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Extra Strength Silymarin

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4.8
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(7389 ratings)
Milk Thistle 450 mg
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Score82
A high extract amount and softgel delivery offer strong value, with missing active-yield data as the main limitation.
How scoring works
Quantity:120 Softgel(s) • (120 servings)
Goals:
Detoxification

Score 82

A high extract amount and softgel delivery offer strong value, with missing active-yield data as the main limitation.
How scoring works
$24.89($0.20 per serving)
Pure Formulas
$ 25.37
Pure Formulas
$ 25.37
Vitacost
$ 26.49
iHerb
$ 25.42
iHerb
$ 25.42
Daily Vita
$ 25.50
Amazon
$ 24.89
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Analysis

Milk thistle extract is supplied at a substantial weight and identifies silymarin flavonoids as the relevant component. The single-active design provides good depth for normal liver-cell antioxidant support.

A fat-containing softgel may help solubilize milk thistle compounds compared with a plain powder capsule. The label still does not state the flavonoid percentage, calculated active yield, or source plant part.

Low serving cost and a large supply support regular use without relying on extra botanicals. It fits buyers who want a concentrated, convenient milk thistle product and can accept incomplete standardization data.

Who is it for
  • Adults seeking a substantial milk thistle serving
  • Softgel users
  • Value-conscious long-term users
Best for
  • Focused liver antioxidant support
  • Long daily routines
  • Avoiding multi-herb blends

Pros

  • High extract amount
  • Silymarin flavonoids are named
  • Softgel delivery at low serving cost

Cons

  • Active percentage is not stated
  • Plant part is unknown
  • No broader liver-support cofactors

Warnings

  • Milk thistle may cause nausea, gas, or loose stools in sensitive users.
  • People allergic to ragweed, daisies, or related plants may also react to milk thistle.
  • Milk thistle may affect blood-sugar control; people using insulin or glucose-lowering medicine should check with their prescriber.

Nutrient quality

85 Highest impact

A substantial extract and fat-containing softgel support focused, potentially improved delivery. Missing active-yield and plant-source details prevent full dose verification.

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Ingredient transparency

79 High impact

Specific extract and softgel amounts make the core label understandable. Missing standardization, plant-source, usage, and full excipient details leave gaps.

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Customer satisfaction

73 High impact

The average rating is exceptionally strong, and the feedback volume supports confidence in it. No specific experience details are supplied to assess recurring complaints or purpose fit.

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Value for money

92 Highest impact

Substantial extract weight, softgel delivery, and economical use support excellent value. Unknown active yield is the main limitation in category comparison.

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Report analysis

Goals

Detoxification
Detoxification
Impact
Highest effect
A- Goal FitB+ Strength of SupportC- CoverageA+ Formula Quality
Milk Thistle · 450 mg

A substantial milk thistle extract directly supports hepatocyte protection, and the fat-containing softgel may aid delivery. Silymarin flavonoids are named, but their percentage is not disclosed.

The single-active formula provides strong depth for liver protection while leaving conjugation and broader antioxidant cofactors unaddressed. Its focused design is clean and coherent.

Study evidence
Milk Thistle Supportive 46 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Total Fat
0.5 Gram(s)
Milk Thistle extract (Silymarin Flavonoids)
 450 mg
Gluten Free Adults 18–50 Kosher Dairy Free
Report overview
Milk Thistle (Silymarin Flavonoids) · 450 mg OverallScore31
D Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyC Value

The softgel supplies a large milk thistle extract amount and an oil-based format that may improve solubility. Silymarin flavonoids are identified, but their percentage, active yield, and source plant part are not stated. The very low serving cost and softgel delivery support good practical value despite incomplete potency data.

View ingredientView products
Loading alternative details
82 Performance

Super Milk Thistle

Nature's Way
Clearly disclosed silybin and silymarin give the milk-thistle component unusually strong active characterization. Its stronger combination of formulation quality and detoxification alignment makes it a more compelling focused option, although the added licorice may be unsuitable for some users.
84 Performance

Milk Thistle

Nature's Answer
A silymarin-labeled milk-thistle extract provides more assessable active disclosure than a plain plant-mass claim. Its stronger combination of formulation quality and detoxification alignment makes it a more compelling focused option, although the formula remains focused rather than broad.
79 Performance

Milk Thistle (Silymarin)

Mason Natural
A silymarin-labeled milk-thistle extract provides more assessable active disclosure than a plain plant-mass claim. Its stronger combination of formulation quality and detoxification alignment makes it a more compelling focused option, although the formula remains focused rather than broad.
84 Budget

Milk Thistle

Kroeger Herb Products Co.
A silymarin-labeled milk-thistle extract provides more assessable active disclosure than a plain plant-mass claim. A lower serving cost improves routine value, although the formula remains focused rather than broad.
87 Budget

Milk Thistle Extract 175 mg

Lake Avenue Nutrition
A clearly labeled total-silymarin extract provides focused and readily assessable milk-thistle activity. A lower serving cost improves routine value, although the formula remains focused rather than broad.
85 Budget

Milk Thistle

Paradise
A silymarin-labeled milk-thistle extract provides more assessable active disclosure than a plain plant-mass claim. A lower serving cost improves routine value, although the formula remains focused rather than broad.
79 Value

Milk Thistle

Solgar
A silymarin-labeled milk-thistle extract provides more assessable active disclosure than a plain plant-mass claim. Favorable serving economics and a well-defined milk-thistle core create a useful quality-to-cost balance, although the formula remains focused rather than broad.
82 Value

Milk Thistle Phytosome 300 mg

Swanson
A named milk-thistle phytosome provides a better-characterized absorption strategy than a basic, unstandardized herb amount. Favorable serving economics and a well-defined milk-thistle core create a useful quality-to-cost balance, although the formula remains focused rather than broad.
80 Value

Milk Thistle

Kirkman
A silymarin-labeled milk-thistle extract provides more assessable active disclosure than a plain plant-mass claim. Favorable serving economics and a well-defined milk-thistle core create a useful quality-to-cost balance, although the formula remains focused rather than broad.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  3. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  4. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  5. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  6. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  7. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  8. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  9. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle