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MotilPro

Pure Encapsulations
3.9
★ ★ ★ ★ ★
(33 ratings)
Acetyl L-Carnitine 500 mg
Ginger
5-HTP 50 mg
Product Image
Score70
A strong ginger-led motility formula with useful supporting actives, but significant 5-HTP interactions and a burdensome serving.
How scoring works
Quantity:180 Capsule(s) • (60 servings)
Goals:
Digestive Health
Anti-Inflammatory Support
Energy
Weight Loss
Metabolism Boost
Mood Support
Anti-Aging
Mental Focus

Score 70

A strong ginger-led motility formula with useful supporting actives, but significant 5-HTP interactions and a burdensome serving.
How scoring works
$66.00($1.10 per serving)
Pure Formulas
$ 66.00
Report prices

Analysis

Ginger extract provides the primary digestive and motility rationale at a substantial amount. Acetyl-L-carnitine adds a separate nerve and energy-related pathway rather than direct bowel bulk.

5-HTP may influence serotonin-linked gut signaling, while active vitamin B6 supports related metabolism. The extract is identified with gingerols, but the actual gingerol percentage is missing.

The formula is more targeted than a general digestive supplement and contains no fiber, enzymes, or probiotics. Its six-capsule daily serving and premium cost reduce convenience.

Who is it for
  • Adults seeking targeted motility support
  • Users who tolerate ginger and 5-HTP
  • People working with a professional on persistent motility concerns
Best for
  • Digestive motility support
  • Ginger-based digestive routines
  • Targeted prokinetic supplementation

Pros

  • Substantial ginger extract amount
  • Includes acetyl-L-carnitine
  • Uses active P-5-P vitamin B6

Cons

  • Gingerol strength is not disclosed
  • Six-capsule daily serving
  • Premium serving cost

Warnings

  • 5-HTP can interact with SSRIs, SNRIs, MAO inhibitors, and other serotonergic medicines
  • Ginger may increase bleeding tendency with anticoagulant or antiplatelet drugs
  • The pro-motility combination may cause cramping or loose stools

Nutrient quality

82 Highest impact

Strong forms and substantial ginger and carnitine doses support the focused formula. Bleeding and serotonergic interaction risks materially limit suitability.

.

Ingredient transparency

84 Highest impact

Active names and doses are clearly disclosed. Non-active ingredients and complete usage directions remain missing.

.

Customer satisfaction

40 Lower impact

The supplied average rating is weak. No specific review comments were supplied, so repeated negative experiences cannot be assessed.

.

Value for money

63 Moderate impact

Strong forms and meaningful doses provide real formula value. High serving cost and a very small satisfaction sample reduce confidence.

.
Report analysis

Goals

Digestive Health
Gas and Bloating Relief
Digestive Health
Impact
Highest effect
A- Goal FitB+ Strength of SupportB+ CoverageA- Formula Quality

Ginger, acetyl-L-carnitine, vitamin B6, and 5-HTP create a targeted pro-motility formula that may also ease nausea. Ginger provides the strongest direct digestive evidence, while the neural ingredients make the combination more specialized.

The ginger amount is meaningful and the extract identifies gingerols, although their percentage is not stated. Because 5-HTP raises serotonin, combining it with serotonergic antidepressants can increase the risk of serotonin toxicity.

Study evidence
Ginger Supportive 31 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B+ Goal FitA- Strength of SupportC+ CoverageC Formula Quality

A substantial ginger extract amount provides direct support for inflammatory signaling and is the formula’s main strength for this goal. P-5-P is a well-chosen supporting nutrient form.

The gingerol percentage is not stated, and the remaining ingredients are organized around digestive motility. The 5-HTP can interact with serotonergic antidepressants and raise serotonin-related adverse-effect risk.

Study evidence
Ginger Supportive 30 studies
Energy
Energy
Impact
High effect
B- Goal FitA- Strength of SupportC+ CoverageC+ Formula Quality
Acetyl L-Carnitine · 500 mg

Acetyl-L-carnitine supports mitochondrial fuel transport and may help mental energy in selected users. The disclosed amount is useful for focused supplementation.

