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BrainEssence

Pure Essence
4.7
★ ★ ★ ★ ★
(86 ratings)
Acetyl L-Carnitine 500 mg
Ashwagandha 200 mg
Rhodiola
Bacopa 300 mg
Product Image
Score68
A broad cognitive formula with several worthwhile actives, held back by weak extract standardization, high cost, and complex interactions.
How scoring works
Quantity:60 Tablet(s) • (30 servings)
Goals:
Brain Health
Cognitive Support
Mental Focus
Productivity Boost
Energy
Anti-Aging
Mood Support
Stress Relief

Score 68

A broad cognitive formula with several worthwhile actives, held back by weak extract standardization, high cost, and complex interactions.
How scoring works
$57.68($1.92 per serving)
Pure Formulas
$ 57.68
Vitacost
$ 57.68
iHerb
$ 57.68
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Analysis

Acetyl-L-carnitine is supplied at a useful amount, while bacopa reaches a familiar extract weight and phosphatidylserine adds membrane support. These are the strongest parts of a formula aimed at memory, focus, and brain energy.

Bacopa lacks bacoside standardization, ashwagandha has no marker potency, and the Rhodiola species and marker percentages are unclear. Mucuna, huperzine A, and numerous adaptogens broaden activity but also make tolerance and medication fit harder to predict.

Two tablets deliver many ingredients, yet the serving cost is high. The formula fits experienced users seeking breadth more than someone who wants a transparent, easily adjusted first nootropic.

Who is it for
  • Experienced nootropic users seeking several cognitive pathways
  • Adults comfortable with a complex two-tablet formula
Best for
  • Broad brain-health support
  • Mental focus and cognitive routines
  • Users prioritizing ingredient breadth

Pros

  • Useful acetyl-L-carnitine amount
  • Bacopa reaches a substantial extract weight
  • Includes phosphatidylserine
  • Provides a stated huperzine A amount
  • Broad cognitive coverage

Cons

  • Most botanicals lack active-marker standardization
  • Rhodiola species is unclear
  • High serving cost
  • Complex formula is difficult to troubleshoot

Warnings

  • Mucuna can supply L-Dopa and may interact with levodopa therapy, monoamine oxidase inhibitors, or antipsychotic medicines.
  • Huperzine A can add to acetylcholinesterase inhibitors such as donepezil and may cause nausea, dizziness, vivid dreams, or slow heart rate.
  • Ashwagandha may affect thyroid activity and has rare liver-injury reports, making thyroid or liver conditions especially relevant.
  • Alpha-lipoic acid may add to glucose-lowering medicine effects.
  • Avoid during pregnancy because the complex botanical and neuroactive blend has an unsuitable safety profile for that setting.

Nutrient quality

69 High impact

Several useful actives are present, but most botanical extracts lack marker standardization. Bacopa and acetyl-L-carnitine are practical, while rhodiola, fisetin, and several extras are modest, and the ingredients cover several cognitive, energy, and stress-related pathways.

.

Ingredient transparency

81 Highest impact

Every listed active has a specific amount and no proprietary blend obscures the formula. Complete intake directions and inactive ingredients are not supplied, leaving part of the label unverified.

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Customer satisfaction

64 Moderate impact

The supplied aggregate satisfaction level is strong. The limited feedback volume leaves more uncertainty than established peers.

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Value for money

51 Moderate impact

The premium cost is only partly justified by the useful anchor ingredients. The serving cost is high relative to the uneven depth of the formula, and more focused formulas may provide stronger value for a specific cognitive goal.

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Report analysis

Goals

Brain Health
Brain Health
Impact
Highest effect
A Goal FitB- Strength of SupportA CoverageB- Formula Quality
Ashwagandha · 200 mgBacopa · 300 mg

Acetyl-L-carnitine, bacopa, phosphatidylserine, huperzine A, adaptogens, and antioxidants cover many cognitive pathways. Useful doses of acetyl-L-carnitine and bacopa anchor the formula.

Several botanical extracts lack active-marker standardization, while rhodiola and fisetin appear modest. The wide ingredient list offers real breadth but also spreads the formula across many unevenly supported components.

Study evidence
Acetyl L-Carnitine Supportive 19 studies
Bacopa Supportive 17 studies
Rhodiola Supportive 8 studies
Cognitive Support
Cognitive Support
Impact
Highest effect
A- Goal FitB Strength of SupportA- CoverageB Formula Quality
Ashwagandha · 200 mgAcetyl L-Carnitine · 500 mgBacopa · 300 mg

Bacopa, acetyl-L-carnitine, phosphatidylserine, ashwagandha, mucuna, and huperzine provide broad direct cognitive support. The formula addresses memory, cellular energy, stress response, and cholinergic signaling.

Bacopa and adaptogen standardization details are missing, while rhodiola and fisetin are lightly dosed. Mucuna and huperzine may interact with dopaminergic or cholinergic medicines, so medication users need product-specific clinical guidance.

Study evidence
Acetyl L-Carnitine Supportive 20 studies
Ashwagandha Supportive 17 studies
Bacopa Supportive 30 studies
Rhodiola Supportive 7 studies
Mental Focus
Mental Processing Speed
Mental Focus
Impact
Highest effect
B+ Goal FitB- Strength of SupportA- CoverageB+ Formula Quality
Acetyl L-Carnitine · 500 mg

Acetyl-L-carnitine, bacopa, phosphatidylserine, Mucuna, and huperzine A create a distinctly cognitive formula with several complementary mechanisms. The combination supports brain energy, memory-related signaling, and neurotransmitter activity more directly than a general stress blend.

Useful disclosed amounts for acetyl-L-carnitine, bacopa, and phosphatidylserine strengthen the formula, but missing standardization limits confidence in several botanicals. Rhodiola is underdosed, and the crowded ingredient list raises more uncertainty than a tighter nootropic stack.

Study evidence
Acetyl L-Carnitine Supportive 7 studies
Bacopa Supportive 13 studies
Rhodiola Supportive 15 studies
Productivity Boost
Productivity Boost
Impact
High effect
A- Goal FitC Strength of SupportB+ CoverageB- Formula Quality
Acetyl L-Carnitine · 500 mgAcetyl L-Carnitine · 500 mg

Bacopa, acetyl-L-carnitine, phosphatidylserine, huperzine, and adaptogens create a broad nootropic formula. The stack targets memory, cellular energy, cholinergic signaling, and stress-related fatigue.

Several main amounts are useful, but key extract standardization and active yields are missing. Broad coverage is compelling, yet multiple low-dose botanicals reduce depth and make the formula harder to evaluate.

Study evidence
Acetyl L-Carnitine Supportive 1 study
Acetyl L-Carnitine Supportive 1 study
Bacopa Supportive 12 studies
Rhodiola Supportive 7 studies
Energy
Energy
Impact
High effect
A- Goal FitC+ Strength of SupportB+ CoverageB- Formula Quality
Acetyl L-Carnitine · 500 mg

Acetyl-L-carnitine supports mitochondrial fuel use, while ashwagandha and rhodiola add stress-resilience pathways. Bacopa and phosphatidylserine broaden the focus toward mental stamina and attention.

The carnitine amount is useful, but rhodiola is low and neither adaptogen has adequate marker standardization. The broad cognitive formula is plausible yet uneven, with several small specialty ingredients weakening dose confidence.

Study evidence
Acetyl L-Carnitine Supportive 19 studies
Ashwagandha Supportive 9 studies
Rhodiola Supportive 18 studies
Anti-Aging
Anti-Aging
Impact
High effect
C+ Goal FitC+ Strength of SupportB- CoverageB Formula Quality

The formula offers meaningful cognitive and mitochondrial support through acetyl-L-carnitine, bacopa, phosphatidylserine, and several stress-response botanicals. Its strongest alignment comes from maintaining mental function and cellular energy rather than covering aging broadly.

All active amounts are disclosed, and the acetyl-L-carnitine and bacopa extract amounts are useful. Unspecified extract potency and small amounts of fisetin, rhodiola, and alpha-lipoic acid make several supporting ingredients less convincing.

