Product Image

Extreme Joint Care

NutraBio
4.3
★ ★ ★ ★ ★
(834 ratings)
Manganese 10 mg
Boron 3 mg
Curcumin 200 mg
Vitamin D 2000 IU
Horsetail 100 mg
Potassium 240 mg
Collagen 200 mg
Product Image
Score83
A broad, coherent joint formula led by full-dose glucosamine and well-chosen curcumin and boswellia forms. Secondary structural ingredients are more modest, and medicine interactions plus high manganese deserve review.
How scoring works
Quantity:120 Capsule(s) • (30 servings)
Goals:
Joint Health
Anti-Inflammatory Support
Anti-Aging
General Health
Fitness
Bone Health
Testosterone Support
Immunity

Score 83

A broad, coherent joint formula led by full-dose glucosamine and well-chosen curcumin and boswellia forms. Secondary structural ingredients are more modest, and medicine interactions plus high manganese deserve review.
How scoring works
$29.99($0.99 per serving)
Amazon
$ 34.99
iHerb
$ 34.99
Nutrition Faktory
$ 29.99
Report prices

Analysis

The joint formula covers cartilage, connective tissue, lubrication, and inflammatory-balance pathways. Glucosamine sulfate is supplied at 1,500 mg, while chondroitin, MSM, type II collagen, hyaluronic acid, Meriva curcumin, and ApresFlex boswellia provide complementary support.

Branded curcumin and boswellia forms improve delivery and standardization, and BioPerine may further increase absorption. Chondroitin and MSM are each 500 mg, however, and the collagen amount is too small to act as a general collagen-protein serving.

Vitamin D3, boron, manganese, vitamin C, and potassium broaden the structural profile without distracting much from the joint focus. It fits active adults seeking an all-in-one capsule formula, provided they review the manganese load and the interaction potential of curcumin, boswellia, and piperine.

Who is it for
  • Active adults seeking broad joint and mobility support
  • People who want glucosamine with curcumin and boswellia
  • Users comfortable taking four capsules per day
Best for
  • Comprehensive joint support
  • Mobility and exercise-related joint comfort
  • Combined cartilage and inflammatory-balance support

Pros

  • Provides 1,500 mg of glucosamine sulfate
  • Uses Meriva curcumin phytosome and ApresFlex boswellia
  • Includes hyaluronic acid, chondroitin, MSM, and type II collagen
  • Adds vitamin D3, boron, and chelated manganese

Cons

  • Chondroitin and MSM are modest compared with focused products
  • The collagen amount is too small for general collagen-protein support
  • Potassium form is not identified
  • The four-capsule serving may be inconvenient

Warnings

  • Curcumin and boswellia may increase bleeding tendency with anticoagulant or antiplatelet medicines.
  • Piperine can alter medicine exposure, which matters for drugs with a narrow safety range or strong metabolism-based interactions.
  • The 10 mg manganese amount sits near the adult upper intake level, so avoid stacking it with other high-manganese supplements.
  • The glucosamine source is not disclosed, so people with shellfish allergy cannot verify source suitability from the label.

Nutrient quality

84 Highest impact

Branded manganese bisglycinate, curcumin phytosome, boswellia, collagen type II, and boron chelate are strong form choices. Glucosamine, vitamin D3, hyaluronic acid, and boswellia are meaningful, while chondroitin, MSM, and collagen are more modest.

Ingredient transparency

87 Highest impact

Every active has a specific listed amount. No proprietary blend hides the dose of a key ingredient.

Customer satisfaction

72 High impact

The supplied average rating is strong. A large review count adds reliability, but no detailed experience or complaint themes were provided.

Value for money

84 Highest impact

High-quality branded actives and broad joint-pathway coverage largely justify the moderate serving cost. The product compares favorably with similar formulas on quality and cost.

