Arginine & Citrulline 500 mg / 250 mg
NOW Sports
Arginine & Citrulline 500 mg / 250 mg
4.7
★ ★ ★ ★ ★
(4240 ratings)
Citrulline 250 mg
Arginine 500 mg
Score 90.0
A larger, more cost-effective version of a combined L-Arginine and L-Citrulline supplement from a trusted brand, promoting nitric oxide production, which is ideal for those who require higher daily dosages.
Quantity: 240 Capsule(s)Servings size: 1 Veg Capsule(s) (240 servings)
Selected goals:
Other goals:
Fitness
Muscle Gain
Cardiovascular Support
Heart Health
leaderboard Score 90.0
A larger, more cost-effective version of a combined L-Arginine and L-Citrulline supplement from a trusted brand, promoting nitric oxide production, which is ideal for those who require higher daily dosages.
insights Analysis
Identical in formulation to the 120-count bottle, this 240-count product from NOW Sports provides L-Arginine and L-Citrulline to support nitric oxide production and blood flow. The combination leverages L-Citrulline's superior bioavailability to boost L-Arginine levels, enhancing the vasodilatory effects. Although the dosage per capsule (500mg L-Arginine, 250mg L-Citrulline) is low for clinically significant effects, this larger quantity offers a better price per serving, making it more economical for users who plan to take multiple capsules daily to reach desired dosages. The long-standing reputation of NOW Sports further adds to its appeal as a reliable and effective supplement.
- Offers excellent value per serving compared to the smaller bottle, significantly reducing the cost when taking higher daily dosages for effective results.
- Combines L-Arginine and L-Citrulline for synergistic nitric oxide production and enhanced bioavailability, providing comprehensive circulatory support.
- Backed by NOW Sports, a highly reputable brand known for stringent quality control, third-party testing, and positive consumer reviews.
- Individual capsule dosages of 500mg L-Arginine and 250mg L-Citrulline are low, still requiring several capsules to achieve research-supported therapeutic levels for performance or cardiovascular benefits.
- While more economical than the smaller bottle, the capsule form may still be less convenient for very high doses compared to powdered supplements where larger amounts can be mixed easily.
- Individuals with low blood pressure should consult a healthcare professional before use, as L-Arginine and L-Citrulline can further lower blood pressure due to their vasodilatory effects.
- People with herpes simplex should exercise caution as Arginine can potentially exacerbate outbreaks by promoting viral replication.
- Consult a doctor if you are pregnant, nursing, have a pre-existing medical condition (especially heart conditions or kidney disease), or are taking any medications, particularly those for blood pressure, nitrates, or erectile dysfunction, before taking this supplement.
$23.76($0.09 per serving)
 Daily Vita | $ 23.76 | |
| Daily Vita | $ 23.76 | |
 Amazon | $ 25.75 | |
 Vitacost | $ 28.19 | |
 iHerb | $ 30.61 |
bolt Effectiveness for goals
Yes, L-Citrulline supplementation can lead to higher and more sustained plasma L-Arginine levels than Arginine supplementation alone. This is because Citrulline bypasses intestinal and liver metabolism, being efficiently converted to Arginine in the kidneys. This indirect pathway can more effectively increase nitric oxide production.
L-Citrulline is often considered more effective at increasing sustained L-Arginine and nitric oxide levels in the body than L-Arginine itself. This is because L-Citrulline bypasses significant metabolism in the gut and liver, converting to L-Arginine more efficiently in the kidneys. This leads to a more pronounced and prolonged increase in circulating L-Arginine.
L-Citrulline is converted to L-Arginine in the kidneys, which then increases nitric oxide production. This can lead to enhanced blood flow to muscles during exercise, potentially reducing fatigue and improving endurance. It's particularly studied for high-intensity activities and resistance training.
Combining L-Arginine and L-Citrulline may offer enhanced and more sustained nitric oxide production. L-Citrulline can recycle back into L-Arginine, creating a continuous supply for nitric oxide synthesis. This combined approach could potentially lead to greater and longer-lasting effects on blood flow compared to taking either supplement alone.
L-Citrulline is converted to L-Arginine in the body, leading to increased nitric oxide production. This can help improve blood flow to muscles during exercise, potentially enhancing endurance and reducing fatigue. Studies have shown L-Citrulline to be effective in improving performance in both aerobic and anaerobic exercises.
schedule Dosage, timing & forms
Yes, Arginine and Citrulline can be taken together, and some individuals choose to combine them. Citrulline is converted to Arginine in the body, which can effectively increase Arginine levels. Taking them together may offer a synergistic approach, potentially providing both immediate and sustained benefits.
Citrulline is generally considered more effective at increasing and sustaining blood Arginine levels when taken orally. This is because Arginine itself undergoes significant breakdown in the gut and liver (first-pass metabolism) before reaching systemic circulation. Citrulline bypasses this metabolism and is efficiently converted to Arginine in the kidneys.
For exercise performance, dosages of L-Citrulline typically range from 6 to 8 grams per day. If using Citrulline Malate (often a 2:1 ratio of Citrulline to Malate), a common dose is 8 to 12 grams, providing an equivalent amount of L-Citrulline. For general cardiovascular support, lower doses around 3-4 grams may be suggested.
For exercise performance, typical dosages are 6 to 8 grams of L-Citrulline, or 8 to 12 grams of Citrulline Malate. Citrulline Malate is often a 2:1 ratio (6-8g L-Citrulline). It's generally recommended to take it about 60 minutes before physical activity.
When combining them, it's generally recommended to start with conservative doses for each. Since Citrulline effectively raises Arginine levels, you might consider slightly lower individual Arginine doses than if taking it alone. Monitoring your body's response is key to finding the optimal combined dosage.
health_and_safety Safety & interactions
Yes, L-Arginine and L-Citrulline can generally be taken together. L-Citrulline is a precursor to L-Arginine, and combining them may lead to sustained increases in nitric oxide levels. However, potential additive effects on blood pressure should be considered.
Yes, L-Arginine can interact with medications for blood pressure, erectile dysfunction (e.g., sildenafil), and nitrates, potentially causing blood pressure to drop too low. It may also interact with blood thinners and diabetes medications. Consulting a healthcare professional is crucial, especially if taking other medications.
Common side effects of L-Arginine can include abdominal pain, bloating, diarrhea, and nausea, especially at higher doses. These effects are generally mild and temporary. Individuals may also experience a drop in blood pressure.
L-Citrulline is generally well-tolerated, but some individuals may experience mild gastrointestinal discomfort, such as nausea or diarrhea. These side effects are more likely at higher doses. It can also potentially lower blood pressure.
Yes, L-Arginine can interact with medications for high blood pressure. Because L-Arginine can lower blood pressure, taking it with antihypertensive drugs might cause blood pressure to drop too low. It is advisable to consult a healthcare professional before combining them.
Ingredients
| Ingredient | Amount per serving |
|---|---|
L-Arginine | 500 mg |
L-Citrulline | 250 mg |
Categories
Citrulline 90.0
Contains L-Citrulline, which is highly effective for raising plasma arginine levels and thus nitric oxide, supporting vascular function. The superior value of this larger bottle makes consistent and higher intake of this beneficial amino acid very practical.
Arginine 88.0
Provides L-Arginine as part of an effective blend from a leading brand. The significant quantity per bottle ensures that users can economically dose L-Arginine to their desired levels for nitric oxide support and its associated benefits.
Goals
Fitness 90.0
Offering the same effective combination of L-Arginine and L-Citrulline in a larger, more economical size, this product significantly enhances the practicality of achieving optimal dosages for improved endurance and workout performance. The better value allows for more consistent higher dosing.
As the largest and most affordable option per capsule within this comparison set, this product is an excellent choice for long-term cardiovascular health support through sustained nitric oxide production. It enables consistent higher dosing, which is often recommended for heart health benefits.
Muscle Gain 88.0
This bulk offering provides a cost-effective way to utilize the nitric oxide-boosting properties of arginine and citrulline for enhanced muscle pump, nutrient delivery, and recovery. It makes it more feasible to take the necessary multiple capsules for noticeable effects related to muscle development.