Study evidence
Acetyl L-Carnitine Supportive 1 study
Bacopa Supportive 4 studies

Ingredients

IngredientAmount per serving
Acetyl-L-Carnitine
500 mg
Bacopa monnieri extract
300 mg
organic Ashwagandha extract
200 mg
Mucuna pruriens
200 mg
Schizandra extract
200 mg
Phosphatidylserine
100 mg
Alpha Lipoic Acid
100 mg
Gotu Kola extract
75 mg
Rhodiola extract (Siberian rhodiola root extract)
 50 mg
Fisetin extract
10 mg
Chinese Club Moss extract (Huperzine-A)
 100 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Acetyl L-Carnitine · 500 mg OverallScore76
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

Acetyl-L-carnitine is the only carnitine form and is supplied at a clearly disclosed, useful amount. The label does not identify its salt form, branded source, or manufacturing and purity assurances, leaving raw-material quality less certain. Phosphatidylserine and several botanicals add breadth, but the cost for each effective ALCAR serving remains high.

View ingredientView products
Ashwagandha · 200 mg OverallScore44
F Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
+1

An organic extract is clearly identified, but its plant part, marker potency, and clinical branding are absent. The 200 mg amount is transparent yet hard to compare with established extract targets, and no absorption aid is present. The high cost and broad cognitive formula make it a weak value for an ashwagandha-focused purchase.

View ingredientView products
Rhodiola (Siberian rhodiola root extract) · 50 mg OverallScore36
F Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyF Value

A small amount of Siberian Rhodiola extract is present, but the rosea species and active-marker standardization are not confirmed. The dose is below the range usually used for meaningful standalone Rhodiola support. Missing standardization prevents a useful value comparison, and excipient details are unavailable.

View ingredientView products
Loading alternative details
78 Performance

Saffron

youtheory
<p>Rhodiola, ashwagandha, and saffron provide a coherent mix for stress and focus, giving it a more focused ingredient profile than BrainEssence. Rhodiola and saffron standardization are not stated.</p>
73 Performance

HPA Adapt

Integrative Therapeutics
<p>Substantial amounts of Sensoril, rhodiola, eleuthero, holy basil, and branded maca provide deeper adaptogen coverage, giving it a more focused ingredient profile than BrainEssence. Marker percentages and excipient details are missing.</p>
81 Performance

AdrenaSense

Natural Factors WS WomenSense
<p>Marker-identified rhodiola, eleuthero, schisandra, and ashwagandha make the adaptogen blend easy to assess, giving it a more focused ingredient profile than BrainEssence. Ashwagandha plays a supporting rather than primary role.</p>
81 Budget

Adrenal Serenity

Natural Factors Stress-Relax
<p>The lower serving cost makes Adrenal Serenity a more economical alternative to BrainEssence. Sensoril ashwagandha is paired with eleuthero, lavender, and rhodiola for focused stress support. Some extract details and inactive ingredients are not disclosed.</p>
80 Budget

Clear Thinking

Nature's Way
<p>The lower serving cost makes Clear Thinking a more economical alternative to BrainEssence. Branded citicoline, bacopa, and ashwagandha create a compact cognitive formula. The bacopa amount is below a more established targeted level.</p>
79 Budget

Cortisol Calm

Pure Encapsulations
<p>The lower serving cost makes Cortisol Calm a more economical alternative to BrainEssence. Standardized ashwagandha, rhodiola, magnolia, and theanine provide a focused stress blend. Duplicate vitamin entries and missing inactive-ingredient details reduce label clarity.</p>
72 Value

RealClarity

Real Mushrooms
<p>Sensoril is combined with lion’s mane, rhodiola, and bacopa for broader stress and cognitive support, while a lower serving cost improves practical value relative to BrainEssence. Several supporting extracts are modest or incompletely characterized.</p>
73 Value

Daily Stress Formula

Pure Encapsulations
<p>Activated B vitamins, tyrosine, bacopa, rhodiola, and ashwagandha cover both energy and stress pathways, while a lower serving cost improves practical value relative to BrainEssence. Duplicated nutrient entries and missing inactive ingredients reduce transparency.</p>
66 Value