Report analysis

Goals

Joint Health
Joint Health
Impact
Highest effect
A Goal FitA- Strength of SupportA CoverageA Formula Quality
Collagen · 200 mgHyaluronic Acid · 100 mgCurcumin · 200 mg

Glucosamine, chondroitin, MSM, type II collagen, hyaluronic acid, curcumin phytosome, and standardized boswellia create a comprehensive joint formula. Glucosamine is fully dosed, hyaluronic acid and boswellia are meaningful, and the remaining structural ingredients provide moderate support.

Some secondary structural ingredients are below standalone target doses, but no major joint pathway is omitted. Nearly every ingredient has a clear joint or connective-tissue role with little unnecessary duplication.

Study evidence
Collagen Supportive 49 studies
Curcumin Supportive 62 studies
Vitamin C Disputed 24 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
A Goal FitA- Strength of SupportA- CoverageA- Formula Quality
Vitamin D · 2000 IUCollagen · 200 mgVitamin C · 120 mgCurcumin · 200 mg

Curcumin phytosome, AKBA-standardized Boswellia, piperine, vitamin D, MSM, glucosamine, and chondroitin directly address inflammatory signaling and joint discomfort pathways. The main actives are present at material amounts and use strong delivery or standardization features.

The formula combines direct botanical modulation with cartilage and connective-tissue support in a clear joint-focused design. Curcumin, Boswellia, and piperine can affect bleeding or medicine levels, so people using anticoagulants, antiplatelet medicines, or narrow-therapeutic-index drugs should check compatibility.

Study evidence
Curcumin Supportive 68 studies
Vitamin D Supportive 101 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B Goal FitB+ Strength of SupportB+ CoverageA+ Formula Quality
Vitamin D · 2000 IUCurcumin · 200 mgCollagen · 200 mg

Glucosamine, chondroitin, MSM, Meriva curcumin, ApresFlex boswellia, hyaluronic acid, vitamin D3, and boron provide broad structural and inflammatory support for mobility with age. Several branded ingredients and clinically relevant amounts strengthen the formula.

Collagen remains too low for meaningful protein support, but the joint pathways otherwise have good depth. The focused design is well aligned with preserving function rather than targeting every biological driver of aging.

Study evidence
Boron Not classified

No linked studies yet.

Collagen Supportive 33 studies
Curcumin Supportive 6 studies
Vitamin D Supportive 50 studies
General Health
General Health
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB CoverageA Formula Quality
Vitamin D · 2000 IUBoron · 3 mgCollagen · 200 mgCurcumin · 200 mgVitamin C · 120 mg

Glucosamine sulfate, branded curcumin and boswellia, collagen type II, vitamin D3, and hyaluronic acid create a coherent joint-support formula. The combination is narrower than a multivitamin but remains relevant to mobility and structural resilience.

Glucosamine reaches a well-established supplemental amount, while chondroitin and MSM are more modest. Branded delivery systems and clearly stated amounts strengthen confidence in the main actives.

Study evidence
Collagen Supportive 31 studies
Curcumin Supportive 64 studies
Vitamin D Supportive 115 studies
Fitness
Fitness
Impact
Highest effect
B+ Goal FitB+ Strength of SupportB CoverageA Formula Quality
Vitamin D · 2000 IU

Glucosamine sulfate, chondroitin, MSM, Meriva curcumin, type II collagen, Boswellia, and hyaluronic acid provide broad joint and recovery support for active users. Several branded forms and absorption aids strengthen the formulation.

Collagen is too low to function as a general collagen-protein dose, and potassium is only modest. People using anticoagulant or antiplatelet medicines should review curcumin and BioPerine because they may increase bleeding or alter medicine exposure.

Study evidence
Collagen Supportive 20 studies
Curcumin Supportive 15 studies
Potassium No effect 7 studies
Bone Health
Bone Health
Impact
High effect
B- Goal FitB Strength of SupportC CoverageC+ Formula Quality
Vitamin D · 2000 IUManganese · 10 mgBoron · 3 mgVitamin C · 120 mgCollagen · 200 mg

Vitamin D3, well-absorbed manganese, and a useful boron amount provide credible support for bone metabolism. Type II collagen adds a matrix-related ingredient, but its amount is far below common nutritional collagen servings.

