Arginine Citrulline
MNP Michael's Naturopathic Programs
Arginine Citrulline
4.8
★ ★ ★ ★ ★
(196 ratings)
Arginine 2250 mg
Citrulline 750 mg
Score 90.0
A premium and highly potent Arginine and Citrulline supplement with added Beet root, delivering exceptional dosages for maximum nitric oxide support, significantly enhancing fitness, muscle gain, and cardiovascular health.
Quantity: 45 Tablet(s)Servings size: 3 Tablet(s) (15 servings)
Selected goals:
Other goals:
Fitness
Muscle Gain
Cardiovascular Support
leaderboard Score 90.0
A premium and highly potent Arginine and Citrulline supplement with added Beet root, delivering exceptional dosages for maximum nitric oxide support, significantly enhancing fitness, muscle gain, and cardiovascular health.
insights Analysis
This MNP Michael's Naturopathic Programs product delivers a powerful blend of 2250mg L-Arginine Hydrochloride and 750mg L-Citrulline per serving, dosages that are significantly higher than most conventional supplements. The inclusion of 600mg of Beet root, a natural source of nitrates, further amplifies its nitric oxide boosting capabilities, offering a comprehensive and highly effective approach to vascular health and athletic performance. While the price per serving is at the higher end, the substantial active ingredient profile justifies the cost for those seeking maximum physiological impact, as evidenced by user reviews often noting pronounced effects on blood flow and 'pumps'.
- Delivers exceptionally high, clinically relevant dosages of both L-Arginine (2250mg) and L-Citrulline (750mg) per serving.
- Includes Beet root, a natural source of nitrates that synergistically boosts nitric oxide production, adding another layer of efficacy.
- Offers a comprehensive and potent approach to enhancing blood flow, muscle pumps, and overall athletic performance and cardiovascular health.
- The price per serving is significantly higher than most other Arginine and Citrulline supplements, making it a substantial investment.
- With only 15 servings per bottle, frequent replenishment is necessary for consistent daily use, adding to the overall cost.
- The high dosage might be too potent for some individuals, potentially leading to more pronounced side effects like significant blood pressure drop if not monitored.
- Due to the very high dosages and potent vasodilating effects, individuals with low blood pressure or those taking blood pressure medications should exercise extreme caution and consult a healthcare provider.
- Monitor for signs of hypotension or lightheadedness, especially when starting supplementation.
$16.63($1.10 per serving)
 iHerb | $ 16.63 |
bolt Effectiveness for goals
Yes, L-Citrulline supplementation can lead to higher and more sustained plasma L-Arginine levels than Arginine supplementation alone. This is because Citrulline bypasses intestinal and liver metabolism, being efficiently converted to Arginine in the kidneys. This indirect pathway can more effectively increase nitric oxide production.
L-Citrulline is often considered more effective at increasing sustained L-Arginine and nitric oxide levels in the body than L-Arginine itself. This is because L-Citrulline bypasses significant metabolism in the gut and liver, converting to L-Arginine more efficiently in the kidneys. This leads to a more pronounced and prolonged increase in circulating L-Arginine.
L-Citrulline is converted to L-Arginine in the kidneys, which then increases nitric oxide production. This can lead to enhanced blood flow to muscles during exercise, potentially reducing fatigue and improving endurance. It's particularly studied for high-intensity activities and resistance training.
Combining L-Arginine and L-Citrulline may offer enhanced and more sustained nitric oxide production. L-Citrulline can recycle back into L-Arginine, creating a continuous supply for nitric oxide synthesis. This combined approach could potentially lead to greater and longer-lasting effects on blood flow compared to taking either supplement alone.
L-Citrulline is converted to L-Arginine in the body, leading to increased nitric oxide production. This can help improve blood flow to muscles during exercise, potentially enhancing endurance and reducing fatigue. Studies have shown L-Citrulline to be effective in improving performance in both aerobic and anaerobic exercises.
schedule Dosage, timing & forms
Yes, Arginine and Citrulline can be taken together, and some individuals choose to combine them. Citrulline is converted to Arginine in the body, which can effectively increase Arginine levels. Taking them together may offer a synergistic approach, potentially providing both immediate and sustained benefits.
