Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
Randomized trial27 participantsflagMental Focus flagBrain Health flagFitness forscienceRhodiola
- The effects of an acute dose of Rhodiola rosea on endurance exercise performance.
Noreen EE; Buckley JG; Lewis SL; Brandauer J; Stuempfle KJ · Journal of strength and conditioning research · 2013
Randomized trial18 participantsflagMental Focus forscienceRhodiola
- Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
Meta-analysis148 participants5 studies pooledflagMental Focus forscienceTheanine
- Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
Randomized trial48 participantsflagMental Focus flagProductivity Boost forscienceTheanine
- Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis.
Sagaro GG; Traini E; Amenta F · Journal of Alzheimer's disease : JAD · 2023
Meta-analysis8 studies pooledflagBrain Health flagCognitive Support forscienceAlpha-GPC
- Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial.
Lee W; Kim M · Medicine · 2024
Randomized trial119 participantsflagBrain Health flagCognitive Support forscienceAlpha-GPC
- Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
Randomized trial36 participantsflagBrain Health flagCognitive Support forscienceAlpha-GPC
- Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.
Kerksick CM · Nutrients · 2024
Randomized trial20 participantsflagBrain Health flagMental Focus flagProductivity Boost forscienceAlpha-GPC
- Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
De Jesus Moreno Moreno M · Clinical therapeutics · 2003
Randomized trial261 participantsflagBrain Health forscienceAlpha-GPC
- Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis.
Tan MS; Yu JT; Tan CC; Wang HF; Meng XF; Wang C; Jiang T; Zhu XC; Tan L · Journal of Alzheimer's disease : JAD · 2015
Meta-analysis2,561 participants9 studies pooledflagBrain Health forscienceGinkgo
- Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review.
von Gunten A; Schlaefke S; Überla K · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2017
Meta-analysis1,628 participants4 studies pooledflagBrain Health flagCognitive Support forscienceGinkgo
- Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.
Riepe M; Hoerr R; Schlaefke S · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025
Meta-analysis782 participants4 studies pooledflagBrain Health flagProductivity Boost forscienceGinkgo
- Ginkgo biloba extract EGb 761® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial.
Cui M; You T; Zhao Y; Liu R; Guan Y; Liu J; Liu X; Wang X; Dong Q · Frontiers in pharmacology · 2023
Randomized trial201 participantsflagBrain Health flagProductivity Boost forscienceGinkgo
- Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg.
Herrschaft H; Nacu A; Likhachev S; Sholomov I; Hoerr R; Schlaefke S · Journal of psychiatric research · 2012
Randomized trial410 participantsflagBrain Health forscienceGinkgo
- Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.
La Monica MB; Raub B; Ziegenfuss EJ; Hartshorn S; Grdic J; Gustat A; Sandrock J; Ziegenfuss TN · Nutrients · 2023
Randomized trialflagBrain Health flagProductivity Boost forscienceHericium mushroom
- Improvement of cognitive functions by oral intake of Hericium erinaceus.
Saitsu Y; Nishide A; Kikushima K; Shimizu K; Ohnuki K · Biomedical research (Tokyo, Japan) · 2020
Randomized trialflagBrain Health flagCognitive Support forscienceHericium mushroom
- Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.
Mori K; Inatomi S; Ouchi K; Azumi Y; Tuchida T · Phytotherapy research : PTR · 2009
Randomized trial30 participantsflagBrain Health flagCognitive Support forscienceHericium mushroom
- A review of the effects of mushrooms on mood and neurocognitive health across the lifespan.
Cha S; Bell L; Shukitt-Hale B; Williams CM · Neuroscience and biobehavioral reviews · 2024
Systematic review34 studies pooledflagBrain Health forscienceHericium mushroom
- Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.
Surendran G; Saye J; Binti Mohd Jalil S; Spreadborough J; Duong K; Shatwan IM; Lilley D; Heinrich M; Dodd GF; Surendran S · Frontiers in nutrition · 2025
Randomized trial18 participantsflagBrain Health flagMental Focus forscienceHericium mushroom
- Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis.
