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Nitri Oxide Support

Pure Encapsulations
4.7
★ ★ ★ ★ ★
(26 ratings)
Arginine 2050 mg
Citrulline 715 mg
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Score73
A useful AAKG powder supports workout blood flow, but poorly defined low-dose citrulline and average value narrow its appeal.
How scoring works
Quantity:5 Ounce(s) • (30 servings)
Goals:
Cardiovascular Support
Energy

Score 73

A useful AAKG powder supports workout blood flow, but poorly defined low-dose citrulline and average value narrow its appeal.
How scoring works
$30.60($1.02 per serving)
Pure Formulas
$ 51.00
Vitacost
$ 30.60
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Analysis

The powder provides 2.05 g of arginine alpha-ketoglutarate and 200 mg of vitamin C. That arginine amount is meaningful for circulation-focused exercise use, and powder delivery avoids swallowing several capsules.

Citrulline malate is listed at 715 mg, but the malate ratio is not disclosed. The likely active citrulline amount is only a fraction of a common performance serving, so it adds limited depth.

One mixed serving is convenient, though ongoing cost is only moderate for the amino-acid quantities. It fits users wanting an AAKG-led powder rather than a balanced high-dose arginine and citrulline formula.

Who is it for
  • Adults seeking an AAKG-centered powder
  • People focused on workout circulation
  • Users who prefer drink mixes to pills
Best for
  • Arginine-led pre-workout use
  • Powder-based dosing
  • Exercise blood-flow support

Pros

  • Useful AAKG amount
  • Powder avoids a multi-capsule serving
  • Vitamin C adds antioxidant support

Cons

  • Citrulline malate is underdosed
  • Malate ratio is not stated
  • Higher ongoing cost than basic amino-acid powders

Warnings

  • Arginine and citrulline may add to nitrates, blood-pressure medicines, or PDE-5 inhibitors and cause dizziness or excessive blood-pressure lowering.
  • Arginine can trigger herpes simplex recurrences in some susceptible users.
  • Higher amino-acid intake may cause nausea, cramping, or diarrhea.

Nutrient quality

84 Highest impact

A substantial AAKG amount provides strong core nitric-oxide support. Low estimated citrulline and an undisclosed malate ratio limit the supporting dose quality.

Ingredient transparency

79 High impact

All active totals are disclosed without a hidden blend. An unspecified malate ratio, missing full directions, and absent excipients reduce precision.

Customer satisfaction

61 Moderate impact

The supplied average rating is strong and the rating volume is limited. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money

62 Moderate impact

Weak dose depth or high cost limits practical value. Better-dosed or more transparent alternatives are more competitive.

Report analysis

Goals

Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitC+ Strength of SupportC- CoverageB+ Formula Quality
Arginine · 2050 mgVitamin C · 200 mgCitrulline · 715 mg

Arginine and citrulline directly support nitric oxide production and blood flow, giving the formula clear cardiovascular relevance. The arginine amount is useful, while the citrulline malate amount is too small and its ratio is not stated.

Vitamin C adds antioxidant support for the vascular pathway, making the combination coherent. The formula depends mainly on arginine because the citrulline contribution is unlikely to add much depth.

Study evidence
Arginine Supportive 47 studies
Citrulline Supportive 33 studies
Vitamin C Supportive 101 studies
Energy
Physical Stamina
Energy
Impact
High effect
C+ Goal FitC Strength of SupportD+ CoverageA Formula Quality

Arginine alpha-ketoglutarate is supplied at a substantial amount that may support exercise blood flow. Vitamin C and citrulline malate add related nitric-oxide and antioxidant support.

The estimated active citrulline amount is far below common performance dosing. The formula supports exercise circulation rather than cellular energy, alertness, or stress resilience.

Study evidence
Arginine No effect 7 studies
Citrulline No effect 14 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 200 mg
L-Arginine (Arginine Alpha-Ketoglutarate)
 2050 mg
Citrulline (Citrulline Malate)
 715 mg
Gluten Free Adults 18–50
Report overview
Arginine (Arginine Alpha-Ketoglutarate) · 2050 mg OverallScore77
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
AAKG and a strong serving amount align well with fitness-focused arginine use. Immediate-release powder is easy to take in one serving but does not prolong delivery. Cost per gram is moderate rather than especially economical.
View ingredientView products
Citrulline (Citrulline Malate) · 715 mg OverallScore28
D Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Citrulline Malate is disclosed, but the missing ratio makes active L-Citrulline content uncertain. Using a conservative conversion, the 715 mg malate serving provides about 358 mg of active L-Citrulline, which is substantially underdosed. Citrulline-specific value is poor because the cost per active gram is high.