The formula lacks meaningful calcium and magnesium, so it cannot serve as comprehensive structural bone support. Its main design remains joint comfort, with bone benefits coming from a few supporting nutrients.

Study evidence
Boron Supportive 5 studies
Collagen Supportive 16 studies
Manganese Adverse 12 studies
Vitamin D Supportive 202 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 120 mg
Vitamin D3 (Cholecalciferol)
 2000 IU
Manganese (TRAACS Manganese Bisglycinate Chelate)
 10 mg
Potassium
240 mg
Sodium
30 mg
Glucosamine Sulfate 2KCI
1500 mg
Chondroitin Sulfate
500 mg
OptiMSM
500 mg
Gelatin
442 mg
Meriva Curcumin Phytosome (Curcuma longa extract, Phosphatidylcholine (Sunflower) Complex)
 200 mg
KollaGen II-XS (Collagen Type II)
 200 mg
ApresFlex (AKBA)
 100 mg
Hyaluronic Acid
100 mg
Horsetail herb S.E. (Silica)
 100 mg
Bioperine (Piperine)
 5 mg
Boron (Bororganic Glycine)
 3 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Manganese (TRAACS Manganese Bisglycinate Chelate) · 10 mg OverallScore84
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

TRAACS Manganese Bisglycinate Chelate is an amino acid chelate with strong absorption potential. The serving amount aligns with the collection target while remaining within the stated upper limit. Cost per serving is high for a manganese-containing formula.

View ingredientView products
Boron (Bororganic Glycine) · 3 mg OverallScore76
A- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Bororganic glycine provides a fully reacted chelate with premium absorption potential. The 3 mg dose sits in the preferred long-term range for bone health and mineral balance. The label clearly states the elemental boron amount. Boron-specific value is poor even if the broader formula supplies other useful nutrients.

View ingredientView products
Curcumin (Curcuma longa extract, Phosphatidylcholine (Sunflower) Complex) · 200 mg OverallScore70
A Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyD+ Value

Meriva supplies a clinically validated phospholipid delivery system, with BioPerine adding further absorption support. The total complex amount is clear, but the active curcuminoid yield and independent testing evidence are not stated. The cost is high for the collection, though the patented form and broader joint-support formula add meaningful value.

View ingredientView products
Loading alternative details
80 Performance

Silica Complex

NOW
<p>Substantial horsetail plus supporting calcium, zinc, manganese, and boron offers focused connective-tissue nutrient support. The product lacks the original's major joint actives, and missing horsetail standardization prevents judging its primary silica contribution.</p>
80 Budget

Silica Complex

NOW
<p>The far lower serving cost provides horsetail with calcium, zinc, manganese, and boron in a focused silica-oriented formula. Missing silica yield and botanical details prevent a reliable assessment, and it does not replace the original glucosamine, chondroitin, MSM, or curcumin.</p>
80 Value

Silica Complex

NOW
<p>A low serving cost and clearly listed supporting minerals create economical silica-oriented support. It is much narrower than the original joint formula, and the undisclosed horsetail species, plant part, and silica yield reduce confidence.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. [Comparative study of the urinary excretion of boron, calcium, magnesium and phosphorus in postmenopausal women with and without osteoporosis].
    José Ramón V; Mora Mora M; Marino Alarcón O; Hernández G; Josefina Linares L; Urdaneta Romero H; Arévalo González E · Investigacion clinica · 2013
    Case-control study45 participantsBone Health forBoron
  2. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes.
    Meacham SL; Taper LJ; Volpe SL · Environmental health perspectives · 1995
    Randomized trial28 participantsBone Health forBoron
  3. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis.
    Wang X; Cicuttini F; Jin X; Wluka AE; Han W; Zhu Z; Blizzard L; Antony B; Winzenberg T; Jones G; Ding C · Osteoarthritis and cartilage · 2018
    Randomized trial413 participantsJoint Health forVitamin D
  4. Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial.
    Zheng S; Wang B; Han W; Zhu Z; Wang X; Jin X; Antony B; Cicuttini F; Wluka A; Winzenberg T; Aitken D; Blizzard L; Jones G; Ding C · The British journal of nutrition · 2019
    Randomized trial200 participantsJoint Health forVitamin D
  5. Identification for heavy metals exposure on osteoarthritis among aging people and Machine learning for prediction: A study based on NHANES 2011-2020.
    Xia F; Li Q; Luo X; Wu J · Frontiers in public health · 2022
    Cross-sectional studyJoint Health forManganese
  6. Essentiality of boron for healthy bones and joints.
    Newnham RE · Environmental health perspectives · 1995
    Randomized trial20 participantsJoint Health forBoron
  7. Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study.
    Henrotin Y; Malaise M; Wittoek R; de Vlam K; Brasseur JP; Luyten FP; Jiangang Q; Van den Berghe M; Uhoda R; Bentin J; De Vroey T; Erpicum L; Donneau AF; Dierckxsens Y · Arthritis research & therapy · 2020
    Randomized trial150 participantsJoint Health forCurcumin
  8. The Oral Administration of Highly-Bioavailable Curcumin for One Year Has Clinical and Chondro-Protective Effects: A Randomized, Double-Blinded, Placebo-Controlled Prospective Study.
    Nakagawa Y; Mori K; Yamada S; Mukai S; Hirose A; Nakamura R · Arthroscopy, sports medicine, and rehabilitation · 2022
    Randomized trial50 participantsJoint Health forCurcumin
  9. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
    Devasia S; Joseph JT; P S S; Koizumi S; Clarke L; V T S; Kailas AP; Madhavan S · Cartilage · 2024
    Randomized trial100 participantsJoint Health forCollagen
  10. Function of the normal meniscus and consequences of meniscal resection.
    Aagaard H; Verdonk R · Scandinavian journal of medicine & science in sports · 1999
    Narrative reviewJoint Health forCollagen
  11. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsAnti-Aging forCollagen
  12. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledAnti-Aging forCollagen
  13. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
    Proksch E; Segger D; Degwert J; Schunck M; Zague V; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial69 participantsAnti-Aging forCollagen
  14. Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Lee E; Ahn DK; Kim JH; Lee S; Kim HJ; Lee HK; Shin JH · Journal of microbiology and biotechnology · 2025
    Randomized trial70 participantsAnti-Aging forCollagen
  15. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
    Proksch E; Schunck M; Zague V; Segger D; Degwert J; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial114 participantsAnti-Aging forCollagen
  16. Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study.
    Cox KHM; White DJ; Pipingas A; Poorun K; Scholey A · Nutrients · 2021
    Randomized trial80 participantsAnti-Aging forCurcumin
  17. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
    Akazawa N; Choi Y; Miyaki A; Tanabe Y; Sugawara J; Ajisaka R; Maeda S · Nutrition research (New York, N.Y.) · 2013
    Clinical trial32 participantsAnti-Aging forCurcumin
  18. A novel phospholipid delivery system of curcumin (Meriva®) preserves muscular mass in healthy aging subjects.
    Franceschi F; Feregalli B; Togni S; Cornelli U; Giacomelli L; Eggenhoffner R; Belcaro G · European review for medical and pharmacological sciences · 2016
    Non-randomized trial86 participantsAnti-Aging forCurcumin
  19. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.
    Nunes YC; Mendes NM; Pereira de Lima E; Chehadi AC; Lamas CB; Haber JFS; Dos Santos Bueno M; Araújo AC; Catharin VCS; Detregiachi CRP; Laurindo LF; Tanaka M; Barbalho SM; Marin MJS · Nutrients · 2024
    Systematic review15 studies pooledAnti-Aging forCurcumin
  20. Curcumin and arterial function in health and disease: impact on oxidative stress and inflammation.
    Fleenor BS; Carlini NA; Campbell MS · Current opinion in clinical nutrition and metabolic care · 2020
    Narrative reviewAnti-Aging forCurcumin
  21. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  22. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  23. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  24. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  25. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  26. Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis.
    Zhang F; Niu B · Medicine · 2025
    Meta-analysis7 studies pooledAnti-Inflammatory Support forCurcumin
  27. Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials.
    Gorabi AM; Abbasifard M; Imani D; Aslani S; Razi B; Alizadeh S; Bagheri-Hosseinabadi Z; Sathyapalan T; Sahebkar A · Phytotherapy research : PTR · 2022
    Meta-analysis32 studies pooledAnti-Inflammatory Support forCurcumin
  28. Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials.
    Derosa G; Maffioli P; Simental-Mendía LE; Bo S; Sahebkar A · Pharmacological research · 2018
    Meta-analysis9 studies pooledAnti-Inflammatory Support forCurcumin
  29. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial.
    Jazayeri-Tehrani SA; Rezayat SM; Mansouri S; Qorbani M; Alavian SM; Daneshi-Maskooni M; Hosseinzadeh-Attar MJ · Nutrition & metabolism · 2024
    Randomized trial84 participantsAnti-Inflammatory Support forCurcumin
  30. Is Curcumin Intake Really Effective for Chronic Inflammatory Metabolic Disease? A Review of Meta-Analyses of Randomized Controlled Trials.
    Lee YM; Kim Y · Nutrients · 2024
    Systematic review54 studies pooledAnti-Inflammatory Support forCurcumin
  31. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  32. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  33. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  34. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  35. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  36. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
    Nielsen FH; Hunt CD; Mullen LM; Hunt JR · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1987
    Single-arm trial12 participantsBone Health forBoron
  37. The relationship between boron and magnesium status and bone mineral density in the human: a review.
    Volpe SL; Taper LJ; Meacham S · Magnesium research · 1994
    Narrative reviewBone Health forBoron
  38. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations
    C D Hunt, J L Herbel, F H Nielsen · The American Journal of Clinical Nutrition · 1997
    Non-randomized trial11 participantsBone Health forBoron
  39. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
    Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
    Randomized trial51 participantsBone Health forCollagen
  40. Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
    Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Randomized trialBone Health forCollagen
  41. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
    Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
    Randomized trial39 participantsBone Health forCollagen
  42. Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
    Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
    Methods validation study189 participantsBone Health forCollagen
  43. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
    Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
    Randomized trial51 participantsBone Health forCollagen
  44. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  45. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  46. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  47. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  48. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  49. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  50. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  51. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  52. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  53. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  54. Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.
    Drummond MDM; Silva RAD; Junior NC; Melo MS; Ferreira MHL · Translational sports medicine · 2026
    Meta-analysis4,755 participants78 studies pooledFitness forCollagen
  55. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial.
    Zdzieblik D; Oesser S; Baumstark MW; Gollhofer A; König D · The British journal of nutrition · 2016
    Randomized trial53 participantsFitness forCollagen
  56. Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-blinded crossover clinical trial.
