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GI Natural Total Digestive Wellness

NaturesPlus
4.7
★ ★ ★ ★ ★
(443 ratings)
Glutamine 4000 mg
Vitamin E 100 IU
Ginger
Turmeric 50 mg
Product Image
Score53
A glutamine-led digestive powder with useful micronutrients, but opaque probiotic and enzyme details make much of the formula hard to evaluate.
How scoring works
Quantity:0 lb(s) • ( servings)
Goals:
Anti-Inflammatory Support
Immunity

Score 53

A glutamine-led digestive powder with useful micronutrients, but opaque probiotic and enzyme details make much of the formula hard to evaluate.
How scoring works
$29.54($0.00 per serving)
Pure Formulas
$ 29.54
iHerb
$ 29.54
Vitacost
$ 32.53
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Analysis

L-glutamine is the clear lead ingredient and is supplied at a substantial amount for a digestive-support powder. Natural-form vitamin E, selenium, zinc, calcium, and vitamin C add a useful micronutrient layer.

The probiotic blend gives no organism counts, and the enzyme blends provide no activity units. Turmeric, ginger, serrapeptase, and the prebiotic blend are modest or poorly characterized, so much of the long label cannot be judged for potency.

Missing serving count and per-serving cost prevent a reliable value assessment. The product is best understood as glutamine with many supporting additions rather than a fully transparent probiotic, enzyme, turmeric, or ginger formula.

Who is it for
  • Adults seeking a glutamine-based digestive powder
  • Users comfortable with a broad supporting blend
  • People not taking blood-thinning medicines
Best for
  • Substantial daily glutamine
  • Broad digestive-support routines
  • Users prioritizing ingredient breadth over transparency

Pros

  • Provides a substantial L-glutamine amount
  • Uses natural-form vitamin E
  • Includes several complementary micronutrients

Cons

  • Probiotic potency is not stated
  • Enzyme activity units are missing
  • Serving count and value cannot be verified

Warnings

  • Serrapeptase and turmeric may increase bleeding tendency with anticoagulant or antiplatelet medicines.

Nutrient quality

71 High impact

No disclosed nutrient amount is obviously excessive. Several tiny blends and botanicals make the formula heavily padded.

Ingredient transparency

34 Situational impact

Some standalone actives are quantified, but blend components and probiotic viability are not. No reliable serving count or clear daily-use structure is supplied.

Customer satisfaction

68 High impact

The aggregate satisfaction metric is strong. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

42 Lower impact

The strong glutamine core is undermined by opaque and lightly dosed extras. Several small proprietary blends appear to inflate the formula.

Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitC Strength of SupportB CoverageB- Formula Quality
Vitamin E · 100 IUVitamin C · 200 mg

High-dose glutamine, natural-form vitamin E, vitamin C, selenium, turmeric, ginger, enzymes, prebiotics, and probiotics link gut-barrier support with antioxidant protection. The formula covers several drivers of inflammatory stress but is not built around a potent direct pathway inhibitor.

Glutamine and vitamin E provide the most credible dosing depth, while turmeric and ginger appear too small to lead the response. Proprietary probiotic and enzyme blends, plus missing serrapeptase activity units, leave important potency details unresolved.

Study evidence
Ginger Supportive 30 studies
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin E Supportive 20 studies
Immunity
Immunity
Impact
High effect
C+ Goal FitC Strength of SupportB CoverageC Formula Quality
Vitamin C · 200 mgZinc · 5 mgSelenium · 35 mcg

Glutamine and several gut-support ingredients may support an intestinal barrier that interacts with immune function. Zinc, selenium, and vitamin C add direct but modest immune nutrition.

Probiotic strains and viable counts are missing, while most botanicals and enzymes have small amounts. The design is coherent but too crowded to provide equal depth across its many pathways.

