SuppHelper
search
Home›Supplements›Vitamin›Vitamin B6›Homocysteine Modulators Solgar
Product Image

Homocysteine Modulators

Solgar
4.8
★ ★ ★ ★ ★
(629 ratings)
Product Image
Score 93

A homocysteine-focused formula combining B6 (mixed forms), unspecified folate, Cyanocobalamin B12, and a strong dose of TMG.

How scoring works
scaleQuantity:120 Capsule(s) • (60 servings)
track_changesGoals:

leaderboard Score 93

A homocysteine-focused formula combining B6 (mixed forms), unspecified folate, Cyanocobalamin B12, and a strong dose of TMG.

How scoring works
$16.99($0.28 per serving)
iHerb
$ 16.99
Vitacost
$ 16.99
Amazon
$ 17.99
Pure Formulas
$ 17.99
Daily Vita
$ 19.80
flagReport prices
psychologyAnalysis

Solgar's Homocysteine Modulators is specifically formulated to support healthy homocysteine levels, featuring a blend of Vitamin B6 (both Pyridoxine Hydrochloride and Pyridoxal 5-Phosphate), Folate, Vitamin B12 (Cyanocobalamin), and Trimethylglycine (TMG). The inclusion of TMG at a robust dose of 1000mg, alongside B vitamins, is a strong point for targeting homocysteine metabolism.

However, while it includes some P-5-P, the primary B6 form is Pyridoxine Hydrochloride, and B12 is provided as Cyanocobalamin. These are common forms that require conversion in the body, which might be less efficient for some individuals compared to directly active forms like methylcobalamin or methylfolate. The folate form is also not specified as an active form.

This product is well-suited for individuals looking for a targeted supplement to support cardiovascular health through homocysteine regulation. It offers a solid foundation of B vitamins, but some form choices could be more optimal for maximum bioavailability and impact.

thumb_upPros
  • Contains a significant dose of Trimethylglycine (TMG) for homocysteine support
  • Includes both Pyridoxine HCl and some P-5-P for Vitamin B6
  • Provides a good dose of B vitamins (B6, Folate, B12)
  • Offers a high quantity of servings per bottle (120 capsules, 60 servings)
thumb_downCons
  • Uses Cyanocobalamin for Vitamin B12, which requires conversion
  • Primary Vitamin B6 form is Pyridoxine Hydrochloride, which needs conversion (though P-5-P is also present)
  • Folate form is not specified as an active L-methylfolate
  • Contains calories and some fat, though minimal
warningWarnings
  • Individuals with a history of sensitivity to B vitamins should start with a lower dose if concerned.
  • B vitamins can cause a harmless yellowish discoloration of urine.
  • Consult a healthcare professional if pregnant, nursing, or taking other medications that affect homocysteine levels.
scienceNutrient quality
70 High impact

The nutrient quality is good due to the inclusion of TMG and some P-5-P. However, the use of Pyridoxine HCl for B6 and Cyanocobalamin for B12 means it's not entirely composed of the most bioavailable forms.

visibilityIngredient transparency
90 Highest impact

All ingredients are clearly listed with their quantities and specific forms (where applicable), offering excellent transparency. The folate form is generically listed, which is a minor point.

workspace_premiumValue for money
80 Highest impact

Considering the price per serving, the substantial TMG dose, and the blend of B vitamins, this product offers good value for money, despite not all B vitamin forms being activated.

thumb_upCustomer satisfaction
85 Highest impact

With 621 reviews, the product has a solid track record of customer satisfaction, suggesting that users generally find it effective for their needs.

storefrontBrand
80 Highest impact

Solgar is a well-established and respected brand, known for producing a wide range of supplements with a focus on quality, which lends credibility to the product.

flagReport analysis
track_changesGoals
flagCardiovascular Support
Impact
Highest effect
This product is specifically designed to modulate homocysteine levels, a key factor in maintaining cardiovascular health, making it highly relevant for this goal.
View goal →
flagHeart Health
Impact
Highest effect
The formulation is targeted at healthy homocysteine metabolism, which is a significant factor in maintaining a healthy heart and overall circulatory system.
View goal →
flagHeart Health
Impact
Highest effect
This formula specifically addresses homocysteine, a biomarker for heart health, with a blend of B vitamins and TMG that work together to maintain cardiovascular wellness.
View goal →
flagCardiovascular Support
Impact
Highest effect
With a specific focus on homocysteine modulation through B vitamins and TMG, this product offers very good support for maintaining the health of the heart and blood vessels.
View goal →
flagGeneral Health
Impact
High effect
This formula provides foundational B vitamins and TMG, supporting a wide array of metabolic and cellular functions crucial for general well-being.
View goal →
flagMetabolism Boost
Impact
High effect
B vitamins are essential coenzymes for various metabolic pathways, including energy production and nutrient utilization, supporting an efficient metabolism.
View goal →
flagMetabolism Boost
Impact
High effect
The B vitamins present are integral to the conversion of carbohydrates, fats, and proteins into energy, thereby enhancing metabolic efficiency.
View goal →
flagEnergy
Impact
High effect
B vitamins are indispensable for cellular energy production. This formulation supports metabolic efficiency, which can contribute to overall energy levels.
View goal →
scienceIngredients
IngredientAmount per serving
Calories
5 Calorie(s)
Vitamin B6
50 mg
Folate
666 mcg DFE
Vitamin B12
500 mcg
Trimethylglycine
1000 mg
Pyridoxal 5-Phosphate
6 mg
grain_off Gluten Free person Adults 18–50 eco Vegan Kosher free_breakfast Dairy Free Sugar Free eco Vegetarian
flagReport overview
Vitamin B6 75
It contains both Pyridoxine Hydrochloride and Pyridoxal 5-Phosphate (P-5-P). While P-5-P is excellent, the presence of Pyridoxine HCl means it's not exclusively using the active form.
scienceView ingredientinventory_2View products
Vitamin B12 60
The product uses Cyanocobalamin, a common but less active form of Vitamin B12, requiring conversion in the body for utilization. This is less optimal than active forms like methylcobalamin.
scienceView ingredientinventory_2View products
inventory_2Alternative products
92 Value