    Kuwaba K; Kusubata M; Taga Y; Igarashi H; Nakazato K; Mizuno K · Journal of the International Society of Sports Nutrition · 2023
    Randomized trial20 participantsFitness forCollagen
  57. Effects of Specific Bioactive Collagen Peptides in Combination with Concurrent Training on Running Performance and Indicators of Endurance Capacity in Men: A Randomized Controlled Trial.
    Jerger S; Jendricke P; Centner C; Bischof K; Kohl J; Keller S; Gollhofer A; König D · Sports medicine - open · 2023
    Randomized trial32 participantsFitness forCollagen
  58. Collagen Peptide Supplementation Enhances Muscle-Tendon Stiffness and Explosive Strength: A 16-wk Randomized Controlled Trial.
    Miyamoto N; Ishihara K; Oshima T; Kawai M; Oritani Y; Iemoto N · Medicine and science in sports and exercise · 2026
    Randomized trial50 participantsFitness forCollagen
  59. The effect of curcumin supplementation on delayed-onset muscle soreness, inflammation, muscle strength, and joint flexibility: A systematic review and dose-response meta-analysis of randomized controlled trials.
    Beba M; Mohammadi H; Clark CCT; Djafarian K · Phytotherapy research : PTR · 2022
    Meta-analysis10 studies pooledFitness forCurcumin
  60. The Effects of Curcumin Supplementation on Muscle Damage, Oxidative Stress, and Inflammatory Markers in Healthy Females with Moderate Physical Activity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Salehi M; Mashhadi NS; Esfahani PS; Feizi A; Hadi A; Askari G · International journal of preventive medicine · 2023
    Randomized trial80 participantsFitness forCurcumin
  61. Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review.
    Fernández-Lázaro D; Mielgo-Ayuso J; Seco Calvo J; Córdova Martínez A; Caballero García A; Fernandez-Lazaro CI · Nutrients · 2020
    Systematic review11 studies pooledFitness forCurcumin
  62. Effects of Turmeric Concentrate on Cardiovascular Risk Factors and Exercise-Induced Oxidative Stress in Healthy Volunteers; an Exploratory Study.
    Hajleh MNA; Al-Dujaili EAS · Advanced pharmaceutical bulletin · 2023
    Randomized trial22 participantsFitness forCurcumin
  63. Effects of curcumin supplementation on sport and physical exercise: a systematic review.
    Suhett LG; de Miranda Monteiro Santos R; Silveira BKS; Leal ACG; de Brito ADM; de Novaes JF; Lucia CMD · Critical reviews in food science and nutrition · 2021
    Systematic review11 studies pooledFitness forCurcumin
  64. Longitudinal Association Between Sodium and Potassium Intake and Physical Performance in Older Adults.
    Lana A; Struijk EA; Ortolá R; Rodríguez-Artalejo F; Lopez-Garcia E · The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Cohort study868 participantsFitness forPotassium
  65. Exercise-induced hyperkalaemia can be reduced in human subjects by moderate training without change in skeletal muscle Na,K-ATPase concentration.
    Kjeldsen K; Nørgaard A; Hau C · European journal of clinical investigation · 1991
    Observational study15 participantsFitness forPotassium
  66. Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
    Zamani P; Shah SJ; Cohen JB; Zhao M; Yang W; Afable JL; Caturla M; Maynard H; Pourmussa B; Demastus C; Mohanty I; Miyake MM; Adusumalli S; Margulies KB; Prenner SB; Poole DC; Wilson N; Reddy R; Townsend RR; Ischiropoulos H; Cappola TP; Chirinos JA · JAMA cardiology · 2025
    Randomized trial84 participantsFitness forPotassium
  67. Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial.
    Dawson-Hughes B; Harris SS; Palermo NJ; Gilhooly CH; Shea MK; Fielding RA; Ceglia L · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Randomized trial244 participantsFitness forPotassium
  68. Exercise-Associated Muscle Cramps in Ironman-Distance Triathletes Over 3 Decades.
    Nilssen PK; Johnson KB; Hiller WDB; Miller TK; Connolly CP · Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine · 2026
    Observational study10,533 participantsFitness forPotassium
  69. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
    Kumar S; Sugihara F; Suzuki K; Inoue N; Venkateswarathirukumara S · Journal of the science of food and agriculture · 2015
    Randomized trialGeneral Health forCollagen
  70. Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
    Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
    Randomized trial101 participantsGeneral Health Joint Health forCollagen
  71. Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.
    Mościcka P; Cwajda-Białasik J; Szewczyk MT; Jawień A · International journal of environmental research and public health · 2022
    Randomized trial100 participantsGeneral Health forCollagen
  72. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
    Shiojima Y; Takahashi M; Takahashi R; Maruyama K; Moriyama H; Bagchi D; Bagchi M; Akanuma M · Journal of the American Nutrition Association · 2023