Study evidence
Glutamine Supportive 36 studies
Selenium Mixed 37 studies
Vitamin C Supportive 53 studies
Zinc Supportive 73 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 200 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 100 IU
Calcium (Calcium Carbonate, Calcium Phosphate)
 100 mg
Zinc (Zinc Gluconate)
 5 mg
Selenium (Selenomethionine)
 35 mcg
L-Glutamine
4000 mg
Short-Chain Fatty-Acid–Promoting Prebiotic Blend
400 mg
Serrapeptase
50 mg
organic Turmeric
50 mg
Ginger
25 mg
Proprietary Probiotic Blend
25 mg
Enzyme-Rich Whole Food Blend
25 mg
Live Enzyme Blend
25 mg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
Glutamine · 4000 mg OverallScore77
C Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyB Value

The powder supplies a substantial L-glutamine amount in one scoop, making a focused daily routine practical. Standard L-glutamine is clearly named, although no premium grade or micronized processing claim is provided. The broader digestive formula adds several supportive ingredients, but the missing serving count prevents a direct cost-per-gram comparison.

View ingredientView products
Vitamin E (D-Alpha-Tocopheryl Succinate) · 100 IU OverallScore68
D Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Natural d-alpha vitamin E is supplied at a therapeutic-range amount. The label clearly identifies the succinate form, though it does not add mixed tocopherols or tocotrienols. Value cannot be judged reliably because a serving cost is not provided.

View ingredientView products
Ginger · 25 mg OverallScore24
F Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value

Generic ginger is included at a very low amount without form or active-marker detail. It is unlikely to provide meaningful standalone ginger support within the broader digestive powder. Missing per-serving cost prevents a reliable value comparison.

View ingredientView products
Loading alternative details
71 Performance

Turmeric Curcumin & Ginger Root

NATURELO Premium Supplements
<p>Turmeric powder, a measured curcuminoid extract, ginger, and BioPerine provide a more assessable anti-inflammatory core than the original tiny or opaque botanical entries. Ginger remains modest, and BioPerine may alter exposure to medicines with narrow therapeutic ranges.</p>
73 Performance

Turmeric

ZHOU
<p>A large turmeric base, separate extract, ginger, and BioPerine create a more substantial botanical formula. Curcuminoid and gingerol yields remain unclear, while BioPerine can alter medicine exposure and the product omits the original digestive components.</p>
74 Performance

Ginger Supreme

Gaia Herbs
<p>A supercritical ginger extract provides a stronger and more clearly targeted ginger component than the original blend. The small turmeric extract lacks curcuminoid standardization, and no glutamine, probiotics, enzymes, or prebiotics are included.</p>
79 Budget

Turmeric Curcumin 500 mg

Spring Valley
<p>A very low-cost turmeric formula includes a small curcuminoid extract and a light ginger addition. Missing standardization and absorption support limit potency, while it does not replace the original glutamine, probiotics, enzymes, or prebiotics.</p>
75 Budget

Turmeric & Ginger

Herbal Secrets
<p>Moderate ginger and turmeric powders provide a simple, inexpensive two-botanical option. Active markers and extraction details are missing, and the formula does not cover the original gut-barrier or digestive components.</p>
76 Budget

Ginger & Turmeric Full Spectrum

Swanson
<p>Moderate ginger and turmeric powders offer low-cost coverage of two original collections. Unknown active-marker yields and no absorption support limit reliability, while glutamine and the digestive blends are omitted.</p>
74 Value

Turmeric & Ginger

Nature's Answer
<p>Standardized turmeric in a lipid base improves delivery quality while maintaining favorable serving value. Both turmeric and ginger are lightly dosed, and the focused pair does not replace the original digestive-wellness ingredients.</p>
65 Value

Premium Curcumin Turmeric

Further Food
<p>A substantial curcuminoid amount provides a clearer active core at a moderate serving cost. The absorption blend is vague, ginger is only a token addition, and the original glutamine and digestive blends are absent.</p>
71 Value

