Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- The effects of L-theanine consumption on sleep outcomes: A systematic review and meta-analysis.
Bulman A; D'Cunha NM; Marx W; Turner M; McKune A; Naumovski N · Sleep medicine reviews · 2025
Meta-analysis897 participants19 studies pooledflagSleep Support forscienceTheanine
- Comparison Between Efficacy of Oral Melatonin and Oral L-theanine in Improving Sleep in Cancer Patients Suffering From Insomnia: A Randomised Double-blinded Placebo-controlled Study.
Kurdi MS; As A; Ladhad DA; Mitragotri MV; Baiju A · Indian journal of palliative care · 2024
Randomized trial120 participantsflagSleep Support forscienceTheanine
- Current Evidence on Common Dietary Supplements for Sleep Quality.
Esquivel MK; Ghosn B · American journal of lifestyle medicine · 2025
Narrative reviewflagSleep Support forscienceTheanine
- In Search of a Safe Natural Sleep Aid.
Rao TP; Ozeki M; Juneja LR · Journal of the American College of Nutrition · 2016
Narrative reviewflagSleep Support forscienceTheanine
- Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
Randomized trial30 participantsflagSleep Support flagBrain Health flagCognitive Support forscienceTheanine
- The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
Williams JL; Everett JM; D'Cunha NM; Sergi D; Georgousopoulou EN; Keegan RJ; McKune AJ; Mellor DD; Anstice N; Naumovski N · Plant foods for human nutrition (Dordrecht, Netherlands) · 2020
Systematic review9 studies pooledflagStress Relief flagMood Support forscienceTheanine
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
Randomized trialflagStress Relief flagBrain Health forscienceTheanine
- Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.
White DJ; de Klerk S; Woods W; Gondalia S; Noonan C; Scholey AB · Nutrients · 2016
Randomized trial34 participantsflagStress Relief forscienceTheanine
- L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.
Sarris J; Byrne GJ; Cribb L; Oliver G; Murphy J; Macdonald P; Nazareth S; Karamacoska D; Galea S; Short A; Ee C; Birling Y; Menon R; Ng CH · Journal of psychiatric research · 2020
Randomized trial46 participantsflagStress Relief flagSleep Support forscienceTheanine
- Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.
Furushima D; Sugiyama I; Nomura Y; Unno K; Yamada H · Journal of nutritional science and vitaminology · 2023
Randomized trial120 participantsflagStress Relief forscienceTheanine
- Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
Mátyus RO; Szikora Z; Bodó D; Vargáné Szabó B; Csupor É; Csupor D; Tóth B · Journal of clinical medicine · 2025
Meta-analysis148 participants5 studies pooledflagMental Focus forscienceTheanine
- Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
Clinical trial20 participantsflagMental Focus flagCognitive Support forscienceTheanine
- L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study.
Dassanayake TL; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2022
Randomized trial27 participantsflagMental Focus forscienceTheanine
- Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
Randomized trial32 participantsflagMental Focus flagCognitive Support forscienceTheanine
- Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.
Rogers PJ; Smith JE; Heatherley SV; Pleydell-Pearce CW · Psychopharmacology · 2008
Randomized trial48 participantsflagMental Focus flagProductivity Boost forscienceTheanine
- Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
Meta-analysis50 studies pooledflagBrain Health flagCognitive Support flagMental Focus forscienceTheanine
- Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
Randomized trial27 participantsflagBrain Health flagCognitive Support forscienceTheanine
- Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
Randomized trialflagBrain Health flagMental Focus flagProductivity Boost forscienceTheanine
- Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
Meta-analysis21 studies pooledflagBrain Health forscienceVitamin B6
- Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
Cross-sectional study266 participantsflagBrain Health forscienceVitamin B6
- A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
Randomized trial180 participantsflagBrain Health forscienceVitamin B6
- Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
Cohort study949 participantsflagBrain Health flagCognitive Support forscienceVitamin B6
- Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
Scoping review12 studies pooledflagBrain Health forscienceVitamin B6
- Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
Randomized trial200 participantsflagCognitive Support forscienceVitamin B6
- Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
Cross-sectional study2,716 participantsflagCognitive Support forscienceVitamin B6
- Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
Cohort study926 participantsflagCognitive Support forscienceVitamin B6
- Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
Observational study4,553 participantsflagCognitive Support forscienceVitamin B6
- Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
Randomized trial30 participantsflagMental Focus flagProductivity Boost flagStress Relief forscienceTheanine
- Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
Randomized trial24 participantsflagMental Focus forscienceTheanine
- Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort.
Deijen JB; van der Beek EJ; Orlebeke JF; van den Berg H · Psychopharmacology · 1995
Randomized trial76 participantsflagMental Focus forscienceVitamin B6
- The effect of vitamin B6 on cognition.