    Randomized trial64 participantsGeneral Health forCollagen
  73. The use of a collagen matrix in hard-to-heal venous leg ulcers.
    Romanelli M; Mulder G; Paggi B; Macchia M; Panduri S; Dini V · Journal of wound care · 2016
    Randomized trial40 participantsGeneral Health forCollagen
  74. The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis.
    Sadeghi N; Mansoori A; Shayesteh A; Hashemi SJ · Phytotherapy research : PTR · 2020
    Randomized trial70 participantsGeneral Health forCurcumin
  75. The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial.
    Parohan M; Sarraf P; Javanbakht MH; Foroushani AR; Ranji-Burachaloo S; Djalali M · Nutritional neuroscience · 2021
    Randomized trial100 participantsGeneral Health forCurcumin
  76. Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Thanawala S; Shah R; Alluri KV; Bhupathiraju K; Prasad N; Agarwal Y · Journal of pain research · 2025
    Randomized trial139 participantsGeneral Health forCurcumin
  77. Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials.
    Onakpoya IJ; Spencer EA; Perera R; Heneghan CJ · International journal of rheumatic diseases · 2018
    Meta-analysis797 participants7 studies pooledGeneral Health forCurcumin
  78. Effectiveness and safety of turmeric for the treatment of COVID-19: An updated systematic review and meta-analysis of randomized controlled trials.
    Sawangjit R; Sadoyu S; Manosanthipaibul S; Teerawattanapong N; Puttarak P; Wanaratna K; Charoensup R; Hiransai P; Meetam T; Chaiyakunapruk N · Complementary therapies in medicine · 2025
    Meta-analysis1,407 participants23 studies pooledGeneral Health forCurcumin
  79. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  80. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  81. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  82. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  83. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  84. The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Alidadi M; Sahebkar A; Eslami S; Vakilian F; Jarahi L; Alinezhad-Namaghi M; Arabi SM; Vakili S; Tohidinezhad F; Nikooiyan Y; Norouzy A · Advances in experimental medicine and biology · 2021
    Randomized trial66 participantsHeart Health forCurcumin
  85. The Effects of Nano-curcumin on Metabolic Status in Patients With Diabetes on Hemodialysis, a Randomized, Double Blind, Placebo-controlled Trial.
    Shafabakhsh R; Asemi Z; Reiner Z; Soleimani A; Aghadavod E; Bahmani F · Iranian journal of kidney diseases · 2021
    Randomized trial60 participantsHeart Health forCurcumin
  86. Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular risk.
    El-Rakabawy OM; Elkholy AA; Mahfouz AA; Abdelsalam MM; El Wakeel LM · Scientific reports · 2025
    Randomized trial72 participantsHeart Health forCurcumin
  87. Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial.
    Helli B; Gerami H; Kavianpour M; Heybar H; Hosseini SK; Haghighian HK · Endocrine, metabolic & immune disorders drug targets · 2022
    Randomized trial90 participantsHeart Health forCurcumin
  88. The Effect of Curcumin on Reducing Atherogenic Risks in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.
    Yaikwawong M; Jansarikit L; Jirawatnotai S; Chuengsamarn S · Nutrients · 2024
    Randomized trial227 participantsHeart Health forCurcumin
  89. Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studies.
    D'Elia L; Barba G; Cappuccio FP; Strazzullo P · Journal of the American College of Cardiology · 2011
    Meta-analysis247,510 participants11 studies pooledHeart Health forPotassium
  90. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials.
    Poorolajal J; Zeraati F; Soltanian AR; Sheikh V; Hooshmand E; Maleki A · PloS one · 2017
    Meta-analysis1,213 participants23 studies pooledHeart Health forPotassium
  91. Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study.
    O'Donnell M; Mente A; Rangarajan S; McQueen MJ; O'Leary N; Yin L; Liu X; Swaminathan S; Khatib R; Rosengren A; Ferguson J; Smyth A; Lopez-Jaramillo P; Diaz R; Avezum A; Lanas F; Ismail N; Yusoff K; Dans A; Iqbal R; Szuba A; Mohammadifard N; Oguz A; Yusufali AH; Alhabib KF; Kruger IM; Yusuf R; Chifamba J; Yeates K; Dagenais G; Wielgosz A; Lear SA; Teo K; Yusuf S; PURE Investigators · BMJ (Clinical research ed.) · 2019
    Cohort study103,570 participantsHeart Health forPotassium
  92. Effect of Potassium Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Studies.
    D'Elia L; Cappuccio FP; Masulli M; La Fata E; Rendina D; Galletti F · Nutrients · 2023
    Meta-analysis332 participants5 studies pooledHeart Health forPotassium
  93. Effects of potassium supplementation on office, home, and 24-h blood pressure in patients with essential hypertension.
    Kawano Y; Minami J; Takishita S; Omae T · American journal of hypertension · 1999
