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CoQ10 100 mg

Nature Made
4.6
★ ★ ★ ★ ★
(93 ratings)
Coenzyme Q-10 100 mg
Product Image
Score84
CoQ10 100 mg provides 100 mg of ubiquinone with excellent serving value. The softgel carrier oil and complete excipients are not shown, though the serving value is highly competitive.
How scoring works
Quantity:72 Softgel(s) • (72 servings)
Goals:
Anti-Aging
Heart Health
Energy
Cardiovascular Support
Metabolism Boost
Anti-Inflammatory Support

Score 84

CoQ10 100 mg provides 100 mg of ubiquinone with excellent serving value. The softgel carrier oil and complete excipients are not shown, though the serving value is highly competitive.
How scoring works
$13.51($0.18 per serving)
Walmart
$ 13.51
Vitacost
$ 33.35
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Analysis

Ubidicarenone clearly identifies ubiquinone at a practical maintenance amount. The serving provides 100 mg of ubiquinone in a softgel.

CoQ10 supports cellular energy production and antioxidant defenses. Ubiquinone is a clearly identified and widely used maintenance form of CoQ10. Softgel delivery is compatible with routine use of a fat-soluble ingredient, although carrier details still matter.

The softgel carrier oil and complete excipients are not shown, though the serving value is highly competitive. The 72-serving supply offers excellent serving value, so form, delivery, and intended dose should guide the choice.

Who is it for
  • Adults seeking 100 mg of CoQ10
  • People who prefer a softgel format
  • Users who want a focused CoQ10 formula
Best for
  • Cellular energy support
  • Antioxidant support
  • Routine CoQ10 supplementation

Pros

  • 100 mg CoQ10 amount is fully disclosed
  • Ubiquinone identifies the active form
  • 72 servings per container
  • Excellent serving value

Cons

  • The softgel carrier oil and complete excipients are not shown, though the serving value is highly competitive.
  • People with oil or excipient sensitivities need the complete label to assess suitability.
  • The focused formula provides limited coverage beyond mitochondrial and antioxidant support.

Warnings

  • CoQ10 may reduce the effect of warfarin, so anticoagulation should be monitored by the prescriber when use starts, stops, or changes.
  • The carrier oil is not fully identified, so people with oil or excipient sensitivities should check the complete label before use.
  • Count the 100 mg CoQ10 serving when combining it with another ubiquinol or ubiquinone product.

Nutrient quality

94 Highest impact

Ubiquinone is a conventional CoQ10 form, and softgel delivery supports uptake of the fat-soluble active. The 100 mg amount is meaningful for routine CoQ10 use.

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Ingredient transparency

83 Highest impact

Active ingredients have stated amounts and no proprietary blend hides a dose. Serving count is supplied, while full directions and the other-ingredients list are missing.

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Customer satisfaction

63 Moderate impact

The supplied aggregate rating is the only evidence of general satisfaction and its reliability depends on rating volume. No comment-level evidence is available to assess recurring complaints or confirm how experience matches the intended purpose.

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Value for money

96 Highest impact

The effective amount and favorable serving cost strongly support formula value. The product compares very well with similar CoQ10 options.

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Report analysis

Goals

Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

A clear 100 mg CoQ10 amount directly supports mitochondrial energy and antioxidant protection. Softgel delivery likely helps handle the fat-soluble active.

Ubiquinone requires conversion to ubiquinol and the carrier oil is not disclosed. The focused formula gives strong depth to one pathway but leaves inflammation, glycation, structural aging, and neurological support unaddressed.

Study evidence
Coenzyme Q-10 Supportive 6 studies
Heart Health
Heart Health
Impact
Highest effect
A Goal FitB+ Strength of SupportD+ CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

A clearly disclosed ubiquinone serving supports mitochondrial energy production in heart muscle at a useful maintenance amount. Softgel delivery is appropriate for a fat-soluble compound and keeps the formula easy to use.