Ginger and 5-HTP make the formula primarily digestive, while 5-HTP may work against alertness in some users. The 5-HTP can raise serotonin-toxicity risk with SSRIs, MAO inhibitors, or other serotonergic medicines.

Study evidence
Acetyl L-Carnitine Supportive 19 studies
Weight Loss
Weight Loss
Impact
High effect
C Goal FitB- Strength of SupportB+ CoverageB+ Formula Quality

Ginger may modestly support thermogenesis and satiety, while 5-HTP may help some people with appetite or carbohydrate cravings. Acetyl-L-carnitine adds a fat-transport pathway with situational value.

Ginger and carnitine amounts are useful, but the gingerol strength and carnitine source details are incomplete and 5-HTP is modest. The 5-HTP should not be combined with serotonergic medicines such as SSRIs or MAO inhibitors because serotonin toxicity can occur.

Study evidence
5-HTP Supportive 5 studies
Ginger Supportive 15 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C+ Goal FitB+ Strength of SupportC CoverageB- Formula Quality
Vitamin B6 · 6.7 mgAcetyl L-Carnitine · 500 mg

Acetyl-L-carnitine directly supports mitochondrial fatty-acid transport, and one gram of ginger adds a secondary metabolic and digestive pathway. The formula is better aligned with motility and cellular energy than with thermogenesis.

The carnitine and ginger amounts are meaningful, though gingerol standardization and carnitine salt details are incomplete. Fifty milligrams of 5-HTP may interact with serotonergic medicines and increase the risk of serotonin toxicity.

Study evidence
Acetyl L-Carnitine Adverse 1 study
Ginger Supportive 13 studies
Vitamin B6 Supportive 16 studies
Mood Support
Mood Support
Impact
High effect
B- Goal FitC+ Strength of SupportC- CoverageC+ Formula Quality
Vitamin B6 · 6.7 mg5-HTP · 50 mg

5-HTP directly supports serotonin synthesis and active B6 supplies a useful conversion cofactor. Acetyl L-carnitine adds a separate mitochondrial and neurological pathway.

The 5-HTP amount suits cautious use, while the large ginger amount reflects the digestive purpose of the formula. 5-HTP should not be combined casually with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonergic agents.

Study evidence
5-HTP Supportive 9 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate)
 6.7 mg
Ginger Root Extract (Gingerols)
 1000 mg
Acetyl-L-Carnitine
500 mg
5-Hydroxytryptophan
50 mg
Gluten Free Adults 18–50 Women
Report overview
Acetyl L-Carnitine · 500 mg OverallScore72
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value

The formula provides an effective ALCAR amount, but the salt and sourcing details are missing. Its exact dose is clearly stated alongside a substantial ginger extract. The cost per effective ALCAR amount remains excessive, and 5-HTP may interact with serotonergic medicines by increasing the risk of serotonin toxicity.

View ingredientView products
Ginger (Gingerols) · 1000 mg OverallScore70
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

An extract identified with gingerols provides some quality detail, but the actual gingerol strength is missing. The 1,000 mg daily dose is well aligned with common therapeutic use. A higher serving cost leaves value only moderate despite the useful dose.

View ingredientView products
5-HTP · 50 mg OverallScore39
D Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyF Value

The label identifies 5-HTP but gives no botanical source or active standardization. A standard capsule offers convenient dosing but no comfort-focused release feature; the serving suits cautious starting use, although the supplied label data include no specific serotonin-medication warning. The normalized cost is poor for the disclosed active amount.

View ingredientView products
Loading alternative details
63 Performance

Healthy Fat Burner

Terra Origin
<p>Acetyl-L-carnitine matches the original dose and ginger is retained at a lower serving cost. The formula is aimed more at stimulation and weight management, with caffeine, bitter orange, and yohimbine adding trade-offs that make it a weak digestive substitute.</p>
68 Performance

Menopause Support

NOW
<p>Ginger and 5-HTP are the only meaningful overlaps, and the lower serving cost makes it cheaper than the original. The small ginger amount and menopause-focused ingredient mix do not establish it as a stronger digestive-motility option.</p>
68 Budget

Menopause Support

NOW
<p>Ginger and 5-HTP are the only meaningful overlaps, and the lower serving cost makes it cheaper than the original. The small ginger amount and menopause-focused ingredient mix do not establish it as a stronger digestive-motility option.</p>
63 Budget