    Randomized trial55 participantsHeart Health forPotassium
  94. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  95. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  96. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  97. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  98. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  99. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  100. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  101. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  102. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  103. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  104. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  105. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  106. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  107. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  108. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  109. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
    Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
    Randomized trial191 participantsJoint Health forCollagen
  110. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial].
    Alekseeva LI; Kashevarova NG; Taskina EA; Strebkova EA; Korotkova TA; Sharapova EP; Savushkina NM; Lila AM; Shostak NA; Mazurov VI; Nesterovich II; Dedkova VA; Vasilyuk VB; Egorova NV; Leontyeva MA; Yakupova SP; Vinogradova IB; Sorotskaya VN; Shirokova LY · Terapevticheskii arkhiv · 2024
    Randomized trial212 participantsJoint Health forCollagen
  111. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial.
    Zdzieblik D; Brame J; Oesser S; Gollhofer A; König D · Nutrients · 2021
    Randomized trial180 participantsJoint Health forCollagen
  112. Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis.
    Zhao J; Liang G; Zhou G; Hong K; Yang W; Liu J; Zeng L · Journal of ethnopharmacology · 2024
    Meta-analysis2,175 participants23 studies pooledJoint Health forCurcumin
  113. Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.
    Zeng L; Yang T; Yang K; Yu G; Li J; Xiang W; Chen H · Frontiers in immunology · 2022
    Meta-analysis2,396 participants29 studies pooledJoint Health forCurcumin
  114. The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses.
    Bideshki MV; Jourabchi-Ghadim N; Radkhah N; Behzadi M; Asemani S; Jamilian P; Zarezadeh M · Phytotherapy research : PTR · 2024
    Meta-analysis11 studies pooledJoint Health forCurcumin
  115. The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis.
    Hsiao AF; Lien YC; Tzeng IS; Liu CT; Chou SH; Horng YS · Complementary therapies in medicine · 2021
    Meta-analysis1,258 participants11 studies pooledJoint Health forCurcumin
  116. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis.
    Zeng L; Yu G; Hao W; Yang K; Chen H · Bioscience reports · 2022
    Meta-analysis1,621 participants15 studies pooledJoint Health forCurcumin
  117. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsJoint Health forVitamin C
  118. Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.
    Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
    Randomized trial100 participantsJoint Health forVitamin C
  119. Osteoarthritis prevalence and modifiable factors: a population study.
    Plotnikoff R; Karunamuni N; Lytvyak E; Penfold C; Schopflocher D; Imayama I; Johnson ST; Raine K · BMC public health · 2016
    Cross-sectional study4,733 participantsJoint Health forVitamin C
  120. Anti-Inflammatory Effect of Vitamin C during the Postoperative Period in Patients Subjected to Total Knee Arthroplasty: A Randomized Controlled Trial.
    Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
    Randomized trial110 participantsJoint Health forVitamin C
  121. Musculoskeletal manifestations of scurvy.
    Fain O · Joint bone spine · 2005
    Narrative reviewJoint Health forVitamin C
  122. Biochemical and physiologic consequences of boron deprivation in humans.
    Nielsen FH · Environmental health perspectives · 1995
    Single-arm trial12 participantsTestosterone Support forBoron
  123. Plasma boron and the effects of boron supplementation in males.
    Green NR; Ferrando AA · Environmental health perspectives · 1995
    Randomized trial19 participantsTestosterone Support forBoron
  124. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
    Mohammad Reza Naghii, Mahmoud Mofid, Ali Reza Asgari, Mehdi Hedayati, Maryam-Saddat Daneshpour · Journal of Trace Elements in Medicine and Biology · 2011
    Non-randomized trial8 participantsTestosterone Support forBoron
  125. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  126. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  127. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  128. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D
  129. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D