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Selenium (Selenomethionine)

Pure Encapsulations
4.7
★ ★ ★ ★ ★
(208 ratings)
Selenium 200 mcg
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Score77
Selenium (Selenomethionine) offers an identified organic form, though the label does not specify the L-isomer at 200 mcg per serving. It fits targeted selenium use, but buyers seeking broader daily nutrient support will need a different formula.
How scoring works
Quantity:180 Capsule(s) • (180 servings)
Goals:
Immunity
General Health

Score 77

Selenium (Selenomethionine) offers an identified organic form, though the label does not specify the L-isomer at 200 mcg per serving. It fits targeted selenium use, but buyers seeking broader daily nutrient support will need a different formula.
How scoring works
$37.50($0.20 per serving)
Pure Formulas
$ 37.50
Walmart
$ 37.50
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Analysis

A 200 mcg serving provides an identified organic form, though the label does not specify the L-isomer in a focused selenium formula. The substantial amount is clearly disclosed and suits people who have a specific reason to supplement selenium.

Selenium supports antioxidant enzymes, normal thyroid hormone conversion, and immune function. The single-active formula is easy to understand, but it does not cover the broader nutrient pathways involved in general wellness or immune support.

180 servings and a comparatively premium cost per serving make the format practical for consistent use. Because the serving already provides a substantial amount, total intake from food and other supplements deserves attention.

Who is it for
  • Adults seeking a 200 mcg selenium supplement
  • People who prefer capsules for routine use
  • Users who want a simple, single-active formula
Best for
  • Targeted selenium supplementation
  • Antioxidant enzyme support
  • Normal thyroid and immune function support

Pros

  • 200 mcg selenium amount is fully disclosed
  • Selenomethionine clearly identifies the active form
  • 180 servings per container support routine use
  • A comparatively premium cost per serving

Cons

  • The supplied label details do not describe inactive ingredients or other formulation features.
  • The focused formula does not provide vitamin D, zinc, vitamin C, or other complementary nutrients.
  • The substantial serving offers less flexibility for people who already get selenium from other sources.

Warnings

  • The 200 mcg selenium serving is substantial; include other selenium supplements when calculating total daily intake.
  • Frequent Brazil-nut intake or another selenium-rich product can materially increase the total alongside this 200 mcg serving.
  • Persistent hair or nail changes, a metallic taste, or a garlic-like breath odor can signal excessive selenium intake and warrant stopping use and seeking advice.

Nutrient quality

88 Highest impact

The focused selenium formula provides a meaningful amount for antioxidant, thyroid, and immune support. Form quality and dose balance determine the main strengths and trade-offs.

Ingredient transparency

77 High impact

The active amount is clearly disclosed without a hidden blend. Intake directions and non-active ingredients are not included, while form specificity varies by product.

Customer satisfaction

65 Moderate impact

The aggregate rating is favorable and the response base provides useful context. No review text is supplied, so repeated complaints and specific product experiences cannot be verified.

Value for money

72 High impact

The formula provides meaningful active nutrition but is less cost-efficient than stronger peers. Focused ingredients help, while price or form limitations reduce competitiveness.

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Goals

Immunity
Impact
Highest effect
B+ Goal FitA Strength of SupportC- CoverageA+ Formula Quality
Selenium · 200 mcg

Selenomethionine supplies a well-absorbed trace mineral needed for antioxidant enzymes and normal immune function. The amount is substantial and clearly disclosed.

Immune benefit beyond adequate selenium status is less certain, and the product does not address mucosal or symptom-focused pathways. The missing L-isomer detail limits precise form assessment.

Study evidence
Selenium Mixed 37 studies
General Health
Impact
High effect
B+ Goal FitA- Strength of SupportC- CoverageA- Formula Quality
Selenium · 200 mcg

Selenomethionine supplies an essential trace mineral involved in antioxidant enzymes and thyroid hormone metabolism. The 200 mcg serving is clearly disclosed and matches a commonly used supplemental amount.

The narrow formula can help correct inadequate selenium intake but does not provide broad daily nutrition. Long-term use deserves care because the amount is well above the adult daily requirement even though it remains below the established upper limit.

Study evidence
Selenium Supportive 70 studies

Ingredients

IngredientAmount per serving
Selenium (Selenomethionine)
200 mcg
Gluten Free Adults 18–50
Report overview
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Selenomethionine supplies an organic selenium form, but the missing L-isomer detail limits confidence in its exact quality. The serving matches the common clinical target and leaves a useful margin below the upper limit. Cost per target amount is favorable, though clearer sourcing would strengthen the offering.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses.
    Wang P; Chen B; Huang Y; Li J; Cao D; Chen Z; Li J; Ran B; Yang J; Wang R; Wei Q; Dong Q; Liu L · Frontiers in nutrition · 2024
    Systematic reviewGeneral Health forSelenium
  2. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forSelenium
  3. Effect of long-term selenium supplementation on mortality: Results from a multiple-dose, randomised controlled trial.
    Rayman MP; Winther KH; Pastor-Barriuso R; Cold F; Thvilum M; Stranges S; Guallar E; Cold S · Free radical biology & medicine · 2019
    Randomized trial491 participantsGeneral Health forSelenium
  4. Selenium and immune function: a systematic review and meta-analysis of experimental human studies.
    Filippini T; Fairweather-Tait S; Vinceti M · The American journal of clinical nutrition · 2023
    Meta-analysis9 studies pooledImmunity forSelenium
  5. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.
    Ivory K; Prieto E; Spinks C; Armah CN; Goldson AJ; Dainty JR; Nicoletti C · Clinical nutrition (Edinburgh, Scotland) · 2018
    Randomized trial117 participantsImmunity forSelenium
  6. Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status.
    Demircan K; Chillon TS; Sun Q; Heller RA; Klingenberg GJ; Hirschbil-Bremer IM; Seemann P; Diegmann J; Bachmann M; Moghaddam A; Schomburg L · Redox biology · 2022
    Cohort study126 participantsImmunity forSelenium
  7. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  8. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  9. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  10. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  11. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  12. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  13. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  14. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  15. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  16. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium