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MegaFolinic 800 mcg

Source Naturals
4.9
★ ★ ★ ★ ★
(5777 ratings)
Folate 800 mcg
Product Image
Score88
A simple folinic-acid tablet provides a useful reduced folate form with excellent value. The high amount and absence of B12 call for deliberate long-term use.
How scoring works
Quantity:240 Tablet(s) • (240 servings)
Goals:
General Health
Hair Health

Score 88

A simple folinic-acid tablet provides a useful reduced folate form with excellent value. The high amount and absence of B12 call for deliberate long-term use.
How scoring works
$11.44($0.04 per serving)
iHerb
$ 12.42
Amazon
$ 12.04
Pure Formulas
$ 11.44
Vitacost
$ 12.93
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Analysis

Each tablet supplies 800 mcg of folate as calcium folinate, also called folinic acid. That reduced form avoids several conversion steps required by folic acid and offers an alternative to methylfolate.

A focused single-active formula and 240-serving bottle make dosing simple and economical. The amount is substantial rather than basic, so it is best used for a defined purpose.

No vitamin B12 is included. It fits users specifically seeking folinic acid who separately maintain B12 status and confirm that the amount matches their plan.

Who is it for
  • Adults seeking folinic acid rather than folic acid
  • Users who do not tolerate or need methylfolate
  • People who separately maintain vitamin B12
Best for
  • Targeted folinic-acid supplementation
  • One-tablet dosing
  • Long-supply value

Pros

  • Uses reduced calcium folinate
  • Clearly states an 800 mcg amount
  • Provides 240 servings
  • Offers excellent value

Cons

  • No vitamin B12 is included
  • The amount exceeds basic daily coverage
  • No separate DFE source breakdown is supplied

Warnings

  • High folate without adequate B12 can mask blood signs of B12 deficiency
  • Calcium folinate can interact with some antifolate medicines and should follow prescriber instructions
  • People using folate for a specific medical protocol should confirm that folinic acid, rather than 5-MTHF or folic acid, is the intended form

Nutrient quality

90 Highest impact

The focused single-nutrient formula contains no active padding. The high amount without vitamin B12 warrants added caution.

Ingredient transparency

90 Highest impact

The calcium folinate amount is stated clearly. The supplied data omit a complete inactive-ingredient list.

Customer satisfaction

74 High impact

Feedback volume is substantial enough to stabilize the aggregate signal. No complaint text is supplied, so repeated negative themes cannot be assessed.

Value for money

98 Highest impact

No extras inflate the formula. The active form and low relative cost provide excellent value.

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Goals

General Health
General Health
Impact
Highest effect
A Goal FitA Strength of SupportC CoverageA+ Formula Quality
Folate · 800 mcg

Calcium folinate provides a reduced folate form that supports methylation, DNA synthesis, and red blood cell formation. The clearly disclosed amount is substantial for targeted folate support.

The single-nutrient formula is clean and focused but does not include vitamin B12 or cover wider daily nutrient needs. People using folate to address a deficiency should ensure that an unrecognized vitamin B12 deficiency is not being masked.

Study evidence
Folate Supportive 80 studies
Hair Health
Hair Health
Impact
High effect
D+ Goal FitA Strength of SupportD- CoverageA Formula Quality

Folate may support rapid follicle cell division when deficiency is present, but it is a narrow and indirect hair intervention. Deficiency biology is established, while extra folate has limited evidence for improving hair in replete users.

The 800 mcg amount is substantial for folate nutrition. The single-nutrient design is coherent for targeted folate support.

Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per serving
Folate (Calcium Folinate)
 800 mcg
Gluten Free Adults 18–50 Vegan Dairy Free Sugar Free Vegetarian
Report overview
Folate (Calcium Folinate) · 800 mcg OverallScore80
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyA+ Value

Calcium folinate provides a useful 800 mcg serving in a metabolically active form. The active amount is clear, although the label does not provide a separate DFE source breakdown. Low serving cost makes the active folate especially economical.

View ingredientView products
Loading alternative details
86 Performance

Methyl B-12 Methyl Folate Lonzenge Natural Cherry Flavor

Solaray
<p>Methylcobalamin and branded methylfolate provide a high-quality active-form pairing at targeted amounts, providing broader B-vitamin cofactor coverage than calcium folinate alone. The vitamin B12 concentration may exceed basic maintenance needs.</p>
86 Performance

B-6 B-12 Folic Acid Drop Ins Natural Mixed Berry Flavor

KAL
<p>Active vitamin B6, methylfolate, and methylcobalamin provide strong form quality in a flexible liquid, providing broader B-vitamin cofactor coverage than calcium folinate alone. The concentrated vitamin B12 amount is more suited to targeted use than basic maintenance.</p>
82 Performance

BioActive Vitamin B

Terry Naturally
<p>Active forms of vitamin B6, vitamin B12, and folate create a compact and well-targeted B-vitamin formula, providing broader B-vitamin cofactor coverage than calcium folinate alone. The vitamin B6 amount may be more than many users need for long-term daily use.</p>
84 Budget

Folic Acid 800 mcg

Spring Valley
<p>A substantial folic acid amount provides simple targeted support at the lowest listed serving cost, making it a more economical alternative to the active folinate-only tablet. Synthetic folic acid requires conversion and the missing vitamin B12 can allow an unrecognized B12 deficiency to remain hidden.</p>
80 Budget

Folic Acid 400 mcg

Carlson
<p>A simple folic acid tablet provides useful daily coverage at very low serving cost, making it a more economical alternative to the active folinate-only tablet. The label does not clearly separate source folic acid from dietary folate equivalents, and vitamin B12 is absent.</p>
80 Budget

Multi Gummies plus Extra C

21st Century Zoo Friends
<p>A low-cost children’s gummy provides a modest spread of vitamins in an easy format, and although no eligible choice fills every cheaper slot below the active folinate-only tablet, it is among the closest low-cost options. Folate and several other forms are basic or unspecified, making it light nutritional coverage rather than targeted folate support.</p>
87 Value

Methyl Folate 800 mcg

KAL
<p>Active 6S methylfolate provides biologically ready folate at a substantial amount and favorable serving value, offering a competitive active-folate trade-off for users choosing between folinate and methylfolate. The high folate exposure is not paired with vitamin B12, which can leave an unrecognized B12 deficiency hidden.</p>
88 Value

Methylfolate 1333 mcg DFE (800 mcg (6S)-5-Methyltetrahydrofolate) Orange Flavor

Country Life
<p>Explicitly identified 6S methylfolate provides a biologically ready form with clear dietary-equivalent context, offering a competitive active-folate trade-off for users choosing between folinate and methylfolate. The substantial amount is not paired with vitamin B12, so prolonged use could mask an unrecognized B12 deficiency.</p>
85 Value

5-Methyl Folate 1000 mcg

Protocol For Life Balance
<p>Quatrefolic provides a body-ready methylfolate form at a high targeted amount with clear isomer detail, offering a competitive active-folate trade-off for users choosing between folinate and methylfolate. The high folate exposure lacks vitamin B12 and could mask an unrecognized B12 deficiency.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsGeneral Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsGeneral Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsGeneral Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewGeneral Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledGeneral Health forFolate
  6. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  7. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate
  8. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  9. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  10. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate