Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study.
Malaguarnera M; Vacante M; Giordano M; Pennisi G; Bella R; Rampello L; Malaguarnera M; Li Volti G; Galvano F · The American journal of clinical nutrition · 2011
Randomized trial121 participantsflagEnergy forscienceAcetyl L-Carnitine
- Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study.
Ledinek AH; Sajko MC; Rot U · Clinical neurology and neurosurgery · 2014
Randomized trial60 participantsflagEnergy forscienceAcetyl L-Carnitine
- The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-α 2b plus ribavirin.
Malaguarnera M; Vacante M; Bertino G; Neri S; Malaguarnera M; Gargante MP; Motta M; Lupo L; Chisari G; Bruno CM; Pennisi G; Bella R · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012
Randomized trial60 participantsflagEnergy forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine in the treatment of mildly demented elderly patients.
Passeri M; Cucinotta D; Bonati PA; Iannuccelli M; Parnetti L; Senin U · International journal of clinical pharmacology research · 1990
Randomized trial60 participantsflagMental Focus flagBrain Health forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial.
Arnold LE; Amato A; Bozzolo H; Hollway J; Cook A; Ramadan Y; Crowl L; Zhang D; Thompson S; Testa G; Kliewer V; Wigal T; McBurnett K; Manos M · Journal of child and adolescent psychopharmacology · 2008
Randomized trial112 participantsflagMental Focus forscienceAcetyl L-Carnitine
- [Psycho-functional changes in attention and learning under the action of L-acetylcarnitine in 17 young subjects. A pilot study of its use in mental deterioration].
Lino A; Boccia MM; Rusconi AC; Bellomonte L; Cocuroccia B · La Clinica terapeutica · 1992
Non-randomized trial17 participantsflagMental Focus forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine treatment in minimal hepatic encephalopathy.
Malaguarnera M; Gargante MP; Cristaldi E; Vacante M; Risino C; Cammalleri L; Pennisi G; Rampello L · Digestive diseases and sciences · 2008
Randomized trial125 participantsflagCognitive Support flagBrain Health forscienceAcetyl L-Carnitine
- A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.
Thal LJ; Calvani M; Amato A; Carta A · Neurology · 2000
Randomized trial229 participantsflagCognitive Support forscienceAcetyl L-Carnitine
- Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach.
Brooks JO; Yesavage JA; Carta A; Bravi D · International psychogeriatrics · 1998
Randomized trial334 participantsflagCognitive Support forscienceAcetyl L-Carnitine
- Low Bioavailability and High TMAO Production: Novel Insights Into Acetylcarnitine and Carnitine Metabolism.
Krims-Davis K; Ozola M; Razzivina V; Gukalova B; Konrade I; Dambrova M; Liepinsh E · Molecular nutrition & food research · 2025
Randomized trialflagMetabolism Boost forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
Malaguarnera G; Catania VE; Bertino G; Chisari LM; Castorina M; Bonfiglio C; Cauli O; Malaguarnera M · Current pharmaceutical design · 2022
Randomized trial92 participantsflagAnti-Aging forscienceAcetyl L-Carnitine
- Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
Spagnoli A; Lucca U; Menasce G; Bandera L; Cizza G; Forloni G; Tettamanti M; Frattura L; Tiraboschi P; Comelli M · Neurology · 1991
Randomized trial130 participantsflagBrain Health flagCognitive Support forscienceAcetyl L-Carnitine
- Pharmaco-electroencephalographic and clinical effects of the cholinergic substance--acetyl-L-carnitine--in patients with organic brain syndrome.
Herrmann WM; Dietrich B; Hiersemenzel R · International journal of clinical pharmacology research · 1990
Randomized trialflagBrain Health forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial.
Malaguarnera M; Vacante M; Motta M; Giordano M; Malaguarnera G; Bella R; Nunnari G; Rampello L; Pennisi G · Metabolic brain disease · 2012
Randomized trial61 participantsflagBrain Health flagCognitive Support forscienceAcetyl L-Carnitine
- Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
Meta-analysis21 studies pooledflagBrain Health forscienceVitamin B6
- Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
Cross-sectional study266 participantsflagBrain Health forscienceVitamin B6
- A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
Randomized trial180 participantsflagBrain Health forscienceVitamin B6
- Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
Cohort study949 participantsflagBrain Health flagCognitive Support forscienceVitamin B6
- Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
Scoping review12 studies pooledflagBrain Health forscienceVitamin B6
- A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys.
Torrioli MG; Vernacotola S; Peruzzi L; Tabolacci E; Mila M; Militerni R; Musumeci S; Ramos FJ; Frontera M; Sorge G; Marzullo E; Romeo G; Vallee L; Veneselli E; Cocchi E; Garbarino E; Moscato U; Chiurazzi P; D'Iddio S; Calvani M; Neri G · American journal of medical genetics. Part A · 2008
Randomized trial63 participantsflagCognitive Support forscienceAcetyl L-Carnitine
- Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue.
Malaguarnera M; Gargante MP; Cristaldi E; Colonna V; Messano M; Koverech A; Neri S; Vacante M; Cammalleri L; Motta M · Archives of gerontology and geriatrics · 2008
Randomized trial96 participantsflagCognitive Support forscienceAcetyl L-Carnitine
- Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.
Zhuo C; Xu Y; Wang H; Fang T; Chen J; Zhou C; Li Q; Liu J; Xu S; Yao C; Yang W; Yang A; Li B; Chen Y; Tian H; Lin C · Frontiers in psychiatry · 2021
Randomized trial200 participantsflagCognitive Support forscienceVitamin B6
- Associations between dietary B vitamin intakes and cognitive function among elderly individuals: An observational study.