Adrenal Response

Innate Response Formulas
<p>Sensoril and a useful rhodiola amount anchor a coherent stress-resilience formula, while a lower serving cost improves practical value relative to BrainEssence. A hidden foods-and-extracts blend limits full assessment.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
    Malaguarnera G; Catania VE; Bertino G; Chisari LM; Castorina M; Bonfiglio C; Cauli O; Malaguarnera M · Current pharmaceutical design · 2022
    Randomized trial92 participantsAnti-Aging forAcetyl L-Carnitine
  2. Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis.
    Valotto Neto LJ; Reverete de Araujo M; Moretti Junior RC; Mendes Machado N; Joshi RK; Dos Santos Buglio D; Barbalho Lamas C; Direito R; Fornari Laurindo L; Tanaka M; Barbalho SM · Antioxidants (Basel, Switzerland) · 2024
    Systematic reviewAnti-Aging forBacopa
  3. Neurometabolite changes in cingulate cortex regions in healthy Indian population and effect of Bacopa monnieri intervention: a H1 MRS study.
    Singh AD; Kumar M; Bh S; P B; Godbole A; Khushu S · Neurochemistry international · 2026
    Clinical trial96 participantsAnti-Aging forBacopa
  4. Efficacy of Integrated Yoga and Ayurveda Rasayana on cognitive functions in elderly with mild cognitive impairment: Non-randomized three-arm clinical trial.
    Chobe S; Patra SK; Chobe M; Metri K · Journal of Ayurveda and integrative medicine · 2022
    Non-randomized trial72 participantsAnti-Aging forBacopa
  5. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.
    Calabrese C; Gregory WL; Leo M; Kraemer D; Bone K; Oken B · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Randomized trial54 participantsAnti-Aging Mood Support Productivity Boost Stress Relief forBacopa
  6. Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
    Malaguarnera M; Gargante MP; Cristaldi E; Vacante M; Risino C; Cammalleri L; Pennisi G; Rampello L · Digestive diseases and sciences · 2008
    Randomized trial125 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  7. Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
    Spagnoli A; Lucca U; Menasce G; Bandera L; Cizza G; Forloni G; Tettamanti M; Frattura L; Tiraboschi P; Comelli M · Neurology · 1991
    Randomized trial130 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  8. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome.
    Herrmann WM; Dietrich B; Hiersemenzel R · International journal of clinical pharmacology research · 1990
    Randomized trialBrain Health forAcetyl L-Carnitine
  9. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
    Malaguarnera M; Vacante M; Motta M; Giordano M; Malaguarnera G; Bella R; Nunnari G; Rampello L; Pennisi G · Metabolic brain disease · 2012
    Randomized trial61 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  10. Acetyl-L-carnitine in the treatment of mildly demented elderly patients.
    Passeri M; Cucinotta D; Bonati PA; Iannuccelli M; Parnetti L; Senin U · International journal of clinical pharmacology research · 1990
    Randomized trial60 participantsBrain Health Mental Focus forAcetyl L-Carnitine
  11. Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis.
    Tiemtad P; Ingkaninan K; Temkitthawon P; Thimkorn P; Rattanachaisit N; Teaktong T; Dhippayom T · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
    Meta-analysis2,107 participants29 studies pooledBrain Health Mental Focus forBacopa
  12. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.
    Kongkeaw C; Dilokthornsakul P; Thanarangsarit P; Limpeanchob N; Norman Scholfield C · Journal of ethnopharmacology · 2014
    Meta-analysis518 participants9 studies pooledBrain Health Mental Focus Productivity Boost forBacopa
  13. Comparative efficacy of Medhya Rasayana,Bacopa monnieri, and Centella asiatica in enhancing memory and IQ of 8-10 year-old healthy boys: A prakriti-based double-blind, randomized controlled trial.
    Verma J; Rathi R; Anamika; Rathi B; Pandey VB · Journal of Ayurveda and integrative medicine · 2025
    Randomized trial180 participantsBrain Health Cognitive Support forBacopa
  14. Plant-derived nootropics and human cognition: A systematic review.
    Lorca C; Mulet M; Arévalo-Caro C; Sanchez MÁ; Perez A; Perrino M; Bach-Faig A; Aguilar-Martínez A; Vilella E; Gallart-Palau X; Serra A · Critical reviews in food science and nutrition · 2023
    Systematic review256 studies pooledBrain Health forBacopa
  15. The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
    Feng X; Fan S; Wei F · Frontiers in pharmacology · 2026
    Meta-analysis1,861 participants25 studies pooledBrain Health Cognitive Support forBacopa
  16. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsBrain Health Mental Focus forRhodiola
  17. A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
    Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
    Randomized trial100 participantsBrain Health forRhodiola
  18. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
    Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
    Narrative reviewBrain Health forRhodiola
  19. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
    Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
