SAMe 400
Jarrow Formulas
SAMe 400
4.5
★ ★ ★ ★ ★
(2200 ratings)
SAMe 400 mg
Score 80.0
A reliable 400mg SAMe from a trusted brand with good reviews, offering effective dosage but at a slightly higher price per serving than top value options.
Quantity: 30 Tablet(s)Servings size: 1 Tablet(s) (30 servings)
Selected goals:
Other goals:
Mood Support
Joint Health
Digestive Health
leaderboard Score 80.0
A reliable 400mg SAMe from a trusted brand with good reviews, offering effective dosage but at a slightly higher price per serving than top value options.
insights Analysis
This Jarrow Formulas SAMe product offers 400mg per serving, a dose frequently recommended by nutritionists for various health objectives. Jarrow is a well-regarded brand, and their SAMe products are known for their crucial enteric coating, which protects the sensitive SAMe compound from stomach acid, thereby maximizing absorption. The product has a high number of positive online reviews (over 2100), indicating strong consumer trust and perceived effectiveness. Priced at $1.03 per serving, it offers a good effective dose, but its value is slightly less competitive compared to larger 400mg packs or more budget-friendly brands that provide similar potency at a lower price point. As a 30-serving bottle, it may require more frequent repurchasing for consistent users.
- Provides a robust 400mg dose of SAMe, effective for various health goals.
- From Jarrow Formulas, a highly reputable brand known for quality and enteric coating.
- High number of positive online reviews, indicating widespread user satisfaction.
- Price per serving ($1.03) is slightly higher compared to more value-oriented 400mg alternatives.
- Only 30 servings, which might require frequent reordering for consistent, long-term users.
- Does not include additional B vitamin cofactors that could enhance SAMe metabolism.
- Individuals taking antidepressants or other mood-altering medications should consult a healthcare professional before using SAMe due to potential interactions.
$24.00($0.80 per serving)
 Daily Vita | $ 24.00 | |
| Daily Vita | $ 35.99 | |
 Amazon | $ 36.74 | |
 iHerb | $ 44.96 |
bolt Effectiveness for goals
Yes, SAMe can potentially interact with certain medications and other supplements. For instance, it may interact with antidepressants, increasing serotonin levels, or with blood-thinning medications. These interactions could alter its effectiveness or lead to adverse effects, so consulting a healthcare professional is advisable.
SAMe is a compound naturally found in the body and is a key player in several biochemical reactions. Supplementation is most commonly studied for its potential roles in supporting mood balance, joint comfort, and liver health. Its effectiveness stems from its involvement in methylation processes.
SAMe has been extensively researched for its potential effectiveness in supporting mood balance, joint comfort, and liver health. It is a compound naturally occurring in the body, and its supplemental form is used to address deficiencies or enhance metabolic pathways. Scientific interest also extends to its role in various neurological and detoxification processes.
Several studies suggest that SAMe may play a role in supporting a healthy mood and emotional well-being. It is believed to influence the synthesis of neurotransmitters like serotonin and dopamine. While promising, individual responses can vary, and it should not replace prescribed treatments for mood disorders without professional guidance.
Research suggests that SAMe may play a role in supporting mood balance, particularly by influencing neurotransmitter synthesis. Several studies have explored its potential benefits in this area. Individual responses can vary.
schedule Dosage, timing & forms
A common starting dosage for SAMe often ranges from 200-400 mg per day. It is generally recommended to begin with a lower dose and gradually increase it if needed. This approach helps the body adjust and assess individual tolerance.
Many SAMe supplements are enteric-coated to protect the compound from stomach acid degradation. This coating allows the SAMe to pass through the stomach intact and dissolve in the more alkaline environment of the small intestine. This helps ensure better absorption and stability of the ingredient.
Enteric coating is crucial for SAMe because it is sensitive to stomach acid. The coating prevents the SAMe from being degraded in the stomach, allowing it to pass into the small intestine intact. This ensures optimal absorption and bioavailability of the supplement.
SAMe is typically recommended to be taken on an empty stomach, at least 30 minutes before a meal or two hours after. This can help improve its absorption and effectiveness. However, some individuals may take it with a small amount of food to reduce potential stomach upset.
Typical starting dosages for SAMe often range from 200 mg to 400 mg per day. These amounts are sometimes gradually increased based on individual response. Consulting a healthcare provider for personalized guidance is often suggested.
health_and_safety Safety & interactions
Yes, SAMe may interact with antidepressant medications, particularly SSRIs and tricyclic antidepressants. This interaction could potentially increase serotonin levels, raising the risk of serotonin syndrome. It is important to discuss SAMe use with a healthcare provider if taking antidepressants.
Common side effects of SAMe may include nausea, upset stomach, diarrhea, constipation, dry mouth, dizziness, and mild anxiety. These effects are usually mild and may subside with continued use or a lower dose.
