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Arginine Citrulline

MNP Michael's Naturopathic Programs
4.8
★ ★ ★ ★ ★
(244 ratings)
Arginine 2250 mg
Citrulline 750 mg
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Score76
A coherent, reasonably dosed blood-flow blend is held back by modest citrulline, unknown beet nitrates, and poor serving value.
How scoring works
Quantity:45 Tablet(s) • (15 servings)
Goals:
Cardiovascular Support
Energy

Score 76

A coherent, reasonably dosed blood-flow blend is held back by modest citrulline, unknown beet nitrates, and poor serving value.
How scoring works
$17.51($1.16 per serving)
iHerb
$ 17.51
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Analysis

The serving provides 2.25 g of arginine hydrochloride, 750 mg of pure L-citrulline, and 600 mg of beet powder. These ingredients converge on nitric-oxide and blood-flow support, with arginine supplying the strongest assessed contribution.

Citrulline reaches only the low end of a meaningful range and remains below common performance servings. Beet can add a complementary nitrate pathway, but no nitrate amount is stated, so its actual contribution cannot be predicted.

Three tablets deliver the full blend but each bottle provides relatively few servings at a high ongoing cost. It fits users who value a combined capsule-free tablet approach more than serving economy.

Who is it for
  • Adults seeking combined arginine, citrulline, and beet
  • People focused on exercise blood flow
  • Users comfortable taking three tablets
Best for
  • Nitric-oxide pathway support
  • Workout circulation
  • People wanting beet included with amino acids

Pros

  • Substantial 2.25 g arginine amount
  • Citrulline reaches a modest useful level
  • Beet adds a complementary pathway

Cons

  • Beet nitrate content is not disclosed
  • Only a small number of servings
  • High ongoing cost and three-tablet burden

Warnings

  • Arginine and citrulline may add to nitrates, blood-pressure medicines, or PDE-5 inhibitors and cause dizziness or excessive blood-pressure lowering.
  • Arginine can trigger herpes simplex recurrences in some susceptible users.
  • Higher amino-acid intake may cause nausea, cramping, or diarrhea.

Nutrient quality

85 Highest impact

A substantial arginine amount and complementary nitric-oxide ingredients provide good focused depth. Modest citrulline, unverified beet nitrate content, and medicine-interaction risk are the main limitations.

Ingredient transparency

81 Highest impact

Active quantities and amino-acid forms are clearly disclosed without a hidden blend. Missing full directions and non-active ingredients leave the label incomplete.

Customer satisfaction

69 High impact

The supplied average rating is very strong and the rating volume is moderate. No specific experience details were provided to judge repeated complaints or purpose alignment.

Value for money

63 Moderate impact

Weak dose depth or high cost limits practical value. Better-dosed or more transparent alternatives are more competitive.

Report analysis

Goals

Cardiovascular Support
Cardiovascular Support
Impact
High effect
A- Goal FitB- Strength of SupportC CoverageA+ Formula Quality
Arginine · 2250 mgCitrulline · 750 mg

Arginine, citrulline, and beet form a clear nitric-oxide strategy that may support blood flow and vascular function. Arginine is meaningful, while citrulline sits at the low end and the beet nitrate content is not disclosed.

The combination is focused but does not cover lipids, cardiac energy, rhythm minerals, or antioxidant protection. Its vasodilating effects may add to nitrates or blood-pressure medicines and cause dizziness or excessive blood-pressure lowering.

Study evidence
Arginine Supportive 47 studies
Citrulline Supportive 33 studies
Energy
Energy
Impact
Moderate effect
D+ Goal FitD+ Strength of SupportD- CoverageB Formula Quality

Arginine and citrulline may support exercise-related energy indirectly by improving nitric oxide production and blood flow. The combination is more relevant to workout endurance than to steady cellular energy or mental alertness.

The arginine amount is useful for general circulation support, but the citrulline serving is modest and the beet powder has no stated nitrate content. Clear amounts and a focused formula are positives, though the product covers only one main pathway.

Study evidence
Arginine No effect 7 studies
Citrulline No effect 14 studies

Ingredients

IngredientAmount per serving
L-Arginine (L-Arginine Hydrochloride)
 2250 mg
L-Citrulline
750 mg
Beet
600 mg
Adults 18–50 Women
Report overview
Arginine (L-Arginine Hydrochloride) · 2250 mg OverallScore65
C- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyD+ Value

The clearly identified L-arginine hydrochloride delivers a solid 2,250 mg serving for circulation and fitness support. No sustained-release technology is stated, and the three-tablet serving is less convenient than a concentrated capsule or powder. Cost efficiency is moderate, while citrulline and beet may complement nitric oxide support without changing the arginine-focused assessment.