Xing SH; Zhu CX; Zhang R; An L · Evidence-based complementary and alternative medicine : eCAM · 2014
Meta-analysis825 participants10 studies pooledflagBrain Health flagCognitive Support forscienceHuperzine
- [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial].
Zhang Z; Wang X; Chen Q; Shu L; Wang J; Shan G · Zhonghua yi xue za zhi · 2002
Randomized trial202 participantsflagBrain Health flagCognitive Support forscienceHuperzine
- Huperzine A associated with improved early postoperative cognitive function after neurosurgery under general anesthesia: a randomized clinical trial.
Zhang Z; Shen Y; Li J; Tang Y; Zhou P; Ying T; Mo R; Ru Z; Zhao G; Zhu J; Li S; Zhao H · International journal of surgery (London, England) · 2026
Randomized trial123 participantsflagBrain Health flagCognitive Support forscienceHuperzine
- Treatment with Huperzine A improves cognition in vascular dementia patients.
Xu ZQ; Liang XM; Juan-Wu; Zhang YF; Zhu CX; Jiang XJ · Cell biochemistry and biophysics · 2012
Randomized trial78 participantsflagBrain Health forscienceHuperzine
- Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease.
Gul A; Bakht J; Mehmood F · Journal of the Chinese Medical Association : JCMA · 2019
Randomized trial100 participantsflagBrain Health forscienceHuperzine
- A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers.
Boyle NB; Billington J; Lawton C; Quadt F; Dye L · Nutritional neuroscience · 2022
Randomized trial100 participantsflagBrain Health forscienceRhodiola
- Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.
Panossian A; Wikman G; Sarris J · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010
Narrative reviewflagBrain Health forscienceRhodiola
- Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
Darbinyan V; Kteyan A; Panossian A; Gabrielian E; Wikman G; Wagner H · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2001
Randomized trial56 participantsflagBrain Health flagProductivity Boost forscienceRhodiola
- Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
Single-arm trial50 participantsflagBrain Health flagCognitive Support forscienceRhodiola
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
Randomized trial30 participantsflagBrain Health flagCognitive Support forscienceTheanine
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
Randomized trialflagBrain Health flagStress Relief forscienceTheanine
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
Meta-analysis50 studies pooledflagBrain Health flagCognitive Support flagMental Focus forscienceTheanine
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
Randomized trial27 participantsflagBrain Health flagCognitive Support forscienceTheanine
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
Randomized trialflagBrain Health flagMental Focus flagProductivity Boost forscienceTheanine
- Combined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players.
Bilgin S; Bozyılan E; Buzdağlı Y; Karaç Öcal Y; Gürkan O; Toktaş S; İnan H; Egil İ; Yarayan YE · Frontiers in nutrition · 2026
Randomized trial24 participantsflagBrain Health forscienceTyrosine
- Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
Jongkees BJ; Hommel B; Kühn S; Colzato LS · Journal of psychiatric research · 2016
Narrative reviewflagBrain Health forscienceTyrosine
- Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans.
Hensel C; Becker M; Düzel S; Demuth I; Norman K; Steinhagen-Thiessen E; Gallinat J; Lindenberger U; Kühn S · NeuroImage · 2019
Cross-sectional study286 participantsflagBrain Health forscienceTyrosine
- Dietary Tyrosine Intake (FFQ) Is Associated with Locus Coeruleus, Attention and Grey Matter Maintenance: An MRI Structural Study on 398 Healthy Individuals of the Berlin Aging Study-II.
Plini ERG; Melnychuk MC; Harkin A; Dahl MJ; McAuslan M; Kühn S; Boyle RT; Whelan R; Andrews R; Düzel S; Drewelies J; Wagner GG; Lindenberger U; Norman K; Robertson IH; Dockree PM · The journal of nutrition, health & aging · 2023
Cross-sectional study398 participantsflagBrain Health forscienceTyrosine
- Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
Jongkees BJ · Cognitive, affective & behavioral neuroscience · 2021
Randomized trial45 participantsflagBrain Health forscienceTyrosine
- [Gliatilin in the Treatment of Cognitive Impairments Not Reaching the Level of Dementia: Meta-Analysis and Systematic Review].
