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Bio E 400 IU + Selenium

Solaray
4.8
★ ★ ★ ★ ★
(1138 ratings)
Selenium 100 mcg
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Score77
A transparent vitamin E and selenium combination with a meaningful lecithin amount. High vitamin E and incomplete lecithin detail reduce everyday flexibility.
How scoring works
Quantity:120 Softgel(s) • (60 servings)
Goals:
General Health
Immunity

Score 77

A transparent vitamin E and selenium combination with a meaningful lecithin amount. High vitamin E and incomplete lecithin detail reduce everyday flexibility.
How scoring works
$28.89($0.48 per serving)
iHerb
$ 28.89
Vitacost
$ 28.89
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Analysis

Vitamin E is provided as d-alpha-tocopherol at 268 mg, with 100 mcg L-selenomethionine adding complementary antioxidant-enzyme support. Lecithin contributes 1,600 mg, though its source and phospholipid composition are not supplied.

The vitamin E amount is far above basic maintenance needs and should be used deliberately. Selenium form and amount are clear, while the lack of lecithin composition prevents judging its meaningful active yield.

Two softgels deliver the full serving and may suit people specifically wanting this combination. Moderate value and a high vitamin E exposure make simpler selenium products more practical when selenium is the main goal.

Who is it for
  • Adults specifically seeking vitamin E with selenium
  • People interested in a lecithin-containing softgel
Best for
  • Antioxidant nutrient intake
  • Combined vitamin E and selenium support
  • Lecithin supplementation

Pros

  • Uses natural d-alpha-tocopherol
  • Uses L-selenomethionine
  • Provides a substantial lecithin amount
  • Clearly lists all active amounts

Cons

  • Vitamin E amount is high
  • Lecithin source and composition are not stated
  • Two-softgel serving
  • Only moderate value

Warnings

  • High-dose vitamin E may increase bleeding risk with warfarin, other anticoagulants, or antiplatelet medicines.
  • Vitamin E may need to be stopped before planned surgery when the surgical team advises.
  • The lecithin source is not supplied here, so people with soy or egg allergy should verify the complete package label.

Nutrient quality

85 Highest impact

L-selenomethionine is a preferred organic form with clear isomer disclosure. The selenium amount leaves a comfortable margin below the adult upper limit.

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Ingredient transparency

83 Highest impact

The selenium amount and source are clearly stated. Complete directions and inactive ingredients are not supplied.

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Customer satisfaction

72 High impact

The supplied aggregate rating indicates very strong customer satisfaction. Specific comments are unavailable, so complaint patterns and intended-use fit cannot be verified.

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Value for money

64 Moderate impact

Premium selenium and natural vitamin E provide quality, but the high vitamin E amount and serving cost reduce value. Simpler selenium products are more efficient.

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Report analysis

Goals

General Health
Impact
High effect
A- Goal FitB Strength of SupportC+ CoverageA Formula Quality
Selenium · 100 mcg

Natural vitamin E and L-selenomethionine provide a focused antioxidant combination, while lecithin supplies a lipid carrier. The forms and amounts are clearly disclosed.

The vitamin E amount is high for routine general-health use and may increase bleeding tendency, especially with anticoagulant or antiplatelet medicines. The formula has meaningful antioxidant depth but limited pathway breadth.

Study evidence
Selenium Supportive 70 studies
Immunity
Impact
High effect
C+ Goal FitA- Strength of SupportC+ CoverageB+ Formula Quality
Selenium · 100 mcg

Selenium and natural vitamin E provide focused antioxidant support relevant to a controlled immune response. L-selenomethionine is a well-absorbed selenium form.

The formula does not address vitamin C, vitamin D, zinc, or barrier support. The high vitamin E amount may increase bleeding risk for people using anticoagulant or antiplatelet medicines.

Study evidence
Selenium Mixed 37 studies
Vitamin E Supportive 21 studies

Ingredients

IngredientAmount per serving
Calories
30 Calorie(s)
Vitamin E (D-Alpha-Tocopherol)
268 mg
Selenium (L-Selenomethionine)
100 mcg
Lecithin
1600 mg
Adults 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
L-selenomethionine provides a highly bioavailable organic source with clear isomer disclosure. The dose supports daily maintenance and remains comfortably below the daily upper limit. Cost efficiency is poor when standardized to a full selenium amount. Value from the broader vitamin E formula may still matter beyond selenium alone.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  2. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  3. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  4. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  5. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  6. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  7. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  8. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  9. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  10. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  11. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
    Meydani SN; Barklund MP; Liu S; Meydani M; Miller RA; Cannon JG; Morrow FD; Rocklin R; Blumberg JB · The American journal of clinical nutrition · 1990
    Randomized trial32 participantsImmunity forVitamin E
  12. Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
    Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
    Randomized trial150 participantsImmunity forVitamin E
  13. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
    Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
    Randomized trialImmunity forVitamin E
  14. Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
    Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
    Randomized trial29,133 participantsImmunity forVitamin E
  15. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial.
    Meydani SN; Meydani M; Blumberg JB; Leka LS; Siber G; Loszewski R; Thompson C; Pedrosa MC; Diamond RD; Stollar BD · JAMA · 1997
    Randomized trial88 participantsImmunity forVitamin E