Turmeric Ginger Gummies Mango Flavored

Nature's Way
<p>A branded curcumin extract supplies a meaningful active amount with reasonable serving value. Ginger is only a trace addition, no absorption enhancer is disclosed, and the gummy format does not address the original gut-barrier support.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis.
    Mazidi M; Gao HK; Rezaie P; Ferns GA · Food & nutrition research · 2022
    Meta-analysis9 studies pooledAnti-Inflammatory Support forGinger
  2. Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.
    Musazadeh V; Morvaridi M; Hosseini-Roknabadi SM; Mahmoudinezhad M; Jafari A; Shidfar F · Diabetology & metabolic syndrome · 2026
    Meta-analysis43,570 participants36 studies pooledAnti-Inflammatory Support forGinger
  3. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
    Mozaffari-Khosravi H; Naderi Z; Dehghan A; Nadjarzadeh A; Fallah Huseini H · Journal of nutrition in gerontology and geriatrics · 2017
    Randomized trial120 participantsAnti-Inflammatory Support forGinger
  4. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.
    Broeckel J; Estes L; Leonard M; Dickerson BL; Gonzalez DE; Purpura M; Jäger R; Sowinski RJ; Rasmussen CJ; Kreider RB · Nutrients · 2025
    Randomized trial30 participantsAnti-Inflammatory Support forGinger
  5. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
    Aryaeian N; Shahram F; Mahmoudi M; Tavakoli H; Yousefi B; Arablou T; Jafari Karegar S · Gene · 2019
    Randomized trial70 participantsAnti-Inflammatory Support forGinger
  6. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  7. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  8. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  9. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  10. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  11. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  12. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  13. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  14. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  15. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  16. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  17. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  18. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  19. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  20. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  21. Meta-analysis of Glutamine on Immune Function and Post-Operative Complications of Patients With Colorectal Cancer.
    Yang T; Yan X; Cao Y; Bao T; Li G; Gu S; Xiong K; Xiao T · Frontiers in nutrition · 2021
    Meta-analysis2,201 participants31 studies pooledImmunity forGlutamine
  22. Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
    Dong S; Zhao Z; Li X; Chen Z; Jiang W; Zhou W · Frontiers in nutrition · 2023
    Meta-analysis1,201 participants30 studies pooledImmunity forGlutamine
  23. Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: a prospective, controlled, randomized clinical trial.
    Garrel D; Patenaude J; Nedelec B; Samson L; Dorais J; Champoux J; D'Elia M; Bernier J · Critical care medicine · 2003
    Randomized trial45 participantsImmunity forGlutamine
  24. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis.
    Huang Y; Yang XZ; Qin SH; Zhang T; Xie M; Wang JW · World journal of gastrointestinal surgery · 2026
    Meta-analysis1,643 participants27 studies pooledImmunity forGlutamine
  25. Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control.
    Wischmeyer PE; Lynch J; Liedel J; Wolfson R; Riehm J; Gottlieb L; Kahana M · Critical care medicine · 2001
    Randomized trial26 participantsImmunity forGlutamine
  26. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  27. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  28. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  29. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  30. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  31. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  32. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  33. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  34. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  35. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  36. Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta-analysis.
    Vlieg-Boerstra B; de Jong N; Meyer R; Agostoni C; De Cosmi V; Grimshaw K; Milani GP; Muraro A; Oude Elberink H; Pali-Schöll I; Roduit C; Sasaki M; Skypala I; Sokolowska M; van Splunter M; Untersmayr E; Venter C; O'Mahony L; Nwaru BI · Allergy · 2022
    Meta-analysis199,055 participants115 studies pooledImmunity forZinc
  37. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial.
    Sazawal S; Black RE; Jalla S; Mazumdar S; Sinha A; Bhan MK · Pediatrics · 1998
    Randomized trial609 participantsImmunity forZinc
  38. A randomized controlled trial of zinc supplementation in the treatment of acute respiratory tract infection in Thai children.
    Rerksuppaphol S; Rerksuppaphol L · Pediatric reports · 2020
    Randomized trial64 participantsImmunity forZinc
  39. The effect of zinc and vitamin A supplementation on immune response in an older population.
    Fortes C; Forastiere F; Agabiti N; Fano V; Pacifici R; Virgili F; Piras G; Guidi L; Bartoloni C; Tricerri A; Zuccaro P; Ebrahim S; Perucci CA · Journal of the American Geriatrics Society · 1998
    Randomized trial136 participantsImmunity forZinc
  40. The role of specific nutrients in preventing immune system and blood cell disorders: an umbrella review.
    Vecchietti A; Strano P; Minutolo G; Grieco V; Cappuccio G; Granvillano G; Confalonieri L; Briganti GL; Raso E; Chimienti M; Pellegrini M; Mercogliano M; Spatari G; Lugli C; Urbano T; Lorenzon A · Journal of preventive medicine and hygiene · 2026
    Systematic review13 studies pooledImmunity forZinc