Common side effects of SAMe can include gastrointestinal issues such as nausea, diarrhea, and constipation. Some individuals may also experience anxiety, restlessness, or insomnia. These effects are typically mild and often resolve with continued use or a dosage adjustment.
SAMe is contraindicated for individuals with bipolar disorder due to the risk of inducing mania. It should also be used with caution or avoided by those taking antidepressant medications, L-dopa, or blood thinners. Pregnant or breastfeeding women and children should generally avoid SAMe unless advised by a healthcare professional.
Individuals with bipolar disorder should use SAMe with extreme caution and under medical supervision. Pregnant or breastfeeding women, and those with compromised immune systems, are also generally advised against using SAMe due to insufficient safety data. Consulting a healthcare provider is recommended for these groups.
Ingredients
| Ingredient | Amount per serving |
|---|---|
S-Adenosyl Methionine | 400 mg |
Categories
SAMe 80.0
As a SAMe product, its effective dosage, stable form, and reputable brand make it a strong contender. However, its price per serving is less competitive than top value alternatives, affecting its overall appeal for budget-conscious consumers.
Goals
Mood Support 85.0
The 400mg dose is effective for mood support, and the product's quality from a trusted brand is a plus. However, more cost-effective 400mg alternatives exist for sustained mood management.
Joint Health 85.0
400mg is an optimal dose for joint support, making this a well-suited product for this goal. Its reliability from Jarrow makes it a good choice, despite other more affordable options.
Digestive Health 85.0
The 400mg dose is relevant for liver and digestive health, offering solid support. While effective, there are better value options available for consistent, long-term supplementation.
Recommended Alternatives
96 Value 
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Offers an outstanding value for 400mg SAMe at $0.59 per serving, far surpassing the analyzed product's cost-effectiveness.
95 Value 
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
This alternative delivers 400mg SAMe at $0.68 per serving, providing excellent value from a highly trusted brand, making it a superior choice for balancing potency and affordability.
98 Value 
SAMe 400 mg
Lake Avenue Nutrition
4.6
★★★★★
(4976 ratings)
Offers 400mg SAMe at $0.77 per serving, combining excellent value with an extremely high number of positive reviews, making it a highly compelling alternative.
85 Performance 
SAMe 400
Jarrow Formulas
4.5
★★★★★
(2124 ratings)
This is the identical product in a larger (60-count) pack from the same trusted brand, offering significantly better value per serving for long-term use.
98 Performance
SAMe 400 mg
Lake Avenue Nutrition
4.6
★★★★★
(4976 ratings)
This alternative provides 400mg SAMe in a stable form, boasts an exceptionally high number of positive reviews, and offers a much better price point, making it a better overall choice.
93 Performance 
SAMe 400 mg
Life Extension
4.8
★★★★★
(3073 ratings)
A premium brand alternative offering 400mg SAMe with extensive positive reviews, providing a more trusted and widely used option at a more competitive price.
96 Budget
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
This alternative offers the same 400mg SAMe dose at a significantly lower price per serving ($0.59 vs $1.03), providing superior cost-effectiveness.
95 Budget
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
Providing 400mg SAMe from a highly trusted brand at $0.68 per serving, this NOW product is significantly more affordable while maintaining high quality and effectiveness.
89 Budget 
SAMe 400 mg
Swanson
4.6
★★★★★
(265 ratings)
This alternative delivers 400mg SAMe at a competitive $0.69 per serving, offering a dramatically better value from a recognized brand.
96 Value
SAMe 400 mg
Nutricost
4.7
★★★★★
(728 ratings)
Offers an outstanding value for 400mg SAMe at $0.59 per serving, far surpassing the analyzed product's cost-effectiveness.
95 Value
SAMe 400 mg
NOW
4.6
★★★★★
(1753 ratings)
This alternative delivers 400mg SAMe at $0.68 per serving, providing excellent value from a highly trusted brand, making it a superior choice for balancing potency and affordability.
98 Value
SAMe 400 mg
Lake Avenue Nutrition
4.6
★★★★★
(4976 ratings)
Offers 400mg SAMe at $0.77 per serving, combining excellent value with an extremely high number of positive reviews, making it a highly compelling alternative.
85 Performance
SAMe 400
Jarrow Formulas
4.5
★★★★★
(2124 ratings)
This is the identical product in a larger (60-count) pack from the same trusted brand, offering significantly better value per serving for long-term use.
98 Performance
SAMe 400 mg
Lake Avenue Nutrition
4.6
★★★★★
(4976 ratings)
This alternative provides 400mg SAMe in a stable form, boasts an exceptionally high number of positive reviews, and offers a much better price point, making it a better overall choice.
93 Performance
SAMe 400 mg
Life Extension
4.8
★★★★★
(3073 ratings)
A premium brand alternative offering 400mg SAMe with extensive positive reviews, providing a more trusted and widely used option at a more competitive price.