Malouf R; Grimley Evans J · The Cochrane database of systematic reviews · 2004
Systematic review109 participants2 studies pooledflagMental Focus forscienceVitamin B6
- Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.
Cho Y; Choi EY; Han JY; Kim H; Choe YJ; Shin JY · BMC medicine · 2025
Cohort study630,904 participantsflagMental Focus forscienceVitamin B6
- A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
Randomized trial44 participantsflagMental Focus flagProductivity Boost forscienceVitamin B6
- B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial
Tammy M Scott, Graham Rogers, Daniel E Weiner, Kathryn Livingston, Jacob Selhub, Paul F Jacques, Irwin H Rosenberg, Aron M Troen · The Journal of Prevention of Alzheimer's Disease · 2017
Randomized trial584 participantsflagMental Focus forscienceVitamin B6
- l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
Randomized trial60 participantsflagMood Support forscienceTheanine
- L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.
Ritsner MS; Miodownik C; Ratner Y; Shleifer T; Mar M; Pintov L; Lerner V · The Journal of clinical psychiatry · 2011
Randomized trial60 participantsflagMood Support flagStress Relief forscienceTheanine
- Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study.
Deshpande SS; Kurdi M; Baiju A; Athira AS; Sarasamma AG; Gangadharan AK · Journal of anaesthesiology, clinical pharmacology · 2025
Randomized trial168 participantsflagMood Support flagStress Relief forscienceTheanine
- Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress.
Unno K; Tanida N; Ishii N; Yamamoto H; Iguchi K; Hoshino M; Takeda A; Ozawa H; Ohkubo T; Juneja LR; Yamada H · Pharmacology, biochemistry, and behavior · 2014
Randomized trial20 participantsflagMood Support forscienceTheanine
- High Dose Vitamin B6 Reduces Depression Symptoms.
Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
Randomized trial267 participantsflagMood Support forscienceVitamin B6
- Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
Randomized trial81 participantsflagMood Support flagStress Relief forscienceVitamin B6
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
Cross-sectional study24,683 participantsflagMood Support forscienceVitamin B6
- Associations of dietary B vitamins intakes with depression in adults.
Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
Observational study17,732 participantsflagMood Support forscienceVitamin B6
- Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
Cohort study88 participantsflagMood Support forscienceVitamin B6
- Cognitive and affective effects of L-Theanine: a systematic review and meta-analysis of 31 randomized trials.
Gerolymos C; Saddier E; Boyer L; Fond G · Molecular psychiatry · 2026
Meta-analysis1,168 participants31 studies pooledflagProductivity Boost forscienceTheanine
- Effects of L-theanine on cognition, mood and sleep: evidence from human trials.
Cotter J; Kilpatrick HE · Frontiers in nutrition · 2026
Narrative reviewflagProductivity Boost forscienceTheanine
- Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011-2014.
Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
Cross-sectional study2,421 participantsflagProductivity Boost forscienceVitamin B6
- Effect of megavitamin treatment on mental performance and plasma vitamin B6 concentrations in mentally retarded young adults.
Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
Non-randomized trialflagProductivity Boost forscienceVitamin B6
- Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
Cohort studyflagProductivity Boost forscienceVitamin B6
- Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
Case-control study49 participantsflagProductivity Boost forscienceVitamin B6
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
Randomized trial66 participantsflagSleep Support forscienceVitamin B6
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
Randomized trial75 participantsflagSleep Support forscienceVitamin B6
- Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
García-García C; Baik I · Nutrition research and practice · 2022
Randomized trial47 participantsflagSleep Support forscienceVitamin B6
- Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
Randomized trial100 participantsflagSleep Support forscienceVitamin B6
- The effect of pyridoxine administration on melatonin secretion in normal men.
Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
Randomized trial12 participantsflagSleep Support forscienceVitamin B6
- Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Noah L; Dye L; Bois De Fer B; Mazur A; Pickering G; Pouteau E · Stress and health : journal of the International Society for the Investigation of Stress · 2021
Randomized trialflagStress Relief forscienceVitamin B6
- RENAL PROTECTIVE EFFECT AND CLINICAL ANALYSIS OF VITAMIN B 6 IN PATIENTS WITH SEPSIS.
Wang Y; Lu WL; Feng WM; Xu W; Liu LH; He LM · Shock (Augusta, Ga.) · 2024
Randomized trial128 participantsflagStress Relief forscienceVitamin B6
- Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
Pouteau E; Kabir-Ahmadi M; Noah L; Mazur A; Dye L; Hellhammer J; Pickering G; Dubray C · PloS one · 2019
Randomized trial264 participantsflagStress Relief forscienceVitamin B6
- Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.
Mozaffari H; Darooghegi Mofrad M; Surkan PJ; Askari M; Azadbakht L · Public health nutrition · 2021
Cross-sectional study447 participantsflagStress Relief forscienceVitamin B6