Citrulline is generally considered more effective at increasing and sustaining blood Arginine levels when taken orally. This is because Arginine itself undergoes significant breakdown in the gut and liver (first-pass metabolism) before reaching systemic circulation. Citrulline bypasses this metabolism and is efficiently converted to Arginine in the kidneys.
For exercise performance, dosages of L-Citrulline typically range from 6 to 8 grams per day. If using Citrulline Malate (often a 2:1 ratio of Citrulline to Malate), a common dose is 8 to 12 grams, providing an equivalent amount of L-Citrulline. For general cardiovascular support, lower doses around 3-4 grams may be suggested.
For exercise performance, typical dosages are 6 to 8 grams of L-Citrulline, or 8 to 12 grams of Citrulline Malate. Citrulline Malate is often a 2:1 ratio (6-8g L-Citrulline). It's generally recommended to take it about 60 minutes before physical activity.
When combining them, it's generally recommended to start with conservative doses for each. Since Citrulline effectively raises Arginine levels, you might consider slightly lower individual Arginine doses than if taking it alone. Monitoring your body's response is key to finding the optimal combined dosage.
health_and_safety Safety & interactions
Yes, L-Arginine and L-Citrulline can generally be taken together. L-Citrulline is a precursor to L-Arginine, and combining them may lead to sustained increases in nitric oxide levels. However, potential additive effects on blood pressure should be considered.
Yes, L-Arginine can interact with medications for blood pressure, erectile dysfunction (e.g., sildenafil), and nitrates, potentially causing blood pressure to drop too low. It may also interact with blood thinners and diabetes medications. Consulting a healthcare professional is crucial, especially if taking other medications.
Common side effects of L-Arginine can include abdominal pain, bloating, diarrhea, and nausea, especially at higher doses. These effects are generally mild and temporary. Individuals may also experience a drop in blood pressure.
L-Citrulline is generally well-tolerated, but some individuals may experience mild gastrointestinal discomfort, such as nausea or diarrhea. These side effects are more likely at higher doses. It can also potentially lower blood pressure.
Yes, L-Arginine can interact with medications for high blood pressure. Because L-Arginine can lower blood pressure, taking it with antihypertensive drugs might cause blood pressure to drop too low. It is advisable to consult a healthcare professional before combining them.
Ingredients
| Ingredient | Amount per serving |
|---|---|
L-Arginine | 2250 mg |
L-Citrulline | 750 mg |
Beet | 600 mg |
Categories
Arginine 95.0
Delivers an exceptionally high 2250mg of L-Arginine Hydrochloride per serving, making it one of the most potent Arginine sources for maximizing nitric oxide levels.
Citrulline 90.0
Provides a substantial 750mg of L-Citrulline per serving, which effectively raises plasma arginine levels and supports strong nitric oxide production, further enhanced by the presence of beet.
Goals
With its robust combination of high-dose Arginine, Citrulline, and natural nitrates from Beet, this product is highly effective for promoting healthy vasodilation and supporting overall cardiovascular function.
Fitness 92.0
The very high, research-backed dosages of Arginine and Citrulline, complemented by Beet root, offer powerful support for improving exercise performance, enhancing pumps, and reducing fatigue during intense training.
Muscle Gain 90.0
The superior nitric oxide boosting capabilities facilitate optimal blood flow, nutrient delivery, and waste removal for muscles, directly aiding in muscle repair, growth, and improved training intensity.
Recommended Alternatives
88 Value 
N.O. Pro with Beet Root
ZHOU
4.2
★★★★★
(3540 ratings)
While slightly lower in total Arginine than the original, it offers a powerful blend with Citrulline Malate and Beet Root at a significantly lower price per serving, providing excellent value for a comprehensive nitric oxide booster.