Voznyuk IA; Nepomnyashchiy IS; Kutkova AK; Tokareva DV; Prokhorova MV; Ovdiienko OA; Shusharina NN · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2025
Meta-analysis10 studies pooledflagCognitive Support forscienceAlpha-GPC
- Vertical Association Between Dietary Total Choline and L-alpha-glycerylphosphorylcholine and the Cognitive Function in Chinese Adults Aged over 55, Result from China Health and Nutrition Survey 1997-2018.
Guan F; Jia X; Huang F; Zhang J; Wei Y; Li L; Bai J; Wang H · Nutrients · 2024
Cohort study7,659 participantsflagCognitive Support forscienceAlpha-GPC
- Efficacy of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke: a predefined exploratory analysis of a multicenter, double-blind, randomized controlled trial.
Tian X; Xu Q; Xia X; Zhang Y; Meng X; Wang A · Journal of neurology · 2024
Randomized trial3,163 participantsflagCognitive Support forscienceGinkgo
- A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
Le Bars PL; Katz MM; Berman N; Itil TM; Freedman AM; Schatzberg AF · JAMA · 1997
Randomized trial309 participantsflagCognitive Support flagProductivity Boost forscienceGinkgo
- Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.
Bachinskaya N; Hoerr R; Ihl R · Neuropsychiatric disease and treatment · 2011
Randomized trial410 participantsflagCognitive Support forscienceGinkgo
- Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial.
Ihl R; Bachinskaya N; Korczyn AD; Vakhapova V; Tribanek M; Hoerr R; Napryeyenko O; GOTADAY Study Group · International journal of geriatric psychiatry · 2013
Randomized trial410 participantsflagCognitive Support forscienceGinkgo
- Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study.
Li IC; Chang HH; Lin CH; Chen WP; Lu TH; Lee LY; Chen YW; Chen YP; Chen CC; Lin DP · Frontiers in aging neuroscience · 2024
Randomized trialflagCognitive Support forscienceHericium mushroom
- Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.
Menon A; Jalal A; Arshad Z; Nawaz FA; Kashyap R · Frontiers in nutrition · 2025
Systematic review26 studies pooledflagCognitive Support forscienceHericium mushroom
- The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.
Docherty S; Doughty FL; Smith EF · Nutrients · 2023
Randomized trial41 participantsflagCognitive Support forscienceHericium mushroom
- Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.
Zheng W; Xiang YQ; Li XB; Ungvari GS; Chiu HF; Sun F; D'Arcy C; Meng X; Xiang YT · Human psychopharmacology · 2017
Meta-analysis1,117 participants12 studies pooledflagCognitive Support forscienceHuperzine
- [Drug evaluation of huperzine A in the treatment of senile memory disorders].
Zhang RW; Tang XC; Han YY; Sang GW; Zhang YD; Ma YX; Zhang CL; Yang RM · Zhongguo yao li xue bao = Acta pharmacologica Sinica · 1992
Randomized trial56 participantsflagCognitive Support forscienceHuperzine
- Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
Panossian A; Wikman G · Current clinical pharmacology · 2009
Narrative reviewflagCognitive Support flagMental Focus forscienceRhodiola
- Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
Clinical trial112 participantsflagCognitive Support forscienceRhodiola
- Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
Systematic review19 studies pooledflagCognitive Support flagStress Relief forscienceRhodiola
- A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
Randomized trial60 participantsflagCognitive Support flagProductivity Boost forscienceRhodiola
- Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
Randomized trial32 participantsflagCognitive Support forscienceTheanine
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
Clinical trial20 participantsflagCognitive Support flagMental Focus forscienceTheanine
- Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine.
