be less efficient and harder to tolerate. Plain ascorbic acid also lacks the gentler stomach profile of calcium or sodium ascorbate.

The larger package provides excellent value for regular users who are comfortable measuring powder. Convenience is lower than capsules, and careful mixing is needed to avoid concentrated acidic exposure.

Who is it for
  • Regular users of vitamin C powder
  • Adults wanting adjustable servings
  • People prioritizing dose-adjusted value
Best for
  • Bulk vitamin C supplementation
  • Divided intake
  • Drink-mix use

Pros

  • Pure L-ascorbic acid
  • Substantial lemon bioflavonoids
  • Adjustable powder format
  • Excellent value for regular use

Cons

  • Unbuffered acidity
  • Very high suggested serving
  • Requires measuring
  • Less portable than capsules

Warnings

  • The full serving can cause digestive upset or loose stools; smaller divided amounts may improve tolerance.
  • Rinse the mouth with water after drinking to reduce prolonged acid contact with tooth enamel.

Nutrient quality

85 Highest impact

L-ascorbic acid is effective but not buffered for sensitive users. Vitamin C and lemon bioflavonoids are supplied at substantial amounts.

.

Ingredient transparency

84 Highest impact

Both active amounts are clearly disclosed. Powder products use few excipients, but the supplied data does not explicitly confirm them.

.

Customer satisfaction

77 High impact

The average rating is very strong. The large rating volume provides a reliable satisfaction signal.

.

Value for money

97 Highest impact

The powder format provides economical servings. No weak extras inflate the formula.

.
Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B+ Goal FitB- Strength of SupportB- CoverageA+ Formula Quality
Vitamin C · 2000 mg

Vitamin C provides strong antioxidant support during inflammatory stress. Lemon bioflavonoids add a complementary plant-antioxidant pathway.

The very large serving is clearly disclosed but exceeds the most efficient single-dose range. The bioflavonoid amount is substantial, although individual constituents are not shown.

Study evidence
Vitamin C Supportive 50 studies
General Health
General Health
Impact
High effect
A- Goal FitC+ Strength of SupportC- CoverageA Formula Quality
Vitamin C · 2000 mg

L-ascorbic acid and lemon bioflavonoids provide concentrated antioxidant support, with vitamin C also contributing to immune and collagen functions. The bioflavonoid complex adds a complementary plant-compound component without crowding the formula.

The 2000 mg vitamin C serving is above the preferred efficient range and may cause loose stools or stomach discomfort, especially when taken at once. Unbuffered powder offers clear dosing but no gastric-comfort or advanced-delivery advantage.

Study evidence
Vitamin C Supportive 56 studies
Immunity
Immunity
Impact
High effect
B Goal FitB- Strength of SupportD+ CoverageA- Formula Quality
Vitamin C · 2000 mg

The powder combines a very large vitamin C amount with a substantial lemon bioflavonoid complex. Vitamin C has established roles in collagen formation, antioxidant defense, and normal immune function, while flavonoids may offer complementary antioxidant activity.

The vitamin C amount reaches the adult upper intake level and exceeds what most people need for routine foundational support. It can cause stomach upset or diarrhea, and sustained high intake may be unsuitable for people prone to oxalate kidney stones.

Study evidence
Vitamin C Supportive 53 studies
Skin Health
Skin Health
Impact
High effect
C+ Goal FitB+ Strength of SupportD+ CoverageB Formula Quality
Vitamin C · 2000 mg

2,000 mg of L-ascorbic acid supplies a strong collagen cofactor and antioxidant, while 500 mg of lemon bioflavonoids may add complementary antioxidant activity. The formula still lacks direct structural or moisture-barrier ingredients.

Both active amounts are clearly disclosed in a simple powder. A two-gram vitamin C serving can cause digestive discomfort in some people and may provide little added skin benefit beyond a moderate intake.

Study evidence
Vitamin C Supportive 53 studies
Vision Support
Vision Support
Impact
High effect
C+ Goal FitB+ Strength of SupportD+ CoverageB+ Formula Quality
Vitamin C · 2000 mg

Vitamin C and lemon bioflavonoids provide broad antioxidant support that may help protect ocular tissues. The formula lacks macular pigments, zinc, copper, and omega-3 fats for comprehensive vision coverage.