Recommended Alternatives
75 Value 
L-Arginine + L-Citrulline 750 mg
Nutricost
4.7
★★★★★
(1239 ratings)
Offers the exact same L-Arginine (500mg) and L-Citrulline (250mg) per serving as the original but at an even lower price per serving, providing superior value for the identical formulation.
70 Value 
L-Arginine 1000 mg
21st Century
4.7
★★★★★
(9054 ratings)
Delivers a higher dose of L-Arginine per serving (1000mg) at a lower price per serving, providing more active ingredient for the cost, which is beneficial for those focusing primarily on arginine.
72 Value 
L-Citrulline 1000 mg
Nutricost
4.5
★★★★★
(327 ratings)
Provides a concentrated 1000mg dose of L-Citrulline per serving at a very competitive price, offering excellent value for those prioritizing Citrulline's NO-boosting pathway.
85 Performance 
N.O. Pro with Beet Root
ZHOU
4.2
★★★★★
(3540 ratings)
Provides a far more comprehensive blend of Arginine forms, Citrulline Malate, and Beet Root, offering superior nitric oxide boosting capabilities for enhanced fitness and cardiovascular benefits.
90 Performance 
SuperPump Aggression Mayhem Mango
Gaspari Nutrition
4.3
★★★★★
(669 ratings)
This pre-workout is packed with a very high dose of L-Citrulline (4000mg) and other performance ingredients, making it significantly more effective for intense fitness and muscle gain goals.
80 Performance 
Arginine Citrulline
MNP Michael's Naturopathic Programs
4.8
★★★★★
(196 ratings)
Offers significantly higher dosages of both L-Arginine (2250mg) and L-Citrulline (750mg) per serving, alongside Beet, making it considerably more potent for nitric oxide support and overall efficacy.
65 Budget 
L-Arginine 500 mg
Swanson
4.7
★★★★★
(3442 ratings)
Significantly cheaper in total price, providing basic L-Arginine support at a low cost, although it lacks Citrulline.
60 Budget 
L-Arginine 500 mg
Mason Natural
4.7
★★★★★
(240 ratings)
Offers L-Arginine at a highly affordable total price, making it a budget-friendly option for general arginine supplementation.
68 Budget 
L-Arginine 500 mg
California Gold Nutrition
4.7
★★★★★
(9664 ratings)
A very reasonably priced L-Arginine product from a reputable brand, providing a basic Arginine dose at a low total cost for those not needing Citrulline.
75 Value
L-Arginine + L-Citrulline 750 mg
Nutricost
4.7
★★★★★
(1239 ratings)
Offers the exact same L-Arginine (500mg) and L-Citrulline (250mg) per serving as the original but at an even lower price per serving, providing superior value for the identical formulation.
70 Value
L-Arginine 1000 mg
21st Century
4.7
★★★★★
(9054 ratings)
Delivers a higher dose of L-Arginine per serving (1000mg) at a lower price per serving, providing more active ingredient for the cost, which is beneficial for those focusing primarily on arginine.
72 Value
L-Citrulline 1000 mg
Nutricost
4.5
★★★★★
(327 ratings)
Provides a concentrated 1000mg dose of L-Citrulline per serving at a very competitive price, offering excellent value for those prioritizing Citrulline's NO-boosting pathway.
85 Performance
N.O. Pro with Beet Root
ZHOU
4.2
★★★★★
(3540 ratings)
Provides a far more comprehensive blend of Arginine forms, Citrulline Malate, and Beet Root, offering superior nitric oxide boosting capabilities for enhanced fitness and cardiovascular benefits.
90 Performance
SuperPump Aggression Mayhem Mango
Gaspari Nutrition
4.3
★★★★★
(669 ratings)
This pre-workout is packed with a very high dose of L-Citrulline (4000mg) and other performance ingredients, making it significantly more effective for intense fitness and muscle gain goals.
80 Performance
Arginine Citrulline
MNP Michael's Naturopathic Programs
4.8
★★★★★
(196 ratings)
Offers significantly higher dosages of both L-Arginine (2250mg) and L-Citrulline (750mg) per serving, alongside Beet, making it considerably more potent for nitric oxide support and overall efficacy.