85 Value 
Nitric Oxide Booster
Nutricost Performance
4.8
★★★★★
(389 ratings)
Provides a robust multi-form Arginine (1500mg) and Citrulline (750mg, including malate) blend, offering high efficacy at a much more accessible price per serving than the MNP product.
80 Value 
L-Arginine L-Citrulline Complex
Source Naturals
4.5
★★★★★
(3843 ratings)
Offers a higher combined dose of L-Arginine (750mg) and L-Citrulline (250mg) than basic products, and at a considerably better price per serving than the MNP product, making it a solid value for consistent NO support.
98 Performance 
SuperPump Aggression Fruit Punch Fury
Gaspari Nutrition
4.7
★★★★★
(213 ratings)
This comprehensive pre-workout not only matches high Citrulline doses (4000mg L-Citrulline) but also includes other performance ingredients like Agmatine, Betaine, and Caffeine for a more intense overall performance boost.
98 Performance 
SuperPump Aggression Mayhem Mango
Gaspari Nutrition
4.3
★★★★★
(669 ratings)
Identical to the Fruit Punch Fury version, offering the same superior high-dose L-Citrulline and multi-ingredient complex for maximal workout intensity and muscle pumps.
98 Performance 
SuperPump Aggression Jersey Mobster Italian Ice
Gaspari Nutrition
4.6
★★★★★
(179 ratings)
Another variant of the SuperPump Aggression, providing the same top-tier formulation with 4000mg L-Citrulline and extensive performance compounds, making it highly effective for athletic goals.
75 Budget 
L-Arginine + L-Citrulline 750 mg
Nutricost
4.7
★★★★★
(1239 ratings)
While significantly lower in dosage, this product offers a combined Arginine/Citrulline solution at a dramatically lower total price, providing basic support for those on a strict budget.
70 Budget 
L-Arginine 500 mg
Swanson
4.7
★★★★★
(3442 ratings)
A very inexpensive pure L-Arginine supplement, representing a minimal investment for initial nitric oxide support.
65 Budget 
Arginine & Citrulline 500 mg / 250 mg
NOW Sports
4.7
★★★★★
(4240 ratings)
Offers a similar ingredient profile (though lower doses) at a much more affordable total price, providing a cost-effective entry into Arginine/Citrulline supplementation.
88 Value
N.O. Pro with Beet Root
ZHOU
4.2
★★★★★
(3540 ratings)
While slightly lower in total Arginine than the original, it offers a powerful blend with Citrulline Malate and Beet Root at a significantly lower price per serving, providing excellent value for a comprehensive nitric oxide booster.
85 Value
Nitric Oxide Booster
Nutricost Performance
4.8
★★★★★
(389 ratings)
Provides a robust multi-form Arginine (1500mg) and Citrulline (750mg, including malate) blend, offering high efficacy at a much more accessible price per serving than the MNP product.
80 Value
L-Arginine L-Citrulline Complex
Source Naturals
4.5
★★★★★
(3843 ratings)
Offers a higher combined dose of L-Arginine (750mg) and L-Citrulline (250mg) than basic products, and at a considerably better price per serving than the MNP product, making it a solid value for consistent NO support.
98 Performance
SuperPump Aggression Fruit Punch Fury
Gaspari Nutrition
4.7
★★★★★
(213 ratings)
This comprehensive pre-workout not only matches high Citrulline doses (4000mg L-Citrulline) but also includes other performance ingredients like Agmatine, Betaine, and Caffeine for a more intense overall performance boost.
98 Performance
SuperPump Aggression Mayhem Mango
Gaspari Nutrition
4.3
★★★★★
(669 ratings)
Identical to the Fruit Punch Fury version, offering the same superior high-dose L-Citrulline and multi-ingredient complex for maximal workout intensity and muscle pumps.
98 Performance
SuperPump Aggression Jersey Mobster Italian Ice
Gaspari Nutrition
4.6
★★★★★
(179 ratings)
Another variant of the SuperPump Aggression, providing the same top-tier formulation with 4000mg L-Citrulline and extensive performance compounds, making it highly effective for athletic goals.