    Randomized trial56 participantsBrain Health Productivity Boost forRhodiola
  20. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsBrain Health Cognitive Support forRhodiola
  21. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
    Torrioli MG; Vernacotola S; Peruzzi L; Tabolacci E; Mila M; Militerni R; Musumeci S; Ramos FJ; Frontera M; Sorge G; Marzullo E; Romeo G; Vallee L; Veneselli E; Cocchi E; Garbarino E; Moscato U; Chiurazzi P; D'Iddio S; Calvani M; Neri G · American journal of medical genetics. Part A · 2008
    Randomized trial63 participantsCognitive Support forAcetyl L-Carnitine
  22. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.
    Malaguarnera M; Gargante MP; Cristaldi E; Colonna V; Messano M; Koverech A; Neri S; Vacante M; Cammalleri L; Motta M · Archives of gerontology and geriatrics · 2008
    Randomized trial96 participantsCognitive Support forAcetyl L-Carnitine
  23. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsCognitive Support forAshwagandha
  24. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsCognitive Support Energy forAshwagandha
  25. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
    Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
    Randomized trial54 participantsCognitive Support forAshwagandha
  26. Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.
    Naik S; Muralidhar G; Rao BS; Agarwal S; Jain M · Journal of medicine and life · 2026
    Randomized trial58 participantsCognitive Support forAshwagandha
  27. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsCognitive Support forAshwagandha
  28. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials.
    Pase MP; Kean J; Sarris J; Neale C; Scholey AB; Stough C · Journal of alternative and complementary medicine (New York, N.Y.) · 2012
    Systematic review6 studies pooledCognitive Support Productivity Boost forBacopa
  29. A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations.
    Kean JD; Downey LA; Stough C · Complementary therapies in medicine · 2017
    Systematic review5 studies pooledCognitive Support forBacopa
  30. Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial.
    Kumar N; Abichandani LG; Thawani V; Gharpure KJ; Naidu MU; Venkat Ramana G · Evidence-based complementary and alternative medicine : eCAM · 2024
    Randomized trial60 participantsCognitive Support forBacopa
  31. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewCognitive Support Mental Focus forRhodiola
  32. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  33. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledCognitive Support Stress Relief forRhodiola
  34. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsCognitive Support Productivity Boost forRhodiola
  35. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
    Malaguarnera M; Vacante M; Giordano M; Pennisi G; Bella R; Rampello L; Malaguarnera M; Li Volti G; Galvano F · The American journal of clinical nutrition · 2011
    Randomized trial121 participantsEnergy forAcetyl L-Carnitine
  36. The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.
    Malaguarnera M; Vacante M; Bertino G; Neri S; Malaguarnera M; Gargante MP; Motta M; Lupo L; Chisari G; Bruno CM; Pennisi G; Bella R · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012
    Randomized trial60 participantsEnergy forAcetyl L-Carnitine
  37. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
    Malaguarnera M; Bella R; Vacante M; Giordano M; Malaguarnera G; Gargante MP; Motta M; Mistretta A; Rampello L; Pennisi G · Scandinavian journal of gastroenterology · 2011
    Randomized trial67 participantsEnergy forAcetyl L-Carnitine
  38. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy.
    Sun Y; Shu Y; Liu B; Liu P; Wu C; Zheng R; Zhang X; Zhuang Z; Deng Y; Zheng L; Xu Q; Jiang B; Ouyang X; Gao J; Xu N; Li X; Jiang S; Liang C; Yao Y · Experimental and therapeutic medicine · 2020
    Randomized trial239 participantsEnergy forAcetyl L-Carnitine
  39. Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.
    Kumar R; Nuñez NA; Joshi N; Joseph B; Verde A; Seshadri A; Cuellar Barboza AB; Prokop LJ; Medeiros GC; Singh B · Bipolar disorders · 2024
    Systematic reviewEnergy forAcetyl L-Carnitine
  40. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsEnergy Mood Support forAshwagandha
  41. Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
    Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
    Randomized trialEnergy forAshwagandha
  42. Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
    Vittal M; Vinciguerra M · Biogerontology · 2025
    Narrative reviewEnergy forAshwagandha
  43. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsEnergy forAshwagandha
  44. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  45. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsEnergy Mental Focus forRhodiola
  46. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  47. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsEnergy Stress Relief forRhodiola
  48. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  49. Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial.
    Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
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