Healthy Fat Burner

Terra Origin
<p>Acetyl-L-carnitine matches the original dose and ginger is retained at a lower serving cost. The formula is aimed more at stimulation and weight management, with caffeine, bitter orange, and yohimbine adding trade-offs that make it a weak digestive substitute.</p>
63 Value

Healthy Fat Burner

Terra Origin
<p>Acetyl-L-carnitine matches the original dose and ginger is retained at a lower serving cost. The formula is aimed more at stimulation and weight management, with caffeine, bitter orange, and yohimbine adding trade-offs that make it a weak digestive substitute.</p>
68 Value

Menopause Support

NOW
<p>Ginger and 5-HTP are the only meaningful overlaps, and the lower serving cost makes it cheaper than the original. The small ginger amount and menopause-focused ingredient mix do not establish it as a stronger digestive-motility option.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of ginger on gastric motility and symptoms of functional dyspepsia.
    Hu ML; Rayner CK; Wu KL; Chuah SK; Tai WC; Chou YP; Chiu YC; Chiu KW; Hu TH · World journal of gastroenterology · 2011
    Randomized trial11 participantsDigestive Health forGinger
  2. Carnitine for fatigue in multiple sclerosis.
    Tejani AM; Wasdell M; Spiwak R; Rowell G; Nathwani S · The Cochrane database of systematic reviews · 2012
    Systematic review1 studies pooledEnergy forAcetyl L-Carnitine
  3. Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients.
    Rossini M; Di Munno O; Valentini G; Bianchi G; Biasi G; Cacace E; Malesci D; La Montagna G; Viapiana O; Adami S · Clinical and experimental rheumatology · 2007
    Randomized trial102 participantsEnergy forAcetyl L-Carnitine
  4. The effects of ginger on gallbladder motility in healthy male humans.
    Chuah SK; Wu KL; Tai WC; Changchien CS · Journal of neurogastroenterology and motility · 2012
    Randomized trial19 participantsDigestive Health forGinger
  5. A Purported Detoxification Supplement Does Not Improve Body Composition, Waist Circumference, Blood Markers, or Gastrointestinal Symptoms in Healthy Adult Females.
    Tinsley G; Urbina S; Santos E; Villa K; Foster C; Wilborn C; Taylor L · Journal of dietary supplements · 2020
    Randomized trialDigestive Health forGinger
  6. Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort.
    Montanari S; Jansen R; Schranner D; Kastenmüller G; Arnold M; Janiri D; Sani G; Bhattacharyya S; Mahmoudian Dehkordi S; Dunlop BW; Rush AJ; Penninx BWHJ; Kaddurah-Daouk R; Milaneschi Y · Translational psychiatry · 2025
    Cohort study2,574 participantsEnergy forAcetyl L-Carnitine
  7. Efficacy and safety of steamed ginger extract for gastric health: a randomized, double-blind, placebo-controlled multi-center clinical trial.
    Baek HI; Ha NR; Kim C; Im TJ; Kim YY; Hwang SH; Bae JW · Food & function · 2025
    Randomized trial80 participantsDigestive Health forGinger
  8. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
    Malaguarnera M; Vacante M; Giordano M; Pennisi G; Bella R; Rampello L; Malaguarnera M; Li Volti G; Galvano F · The American journal of clinical nutrition · 2011
    Randomized trial121 participantsEnergy forAcetyl L-Carnitine
  9. A Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Comparative Clinical Study to Evaluate the Efficacy and Safety of OLNP-06 versus Placebo in Subjects with Functional Dyspepsia.
    Panda MPharm SK; Nirvanashetty PhD S; Parachur BTech VA; Krishnamoorthy MPharm C; Dey MSc S · Journal of dietary supplements · 2022
    Randomized trial50 participantsDigestive Health forGinger
  10. The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.
    Malaguarnera M; Vacante M; Bertino G; Neri S; Malaguarnera M; Gargante MP; Motta M; Lupo L; Chisari G; Bruno CM; Pennisi G; Bella R · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012
    Randomized trial60 participantsEnergy forAcetyl L-Carnitine
  11. The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial.
    Foshati S; Poursadeghfard M; Heidari Z; Amani R · BMC complementary medicine and therapies · 2023
    Randomized trial52 participantsDigestive Health forGinger
  12. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
    Malaguarnera M; Bella R; Vacante M; Giordano M; Malaguarnera G; Gargante MP; Motta M; Mistretta A; Rampello L; Pennisi G · Scandinavian journal of gastroenterology · 2011
    Randomized trial67 participantsEnergy forAcetyl L-Carnitine
  13. Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials.