Haskell CF; Kennedy DO; Wesnes KA; Scholey AB · Psychopharmacology · 2005
Randomized trial48 participantsflagEnergy forscienceCaffeine
- Caffeine-containing energy drink improves physical performance of elite rugby players during a simulated match.
Del Coso J; Ramírez JA; Muñoz G; Portillo J; Gonzalez-Millán C; Muñoz V; Barbero-Álvarez JC; Muñoz-Guerra J · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016
Randomized trial26 participantsflagEnergy forscienceCaffeine
- Differential cognitive effects of energy drink ingredients: caffeine, taurine, and glucose.
Giles GE; Mahoney CR; Brunyé TT; Gardony AL; Taylor HA; Kanarek RB · Pharmacology, biochemistry, and behavior · 2013
Randomized trial48 participantsflagEnergy forscienceCaffeine
- Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study.
Ozan M; Buzdagli Y; Eyipinar CD; Baygutalp NK; Yüce N; Oget F; Kan E; Baygutalp F · Nutrients · 2022
Randomized trial20 participantsflagEnergy forscienceCaffeine
- Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study.
Fuller DT; Smith ML; Boolani A · Nutrients · 2021
Randomized trialflagEnergy forscienceCaffeine
- The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
Randomized trial48 participantsflagEnergy flagFitness forscienceRhodiola
- Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
Randomized trial24 participantsflagEnergy flagFitness flagMental Focus forscienceRhodiola
- Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
Randomized trial96 participantsflagEnergy forscienceRhodiola
- Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
Single-arm trial100 participantsflagEnergy flagStress Relief forscienceRhodiola
- Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
Randomized trial30 participantsflagEnergy flagFitness forscienceRhodiola
- Effect of caffeine ingestion on cycling performance: a systematic review and meta-analysis.
Wu J; Xu K; Yin M; Ding X; Wang T; Zhang Q; Wu X; Xiao N · Frontiers in nutrition · 2026
Meta-analysis226 participants20 studies pooledflagFitness forscienceCaffeine
- Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis.
Wang Z; Qiu B; Gao J; Del Coso J · Nutrients · 2023
Meta-analysis254 participants21 studies pooledflagFitness forscienceCaffeine
- Acute Effects of Caffeine Supplementation on Movement Velocity in Resistance Exercise: A Systematic Review and Meta-analysis.
Raya-González J; Rendo-Urteaga T; Domínguez R; Castillo D; Rodríguez-Fernández A; Grgic J · Sports medicine (Auckland, N.Z.) · 2021
Meta-analysis12 studies pooledflagFitness forscienceCaffeine
- Sex Differences in the Ergogenic Response of Acute Caffeine Intake on Muscular Strength, Power and Endurance Performance in Resistance-Trained Individuals: A Randomized Controlled Trial.
Montalvo-Alonso JJ; Ferragut C; Del Val-Manzano M; Valadés D; Roberts J; Pérez-López A · Nutrients · 2024
Randomized trial76 participantsflagFitness forscienceCaffeine
- Can I Have My Coffee and Drink It? A Systematic Review and Meta-analysis to Determine Whether Habitual Caffeine Consumption Affects the Ergogenic Effect of Caffeine.
Carvalho A; Marticorena FM; Grecco BH; Barreto G; Saunders B · Sports medicine (Auckland, N.Z.) · 2022
Meta-analysis60 studies pooledflagFitness forscienceCaffeine
- The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.
Marcos-Frutos D; Leban Ž; Li Z; Zhang X; Lara PM; Alix-Fages C; Jiménez-Martínez P; Zebboudji N; Caillet A; Redondo B; Vera J; Janicijevic D; García-Ramos A · Nutrients · 2025
Randomized trial18 participantsflagFitness forscienceRhodiola
- Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Wingelaar-Jagt YQ; Bottenheft C; Riedel WJ; Ramaekers JG · Journal of psychopharmacology (Oxford, England) · 2023
Randomized trial32 participantsflagMental Focus forscienceCaffeine
- Acute effects of caffeine on attention: a comparison of non-consumers and withdrawn consumers.
