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DefensePlus

NutriBiotic
4.9
★ ★ ★ ★ ★
(4291 ratings)
Ginger
Maitake Mushroom 50 mg
Astragalus 100 mg
Reishi mushroom 100 mg
Shiitake Mushroom 50 mg
Product Image
Score73
A broad, affordable immune-oriented tablet has a solid vitamin-and-botanical base, though most herbs and mushrooms are modest and unstandardized.
How scoring works
Quantity:45 Tablet(s) • (45 servings)
Goals:

Score 73

A broad, affordable immune-oriented tablet has a solid vitamin-and-botanical base, though most herbs and mushrooms are modest and unstandardized.
How scoring works

Also available as

1 option
90 servings 1 Tablet(s) • 90 Tablet(s) • 90 servings $22.25 ($0.24 per serving)
$13.12($0.29 per serving)
iHerb
$ 13.12
Pure Formulas
$ 13.12
Amazon
$ 13.49
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Analysis

Vitamin C and zinc form a simple nutritional base, while grapefruit seed extract leads the botanical side at 250 mg. Astragalus and reishi add moderate amounts within a wider immune-oriented mixture.

Echinacea, ginger, maitake, shiitake, Oregon grape, and yarrow are each supplied at 50 mg. That breadth may suit general use, but none is characterized well enough for focused botanical dosing.

One tablet per serving and a compact bottle make short seasonal use easy. People taking medicines should pay particular attention to grapefruit seed extract because interaction potential depends on composition.

Who is it for
  • Adults seeking short seasonal support
  • People wanting a one-tablet multi-ingredient formula
Best for
  • Broad immune nutrition
  • Short-term botanical routines

Pros

  • Vitamin C and zinc are clearly dosed
  • Substantial grapefruit seed extract
  • All botanical amounts are listed
  • One-tablet serving

Cons

  • Mushroom doses are small
  • Most extracts lack active markers
  • Ginger amount is low
  • Shorter container supply

Warnings

  • Grapefruit seed extract may interact with medicines metabolized through grapefruit-sensitive pathways.
  • Echinacea may trigger reactions in people allergic to ragweed-family plants.
  • Reishi and other mushrooms need care with immunosuppressant medicines because they may affect immune activity.

Nutrient quality

69 High impact

A coherent immune theme and safe core nutrients provide basic quality. Missing standardization and many lightly dosed botanicals make the formula shallow and padding-prone.

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Ingredient transparency

77 High impact

Every active amount is explicit without a proprietary blend. Missing potency markers, timing, and excipient details limit the usefulness of that disclosure.

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Customer satisfaction

73 High impact

The aggregate rating is very favorable, but it provides no specific experience evidence. The very large review count gives the broad signal a useful volume base, while no detailed feedback supports taste, tolerance, or recurring-problem assessment.

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Value for money

70 High impact

A low relative serving cost and broad immune coverage provide fair value. Shallow dosing keeps the formula from matching more concentrated competitors.

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Ingredients

IngredientAmount per serving
Vitamin C (Meta-C)
 125 mg
Zinc (Zinc Gluconate)
 5 mg
Grapefruit seed extract
250 mg
Astragalus
100 mg
Reishi Mushroom Extract
100 mg
Echinacea angustifolia extract
50 mg
Ginger root extract
50 mg
Maitake Mushroom Extract
50 mg
Oregon grape
50 mg
Shiitake Extract
50 mg
Yarrow extract
50 mg
Gluten Free Adults 18–50 Dairy Free Children 4+
Report overview
Ginger · 50 mg OverallScore45
D- Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyD+ Value

The label identifies ginger root extract but gives no extract ratio or gingerol standardization. Naming the root improves botanical specificity, while the extraction method remains unknown. The dose is low, though the inexpensive serving partly limits the value concern.

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Maitake Mushroom · 50 mg OverallScore41
F Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyB- Value

The low-cost serving includes a clearly stated amount of Maitake extract. Potency remains limited because the amount is low and the mushroom part, extraction method, and active markers are not disclosed. It fits better as a broad multi-ingredient immune formula than as a concentrated Maitake supplement.

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Astragalus · 100 mg OverallScore36
F Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value

The disclosed amount is clear, but the label does not identify a root extract, species, or active marker. No organic or other purity claim is provided, and additive quality cannot be checked from the available label data. Cost per standardized extract equivalent is high for such limited form detail.

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79 Performance

Shiitake Maitake 250 mg

Nature's Way
Clearly dosed maitake and shiitake extracts provide a concise alternative to the original’s lightly dosed multi-botanical blend. Polysaccharides are named, but mushroom parts, extraction method, and beta-glucan yield remain missing.
79 Performance

M/R/S Mushroom Formula

Pure Encapsulations
Equal amounts of maitake, reishi, and shiitake fruiting-body extracts provide stronger mushroom-part disclosure and focused coverage. Extraction method and beta-glucan yield are still unknown, and the formula omits vitamin C, zinc, ginger, and astragalus.
79 Performance

Reishi Shiitake Maitake Mushroom Extract

Solgar
Organic reishi, shiitake, and maitake extracts provide a focused mushroom blend, with extra reishi marker details improving confidence. Maitake and shiitake remain modest, while mushroom parts and extraction methods are unclear.
79 Budget

Rei-Shi Mushrooms 270 mg

NOW
Reishi powder and extract with shiitake provide focused mushroom coverage at lower serving cost than the broad immune blend. Missing fruiting-body, extraction-ratio, and standardization details limit confidence in potency.
72 Budget

Immune Action

NaturesPlus
Astragalus, shiitake, echinacea, schisandra, and ligustrum preserve a broad botanical immune strategy at lower serving cost. Most amounts are modest and the label lacks plant parts, extract details, and active-marker standardization.
73 Budget

Mushroom Immune Complex with Maitake Reishi & Shiitake

Solaray
Maitake, reishi, and shiitake provide a coherent mushroom formula with favorable serving economics and disclosed species. Repeated entries make totals less clear, while mushroom parts, extraction, and beta-glucans are missing.
76 Value

Immune Essentials Comprehensive Formula

Swanson
Larch arabinogalactan, bovine colostrum, oat beta-glucan, elderberry, maitake, and shiitake provide broad immune coverage with good serving value. The mushrooms are lightly dosed and bovine colostrum makes the formula unsuitable for people with a milk allergy.
72 Value

Beyond Wellness

KAL
Buffered vitamin C, zinc picolinate, echinacea, standardized andrographis, elderberry, astragalus, and mushrooms create broad immune support with clearer marker disclosure. Many mushroom and herbal additions are modest, but the core actives provide reasonable effective value.
75 Value

Brain & Body

Host Defense MycoBotanicals
Substantial lion’s mane plus turmeric, reishi, ginger, cinnamon, and black pepper provide broader mushroom and botanical depth than the original’s many small additions. Active-marker and processing details are limited, but the disclosed amounts support fair value for broad use.
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