    Anh NH; Kim SJ; Long NP; Min JE; Yoon YC; Lee EG; Kim M; Kim TJ; Yang YY; Son EY; Yoon SJ; Diem NC; Kim HM; Kwon SW · Nutrients · 2020
    Systematic review109 studies pooledDigestive Health forGinger
  14. A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy.
    Sun Y; Shu Y; Liu B; Liu P; Wu C; Zheng R; Zhang X; Zhuang Z; Deng Y; Zheng L; Xu Q; Jiang B; Ouyang X; Gao J; Xu N; Li X; Jiang S; Liang C; Yao Y · Experimental and therapeutic medicine · 2020
    Randomized trial239 participantsEnergy forAcetyl L-Carnitine
  15. [Is ginger a relevant antiemetic for postoperative nausea and vomiting?].
    Morin AM; Betz O; Kranke P; Geldner G; Wulf H; Eberhart LH · Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS · 2004
    Meta-analysis538 participantsDigestive Health forGinger
  16. Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study.
    Ledinek AH; Sajko MC; Rot U · Clinical neurology and neurosurgery · 2014
    Randomized trial60 participantsEnergy forAcetyl L-Carnitine
  17. Clinical Evaluation of the Use of Ginger Extract in the Preventive Management of Motion Sickness.
    Nunes CP; Rodrigues CC; Cardoso CAF; Cytrynbaum N; Kaufman R; Rzetelna H; Goldwasser G; Santos A; Oliveira L; Geller M · Current therapeutic research, clinical and experimental · 2022
    Randomized trial31 participantsDigestive Health forGinger
  18. Carnitine for fatigue in multiple sclerosis.
    Tejani AM; Wasdell M; Spiwak R; Rowell G; Nathwani S · The Cochrane database of systematic reviews · 2010
    Systematic review1 studies pooledEnergy forAcetyl L-Carnitine
  19. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial.
    Giacosa A; Guido D; Grassi M; Riva A; Morazzoni P; Bombardelli E; Perna S; Faliva MA; Rondanelli M · Evidence-based complementary and alternative medicine : eCAM · 2015
    Randomized trialDigestive Health forGinger
  20. Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.
    Kumar R; Nuñez NA; Joshi N; Joseph B; Verde A; Seshadri A; Cuellar Barboza AB; Prokop LJ; Medeiros GC; Singh B · Bipolar disorders · 2024
    Systematic reviewEnergy forAcetyl L-Carnitine
  21. Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
    Malaguarnera G; Catania VE; Bertino G; Chisari LM; Castorina M; Bonfiglio C; Cauli O; Malaguarnera M · Current pharmaceutical design · 2022
    Randomized trial92 participantsAnti-Aging forAcetyl L-Carnitine
  22. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis.
    Mazidi M; Gao HK; Rezaie P; Ferns GA · Food & nutrition research · 2022
    Meta-analysis9 studies pooledAnti-Inflammatory Support forGinger
  23. Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.
    Musazadeh V; Morvaridi M; Hosseini-Roknabadi SM; Mahmoudinezhad M; Jafari A; Shidfar F · Diabetology & metabolic syndrome · 2026
    Meta-analysis43,570 participants36 studies pooledAnti-Inflammatory Support forGinger
  24. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
    Mozaffari-Khosravi H; Naderi Z; Dehghan A; Nadjarzadeh A; Fallah Huseini H · Journal of nutrition in gerontology and geriatrics · 2017
    Randomized trial120 participantsAnti-Inflammatory Support forGinger
  25. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.
    Broeckel J; Estes L; Leonard M; Dickerson BL; Gonzalez DE; Purpura M; Jäger R; Sowinski RJ; Rasmussen CJ; Kreider RB · Nutrients · 2025
    Randomized trial30 participantsAnti-Inflammatory Support forGinger
  26. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
    Aryaeian N; Shahram F; Mahmoudi M; Tavakoli H; Yousefi B; Arablou T; Jafari Karegar S · Gene · 2019
    Randomized trial70 participantsAnti-Inflammatory Support forGinger
  27. Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
    Malaguarnera M; Gargante MP; Cristaldi E; Vacante M; Risino C; Cammalleri L; Pennisi G; Rampello L · Digestive diseases and sciences · 2008
    Randomized trial125 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  28. Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
    Spagnoli A; Lucca U; Menasce G; Bandera L; Cizza G; Forloni G; Tettamanti M; Frattura L; Tiraboschi P; Comelli M · Neurology · 1991
    Randomized trial130 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  29. Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome.
    Herrmann WM; Dietrich B; Hiersemenzel R · International journal of clinical pharmacology research · 1990
    Randomized trialBrain Health forAcetyl L-Carnitine
  30. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