Smith AP; Christopher G; Sutherland D · Journal of psychopharmacology (Oxford, England) · 2013
Randomized trial70 participantsflagMental Focus forscienceCaffeine
- Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
Wesensten NJ; Killgore WD; Balkin TJ · Journal of sleep research · 2006
Randomized trial48 participantsflagMental Focus forscienceCaffeine
- Effects of caffeine on mood and performance: a study of realistic consumption.
Brice CF; Smith AP · Psychopharmacology · 2003
Clinical trial24 participantsflagMental Focus forscienceCaffeine
- Effects of caffeine or diphenhydramine on visual vigilance.
Fine BJ; Kobrick JL; Lieberman HR; Marlowe B; Riley RH; Tharion WJ · Psychopharmacology · 1995
Randomized trial24 participantsflagMental Focus forscienceCaffeine
- Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review.
Hort J; Duning T; Hoerr R · Neuropsychiatric disease and treatment · 2023
Systematic review946 participants9 studies pooledflagMental Focus forscienceGinkgo
- Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
Randomized trial216 participantsflagMental Focus forscienceGinkgo
- Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia.
Kanowski S; Herrmann WM; Stephan K; Wierich W; Hörr R · Pharmacopsychiatry · 1996
Randomized trial216 participantsflagMental Focus forscienceGinkgo
- Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke: a randomised controlled trial.
Li S; Zhang X; Fang Q; Zhou J; Zhang M; Wang H; Chen Y; Xu B; Wu Y; Qian L; Xu Y · Stroke and vascular neurology · 2021
Randomized trial348 participantsflagMental Focus forscienceGinkgo
- Ginkgo biloba in the Aging Process: A Narrative Review.
Barbalho SM; Direito R; Laurindo LF; Marton LT; Guiguer EL; Goulart RA; Tofano RJ; Carvalho ACA; Flato UAP; Capelluppi Tofano VA; Detregiachi CRP; Bueno PCS; Girio RSJ; Araújo AC · Antioxidants (Basel, Switzerland) · 2024
Narrative review14 studies pooledflagMental Focus forscienceGinkgo
- The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
Systematic review11 studies pooledflagMental Focus forscienceRhodiola
- Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
Randomized trial26 participantsflagMental Focus flagProductivity Boost forscienceRhodiola
- Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
Randomized trial30 participantsflagMental Focus flagProductivity Boost flagStress Relief forscienceTheanine
- Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
Randomized trial24 participantsflagMental Focus forscienceTheanine
- A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, and Cognitive Performance.
Krieger J; Schrautemeier A; Hagele A; Gaige C; Mennemeyer O; Tolbert S; Iannotti J; Kerksick C; Noonan C; Mumford P · Nutrients · 2025
Randomized trial60 participantsflagMetabolism Boost forscienceCaffeine
- Oolong tea increases metabolic rate and fat oxidation in men.
Rumpler W; Seale J; Clevidence B; Judd J; Wiley E; Yamamoto S; Komatsu T; Sawaki T; Ishikura Y; Hosoda K · The Journal of nutrition · 2001
Randomized trial12 participantsflagMetabolism Boost forscienceCaffeine
- Effect of caffeine intake on fat oxidation rate during exercise: is there a dose-response effect?
Gutiérrez-Hellín J; Aguilar-Navarro M; Ruiz-Moreno C; Muñoz A; Varillas-Delgado D; Amaro-Gahete FJ; Del Coso J · European journal of nutrition · 2023
Randomized trial18 participantsflagMetabolism Boost forscienceCaffeine
- Comparison of changes in energy expenditure and body temperatures after caffeine consumption.
Koot P; Deurenberg P · Annals of nutrition & metabolism · 1995
Randomized trial12 participantsflagMetabolism Boost forscienceCaffeine
- Caffeine Increases Work Done above Critical Power, but Not Anaerobic Work.
Silveira R; Andrade-Souza VA; Arcoverde L; Tomazini F; Sansonio A; Bishop DJ; Bertuzzi R; Lima-Silva AE · Medicine and science in sports and exercise · 2018
Randomized trial9 participantsflagMetabolism Boost forscienceCaffeine
- Association Between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in the Treatment of Depression in Patients with Alzheimer's Disease
Anna Carotenuto, Angiola Maria Fasanaro, Valentino Manzo, Francesco Amenta, Enea Traini · Journal of Alzheimer's disease reports · 2022
Randomized trial90 participantsflagMood Support forscienceAlpha-GPC
- Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
Urata M; Sakurai H; Ueno F; Maruki T; Tada T; Uchida T; Matsumoto Y; Murao M; Tomita M; Baba H; Kato M; Tsuboi T; Watanabe K · Neuropsychopharmacology reports · 2025
Meta-analysis1,049 participants2 studies pooledflagMood Support forscienceRhodiola
- The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men.
Duncan MJ; Clarke ND · Journal of sports medicine (Hindawi Publishing Corporation) · 2015
Clinical trial10 participantsflagMood Support forscienceRhodiola
- Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.
Sarris J; Panossian A; Schweitzer I; Stough C; Scholey A · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2012
Systematic review66 studies pooledflagMood Support forscienceRhodiola
- Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.
Moragrega I; Ríos JL · Planta medica · 2022
Systematic reviewflagMood Support forscienceRhodiola
- Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.
Kasper S; Dienel A · Neuropsychiatric disease and treatment · 2020
Single-arm trial118 participantsflagMood Support forscienceRhodiola
- l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
Randomized trial60 participantsflagMood Support forscienceTheanine
- L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
Randomized trial60 participantsflagMood Support flagStress Relief forscienceTheanine
- The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
Systematic review9 studies pooledflagMood Support forscienceTheanine
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagMood Support flagStress Relief forscienceTheanine
- Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
Randomized trial20 participantsflagMood Support forscienceTheanine
- Treatment of dementia with neurotransmission modulation.
Doggrell SA; Evans S · Expert opinion on investigational drugs · 2004
Narrative reviewflagProductivity Boost forscienceAlpha-GPC
- Effects of caffeine on alertness.
Zwyghuizen-Doorenbos A; Roehrs TA; Lipschutz L; Timms V; Roth T · Psychopharmacology · 1990
Randomized trial24 participantsflagProductivity Boost forscienceCaffeine
- Effects of Different Sources of Low-Dose Caffeine on Mood/Arousal and Cognitive Performance.
Irwin C; McCartney D; Grant G; Delang N; Bartrim K; Cox GR; Desbrow B · Perceptual and motor skills · 2023
Randomized trial22 participantsflagProductivity Boost forscienceCaffeine
- Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land.
Lieberman HR; Tharion WJ; Shukitt-Hale B; Speckman KL; Tulley R · Psychopharmacology · 2003
Randomized trial68 participantsflagProductivity Boost forscienceCaffeine
- A review of caffeine's effects on cognitive, physical and occupational performance.
McLellan TM; Caldwell JA; Lieberman HR · Neuroscience and biobehavioral reviews · 2017
Narrative reviewflagProductivity Boost forscienceCaffeine
- Acute caffeine supplementation as a nutrition-based strategy to mitigate sleep-loss-related cognitive and operational performance impairments in military personnel: a systematic review and meta-analysis.
Wang R; Wang W; Meng L; Hao G; Gu G · Frontiers in nutrition · 2026
Meta-analysis7 studies pooledflagProductivity Boost forscienceCaffeine
- [Ginkgo biloba extract EGb 761 in the treatment of dementia: evidence of efficacy and tolerability].
Kasper S; Schubert H · Fortschritte der Neurologie-Psychiatrie · 2009
Meta-analysis10 studies pooledflagProductivity Boost forscienceGinkgo
- Dietary Flavonoids and Human Cognition: A Meta-Analysis.
Cheng N; Bell L; Lamport DJ; Williams CM · Molecular nutrition & food research · 2022
Meta-analysis5,519 participants80 studies pooledflagProductivity Boost forscienceGinkgo
- Limited cognitive benefits in Stage +2 postmenopausal women after 6 weeks of treatment with Ginkgo biloba.
Elsabagh S; Hartley DE; File SE · Journal of psychopharmacology (Oxford, England) · 2005
Randomized trial87 participantsflagProductivity Boost forscienceGinkgo
- Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial.
Gavrilova SI; Preuss UW; Wong JW; Hoerr R; Kaschel R; Bachinskaya N; GIMCIPlus Study Group · International journal of geriatric psychiatry · 2015
Randomized trial160 participantsflagProductivity Boost forscienceGinkgo
- Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers.
Kennedy DO; Jackson PA; Haskell CF; Scholey AB · Human psychopharmacology · 2008
Randomized trial78 participantsflagProductivity Boost forscienceGinkgo
- Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.
Grozier CD; Alves VA; Killen LG; Simpson JD; O'Neal EK; Waldman HS · International journal of exercise science · 2025
Non-randomized trial24 participantsflagProductivity Boost forscienceHericium mushroom
- A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
Spasov AA; Wikman GK; Mandrikov VB; Mironova IA; Neumoin VV · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2000
Randomized trialflagProductivity Boost forscienceRhodiola
- The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
Ivanova Stojcheva E; Quintela JC · Molecules (Basel, Switzerland) · 2022
Narrative reviewflagProductivity Boost flagStress Relief forscienceRhodiola
- Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
Meta-analysis1,168 participants31 studies pooledflagProductivity Boost forscienceTheanine
- Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
Narrative reviewflagProductivity Boost forscienceTheanine
- Stress management and the role of Rhodiola rosea: a review.
Anghelescu IG; Edwards D; Seifritz E; Kasper S · International journal of psychiatry in clinical practice · 2019
Narrative reviewflagStress Relief forscienceRhodiola
- Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
Sarris J; McIntyre E; Camfield DA · CNS drugs · 2013
Narrative reviewflagStress Relief forscienceRhodiola
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
Randomized trial34 participantsflagStress Relief forscienceTheanine
- Changes in caffeine intake and long-term weight change in men and women.
Lopez-Garcia E; van Dam RM; Rajpathak S; Willett WC; Manson JE; Hu FB · The American journal of clinical nutrition · 2006
Cohort study58,157 participantsflagWeight Loss forscienceCaffeine
- Does caffeine ingestion before a short-term sprint interval training promote body fat loss?
Ferreira GA; Felippe LC; Bertuzzi R; Bishop DJ; Ramos IS; De-Oliveira FR; Lima-Silva AE · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2020
Randomized trial20 participantsflagWeight Loss forscienceCaffeine
- Eight Weeks of Sprint Interval Training With Adding Caffeine Ingestion Leads to Greater Improvements in Health-Related Physiological Parameters in Obese Male Adults.
Zhiang J; Song Q · Physiological research · 2026
Randomized trial30 participantsflagWeight Loss forscienceCaffeine
- Caffeine treatment prevented from weight regain after calorie shifting diet induced weight loss.
Davoodi SH; Hajimiresmaiel SJ; Ajami M; Mohseni-Bandpei A; Ayatollahi SA; Dowlatshahi K; Javedan G; Pazoki-Toroudi H · Iranian journal of pharmaceutical research : IJPR · 2014
Non-randomized trial60 participantsflagWeight Loss forscienceCaffeine
- The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.
Tabrizi R; Saneei P; Lankarani KB; Akbari M; Kolahdooz F; Esmaillzadeh A; Nadi-Ravandi S; Mazoochi M; Asemi Z · Critical reviews in food science and nutrition · 2020
Meta-analysis606 participants13 studies pooledflagWeight Loss forscienceCaffeine