Chen Q; Huang J; Shi X; Peng Y; Chen A; Huang L; Zhang Y; Chen X · Nutrition (Burbank, Los Angeles County, Calif.) · 2025
Cross-sectional study2,716 participantsflagCognitive Support forscienceVitamin B6
- Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.
Zhang C; Hu Y; Cao X; Deng Y; Wang Y; Guan M; Wu X; Jiang H · Scientific reports · 2025
Cohort study926 participantsflagCognitive Support forscienceVitamin B6
- Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction.
Gordon S; Hoey L; McNulty H; Keenan J; Pangilinan F; Brody LC; Ward M; Strain JJ; McAnena L; McCann A; Molloy AM; Cunningham C; McCarroll K; Hughes CF · BMC medicine · 2025
Observational study4,553 participantsflagCognitive Support forscienceVitamin B6
- Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy.
Malaguarnera M; Bella R; Vacante M; Giordano M; Malaguarnera G; Gargante MP; Motta M; Mistretta A; Rampello L; Pennisi G · Scandinavian journal of gastroenterology · 2011
Randomized trial67 participantsflagEnergy forscienceAcetyl L-Carnitine
- A prospective study to evaluate the efficacy and safety of oral acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy.
Sun Y; Shu Y; Liu B; Liu P; Wu C; Zheng R; Zhang X; Zhuang Z; Deng Y; Zheng L; Xu Q; Jiang B; Ouyang X; Gao J; Xu N; Li X; Jiang S; Liang C; Yao Y · Experimental and therapeutic medicine · 2020
Randomized trial239 participantsflagEnergy forscienceAcetyl L-Carnitine
- Metabolomic biomarkers for (R, S)-ketamine and (S)-ketamine in treatment-resistant depression and healthy controls: A systematic review.
Kumar R; Nuñez NA; Joshi N; Joseph B; Verde A; Seshadri A; Cuellar Barboza AB; Prokop LJ; Medeiros GC; Singh B · Bipolar disorders · 2024
Systematic reviewflagEnergy forscienceAcetyl L-Carnitine
- Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial.
Malaguarnera G; Pennisi M; Gagliano C; Vacante M; Malaguarnera M; Salomone S; Drago F; Bertino G; Caraci F; Nunnari G; Malaguarnera M · Hepatitis monthly · 2014
Randomized trial62 participantsflagMental Focus flagProductivity Boost forscienceAcetyl L-Carnitine
- Acetyl-L-carnitine for patients with hepatic encephalopathy.
Martí-Carvajal AJ; Gluud C; Arevalo-Rodriguez I; Martí-Amarista CE · The Cochrane database of systematic reviews · 2019
Meta-analysis398 participants5 studies pooledflagMental Focus forscienceAcetyl L-Carnitine
- Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
Bor MV; Refsum H; Bisp MR; Bleie Ø; Schneede J; Nordrehaug JE; Ueland PM; Nygard OK; Nexø E · Clinical chemistry · 2003
Randomized trial90 participantsflagMetabolism Boost forscienceVitamin B6
- Dietary one-carbon metabolism nutrients and risk of MASLD progression: a prospective cohort study.
Shen L; Wang K; Li R; Li Y; Guo Y; Li F; Yuan J; Yang Z; Xia B; Lin X · European journal of clinical nutrition · 2026
Cohort study46,800 participantsflagMetabolism Boost forscienceVitamin B6
- Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004.
Kim H; Enrione EB; Narayanan V; Li T; Campa A · Nutrients · 2022
Cross-sectional study461 participantsflagMetabolism Boost forscienceVitamin B6
- Influence of oral contraceptives, pyridoxine (vitamin B6), and tryptophan on carbohydrate metabolism.
Adams PW; Wynn V; Folkard J; Seed M · Lancet (London, England) · 1976
Clinical trial46 participantsflagMetabolism Boost forscienceVitamin B6
- Effect of oral contraceptives and vitamin B6 deficiency on carbohydrate metabolism.
Rose DP; Leklem JE; Brown RR; Linkswiler HM · The American journal of clinical nutrition · 1975
Clinical trialflagMetabolism Boost forscienceVitamin B6
- Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011-2014.
Xu H; Wang S; Gao F; Li C · Neuropsychiatric disease and treatment · 2022
Cross-sectional study2,421 participantsflagProductivity Boost forscienceVitamin B6
- Effect of megavitamin treatment on mental performance and plasma vitamin B6 concentrations in mentally retarded young adults.
Coburn SP; Schaltenbrand WE; Mahuren JD; Clausman RJ; Townsend D · The American journal of clinical nutrition · 1983
Non-randomized trialflagProductivity Boost forscienceVitamin B6
- Identifying Key Predictors of Cognitive Dysfunction in Older People Using Supervised Machine Learning Techniques: Observational Study.
Rankin D; Black M; Flanagan B; Hughes CF; Moore A; Hoey L; Wallace J; Gill C; Carlin P; Molloy AM; Cunningham C; McNulty H · JMIR medical informatics · 2024
Cohort studyflagProductivity Boost forscienceVitamin B6
- Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression.
Guligowska A; Pigłowska M; Fife E; Kostka J; Sołtysik BK; Kroc Ł; Kostka T · Clinical interventions in aging · 2017
Case-control study49 participantsflagProductivity Boost forscienceVitamin B6
- A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.
Anlacan VM; Jamora RDG; Krattinger LF; De Longis E; Hartweg M; Steinmann M; Trovò L · Frontiers in nutrition · 2026
Randomized trial44 participantsflagProductivity Boost forscienceVitamin B6