    Malaguarnera M; Vacante M; Motta M; Giordano M; Malaguarnera G; Bella R; Nunnari G; Rampello L; Pennisi G · Metabolic brain disease · 2012
    Randomized trial61 participantsBrain Health Cognitive Support forAcetyl L-Carnitine
  31. Acetyl-L-carnitine in the treatment of mildly demented elderly patients.
    Passeri M; Cucinotta D; Bonati PA; Iannuccelli M; Parnetti L; Senin U · International journal of clinical pharmacology research · 1990
    Randomized trial60 participantsBrain Health Mental Focus forAcetyl L-Carnitine
  32. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  33. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  34. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  35. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health forVitamin B6
  36. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  37. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
    Torrioli MG; Vernacotola S; Peruzzi L; Tabolacci E; Mila M; Militerni R; Musumeci S; Ramos FJ; Frontera M; Sorge G; Marzullo E; Romeo G; Vallee L; Veneselli E; Cocchi E; Garbarino E; Moscato U; Chiurazzi P; D'Iddio S; Calvani M; Neri G · American journal of medical genetics. Part A · 2008
    Randomized trial63 participantsCognitive Support forAcetyl L-Carnitine
  38. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.
    Malaguarnera M; Gargante MP; Cristaldi E; Colonna V; Messano M; Koverech A; Neri S; Vacante M; Cammalleri L; Motta M · Archives of gerontology and geriatrics · 2008
    Randomized trial96 participantsCognitive Support forAcetyl L-Carnitine
  39. Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial.
    Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
    Randomized trial62 participantsMental Focus Productivity Boost forAcetyl L-Carnitine
  40. [Psycho-functional changes in attention and learning under the action of L-acetylcarnitine in 17 young subjects. A pilot study of its use in mental deterioration].
    Lino A; Boccia MM; Rusconi AC; Bellomonte L; Cocuroccia B · La Clinica terapeutica · 1992
    Non-randomized trial17 participantsMental Focus forAcetyl L-Carnitine
  41. Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial.
    Arnold LE; Amato A; Bozzolo H; Hollway J; Cook A; Ramadan Y; Crowl L; Zhang D; Thompson S; Testa G; Kliewer V; Wigal T; McBurnett K; Manos M · Journal of child and adolescent psychopharmacology · 2008
    Randomized trial112 participantsMental Focus forAcetyl L-Carnitine
  42. Acetyl-L-carnitine for patients with hepatic encephalopathy.
    Martí-Carvajal AJ; Gluud C; Arevalo-Rodriguez I; Martí-Amarista CE · The Cochrane database of systematic reviews · 2019
    Meta-analysis398 participants5 studies pooledMental Focus forAcetyl L-Carnitine
  43. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort.
    Deijen JB; van der Beek EJ; Orlebeke JF; van den Berg H · Psychopharmacology · 1995
    Randomized trial76 participantsMental Focus forVitamin B6
  44. The effect of vitamin B6 on cognition.
    Malouf R; Grimley Evans J · The Cochrane database of systematic reviews · 2004
    Systematic review109 participants2 studies pooledMental Focus forVitamin B6
  45. Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.
    Cho Y; Choi EY; Han JY; Kim H; Choe YJ; Shin JY · BMC medicine · 2025
    Cohort study630,904 participantsMental Focus forVitamin B6
  46. A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
    Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
    Randomized trial44 participantsMental Focus forVitamin B6
  47. B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial
    Tammy M Scott, Graham Rogers, Daniel E Weiner, Kathryn Livingston, Jacob Selhub, Paul F Jacques, Irwin H Rosenberg, Aron M Troen · The Journal of Prevention of Alzheimer's Disease · 2017
    Randomized trial584 participantsMental Focus forVitamin B6
  48. Low Bioavailability and High TMAO Production: Novel Insights Into Acetylcarnitine and Carnitine Metabolism.
    Krims-Davis K; Ozola M; Razzivina V; Gukalova B; Konrade I; Dambrova M; Liepinsh E · Molecular nutrition & food research · 2025
    Randomized trialMetabolism Boost forAcetyl L-Carnitine
  49. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.
    Arablou T; Aryaeian N; Valizadeh M; Sharifi F; Hosseini A; Djalali M · International journal of food sciences and nutrition · 2015
    Randomized trial70 participantsMetabolism Boost forGinger
  50. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
    Mozaffari-Khosravi H; Talaei B; Jalali BA; Najarzadeh A; Mozayan MR · Complementary therapies in medicine · 2014
    Randomized trial88 participantsMetabolism Boost forGinger
  51. Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT.
    Ebrahimzadeh Attari V; Ostadrahimi A; Asghari Jafarabadi M; Mehralizadeh S; Mahluji S · European journal of nutrition · 2017
    Randomized trial80 participantsMetabolism Boost Weight Loss forGinger
  52. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients.
    Mahluji S; Attari VE; Mobasseri M; Payahoo L; Ostadrahimi A; Golzari SE · International journal of food sciences and nutrition · 2014
    Randomized trial64 participantsMetabolism Boost forGinger
  53. Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial.
    Rafie R; Hosseini SA; Hajiani E; Saki Malehi A; Mard SA · Clinical and experimental gastroenterology · 2022
    Randomized trial46 participantsMetabolism Boost forGinger
  54. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
    Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
    Randomized trial90 participantsMetabolism Boost forVitamin B6
  55. Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
    Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
    Cohort study46,800 participantsMetabolism Boost forVitamin B6
  56. Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
    Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
    Cross-sectional study461 participantsMetabolism Boost forVitamin B6
  57. Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
    Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
    Clinical trial46 participantsMetabolism Boost forVitamin B6
  58. Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
    Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
    Clinical trialMetabolism Boost forVitamin B6
  59. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  60. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  61. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  62. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  63. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  64. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  65. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  66. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  67. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  68. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  69. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
    Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Randomized trialStress Relief forVitamin B6
  70. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsStress Relief forVitamin B6
  71. RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
    Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
    Randomized trial128 participantsStress Relief forVitamin B6
  72. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
    Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
    Randomized trial264 participantsStress Relief forVitamin B6
  73. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
    Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
    Cross-sectional study447 participantsStress Relief forVitamin B6
  74. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  75. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  76. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  77. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  78. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP
  79. The Effect of Ginger (Zingiber officinale) on Improving Blood Lipids and Body Weight; A Systematic Review and Multivariate Meta-analysis of Clinical Trials.
    Asghari-Jafarabadi M; Khalili L · Current pharmaceutical design · 2022
    Meta-analysis26 participants26 studies pooledWeight Loss forGinger
  80. Efficacy and Safety of Steamed Ginger Extract for Body Weight and Body Fat Reduction in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Kwon JE; Lee YG; Kim I; Bae J; Kang SC; Baek HI · Nutrients · 2026
    Randomized trial80 participantsWeight Loss forGinger
  81. The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial.
    Park SH; Jung SJ; Choi EK; Ha KC; Baek HI; Park YK; Han KH; Jeong SY; Oh JH; Cha YS; Park BH; Chae SW · Food science and biotechnology · 2020
    Randomized trial80 participantsWeight Loss forGinger
  82. Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Ashraf H; Heydari M; Shams M; Zarshenas MM; Tavakoli A; Sayadi M · Evidence-based complementary and alternative medicine : eCAM · 2024
    Randomized trial60 participantsWeight Loss forGinger