Fully Active B Complex with Quatrefolic

Doctor's Best
4.7
★★★★★
(23057 ratings)
Offers a superior full B-complex with highly active forms of B6, Folate, and B12 for a price per serving that is very competitive with the original, providing significantly more comprehensive benefits for the cost.
Other sellers (2)
78 Value

Dopamine Brain Food

NS Natural Stacks
4.5
★★★★★
(441 ratings)
While pricier, this alternative includes active B vitamins and TMG similar to your product, plus amino acids for targeted mood and mental focus support, offering unique value for those specific goals.
Other sellers (0)
85 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
4.8
★★★★★
(14578 ratings)
If the active B12 is a core interest for homocysteine support, this offers a good dose of Methylcobalamin at a very attractive price point, representing excellent value for high-quality B12.
Other sellers (3)
92 Performance

HomocysteX Plus

Seeking Health
4.8
★★★★★
(2120 ratings)
Features superior, active forms of B vitamins (P5P B6, Quatrefolic Folate, MecobalActive B12) and TMG, offering a highly bioavailable and targeted solution for comprehensive homocysteine support.
Other sellers (2)
92 Performance

Fully Active B Complex with Quatrefolic

Doctor's Best
4.7
★★★★★
(23057 ratings)
This comprehensive B-complex provides active forms of B6 (P5P), Folate (Quatrefolic), and B12 (Methylcobalamin), which are all excellent for homocysteine metabolism and offer broad support for energy and brain health.
Other sellers (2)
93 Performance

PureGenomics B-Complex

Pure Encapsulations
4.9
★★★★★
(17 ratings)
A premium, full-spectrum B-complex that delivers a wide array of highly active and well-utilized B vitamin forms, providing superior support for metabolism, nerve function, and overall vitality.
Other sellers (0)
70 Budget

Folic Acid B6 & B12

Mason Natural
4.8
★★★★★
(2742 ratings)
Provides a basic yet effective blend of B6, Folate, and B12 that can contribute to homocysteine management and general well-being, at a significantly more budget-friendly price.
Other sellers (1)
60 Budget

Tri-B

Carlson
4.8
★★★★★
(1185 ratings)
Offers a foundational combination of B6, Folate, and B12 essential for various metabolic functions, including homocysteine conversion, at a much lower cost per serving.
Other sellers (0)
60 Budget

Homocysteine Defense

Source Naturals
4.6
★★★★★
(3678 ratings)
This alternative closely mirrors the original's profile with B6, Folate, B12, and a high dose of TMG, specifically targeting homocysteine support, but at a more economical price.
Other sellers (3)
92 Value

Fully Active B Complex with Quatrefolic

Doctor's Best
4.7
★★★★★
(23057 ratings)
Offers a superior full B-complex with highly active forms of B6, Folate, and B12 for a price per serving that is very competitive with the original, providing significantly more comprehensive benefits for the cost.
Other sellers (2)
78 Value

Dopamine Brain Food

NS Natural Stacks
4.5
★★★★★
(441 ratings)
While pricier, this alternative includes active B vitamins and TMG similar to your product, plus amino acids for targeted mood and mental focus support, offering unique value for those specific goals.
Other sellers (0)
85 Value

Sublingual Methylcobalamin 1000 mcg

Solgar
4.8
★★★★★
(14578 ratings)
If the active B12 is a core interest for homocysteine support, this offers a good dose of Methylcobalamin at a very attractive price point, representing excellent value for high-quality B12.
Other sellers (3)
92 Performance

HomocysteX Plus

Seeking Health
4.8
★★★★★
(2120 ratings)
Features superior, active forms of B vitamins (P5P B6, Quatrefolic Folate, MecobalActive B12) and TMG, offering a highly bioavailable and targeted solution for comprehensive homocysteine support.
Other sellers (2)
92 Performance

Fully Active B Complex with Quatrefolic

Doctor's Best
4.7
★★★★★
(23057 ratings)
This comprehensive B-complex provides active forms of B6 (P5P), Folate (Quatrefolic), and B12 (Methylcobalamin), which are all excellent for homocysteine metabolism and offer broad support for energy and brain health.
Other sellers (2)
93 Performance

PureGenomics B-Complex

Pure Encapsulations
4.9
★★★★★
(17 ratings)
A premium, full-spectrum B-complex that delivers a wide array of highly active and well-utilized B vitamin forms, providing superior support for metabolism, nerve function, and overall vitality.
Other sellers (0)
flagReport alternatives

SuppHelper

Compare supplements smarter. Science-backed, user-rated, updated daily.

Explore

  • Compare Supplements
  • Health Goals
  • Stacks

Legal

  • Privacy Policy
  • Terms of Use
  • Medical Disclaimer

Stay in the Loop

Medical disclaimer: Information on SuppHelper is for educational purposes only and is not medical advice. Statements on this site about dietary supplements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before using supplements. Read full disclaimer

© 2025 SuppHelper. All rights reserved.