View ingredientView products
Citrulline · 750 mg OverallScore54
B- Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyF Value

Pure L-citrulline is clearly identified, which makes the active form and amount easy to assess. The serving reaches only the low end of the meaningful dose range and may be modest for exercise performance. High cost per gram and missing sourcing or purity details limit its appeal as a citrulline-focused option.

View ingredientView products
Loading alternative details
67 Performance

Pump-Ocalypse Blue Raz

Bucked Up
Glycerol, citrulline, arginine, and agmatine form a coherent stimulant-free pump formula, but several amounts are moderate rather than full strength. An opaque mushroom blend and low betaine amount weaken dose quality and disclosure. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
73 Performance

Wellness ImmuNitric

Source Naturals
A substantial arginine amount with modest citrulline and B-vitamin support creates a coherent vascular formula at reasonable value. Duplicate folate entries reduce label clarity, and the vasodilating combination may add to nitrates or blood-pressure medicines. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
78 Performance

Arginine & Citrulline 500 mg / 250 mg

NOW Sports
A large supply of clearly disclosed L-arginine and L-citrulline offers efficient routine value. Very low serving amounts mean targeted nitric-oxide or exercise use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and stronger formulation depth make it a better quality-focused match.
74 Budget

Wellness ImmuNitric

Source Naturals
A substantial arginine amount with modest citrulline and B-vitamin support creates a coherent vascular formula at favorable value. Duplicate folate entries reduce clarity, and the three-tablet serving may add to the effects of nitrates or blood-pressure medicines. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
79 Budget

L-Arginine + L-Citrulline 750 mg

Nutricost
A large supply of clearly separated L-arginine and L-citrulline provides economical but basic nitric-oxide support. Both amounts are too low for targeted performance use without taking multiple capsules. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Budget

L-Arginine L-Citrulline Complex 1000 mg

Best Naturals
L-arginine hydrochloride and free-form citrulline provide a focused combination with good supply economy. The arginine amount is only moderate and the citrulline amount is far below targeted performance use. Compared with the original, its lower serving cost improves affordability while retaining Arginine and Citrulline support.
78 Value

L-Arginine L-Citrulline Complex

Source Naturals
A large supply of focused arginine and citrulline offers reasonable routine value. The arginine amount is modest, the citrulline amount is far below targeted use, and arginine may add to blood-pressure-lowering medicines. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
77 Value

Arginine & Citrulline 500 mg/250 mg

NOW Sports
Clearly disclosed L-arginine and L-citrulline provide a focused nitric-oxide formula at a low serving cost. Both amounts are far below targeted performance ranges, so meaningful use would require many capsules. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
80 Value

Nitric Oxide Booster

Nutricost Performance
Three arginine forms provide a moderate combined amount and clear nitric-oxide focus at favorable value. Citrulline remains underdosed, and the undisclosed citrulline-malate ratio makes its active contribution uncertain. Compared with the original, its Arginine and Citrulline coverage and balance of formula depth and serving cost provide better practical value.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
    Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
    Randomized trial15 participantsCardiovascular Support forCitrulline
  2. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease.
    Yin WH; Chen JW; Tsai C; Chiang MC; Young MS; Lin SJ · Clinical nutrition (Edinburgh, Scotland) · 2006
    Randomized trial31 participantsCardiovascular Support forArginine
  3. Effects of l-citrulline supplementation and watermelon consumption on longer-term and postprandial vascular function and cardiometabolic risk markers: a meta-analysis of randomised controlled trials in adults.
    Smeets ETHC; Mensink RP; Joris PJ · The British journal of nutrition · 2026
    Meta-analysis17 studies pooledCardiovascular Support forCitrulline
  4. Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Rodrigues-Krause J; Krause M; Rocha IMGD; Umpierre D; Fayh APT · Nutrients · 2019
    Meta-analysis13 studies pooledCardiovascular Support forArginine
  5. The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials.
    Hadi A; Arab A; Moradi S; Pantovic A; Clark CCT; Ghaedi E · The British journal of nutrition · 2020
    Meta-analysis12 studies pooledCardiovascular Support forArginine
  6. Oral citrulline supplementation in pregnancies with preeclampsia: a multicenter, randomized, double-blind clinical trial.
    Winer N; Misbert E; Masson D; Girault A; Alexandre-Gouabau MC; Ducarme G; Dochez V; Thubert T; Boivin M; Ferchaud-Roucher V; Péré M; Darmaun D · The American journal of clinical nutrition · 2025
    Randomized trial115 participantsCardiovascular Support forCitrulline
  7. Serum concentrations of L-arginine and L-homoarginine in male patients with intermittent claudication: a cross-sectional and prospective investigation in the CAVASIC Study.
    Vogl L; Pohlhammer J; Meinitzer A; Rantner B; Stadler M; Peric S; Hammerer-Lercher A; Klein-Weigel P; Fraedrich G; Kronenberg F; Kollerits B · Atherosclerosis · 2015
    Cohort study478 participantsCardiovascular Support forArginine
  8. Reassessment of the effect of oral l-arginine on blood pressure: A systematic review and meta-analysis based on ambulatory blood pressure monitoring.
    Shi Y; Liu Y; Zhou Z; Xu S; Luo P · Nitric oxide : biology and chemistry · 2026
    Meta-analysis202 participants5 studies pooledCardiovascular Support forArginine
  9. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study.
    Guttman H; Zimlichman R; Boaz M; Matas Z; Shargorodsky M · Journal of cardiovascular pharmacology · 2024
    Randomized trial90 participantsCardiovascular Support forArginine
  10. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.
    Bai Y; Sun L; Yang T; Sun K; Chen J; Hui R · The American journal of clinical nutrition · 2009
    Meta-analysis492 participants13 studies pooledCardiovascular Support forArginine
  11. Oral L-Arginine Administration Improves Anthropometric and Biochemical Indices Associated With Cardiovascular Diseases in Obese Patients: A Randomized, Single Blind Placebo Controlled Clinical Trial.
    Dashtabi A; Mazloom Z; Fararouei M; Hejazi N · Research in cardiovascular medicine · 2016
    Randomized trial90 participantsCardiovascular Support forArginine
  12. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
    Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
    Meta-analysis415 participants15 studies pooledCardiovascular Support forCitrulline
  13. Micronutrient Supplementation to Reduce Cardiovascular Risk.
    An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
    Meta-analysis883,627 participants884 studies pooledCardiovascular Support forCitrulline
  14. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
    Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
    Randomized trial10 participantsCardiovascular Support forCitrulline
  15. Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
    Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
    Randomized trial25 participantsCardiovascular Support forCitrulline
  16. Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.
    Kavcı Z; Ozan M; Buzdağlı Y; Savaş A; Uçar H · Journal of the International Society of Sports Nutrition · 2024
    Randomized trial15 participantsEnergy forArginine
  17. The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania.
    Turcu-Stiolica A; Ionele CM; Ungureanu BS; Subtirelu MS · Healthcare (Basel, Switzerland) · 2023
    Non-randomized trial505 participantsEnergy forArginine
  18. Isolated but not combined ergogenic effects of caffeine and L-arginine during an isokinetic knee extension.
    Zart S; Brachtendorf M; Becker S; Fröhlich M · Frontiers in nutrition · 2024
    Randomized trial29 participantsEnergy forArginine
  19. L-Arginine but not L-glutamine likely increases exogenous carbohydrate oxidation during endurance exercise.
    Rowlands DS; Clarke J; Green JG; Shi X · European journal of applied physiology · 2012
    Randomized trial8 participantsEnergy forArginine
  20. Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
    Boon MR; Hanssen MJW; Brans B; Hülsman CJM; Hoeks J; Nahon KJ; Bakker C; van Klinken JB; Havekes B; Schaart G; Jazet IM; Rensen PCN; van Marken Lichtenbelt WD · Diabetologia · 2019
    Randomized trial20 participantsEnergy forArginine
  21. Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
    Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
    Meta-analysis137 participants8 studies pooledEnergy forCitrulline
  22. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
    Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
    Randomized trial22 participantsEnergy forCitrulline
  23. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
    Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
    Randomized trial41 participantsEnergy forCitrulline
  24. Citrulline/malate promotes aerobic energy production in human exercising muscle.
    Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
    Single-arm trial18 participantsEnergy forCitrulline
  25. The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
    Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
    Randomized trial12 participantsEnergy forCitrulline