Ubiquinone may be less readily used than ubiquinol for some older adults or people with absorption challenges. The single-active design provides depth for cardiac energy but leaves other cardiovascular pathways untouched.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Energy
Energy
Impact
Highest effect
A- Goal FitB+ Strength of SupportC- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly participates in mitochondrial energy production and is supplied at a clear maintenance amount. The softgel format is suitable for this fat-soluble compound.

Ubiquinone is less directly usable than ubiquinol for some people, and carrier details are missing. The single pathway focus is appropriate but does not address alertness or stress resilience.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
B+ Goal FitB+ Strength of SupportC- CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

Ubiquinone at 100 mg provides a meaningful maintenance amount for cardiac cellular energy and antioxidant support. A softgel may support absorption of this fat-soluble compound, although full carrier details are not provided.

The single-active design offers strong depth without pretending to cover every cardiovascular pathway. People using warfarin should discuss CoQ10 with their prescriber because it may affect anticoagulation control.

Study evidence
Coenzyme Q-10 Supportive 89 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
B- Goal FitB- Strength of SupportD- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 supports mitochondrial electron transport and normal cellular energy generation. The single-active softgel is focused but does not directly increase thermogenesis or support thyroid and glucose pathways.

The 100 mg ubiquinone amount is fully disclosed and appropriate for routine use. Softgel delivery likely supports absorption, although carrier-oil details are not provided.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C+ Goal FitB- Strength of SupportD- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

A maintenance ubiquinone amount provides focused mitochondrial antioxidant support. Softgel delivery should help absorption of the fat-soluble active.

CoQ10 is not a direct inhibitor of the main inflammatory pathways emphasized for this goal. The formula is therefore narrow and better suited to general antioxidant support.

Study evidence
Coenzyme Q-10 Supportive 46 studies

Ingredients

IngredientAmount per serving
Coenzyme Q-10 (Ubidicarenone)
 100 mg
Gluten Free Adults 18–50
Report overview
Coenzyme Q-10 (Ubidicarenone) · 100 mg OverallScore78
C+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyA+ Value
Ubidicarenone is ubiquinone, providing a clear maintenance dose in one softgel. The format likely supports fat-soluble absorption, although the carrier oil and complete excipients are not shown. Its normalized cost is highly competitive.
View ingredientView products
Loading alternative details
87 Performance

Extra Strength Ubiquinol 200 mg

NOW
<p>Ingredient quality is better supported by 200 mg ubiquinol, the reduced CoQ10 form, keeping the alternative closely aligned with the CoQ10 collection. Naming the reduced CoQ10 form gives clearer form information than the original's ubiquinone or unspecified CoQ10.</p>
87 Performance

Mega CoQ10 Ubiquinol 100 mg

Qunol
<p>Ingredient quality is better supported by 100 mg ubiquinol, the reduced CoQ10 form, keeping the alternative closely aligned with the CoQ10 collection. Naming the reduced CoQ10 form gives clearer form information than the original's ubiquinone or unspecified CoQ10.</p>
87 Performance

QH-absorb 100 mg

Jarrow Formulas
<p>Ingredient quality is better supported by 100 mg ubiquinol, the reduced CoQ10 form, keeping the alternative closely aligned with the CoQ10 collection. Naming the reduced CoQ10 form gives clearer form information than the original's ubiquinone or unspecified CoQ10.</p>
84 Budget

CoQ10 100 mg

Best Naturals
<p>100 mg ubiquinone retains the core ingredient at a lower serving cost. The focused label keeps the comparison close to the original while making the CoQ10 form straightforward to assess.</p>
85 Budget

High Absorption CoQ10 with BioPerine 100 mg

Doctor's Best
<p>100 mg ubiquinone retains the core ingredient at a lower serving cost. Black-pepper extract adds an absorption-oriented companion ingredient, though medicine interactions may need consideration.</p>
84 Budget

CoQ10 100 mg

California Gold Nutrition
<p>100 mg ubiquinone retains the core ingredient at a lower serving cost. The focused label keeps the comparison close to the original while making the CoQ10 form straightforward to assess.</p>
86 Value