Both active amounts are clear, though the bioflavonoid composition is not detailed. The 2,000 mg vitamin C amount may cause diarrhea or raise kidney-stone risk in susceptible users.

Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Vitamin C (L-Ascorbic Acid)
 2000 mg
Lemon Bioflavonoid Complex
500 mg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Vitamin C (L-Ascorbic Acid) · 2000 mg OverallScore64
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

Pure L-ascorbic acid powder offers a concentrated dose with added lemon bioflavonoids, but it lacks buffering for sensitive stomachs. The two-gram serving may be harder to tolerate than smaller divided doses. Cost per gram is very low, and no unnecessary additives are disclosed.

View ingredientView products
Loading alternative details
89 Performance

C-500 Calcium Ascorbate-C

NOW
<p>The ingredient profile makes it a stronger quality-focused alternative for the same vitamin C goals. Buffered calcium ascorbate delivers a practical vitamin C amount with clear mineral disclosure and exceptional relative value. The small bioflavonoid addition is unlikely to contribute much but does not undermine the strong core formula.</p>
86 Performance

C

Swanson
<p>The ingredient profile makes it a stronger quality-focused alternative for the same vitamin C goals. Fully buffered calcium ascorbate provides a meaningful vitamin C serving with good stomach-comfort potential. The focused formula keeps the active nutrient clear and avoids decorative additions.</p>
87 Performance

Ester-C with Citrus Bioflavonoids

American Health
<p>The ingredient profile makes it a stronger quality-focused alternative for the same vitamin C goals. A buffered vitamin C form and a substantial citrus bioflavonoid amount create a simple, well-dosed antioxidant formula. Strong satisfaction signals and a long supply support value, though excipients and intake directions are not shown.</p>
89 Budget

Pure Buffered Calcium Ascorbate

NOW
<p>The lower serving cost makes it a more economical alternative while retaining the same vitamin C focus. the buffered mineral ascorbate form supplies a meaningful vitamin C amount with a digestive-comfort advantage over plain ascorbic acid. Clear active dosing and favorable serving value are strengths, though complete use directions and inactive ingredients are not supplied.</p>
87 Budget

100% Pure Vitamin C Powder

Swanson Premium Brand
<p>The lower serving cost makes it a more economical alternative while retaining the same vitamin C focus. The pure powder supplies a flexible, meaningful vitamin C serving with exceptional economy and no active padding. Plain ascorbic acid remains acidic, so sensitive users may prefer a buffered form.</p>
87 Budget

C 500 mg

Mason Natural
<p>The lower serving cost makes it a more economical alternative while retaining the same vitamin C focus. A simple moderate-dose tablet provides useful vitamin C at excellent relative value and with extensive aggregate feedback. Generic ascorbic acid and missing inactive-ingredient details are the main limitations.</p>
87 Value

Pure Buffered Magnesium Ascorbate

NOW
<p>The formula offers a more favorable balance of vitamin C quality and serving value than the original. Magnesium ascorbate provides a substantial fully buffered vitamin C serving with excellent relative value and clear mineral disclosure. Feedback volume is limited, and detailed use directions or non-active ingredients are not supplied.</p>
83 Value

C 500 mg

21st Century
<p>The formula offers a more favorable balance of vitamin C quality and serving value than the original. A large supply of straightforward vitamin C provides meaningful daily support with excellent value. Basic ascorbic acid and incomplete inactive-ingredient details keep the formula from feeling premium.</p>
84 Value

Ester-C 500 mg With Citrus Bioflavoinds

American Health
<p>The formula offers a more favorable balance of vitamin C quality and serving value than the original. Buffered Ester-C provides a substantial vitamin C serving with good stomach-comfort potential. Citrus bioflavonoids add compatible plant compounds without distracting from the core nutrient.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  2. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  3. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  4. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  5. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  6. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  7. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  8. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  9. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  10. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  11. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  12. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  13. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  14. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  15. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  16. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  17. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  18. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  19. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  20. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  21. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  22. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  23. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  24. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  25. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C