View ingredientView products
Loading alternative details
67 Performance

Pump-Ocalypse Blue Raz

Bucked Up
Glycerol, citrulline, arginine, and agmatine form a coherent stimulant-free pump formula, but several amounts are moderate rather than full strength. An opaque mushroom blend and low betaine amount weaken dose quality and disclosure. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
73 Performance

Wellness ImmuNitric

Source Naturals
A substantial arginine amount with modest citrulline and B-vitamin support creates a coherent vascular formula at reasonable value. Duplicate folate entries reduce label clarity, and the vasodilating combination may add to nitrates or blood-pressure medicines. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
78 Performance

Arginine & Citrulline 500 mg / 250 mg

NOW Sports
A large supply of clearly disclosed L-arginine and L-citrulline offers efficient routine value. Very low serving amounts mean targeted nitric-oxide or exercise use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
74 Budget

Wellness ImmuNitric

Source Naturals
A substantial arginine amount with modest citrulline and B-vitamin support creates a coherent vascular formula at favorable value. Duplicate folate entries reduce clarity, and the three-tablet serving may add to the effects of nitrates or blood-pressure medicines. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
79 Budget

L-Arginine + L-Citrulline 750 mg

Nutricost
A large supply of clearly separated L-arginine and L-citrulline provides economical but basic nitric-oxide support. Both amounts are too low for targeted performance use without taking multiple capsules. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Budget

L-Arginine L-Citrulline Complex 1000 mg

Best Naturals
L-arginine hydrochloride and free-form citrulline provide a focused combination with good supply economy. The arginine amount is only moderate and the citrulline amount is far below targeted performance use. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Value

L-Arginine L-Citrulline Complex

Source Naturals
A large supply of focused arginine and citrulline offers reasonable routine value. The arginine amount is modest, the citrulline amount is far below targeted use, and arginine may add to blood-pressure-lowering medicines. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
77 Value

Arginine & Citrulline 500 mg/250 mg

NOW Sports
Clearly disclosed L-arginine and L-citrulline provide a focused nitric-oxide formula at a low serving cost. Both amounts are far below targeted performance ranges, so meaningful use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
80 Value

Nitric Oxide Booster

Nutricost Performance
Three arginine forms provide a moderate combined amount and clear nitric-oxide focus at favorable value. Citrulline remains underdosed, and the undisclosed citrulline-malate ratio makes its active contribution uncertain. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  2. Atorvastatin but not L-arginine improves endothelial function in type I diabetes mellitus: a double-blind study.
    Mullen MJ; Wright D; Donald AE; Thorne S; Thomson H; Deanfield JE · Journal of the American College of Cardiology · 2000
    Randomized trial84 participantsCardiovascular Support forArginine
  3. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  4. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  5. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  6. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  7. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
    Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
    Meta-analysis415 participants15 studies pooledCardiovascular Support forCitrulline
  8. Micronutrient Supplementation to Reduce Cardiovascular Risk.
    An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
    Meta-analysis883,627 participants884 studies pooledCardiovascular Support forCitrulline
  9. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
    Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Randomized trial10 participantsCardiovascular Support forCitrulline
  10. Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
    Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
    Randomized trial25 participantsCardiovascular Support forCitrulline
  11. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
    Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
    Randomized trial15 participantsCardiovascular Support forCitrulline
  12. Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
    Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
    Meta-analysis872 participants7 studies pooledCardiovascular Support forVitamin C
  13. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
    Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
    Clinical trial49 participantsCardiovascular Support forVitamin C
  14. Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
    Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
    Randomized trial24 participantsCardiovascular Support forVitamin C
  15. Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
    Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
    Randomized trial58 participantsCardiovascular Support forVitamin C
  16. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
    Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
    Randomized trial30 participantsCardiovascular Support forVitamin C
  17. Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
    Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
    Randomized trial15 participantsEnergy forArginine
  18. The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
    Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
    Non-randomized trial505 participantsEnergy forArginine
  19. Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
    Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
    Randomized trial29 participantsEnergy forArginine
  20. L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
    Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
    Randomized trial8 participantsEnergy forArginine
  21. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
    Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
    Randomized trial20 participantsEnergy forArginine
  22. Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
    Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
    Meta-analysis137 participants8 studies pooledEnergy forCitrulline
  23. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
    Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
    Randomized trial22 participantsEnergy forCitrulline
  24. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
    Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
    Randomized trial41 participantsEnergy forCitrulline
  25. Citrulline/malate promotes aerobic energy production in human exercising muscle.
    Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
    Single-arm trial18 participantsEnergy forCitrulline
  26. The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
    Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
    Randomized trial12 participantsEnergy forCitrulline