Ubiquinol 100 mg

NOW
<p>100 mg ubiquinol, the reduced CoQ10 form combines a relevant CoQ10 serving with favorable value evidence. Naming the reduced CoQ10 form gives clearer form information than the original's ubiquinone or unspecified CoQ10.</p>
85 Value

Mega Ubiquinol CoQ10 100 mg

Qunol
<p>100 mg ubiquinol, the reduced CoQ10 form combines a relevant CoQ10 serving with favorable value evidence. Naming the reduced CoQ10 form gives clearer form information than the original's ubiquinone or unspecified CoQ10.</p>
87 Value

QH-absorb 100 mg

Jarrow Formulas
<p>100 mg ubiquinol, the reduced CoQ10 form combines a relevant CoQ10 serving with favorable value evidence. Naming the reduced CoQ10 form gives clearer form information than the original's ubiquinone or unspecified CoQ10.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  2. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  3. Platelet mitochondrial function and endogenous coenzyme Q10 levels are reduced in patients after COVID-19.
    Sumbalova Z; Kucharska J; Palacka P; Rausova Z; Langsjoen PH; Langsjoen AM; Gvozdjakova A · Bratislavske lekarske listy · 2022
    Cross-sectional study25 participantsEnergy forCoenzyme Q-10
  4. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  5. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  6. Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia?
    Cordero MD; Alcocer-Gómez E; de Miguel M; Culic O; Carrión AM; Alvarez-Suarez JM; Bullón P; Battino M; Fernández-Rodríguez A; Sánchez-Alcazar JA · Antioxidants & redox signaling · 2014
    Randomized trial20 participantsEnergy forCoenzyme Q-10
  7. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  8. Coenzyme Q10 supplementation in rheumatic diseases: A systematic review.
    Freire de Carvalho J; Skare T · Clinical nutrition ESPEN · 2024
    Systematic review483 participants20 studies pooledEnergy forCoenzyme Q-10
  9. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.
    Fukuda S; Nojima J; Kajimoto O; Yamaguti K; Nakatomi Y; Kuratsune H; Watanabe Y · BioFactors (Oxford, England) · 2017
    Randomized trial63 participantsEnergy forCoenzyme Q-10
  10. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals.
    Mizuno K; Sasaki AT; Watanabe K; Watanabe Y · Nutrients · 2021
    Clinical trial62 participantsEnergy forCoenzyme Q-10
  11. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
    Mantle D; Hargreaves I · Antioxidants (Basel, Switzerland) · 2020
    Narrative reviewAnti-Aging forCoenzyme Q-10
  12. Coenzyme Q10 Supplementation in Aging and Disease.
    Hernández-Camacho JD; Bernier M; López-Lluch G; Navas P · Frontiers in physiology · 2022
    Narrative reviewAnti-Aging forCoenzyme Q-10
  13. Coenzyme Q10, a cutaneous antioxidant and energizer.
    Hoppe U; Bergemann J; Diembeck W; Ennen J; Gohla S; Harris I; Jacob J; Kielholz J; Mei W; Pollet D; Schachtschabel D; Sauermann G; Schreiner V; Stäb F; Steckel F · BioFactors (Oxford, England) · 1999
    Clinical trialAnti-Aging forCoenzyme Q-10
  14. Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
    Pabis K; Wang W; Selvarajoo K; Budovskaya YV; Sorrentino V; Gruber J; Kennedy BK · Aging cell · 2026
    Cross-sectional study4,260 participantsAnti-Aging forCoenzyme Q-10
  15. Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
    Schmücker M; Tranberg C; Borch J; Kaae MK; Damgaard M; Flensted-Jensen M; Blom I; Morosetti M; Barbarossa S; Orlando P; Tiano L; Dela F; Helge JW; Larsen S · GeroScience · 2026
    Randomized trial40 participantsAnti-Aging forCoenzyme Q-10
  16. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  17. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  18. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  19. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  20. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  21. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  22. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  23. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  24. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  25. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  26. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  27. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  28. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  29. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  30. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  31. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  32. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  33. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  34. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  35. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10