Glutathione-SR
Thorne
Glutathione-SR
4.6
★ ★ ★ ★ ★
(2996 ratings)
Glutathione 175 mg
Score 75.0
A 175mg sustained-release glutathione supplement from Thorne, designed for enhanced absorption and prolonged activity for anti-aging and detoxification, but at a premium price.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Anti-Aging
Detoxification
Skin Health
Anti-Inflammatory Support
leaderboard Score 75.0
A 175mg sustained-release glutathione supplement from Thorne, designed for enhanced absorption and prolonged activity for anti-aging and detoxification, but at a premium price.
insights Analysis
Thorne Glutathione-SR provides 175mg of glutathione in a sustained-release capsule. This SR technology aims to protect glutathione from stomach acid and digestive enzymes, allowing for gradual release and potentially improved absorption and sustained levels in the body, a key concern for oral glutathione. This product is formulated as a capsule(s) and aims to support Anti-Aging, Detoxification, Skin Health, Anti-Inflammatory Support. With over 2800 reviews, it's a popular choice from a highly regarded professional brand. Nutritionists often recommend Thorne for its high quality and advanced formulations, recognizing the value of improved delivery methods for glutathione.
- Sustained-release (SR) technology may enhance absorption and extend glutathione's presence in the body.
- From Thorne, a highly reputable brand known for professional-grade, high-quality supplements.
- Aims to overcome the traditional bioavailability issues of oral glutathione.
- Relatively low dosage of 175mg per serving for a primary glutathione supplement.
- Very high price per serving (85 cents), making it one of the most expensive options per milligram of glutathione.
- Lacks additional synergistic co-factors beyond glutathione itself.
- While glutathione is a powerful antioxidant, its direct oral supplementation can be less effective than precursors or specialized delivery methods due to poor absorption.
- Individual responses to glutathione supplements can vary; consult with a healthcare professional before starting any new supplement regimen.
$45.90($0.76 per serving)
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bolt Effectiveness for goals
The effectiveness of oral glutathione supplementation for directly increasing intracellular glutathione levels is a subject of ongoing research. While some studies suggest that specific forms, like liposomal or S-acetyl-glutathione, may help raise plasma glutathione, traditional forms face challenges with absorption. The body's natural synthesis of glutathione is a primary regulator of its levels.
The effectiveness of oral glutathione can vary due to challenges with absorption and degradation in the digestive system. Some forms, like liposomal or S-acetyl glutathione, are designed to improve bioavailability. Research on the systemic impact of various oral forms is ongoing.
Traditional reduced glutathione supplements have historically faced challenges with absorption due to degradation in the digestive tract. Newer forms, such as liposomal or S-acetyl-glutathione, are specifically designed to improve bioavailability and are generally considered more effectively absorbed. Research continues to evaluate the optimal delivery methods for glutathione.
Glutathione is a primary antioxidant in the body, crucial for neutralizing free radicals and combating oxidative stress. Supplementation is hypothesized to support the body's natural antioxidant defenses. The extent of this effect can depend on the supplement form and individual physiological factors.
Some research suggests that high doses of oral glutathione might have skin-lightening effects by inhibiting melanin production, but the evidence is not conclusive and often involves specific populations. These studies often require high dosages and more robust, larger-scale research is needed to confirm efficacy for this purpose. It is not approved for this use by major health authorities.
schedule Dosage, timing & forms
Liposomal glutathione encapsulates glutathione in tiny lipid bubbles (liposomes), which are designed to protect it from degradation in the digestive tract. This delivery method aims to enhance its absorption and bioavailability compared to standard oral reduced glutathione. The liposomal structure helps transport the glutathione more efficiently into the bloodstream.
N-acetylcysteine (NAC) is a precursor that the body uses to synthesize its own glutathione. While not glutathione itself, supplementing with NAC is a common strategy to support the body's endogenous glutathione production. It provides cysteine, a crucial amino acid needed for glutathione synthesis.
Oral glutathione dosages can vary widely depending on the specific form and individual needs, often ranging from 250 mg to 1000 mg per day. It's best to follow the manufacturer's recommendations on the product label. Consulting with a healthcare professional can provide personalized guidance.
Typical oral glutathione dosages can range from 250 mg to 1000 mg per day. The specific amount may vary depending on the product formulation and individual needs. It is advisable to follow the manufacturer's recommendations.
Reduced glutathione (GSH) is the active form naturally found in the body, but it can be prone to degradation during digestion when taken orally. S-acetyl glutathione is a modified form designed for improved stability and bioavailability. The acetyl group is intended to protect it until absorption, allowing it to be cleaved off inside cells to release active glutathione.
health_and_safety Safety & interactions
Oral glutathione is generally considered safe for most adults when taken in appropriate doses. Some individuals have reported mild side effects such as abdominal cramps, bloating, or allergic reactions like rash. Inhaled glutathione might cause asthma exacerbation in sensitive individuals.
Oral glutathione supplements are generally well-tolerated by most individuals. Some people might experience mild gastrointestinal discomfort, such as abdominal cramps or bloating. Rarely, allergic reactions like rash have been reported, and inhaled forms might trigger asthma in susceptible individuals.
There is limited information on significant drug interactions with glutathione supplements. However, it is always advisable to consult a healthcare professional, especially when taking prescription medications. They can assess potential interactions based on your specific health profile.
The maximum safe dosage for glutathione can vary depending on the form, individual health, and specific application. While studies have used oral doses up to 1000 mg/day, it is crucial to follow product label instructions and consult a healthcare provider for personalized guidance. Excessive doses may not provide additional benefits and could lead to unknown effects.
Insufficient research is available regarding the safety of glutathione supplementation during pregnancy and breastfeeding. For this reason, it is generally recommended to avoid use or consult a healthcare provider before considering supplementation. A healthcare professional can weigh the potential benefits against any unknown risks.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Glutathione | 175 mg |
Categories
Glutathione 75.0
This product is a core Glutathione supplement. Its score reflects its overall efficacy within this category, considering form, dosage, and synergistic ingredients.
Goals
Detoxification 78.0
The enhanced and prolonged absorption via SR technology makes this product more effective for supporting the body's detoxification pathways, despite the moderate dose.
Anti-Aging 75.0
The sustained-release mechanism should improve glutathione's ability to combat oxidative stress for anti-aging, though the 175mg dose is moderate for this broad goal.
The improved delivery of glutathione through sustained release enhances its potential to modulate immune responses and reduce inflammation effectively.
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